Journal of dentistry (Shiraz, Iran)最新文献

{"title":"CD1a Expression in Oral Dysplastic Lesions: An Immunohistochemical Analysis.","authors":"Parsa Eftekhari Moghadam, Saede Atarbashi-Moghadam","doi":"10.30476/dentjods.2025.106737.2685","DOIUrl":"10.30476/dentjods.2025.106737.2685","url":null,"abstract":"<p><strong>Background: </strong>Leukoplakia is among the most prevalent oral potentially malignant disorders, and its association with oral epithelial dysplasia (OED) markedly increases the risk of malignant transformation. Although histopathological grading systems have evolved, accurately predicting which lesions will undergo malignant progression remains a significant challenge. CD1a, a marker expressed by Langerhans cells, may reflect local immune responses and serve as a potential indicator of dysplastic progression.</p><p><strong>Purpose: </strong>Given the inconsistencies in previous findings, the present study aimed to assess CD1a-positive cells in OED associated with leukoplakia and investigate their potential role in the pathogenesis of these lesions.</p><p><strong>Materials and method: </strong>In this retrospective cross-sectional study, 60 formalin-fixed paraffin- embedded tissue samples were analyzed, comprising 53 OED cases and 7 control samples. Immunohistochemical staining was performed using a monoclonal anti-CD1a antibody. CD1a-positive cells were counted in five high-power fields (40×) in hotspot regions. The severity of dysplasia was categorized according to both 2022 WHO classification and binary grading system; inflammation severity was also scored. Statistical analyses were conducted using the Shapiro-Wilk test, Spearman's correlation, the Mann-Whitney U test, and the Kruskal-Wallis test in SPSS version 28.</p><p><strong>Results: </strong>CD1a expression was elevated in dysplastic tissues compared to controls; however, this difference was not statistically significant (<i>p</i>= 0.071). According to the binary grading system, CD1a levels were significantly higher in high-risk lesions than in low-risk ones (<i>p</i>= 0.044). Although the correlation between CD1a expression and inflammation severity was not statistically significant (<i>p</i>= 0.137), the association between severity of inflammation and the grade of dysplasia was statistically significant (<i>p</i>= 0.015 for WHO classification; <i>p</i>= 0.023 for binary grading). No statistically significant association was found between CD1a expression and patient age, gender, or lesion location.</p><p><strong>Conclusion: </strong>CD1a may contribute to the process of dysplastic transformation and serve as an indicator of local immune activation. Its increased expression in higher-grade dysplasia was associated with more pronounced inflammatory cell infiltration and a more immune-active microenvironment.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"27 3","pages":"276-282"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Antibacterial Effect and Mechanical Properties of Thermoformed Clear Aligners Coated with Chitosan and Cellulose Nanocrystals.","authors":"Seyyed Hadi Hosseini, Mohammad Motamedifar, Shabnam Ajami","doi":"10.30476/dentjods.2025.105163.2575","DOIUrl":"10.30476/dentjods.2025.105163.2575","url":null,"abstract":"<p><strong>Background: </strong>Though aligners are considered more hygienic, they are linked to a higher occurrence of white spot lesions. These lesions pose clinical challenges and compromise aesthetics.</p><p><strong>Purpose: </strong>The aim of present study was the evaluation of antibacterial effect and mechanical properties of thermoformed clear aligners coated with chitosan and cellulose nanocrystals.</p><p><strong>Materials and method: </strong>This <i>in vitro</i> study evaluated five experimental groups of aligners including (1) Passive control, (2) Active control, (3) Aligners coated with chitosan (CH), (4) Aligners coated with cellulose nanocrystals (CNCs), and (5) Aligners coated with a combination of CH/CNCs. Each group consisted of 30 samples that consisted of 10 discs for antimicrobial testing, 5 cubes for surface microhardness, and 15 cubes for the three-point bending test. Surface morphology was analyzed using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). Antibacterial properties were assessed through disc diffusion and serial dilution methods against <i>Escherichia coli</i> (<i>E. coli</i>) and <i>Streptococcus mutans</i> (<i>S. mutans</i>). Mechanical properties, including surface microhardness and maximum force under bending, were evaluated using Vickers hardness and three-point bending tests. Statistical analysis was performed using ANOVA and Kruskal-Wallis tests, with <i>p</i> Value< 0.05 considered significant.</p><p><strong>Results: </strong>The CH/CNC group showing the highest microhardness (13.37±1.00 VHN) and the CNC group demonstrated the highest force resistance (62.31±7.36 MPa), though the difference was not statistically significant (<i>p</i>> 0.05). In the disc diffusion test, CH coatings showed significant antibacterial activity, especially against <i>E. coli</i> (10.8±1.09mm zone of inhibition, <i>p</i>= 0.006), and while CH/CNC showed significant antibacterial activity, especially against <i>S. mutans</i> (6.00±5.47, <i>p</i>= 0.020). CNC coatings showed no bacterial inhibitory effect (<i>p</i>> 0.05).