Journal of dentistry (Shiraz, Iran)最新文献

{"title":"Efficacy of Leukocyte Platelet Rich Fibrin (L-PRF) Versus L-PRF with βeta Tri-calcium Phosphate (β-TCP) Bone Graft in Mandibular Impacted Third Molar Surgery: A Split-Mouth Double Blinded Randomized Control Study.","authors":"George Samyo Stephenson, Deepak Abraham Pandyan, Satheesh Chandran, Deenadayalan Narasimman, Karthik Kattur Premkumar, Balamurugan Rajendran, Vijayalakshmi Pethuraj","doi":"10.30476/dentjods.2025.106480.2667","DOIUrl":"10.30476/dentjods.2025.106480.2667","url":null,"abstract":"<p><strong>Background: </strong>Mandibular third molar removal surgically exhibits severe pain, edema, limitation in mouth opening, impaired wound healing, and delayed bone formation postoperatively.</p><p><strong>Purpose: </strong>To compare the effectiveness of leukocyte platelet-rich fibrin (L-PRF) and L-PRF with β-Tricalcium phosphate (β-TCP) bone graft on postoperative outcomes after mandibular impacted third molar surgery.</p><p><strong>Materials and method: </strong>This split-mouth double-blinded randomized controlled study was conducted on 100 patients, who presented for bilateral extraction of mandibular impacted third molars. Group I included 50 patients who were subjected to L-PRF, and group II included 50 patients who were subjected to L-PRF with β-TCP in the extracted socket after removal of the mandibular third molar. The surgical site bleeding was assessed intraoperatively. The pain, swelling, and trismus were evaluated on the 1^st, 3^rd, and 7^th postoperative days. Wound healing was evaluated on the 3rd and 7th postoperative days, and bone density was assessed on the 3rd postoperative month using cone beam computed tomography (CBCT).</p><p><strong>Results: </strong>Group II patients experienced reduced surgical site bleeding, less postoperative swelling, maximum mouth opening, and improved bone regeneration (<i>p</i> Value< 0.05). Group I patients exhibited faster wound healing and less postoperative pain (<i>p</i>< 0.05).</p><p><strong>Conclusion: </strong>The results of our study indicate that L-PRF combined with β-TCP remains an excellent and promising biocompatible material for achieving better postoperative outcomes compared to L-PRF alone.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"27 3","pages":"243-251"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Mechanical Characteristics of Three Different Types of Wires for Bonded Lingual Retainer Fabrication.","authors":"Fatemeh Keikhaee, Neda Shahraki, Hedie Mohsenzade","doi":"10.30476/dentjods.2025.106705.2684","DOIUrl":"10.30476/dentjods.2025.106705.2684","url":null,"abstract":"<p><strong>Background: </strong>Bonded lingual retainers (BLRs) are essential in orthodontics to maintain post-treatment alignment, particularly for mandibular and maxillary anterior teeth. The mechanical properties of the wires used in BLRs significantly influence their performance and longevity.</p><p><strong>Purpose: </strong>This study evaluates the mechanical characteristics of three wire types commonly used in BLRs including Coaxial, Dead Soft, and Multi-Strand Retainer wires.</p><p><strong>Materials and method: </strong>This <i>in vitro</i> study was description-analytical. A total of 120 extracted human premolar teeth (60 dental double blocks and 60 acrylic blocks) were divided into three groups based on wire type. Teeth were prepared using standard etching and bonding procedures, followed by wire placement and curing. Mechanical tests, including detachment force evaluation, fracture mode analysis, deformation measurement, and pull-out testing were conducted using an Instron Testing Machine. Statistical analysis was performed using SPSS software (version 23.0), employing ANOVA and non-parametric tests where appropriate.</p><p><strong>Results: </strong>The Dead Soft wire exhibited the highest pull-out force (92.92 N) and detachment force (51.68 N), while the Multi-Strand Retainer wire showed the lowest pull-out force (58.38 N). The Coaxial wire demonstrated the highest deformation (1.34mm), whereas the Dead Soft wire had the least deformation (0.91mm). Fracture mode analysis revealed significant differences among groups; Coaxial wires predominantly exhibited type 3 fractures (90%), while Dead Soft wires had no type 3 fractures.