Journal of frailty, sarcopenia and falls最新文献_第4页

A Narrative Review of the Utilisation of the SHARE Frailty Instruments (SHARE-FI and SHARE-FI75+) in the Literature. 文献中SHARE脆弱性工具(SHARE- fi和SHARE- fi75 +)使用情况的叙述性回顾。

Journal of frailty, sarcopenia and falls Pub Date : 2023-12-01 DOI: 10.22540/JFSF-08-221

Helen Doherty, Aurora Higgins Jennings, Matej Kocka, Auriane Neichel, Juliette Scauso, Elena Lionetti, Chenhui Chenhuichen, Roman Romero-Ortuno

{"title":"A Narrative Review of the Utilisation of the SHARE Frailty Instruments (SHARE-FI and SHARE-FI75+) in the Literature.","authors":"Helen Doherty, Aurora Higgins Jennings, Matej Kocka, Auriane Neichel, Juliette Scauso, Elena Lionetti, Chenhui Chenhuichen, Roman Romero-Ortuno","doi":"10.22540/JFSF-08-221","DOIUrl":"10.22540/JFSF-08-221","url":null,"abstract":"This narrative literature review aimed to examine the utilisation of the Survey of Health, Ageing and Retirement in Europe (SHARE) frailty instruments: SHARE-FI and SHARE-FI75+. We used the Google Scholar \"cited by\" function (accessed on February 20th, 2023) to identify all citations of the original SHARE-FI and SHARE-FI75+ studies. Included articles were categorised into four themes: epidemiological studies (prevalence and associated factors); associations with geriatric syndromes, diseases and health outcomes; randomised clinical trials (RCTs); and expert consensus and practice guidelines. Of 529 articles screened (446 citing SHARE-FI and 83 citing SHARE-FI75+), 64 (12.1%) were included. Sixteen (25.0%) were epidemiological; 35 (54.7%) described associations; 10 (15.6%) were RCTs; and 3 (4.7%) were expert consensus or practice guidelines. Frailty was associated with older age; female sex; higher morbidity; lower education; social isolation; worse nutrition and mobility; rheumatological, cardiovascular, and endocrine diseases; and greater healthcare utilisation and mortality. SHARE-FI was used in RCTs as entry criterion, controlling variable, and intervention outcome. SHARE-FI and SHARE-FI75+ have been recommended to aid the management of atrial fibrillation anticoagulation and hypertension, respectively. SHARE-FI and SHARE-FI75+, two open access phenotypical frailty measurement tools, have been utilised for a range of purposes, and mostly in epidemiological/associational studies.","PeriodicalId":73754,"journal":{"name":"Journal of frailty, sarcopenia and falls","volume":"8 4","pages":"221-229"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138479728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why are older adults living with the complexity of multiple long-term conditions, frailty and a recent deterioration in health under-served by research? A narrative synthesis review of the literature. 为什么生活在多种长期疾病、身体虚弱和最近健康状况恶化的复杂环境中的老年人得不到研究的关注?一篇文献综述。

Journal of frailty, sarcopenia and falls Pub Date : 2023-12-01 DOI: 10.22540/JFSF-08-230

Lorelle Dismore, Christopher Hurst, Antoneta Granic, Ellen Tullo, Miles D Witham, Richard M Dodds, Avan A Sayer, Sian M Robinson