</p><p><strong>Conclusion: </strong>The results of our study suggested that applying CNC combined with chitosan as coatings on orthodontic aligners offers a viable strategy to improve both antimicrobial and mechanical properties.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"27 3","pages":"234-242"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Craniofacial Features in Children with Sleep-Disordered Breathing: A Comparative Study.","authors":"Maryam Karandish, Sara Nemati, Alireza Sharifinejad, Mohammad Ashkan Moslehi","doi":"10.30476/dentjods.2025.106103.2632","DOIUrl":"10.30476/dentjods.2025.106103.2632","url":null,"abstract":"<p><strong>Background: </strong>Sleep-disordered breathing (SDB) consists of a range of symptoms that can negatively affect children's quality of life. Earlier diagnosis of SDB in children can result in the prevention of severe outcomes.</p><p><strong>Purpose: </strong>This study aimed to evaluate the craniofacial features and skeletal growth patterns of children with SDB.</p><p><strong>Materials and method: </strong>This comparative case-control study was conducted on 150 patients aged 8 to 12 years who attended the orthodontic department. Based on the Berlin questionnaire, selected patients were divided into two groups of 25, including children with a high risk of SDB (SDB group) and those without the risk (control group). Craniofacial analysis of all patients was carried out on their lateral cephalometric radiographs. Cephalometric sagittal and vertical parameters were compared between groups using the Mann-Whitney U test with effect sizes reported. Data normality was assessed to justify statistical methods.</p><p><strong>Results: </strong>Vertical parameters, including FMA (<i>p</i> Value= 0.019, Cohen's d= 0.69) and GoGn-SN angles (<i>p</i>= 0.038, Cohen's d= 0.46), were significantly higher, and the Jarabak index was lower (<i>p</i>= 0.022, Cohen's d= 0.51) in the SDB group, indicating a vertical growth pattern. However, the anterior-posterior position of both jaws was not significantly different between the two groups (<i>p</i>> 0.05).</p><p><strong>Conclusion: </strong>In this study, considerable differences were observed in the craniofacial features of children with SDB, particularly in the vertical dimension.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"27 3","pages":"218-224"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overexpression of MIEN1 in Oral Squamous Cell Carcinoma: Correlation with Tumor Invasion and Lymph Node Metastasis.","authors":"Mahsa Kalantari, Nima Malekhoseini, Reza Malekpour Afshar, Saba Fouladi","doi":"10.30476/dentjods.2025.106409.2659","DOIUrl":"10.30476/dentjods.2025.106409.2659","url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) is a malignant tumor with a high potential for local invasion and distant metastasis. Migration and invasion enhancer 1 (MIEN1) is a recently identified protein that contributes to the pathogenesis of various cancers by promoting cell migration and invasion.</p><p><strong>Purpose: </strong>This study aimed to assess the expression of MIEN1 in OSCC and to compare it with its expression in dysplastic and hyperkeratotic oral epithelium.</p><p><strong>Materials and method: </strong>In this retrospective study, MIEN1 expression was evaluated in 79 formalin-fixed, paraffin-embedded tissue samples, including 43 cases of OSCC, 23 of oral epithelial dysplasia, and 13 of hyperkeratotic oral epithelium, using immunohistochemical staining. The association between MIEN1 expression and clinicopathological parameters including patients age, sex, lesion location, tumor size, lymph node metastasis, and tumor-node-metastasis (TNM) stages was analyzed using the chi-square test, Fisher's exact test, and Mann-Whitney test at a significance level of <i>p</i> Value< 0.05.</p><p><strong>Results: </strong>MIEN1 overexpression was significantly higher in OSCC compared to both moderate and mild dysplastic epithelium (<i>p</i>< 0.05). None of hyperkeratotic epithelial samples exhibited positive MIEN1 expression. Additionally, MIEN1 expression was significantly associated with lymph node metastasis and TNM stage (<i>p</i>< 0.05). However, no significant correlation was found between MIEN1 expression and patient age, sex, lesion location, or tumor size (<i>p</i>> 0.05).</p><p><strong>Conclusion: </strong>Our findings indicate that MIEN1 expression is correlated with the progression of OSCC. It likely plays a crucial role in the migration and invasion of cancer cells, as well as in the metastatic spread of the disease.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"27 3","pages":"252-258"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-37 Serum Levels in Oral Squamous Cell Carcinoma.","authors":"Hamid Ghaderi, Mohammad Javad Fattahi, Hossain Shirmardi Dezaki, Mahyar Malekzadeh, Bijan Khademi, Abbas Ghaderi, Mohammad Reza Haghshenas","doi":"10.30476/dentjods.2025.105421.2595","DOIUrl":"10.30476/dentjods.2025.105421.2595","url":null,"abstract":"<p><strong>Background: </strong>Squamous cell carcinoma (SCC) is the most common cancer of the maxillofacial area, known for its high mortality and morbidity rates. Increasing evidence highlights the critical role of chronic inflammation in human malignancies by modulating inflammatory cells and cytokine synthesis. IL-37 is recognized as a cytokine that may play a dual role in cancer.