</p><p><strong>Conclusion: </strong>The Dead Soft wire outperformed other wire types in terms of pull-out and detachment forces, making it a robust choice for BLRs. However, its lower deformation may reduce flexibility under stress. These findings provide valuable insights for orthodontists in selecting optimal wires for BLR fabrication to enhance clinical outcomes and device longevity.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"27 3","pages":"225-233"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Artificial Intelligence in the Early Diagnosis of Oral Cancer: Current Update, Limitations and Future Perspectives.","authors":"Manas Bajpai","doi":"10.30476/dentjods.2025.105757.2609","DOIUrl":"10.30476/dentjods.2025.105757.2609","url":null,"abstract":"<p><p>Oral cancer represents a significant global health challenge with rising incidence and mortality rates in various regions. The prognosis of oral cancer significantly increases if it is diagnosed in early stages. Artificial intelligence (AI) has demonstrated significant potential in enhancing early oral cancer diagnosis through various applications, revolutionizing the field of oral pathology. These innovative approaches are transforming the way healthcare professionals detect, asses and mange the cases of oral cancer cases, potentially leading to improved patient outcomes and reduced mortality rates. This brief communication explores the integration AI in the early diagnosis of oral cancer, highlighting recent advancements and potential future applications. The study reviews current methodologies employing AI technologies, such as machine learning and deep learning algorithms, to enhance the accuracy and efficiency of oral cancer detection. It discusses the role of AI in analyzing clinical images, patient data, and other diagnostic tools, emphasizing its ability to identify precancerous lesions and reduce diagnostic delays.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"27 2","pages":"187-191"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13242053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Growth Markers for Effective Palatal Expansion: A Comparative Study of DMPS, SMPS, and CVM.","authors":"Farzaneh Golfeshan, Amir Hossein Hajmohammadi, Hooman Zarif Najafi, Fatemeh Dehghani","doi":"10.30476/dentjods.2025.103814.2478","DOIUrl":"10.30476/dentjods.2025.103814.2478","url":null,"abstract":"<p><strong>Background: </strong>Effective planning and prediction of outcomes in orthodontic treatments require clinicians to identify precise growth markers. These markers play a critical role in determining the appropriate treatment strategy for patients.</p><p><strong>Purpose: </strong>The present study was conducted to evaluate the relationship between midpalatal suture density (DMPS), the stage of maturation and morphology of the midpalatal suture (SMPS), and cervical vertebra maturation (CVM) across age groups and sexes to provide insight into their interdependence.</p><p><strong>Materials and method: </strong>The sample size of this cross-sectional study was estimated using the sample size tables for logistic regression, with α=0.05 and a power of 80%. This study analyzed archived CBCT images and lateral cephalograms of 80 patients aged 7-30 years. The sample was divided into eight age groups. Spearman's correlation coefficient was used to assess the relationships between DMPS, SMPS, and CVM. p Value< 0.05 was considered significant.</p><p><strong>Results: </strong>The findings revealed significant correlations between CVM, DMPS, and SMPS in both males and females. Among females, the strongest correlations were between age and DMPS (r= 0.791), age and CVM (r= 0.750), and CVM and DMPS (r= 0.769). Similar trends were observed in males, with the highest correlations between age and DMPS (r= 0.832) and CVM and DMPS (r= 0.805). Across all age groups, DMPS showed the highest correlation with age, while SMPS exhibited the lowest.</p><p><strong>Conclusion: </strong>A highly significant relationship was identified between the SMPS, DMPS, and CVM parameters at all ages and in both sexes. The highest correlation belonged to age and DMPS, and the lowest correlation belonged to age and SMPS. Therefore, it can be concluded that DMPS can be estimated based on the patient's age, and vice versa to some extent. Furthermore, the correlation was stronger in men than in women, indicating a higher likelihood of a relationship.