{"title":"Why are older adults living with the complexity of multiple long-term conditions, frailty and a recent deterioration in health under-served by research? A narrative synthesis review of the literature.","authors":"Lorelle Dismore, Christopher Hurst, Antoneta Granic, Ellen Tullo, Miles D Witham, Richard M Dodds, Avan A Sayer, Sian M Robinson","doi":"10.22540/JFSF-08-230","DOIUrl":"10.22540/JFSF-08-230","url":null,"abstract":"Older adults living with the complexity of multiple long-term conditions (MLTC), frailty and a recent deterioration in health are under-served by research. As a result, current treatment guidelines are often based on data from studies of younger and less frail participants, and often single disease focused. The aims of this review were (i) to identify why older adults living with the complexity of MLTC, frailty and a recent deterioration in health are under-served by research and (ii) to identify strategies for increasing their recruitment and retention. Although a range of factors have been suggested to affect the participation of older adults with MLTC and frailty in research, this review shows that much less is known about the inclusion of older adults living with the complexity of MLTC, frailty and a recent deterioration in health. Researchers should focus on strategies that minimise participation burden for these patients, maintaining an adaptive and flexible approach, to increase their recruitment and retention. Future research should include qualitative interviews to provide further insights into how best to design and conduct research to suit the needs of this population group.","PeriodicalId":73754,"journal":{"name":"Journal of frailty, sarcopenia and falls","volume":"8 4","pages":"230-239"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138479692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Turkish version of the SHARE-Frailty Instrument for primary care: reliability and validity in the nursing home setting. 土耳其版初级保健share -脆弱量表:养老院环境中的信度和效度。

Journal of frailty, sarcopenia and falls Pub Date : 2023-09-01 DOI: 10.22540/JFSF-08-195

Gülendam Hakverdioğlu Yönt, Román Romero Ortuño, Fisun Şenuzun Aykar, Duygu İlbay

{"title":"Turkish version of the SHARE-Frailty Instrument for primary care: reliability and validity in the nursing home setting.","authors":"Gülendam Hakverdioğlu Yönt, Román Romero Ortuño, Fisun Şenuzun Aykar, Duygu İlbay","doi":"10.22540/JFSF-08-195","DOIUrl":"https://doi.org/10.22540/JFSF-08-195","url":null,"abstract":"In Turkey, physical frailty instruments have not been studied in the nursing home setting. We determined the reliability and validity of a Turkish version of the SHARE-Frailty Instrument for primary care (SHARE-FI) in Turkish nursing home residents. Cronbach's alpha reliability analysis was performed to determine internal consistency. Factor analysis was conducted to explore construct validity. Concurrent validity was assessed by correlation with the Care Dependency Scale (CDS). One hundred and fifty-one residents were included (mean age 73 years, 41% women). Fifty (33.1%) were identified as non-frail, 49 (32.5%) as pre-frail, and 52 (34.4%) as frail by SHARE-FI. The overall Cronbach's alpha coefficient was 0.81. Factor analysis identified two components accounting for 69% of the variance, with the first and most important component being handgrip strength. SHARE-FI groups were significantly correlated with CDS scores (p<0.05). The Turkish version of SHARE-FI had good reliability and validity in a nursing home setting.","PeriodicalId":73754,"journal":{"name":"Journal of frailty, sarcopenia and falls","volume":"8 3","pages":"195-199"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f4/55/JFSF-8-195.PMC10472041.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10143346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does stretching of anterior structures alone, or in combination with strengthening of posterior structures, decrease hyperkyphosis and improve posture in adults? A Systematic Review and Meta-analysis. 单独拉伸前部结构，或联合加强后部结构，是否能减轻成人后凸过度并改善姿势?系统回顾和荟萃分析。

Journal of frailty, sarcopenia and falls Pub Date : 2023-09-01 DOI: 10.22540/JFSF-08-174