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"27 2","pages":"132-138"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13242049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148200970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fracture Resistance of Mineral Trioxide Aggregate- and Biodentine-Pulpotomized teeth with Different Restorative Techniques: An in vitro Study.","authors":"Hajar Farhadpour, Yasamin Ghahramani, Mohammadhossein Jahani, Hanie Poursoleyman, Mahshid Mohammadi-Bassir","doi":"10.30476/dentjods.2025.105152.2573","DOIUrl":"10.30476/dentjods.2025.105152.2573","url":null,"abstract":"<p><strong>Background: </strong>Preserving the radicular pulp in traumatically or mechanically exposed teeth through coronal pulpotomy (CP) is an advantageous endodontic procedure.</p><p><strong>Purpose: </strong>This study compared the fracture resistance (FR) of mineral trioxide aggregate (MTA) and Biodentine (BD) in pulpotomized maxillary premolars restored with different materials.</p><p><strong>Materials and method: </strong>Ninety extracted maxillary premolars were divided into 9 groups (n=10). Group 1 served as intact controls. For the other groups, after access cavity preparation, half of the teeth were pulpotomized with MTA, and the others with BD. Groups 2 (MTA/unrestored) and 3 (BD/unrestored) remained unrestored. Restorations were as follows: Groups 4 (MTA/GI+Am) and 5 (BD/GI+Am) were restored with glass ionomer and amalgam; groups 6 (MTA/RMGI+ conventional com) and 7 (BD/RMGI+conventional com) with resin-modified glass-ionomer and conventional composite resin; groups 8 (MTA/bulk-fill com) and 9 (BD/bulk-fill com) with bulk-fill composite. After 24 hours, the FR test was conducted. Data were analyzed by one-way ANOVA and the Tukey test (<i>p</i> Value< 0.05).</p><p><strong>Results: </strong>FR of control group was significantly higher than the all other groups (<i>p</i>> 0.05). There was no significant difference between two unrestored MTA and BD groups (2 and 3) (p= 0.62). Group 2 (MTA/unrestored) showed significantly lower FR compared to all composite restored groups (6-9) (<i>p</i>< 0.05), and comparable to amalgam restored groups (4 and 5). The higher FR of all the restored groups (4-9) compared to BD/unrestored group (group 3) was not significant <i>p</i>> 0.05). There was no significant difference between all the restored groups in terms of FR and fracture type rate (<i>p</i>.> 0.05).</p><p><strong>Conclusion: </strong>Both composite resins increased the strength of MTA-pulpotomized premolars, but this was not the case for BD. FR of amalgam restorations did not significantly differ from both composite resin restorations. However, none of the tested restorations was capable to recover the fracture strength completely.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"27 2","pages":"139-147"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13242046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Serum Levels of CD73 in Patients with Head and Neck Squamous Cell Carcinoma.","authors":"Razieh Zare, Mohammad Ali Ranjbar, Ava Ebrahimi, Mahyar Malekzadeh, Bijan Khademi, Najmeh Savadi","doi":"10.30476/dentjods.2025.102855.2403","DOIUrl":"10.30476/dentjods.2025.102855.2403","url":null,"abstract":"<p><strong>Background: </strong>The expression of CD73 antigen is associated with different prognoses in different carcinomas. However, few studies have assessed the level of this marker in squamous cell carcinoma (SCC) as the most common malignancy of the head and neck region.</p><p><strong>Purpose: </strong>The aim of this study was to determine the serum levels of CD73 in patients with head and neck SCC to explain their association with clinicopathological parameters.</p><p><strong>Materials and method: </strong>This cross-sectional study was done on 60 samples taken from patients with head and neck SCC. A total of 28 healthy individuals were enrolled as the control group. Using the sandwich ELISA method, the serum levels of CD73 were measured. The data were statistically analyzed using the independent t-test and the Kruskal-Wallis test.</p><p><strong>Results: </strong>The mean serum level of CD73 in the SCC patients (114.38 ng/ml, n=60) was almost similar to that of the healthy controls (137.22 ng/ml, n=28; <i>p</i> Value=0.098). The mean serum levels of CD73 were greater in patients with III/IV-stage tumors than in those with I/II-stage tumors (121.37±55.96 ng/ml, n=28 vs 108.27±39.44 ng/ml, n=32; <i>p</i>= 0.294). No correlation was found between the serum levels of CD73 and sex, age, tumor size, lymph node metastasis, and other organ metastasis.</p><p><strong>Conclusion: </strong>The results of the current study revealed no significant relationship between the serum levels of CD73 and the clinicopathological factors in patients with head and neck SCC. These results suggest that the serum levels of CD73 may not be a useful biomarker for the recognition of the clinical behavior of head and neck SCC. However, the actual role of CD73 in SCC remains unclear and requires further research.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"27 2","pages":"120-124"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13242042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Herbal Medicine in the Management of Oral Conditions: A Comprehensive Review.","authors":"Mehrdad Kolahi, Mohammad Sobootkar, Sarah Hamidzade, Kimia Ghods","doi":"10.30476/dentjods.2025.106062.2629","DOIUrl":"10.30476/dentjods.2025.106062.2629","url":null,"abstract":"<p><p>Herbal medicine has been traditionally used in managing various health conditions, including oral diseases. With growing interest in natural treatments, numerous plant-derived compounds have been studied for their antimicrobial, anti-inflammatory, analgesic, and wound-healing properties. The present study aims to evaluate the influence of various types of herbal medicine in the management of oral conditions, along with their advantages and disadvantages. For this review article, a complete query was carried out on PubMed, Google Scholar, Embase, and Scopus databases, and the studies published during 2015-2024 were collected using the keywords such as \"Herbal Medicine,\" \"Oral Disorder,\" \"Complementary Therapies\", \"Treatment Outcome,\" and \"Drug Effects.\" After applying appropriate inclusion and exclusion criteria, 64 relevant articles focused on the application of herbal medicine in the treatment of oral diseases were selected and evaluated. Among all the medical herbs, aloe vera, turmeric, ginger, and green tea have shown more promising antimicrobial and anti-inflammatory properties that contribute to oral health. In other words, studies suggest that the mentioned herbs may aid in reducing plaque formation, managing gingival inflammation, promoting wound healing, and controlling oral microbial infections better than other herbs. As evidenced by the obtained results, herbal medicine holds promise as a complementary or alternative approach in oral care due to its bioactive properties and potential therapeutic benefits. However, further clinical trials and scientific validation is necessary to ensure safety, efficacy, and standardization before herbal treatments can be fully integrated into modern practice.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"27 2","pages":"95-110"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13242043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148200890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Presentation of Follicular Odontogenic Keratocyst of Maxillary Sinus Mimicking Dentigerous Cyst: A Case Report with 3-Year- Follow-Up.","authors":"Satheesh Chandran, Deepak Abraham Pandyan, Deenadayalan Narasimman, Karthik Kattur Premkumar, George Samyo Stephenson, Balamurugan Rajendran","doi":"10.30476/dentjods.2025.107603.2756","DOIUrl":"10.30476/dentjods.2025.107603.2756","url":null,"abstract":"<p><p>Follicular keratocyst is a rare variant of odontogenic keratocyst (OKC), which surrounds the neck of an impacted tooth resembling a dentigerous cyst, usually diagnosed through radiographic and histological investigations. A 22-year-old female patient presented with pain in the right maxilla for the past 3 years. Intraoral examination revealed a missing right maxillary third molar. Computed tomography (CT) showed a well-defined hyperdense area in the right maxillary sinus involving the crown of an impacted right maxillary third molar within the cystic lesion. A provisional diagnosis of dentigerous cyst was made. The cystic lesion was then surgically enucleated with an impacted right maxillary third molar under general anesthesia. Histological investigation of the enucleated lesion was suggestive of a follicular keratocyst. No adverse effects or recurrence were elicited postoperatively at the 3-year follow-up. OKC, in relation to the third molar, clinically may represent any other odontogenic cysts. Histopathological examination remains the gold standard for assessing the final diagnosis and guides the selection of a definitive treatment modality.