Rebecca A Withers, C Ryanne Plesh, Dawn A Skelton

{"title":"Does stretching of anterior structures alone, or in combination with strengthening of posterior structures, decrease hyperkyphosis and improve posture in adults? A Systematic Review and Meta-analysis.","authors":"Rebecca A Withers, C Ryanne Plesh, Dawn A Skelton","doi":"10.22540/JFSF-08-174","DOIUrl":"https://doi.org/10.22540/JFSF-08-174","url":null,"abstract":"Kyphosis can lead to back pain, poor posture, and increased falls risk. This systematic review aimed to synthesize research on stretching alone, or in combination with strengthening, as a management for hyperkyphosis in the adult population (≥18 years old). An electronic database search was conducted from February to March 2022. The author and an independent reviewer screened titles and abstracts for inclusion criteria - those whose intervention involved stretching alone or with strengthening exercises. The author appraised and extracted data from included articles and performed a meta-analysis where appropriate. The database and citation search yielded 327 articles, 18 of which met inclusion criteria. One study included performed stretching as a standalone intervention; the remainder used a combination of stretching and strengthening. The meta-analysis (n=3, with 5 exercise groups) found a statistically significant difference (MD = -6.97 (95% CI -9.84, -4.10), p<0.00001) in post-intervention measures of hyperkyphosis favouring the exercise group. The narrative review of studies agrees with this finding, demonstrating statistically significant improvement in hyperkyphosis following various exercise programs. This review suggests that stretching and strengthening exercises improve hyperkyphosis in the short and long term. Low-quality evidence supports stretching as a standalone intervention. Further, more robust research is required to recommend procedures and determine if stretching alone is effective for treating hyperkyphosis in adults.","PeriodicalId":73754,"journal":{"name":"Journal of frailty, sarcopenia and falls","volume":"8 3","pages":"174-187"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/08/5f/JFSF-8-174.PMC10472040.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10143351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Superimposed electromyostimulation of the thigh muscles during passive isokinetic cycling increases muscle strength without effort. 在被动等速循环中，大腿肌肉的叠加肌电刺激可以不费力地增加肌肉力量。

Journal of frailty, sarcopenia and falls Pub Date : 2023-09-01 DOI: 10.22540/JFSF-08-163

Kazuyuki Ogiso, Takuto Horasawa

{"title":"Superimposed electromyostimulation of the thigh muscles during passive isokinetic cycling increases muscle strength without effort.","authors":"Kazuyuki Ogiso, Takuto Horasawa","doi":"10.22540/JFSF-08-163","DOIUrl":"https://doi.org/10.22540/JFSF-08-163","url":null,"abstract":"Objectives: This study was designed to investigate the effects of a completely passive isokinetic cycle (PIC) exercise with electromyostimulation (EMS) on improving muscle strength and the changes in kinesthesia during daily activities.Methods: Twenty-nine sedentary females were divided into three groups. The EMS anterior and whole groups performed the PIC exercise without EMS 3 times a week for 3 weeks, followed by a 1-week break, and then performed it with EMS applied to the anterior and entire thigh muscles, respectively, 3 times a week for 3 weeks. The control group did not perform any training.Results: The PIC exercise with EMS significantly increased the 30s chair stand test scores by 12-16% and the maximum isometric knee extension and flexion torques by 38-68% in both EMS-applied groups. The participants found its exercise easy and felt more comfortable with daily physical activities. The exercise without EMS did not show similar improvements. Muscle soreness was significantly greater in the EMS anterior group than in the EMS whole group; however, it was not severe.Conclusions: The PIC exercise with EMS resulted in significant increases in muscle strength, facilitating a perceived ease of daily physical activities, while minimizing difficulties, effort, and notable muscle soreness.","PeriodicalId":73754,"journal":{"name":"Journal of frailty, sarcopenia and falls","volume":"8 3","pages":"163-173"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e2/a6/JFSF-8-163.PMC10472036.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10149869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resistance Training in Post-COVID Recovery: Rationale and Current Evidence. 抗阻训练在covid - 19后恢复:基本原理和当前证据。

Journal of frailty, sarcopenia and falls Pub Date : 2023-09-01 DOI: 10.22540/JFSF-08-188

George Mills, Enya Daynes, Hamish J C McAuley, Neil J Greening, Samuel Briggs-Price, Molly M Baldwin, Sally J Singh