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"27 2","pages":"181-186"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13242052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stationary Intraoral Tomosynthesis: A Step toward the Future of Routine Dental Imaging.","authors":"Shahram Hamedani, Sepideh Zaeri","doi":"10.30476/dentjods.2026.109821.2917","DOIUrl":"10.30476/dentjods.2026.109821.2917","url":null,"abstract":"<p><p>Stationary intraoral tomosynthesis (s-IOT) is an innovative imaging modality designed to overcome limitations of conventional bitewing radiography, notably proximal overlap. Based on carbon nanotube field emission technology, s-IOT acquires multiple projections across a 12° span and reconstructs them into high-resolution tomographic slices. Research indicates lower radiation dose compared to standard techniques and improved detection of proximal caries, periodontal bone loss, root fractures, and complex root morphologies including the direction and degree of dilaceration. Integration with synthetic radiography reduces artifacts and enhances interpretation. Future developments combining s-IOT with artificial intelligence and dual-energy imaging may further expand diagnostic potential, positioning s-IOT as a promising clinical tool.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"27 1","pages":"192-194"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13242041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Serum Vitamin D Levels and <i>VDR</i> <i>BsmI</i> Polymorphism in Temporomandibular Joint Dysfunction Patients (in the Iranian Population).","authors":"Maryam Mostafavi, Fahimeh Rezazadeh, Mohammad Javad Fattahi, Fatemeh Tavakoli, Abbas Ghaderi","doi":"10.30476/dentjods.2025.106238.2644","DOIUrl":"10.30476/dentjods.2025.106238.2644","url":null,"abstract":"<p><strong>Background: </strong>Multiple studies have revealed an association between vitamin D levels, genetic polymorphisms of the <i>VDR</i> (vitamin D receptor) gene, and the underlying causes of various bone and cartilage disorders.</p><p><strong>Purpose: </strong>This study aimed to investigate the association between the <i>BsmI</i> polymorphism of the <i>VDR</i> gene and serum vitamin D levels in a group of temporomandibular joint dysfunction (TMD) patients compared to healthy controls.</p><p><strong>Materials and method: </strong>Our cross-sectional study encompassed 42 TMD patients diagnosed according to the research diagnostic criteria for temporomandibular disorders (RDC /TMD) and 41 healthy subjects. Genomic DNA was prepared, the <i>BsmI</i> variant was analyzed by PCR-RFLP, and the serum vitamin D level was measured by ELISA technique. Chi square and ANOVA test was used for analysis and statistical significance was set at <i>p</i> Value < 0.05.</p><p><strong>Results: </strong>The serum levels of vitamin D in the TMD group were significantly lower than those in the control group, with values of 43.52±18.16 ng/mL compared to 57.56±21.29 ng/mL (<i>p</i>= 0.002). The prevalence of vitamin D insufficiency was remarkably higher in the patients than in the controls, at 26.19% vs. 4.87%, respectively (<i>p</i>= 0.008). Our analysis revealed no significant differences in the genotype and allele frequencies of the <i>VDR</i> <i>BsmI</i> variant between TMD patients and controls (<i>p</i>= 0.475 and <i>p</i>= 1.000, respectively). Additionally, our study found no significant association between the genotypes of the <i>VDR</i> <i>BsmI</i> variant and vitamin D status (<i>p</i>= 0.363).</p><p><strong>Conclusion: </strong>Monitoring vitamin D levels in TMD patients is important, as deficiency may impact disease development. Further research is needed on the role of vitamin D and <i>VDR</i> gene variants in managing temporomandibular disorders.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"27 2","pages":"168-175"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13242040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}