{"title":"Resistance Training in Post-COVID Recovery: Rationale and Current Evidence.","authors":"George Mills, Enya Daynes, Hamish J C McAuley, Neil J Greening, Samuel Briggs-Price, Molly M Baldwin, Sally J Singh","doi":"10.22540/JFSF-08-188","DOIUrl":"https://doi.org/10.22540/JFSF-08-188","url":null,"abstract":"During hospitalisation with COVID-19, individuals may experience prolonged periods of immobilisation. Combined with the inflammatory effects of the virus, this may lead to a significant reduction in both muscle mass and strength. Data from several long-term studies suggest that these symptoms may not fully resolve within one year. Owing to its effectiveness at inducing muscle fibre hypertrophy and improving neuromuscular efficiency, resistance training is of great interest in the rehabilitation of this population. This narrative review aims to identify the rationale and potential efficacy of resistance training for restoring physical function following infection with SARS-CoV-2, as well as evidence of its use in clinical practice. The studies included in this narrative review consisted mostly of multi-component rehabilitation trials. Of these, widespread improvements in muscle strength were reported using intensities of up to 80% of participants' 1-repetition-maximum. Evidence thus far indicates that resistance training may be safe and effective in patients following COVID-19, although its individual contribution is difficult to discern. Future exercise intervention studies investigating the efficacy of resistance training as a sole modality are needed.","PeriodicalId":73754,"journal":{"name":"Journal of frailty, sarcopenia and falls","volume":"8 3","pages":"188-194"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e7/b7/JFSF-8-188.PMC10472035.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10143348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between quadriceps femoris thickness measured by US and femoral cartilage thickness in knee osteoarthritis, its effect on radiographic stage and clinical parameters: comparison with healthy young population. 膝关节骨性关节炎患者股骨股四头肌厚度与股骨软骨厚度的关系及其对x线分期和临床参数的影响:与健康青年人群的比较

Journal of frailty, sarcopenia and falls Pub Date : 2023-09-01 DOI: 10.22540/JFSF-08-155

Ahmet Bozan, Belgin Erhan

{"title":"The relationship between quadriceps femoris thickness measured by US and femoral cartilage thickness in knee osteoarthritis, its effect on radiographic stage and clinical parameters: comparison with healthy young population.","authors":"Ahmet Bozan, Belgin Erhan","doi":"10.22540/JFSF-08-155","DOIUrl":"https://doi.org/10.22540/JFSF-08-155","url":null,"abstract":"Objective: In this study, we aimed to investigate the relationship between quadriceps muscle thickness and femoral cartilage thickness measured by ultrasonography (US) in knee osteoarthritis (OA), to correlate this relationship with radiographic stage and clinical parameters, and to compare these values with those in healthy young adults.Methods: A total of 71 patients with knee osteoarthritis and 31 healthy young adults were included in the study. Patients with knee osteoarthritis (Group 1) and healthy young adults (Group 2) were divided into two groups. Muscle thickness measurements of the quadriceps femoris muscle (M. vastus intermedius + M. rectus femoris) were performed by US.Results: Bilateral quadriceps muscle thickness and bilateral femoral cartilage thickness values were significantly lower in Group 1 than in Group 2. The 10-metre walk test score and Time Up and Go (TUG) test score were significantly higher in Group 1 than in Group 2. A strong positive correlation was found between bilateral quadriceps (RF+VI) muscle thickness and bilateral femoral cartilage thickness (medial, intercondylar, lateral) in Group 1.Conclusions: This study showed a strong positive correlation between quadriceps thickness and femoral cartilage thickness. According to these results, we conclude that US may have a place in the diagnosis of knee osteoarthritis.","PeriodicalId":73754,"journal":{"name":"Journal of frailty, sarcopenia and falls","volume":"8 3","pages":"155-162"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fd/7f/JFSF-8-155.PMC10472037.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10143352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing intrinsic capacity to prevent frailty and sarcopenia in old age. 优化内在能力，预防老年虚弱和肌肉减少症。

Journal of frailty, sarcopenia and falls Pub Date : 2023-09-01 DOI: 10.22540/JFSF-08-136

Jagadish K Chhetri, Lina Ma, Lin Kang, Piu Chan

引用次数: 0

Older Hospitalised Patients' Reported Confidence in Managing Discharge Needs: A Retrospective Observational Study. 老年住院患者对出院需求管理的信心:一项回顾性观察性研究。

Journal of frailty, sarcopenia and falls Pub Date : 2023-09-01 DOI: 10.22540/JFSF-08-139

Peter Hartley, Olivia Sharpe, Roman Romero-Ortuno

{"title":"Older Hospitalised Patients' Reported Confidence in Managing Discharge Needs: A Retrospective Observational Study.","authors":"Peter Hartley, Olivia Sharpe, Roman Romero-Ortuno","doi":"10.22540/JFSF-08-139","DOIUrl":"https://doi.org/10.22540/JFSF-08-139","url":null,"abstract":"Objectives: To evaluate the introduction of a patient-reported outcome measure (PROM) of self-confidence in managing discharge needs in an acutely hospitalised older adult population.Methods: A retrospective service evaluation in an English hospital. The PROM measure consisted of a visual analogue scale asking patients to rate their confidence with managing the things that they would need to do at home. This was collected on admission and discharge.Results: Of 923 patients, 461 had both admission and discharge confidence scores. Median confidence was higher at discharge (8.00, IQR: 6.20-9.80) than on admission (7.20, 5.00-9.00) (P<0.001). Predictors of high confidence with managing discharge needs at admission were: being male; having a lower number of morbidities; self-reporting fewer falls over the last year; and a higher level of functional mobility. Low confidence score on admission, being from one's own home, and a higher number of physiotherapy contacts were associated with improvement in PROM scores. Self-confidence in managing discharge needs at discharge was not associated with readmission within 30 days.Conclusions: Measuring patient-reported confidence to manage discharge needs is feasible in an older inpatient population. Confidence improved from admission to discharge, and more frequent physiotherapy input was associated with improved confidence.","PeriodicalId":73754,"journal":{"name":"Journal of frailty, sarcopenia and falls","volume":"8 3","pages":"139-147"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/90/94/JFSF-8-139.PMC10472038.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10505548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do low levels of alanine aminotransferase, a baseline marker of sarcopenia and frailty, associate with worse clinical outcomes among hospitalized COVID-19 patients? A Retrospective Cohort Study. 在住院的COVID-19患者中，低水平的丙氨酸转氨酶(肌肉减少和虚弱的基线标志物)是否与较差的临床结果相关?回顾性队列研究。

Journal of frailty, sarcopenia and falls Pub Date : 2023-09-01 DOI: 10.22540/JFSF-08-148

Ehud Raz Gatt, Eyal Zilber, Max Perelman, Nitsan Landau, Maya Yakir, Noam Glick, Liat Negru, Gad Segal, Edward Itelman

{"title":"Do low levels of alanine aminotransferase, a baseline marker of sarcopenia and frailty, associate with worse clinical outcomes among hospitalized COVID-19 patients? A Retrospective Cohort Study.","authors":"Ehud Raz Gatt, Eyal Zilber, Max Perelman, Nitsan Landau, Maya Yakir, Noam Glick, Liat Negru, Gad Segal, Edward Itelman","doi":"10.22540/JFSF-08-148","DOIUrl":"https://doi.org/10.22540/JFSF-08-148","url":null,"abstract":"Objectives: COVID-19 geoperdize lives. Not all the risk factors for negative outcomes are known. Sarcopenia and frailty are common, negatively affecting clinical outcomes. Studies have shown that sarcopenia and frailty are associated with worse outcomes. Our objective was to examine whether low ALT (Alanine-aminotranferase), a surrogate marker for sarcopenia, is associated with worse clinical outcomes among hospitalized COVID-19 patients.Methods: We reviewed cases of COVID-19 in a tertiary hospital, during three COVID-19 waves and examined correlations between ALT and mortality using crude, univariate and multivariate analysis for age, gender, hypertension, Chronic obstructive pulmonary disease and Congestive heart failure.Results: 357 patients were included in this analysis. Median age was 69, 54% were males. Median ALT was 19 IU/L. During follow-up, 73 (20%) died. Patients with low ALT were more likely to die (HR 1.82, 95% CI 1.06-3.09, P=0.028). Other predictors for mortality were low albumin, background COPD, dyslipidemia, dementia, and malignancy. The multivariate analysis showed that low ALT was still an independent predictor of poor prognosis (HR 1.7, 95% CI 1.0-2.9, P=0.049).Conclusions: In our analysis of COVID-19 patients, low ALT levels were independently associated with increased risk of mortality, both as standalone and when incorporated into a multivariate analysis.","PeriodicalId":73754,"journal":{"name":"Journal of frailty, sarcopenia and falls","volume":"8 3","pages":"148-154"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d9/23/JFSF-8-148.PMC10472039.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10524611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0