</p><p><strong>Purpose: </strong>This study sought to investigate IL-37 serum concentrations in individuals with oral SCC, specifically SCC of the tongue.</p><p><strong>Materials and method: </strong>This case-control study investigated IL-37 serum levels and their association with the patients' clinicopathological characteristics in 65 cases of oral SCC compared to 65 healthy controls using the ELISA technique. The study further assessed the diagnostic significance of IL-37 serum concentrations using receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>The results indicated that IL-37 serum concentrations were markedly higher in patients than in the control group, although no association with the patients' clinicopathological characteristics was found. The best cut-off point for the serum IL-37 level was 61.95 pg/ml, with a sensitivity of 92.30% and specificity of 87.70%. The ROC curve area was 0.90.</p><p><strong>Conclusion: </strong>The significant increase of serum IL-37 levels in oral SCC patients underscores its involvement in the disease's pathology and suggests its potential use in early detection and screening. Future studies should aim to elucidate the interplay of this cytokine with the tumor microenvironment (TME) and explore its possible diagnostic and therapeutic applications in cancer.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"27 3","pages":"259-264"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> Evaluation of the Remineralizing Potential and Color Change of Modified Fluoride Varnish with Polyvinylpyrrolidone-Coated Silver Nanoparticles on Incipient Enamel Lesions in Primary Teeth.","authors":"Faranak Farahmand, Azade Rafiee, Najmeh Mohammadi","doi":"10.30476/dentjods.2025.107027.2711","DOIUrl":"10.30476/dentjods.2025.107027.2711","url":null,"abstract":"<p><strong>Background: </strong>Dental caries is closely associated with biofilms and characterized by cycles of demineralization and remineralization that weaken tooth structure over time. Given the need for effective prevention and enhanced remineralization, developing a more esthetic and efficient approach is essential in improving oral health outcomes.</p><p><strong>Purpose: </strong>The present study aimed to assess the remineralizing potential and color change of modified fluoride varnish with polyvinylpyrrolidone-coated silver nanoparticles (PVP-coated AgNPs) on incipient enamel lesions in primary teeth.</p><p><strong>Materials and method: </strong>In this <i>in vitro</i> study, 130 caries-free primary canine teeth underwent caries induction and were randomly assigned to one of three treatments: (1) fluoride varnish (FV), (2) silver diamine fluoride (SDF), and (3) FV with PVP-coated AgNPs. After thermocycling-aging and an eight-day pH cycling regimen, the remineralization effects and color change were evaluated by enamel microhardness (EMH) test and spectrophotometric color assessment. Ten samples were used for surface morphology assessment with field emission scanning electron microscopy and energy-dispersive X-ray spectrometry (FESEM-EDS). One-way ANOVA and Tukey's post-hoc tests were used for data analysis (<i>p</i> Value<0.05).</p><p><strong>Results: </strong>The highest average±SD recovery of EMH values was found in the SDF group (52.43±2.58), followed by FV with PVP-coated AgNPs group (43.21±1.73), and FV group (35.60±1.36), respectively (all, <i>p</i>< 0.001). The voids on the demineralized enamel surface were partially coated with newly deposited minerals in FESEM images of all groups. SDF Group had the best calcium/ phosphorus ratio among the intervention groups (2.58± 0.001); followed by FV with PVP-coated AgNPs group (1.94±0.001) and FV group (1.91± 0.001), respectively. The color change of enamel samples treated with FV and modified FV with PVP-coated AgNPs was clinically imperceptible (all, ∆E < 3.3), whereas SDF-treated samples caused distinct staining (<i>p</i>< 0.001).</p><p><strong>Conclusion: </strong>FV with PVP-coated AgNPs effectively remineralizes incipient enamel lesions in primary teeth with minimal color change, offering a promising alternative to SDF.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"27 3","pages":"265-275"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digitally Planned Reconstruction of a Case of Mandibular Central Giant Cell Granuloma in a Young Female: A Case Report.","authors":"Harish Saluja, Anuj Dadhich, Seemit Shah, Shivani Sachdeva","doi":"10.30476/dentjods.2026.107038.2713","DOIUrl":"10.30476/dentjods.2026.107038.2713","url":null,"abstract":"<p><p>Reconstruction of maxillofacial continuity defects has invariably been a difficult task for oral and maxillofacial surgeons over the years. Maxillofacial bone defects are caused by the trauma, clefts, burns, and infection, benign, or malignant tumors. To reconstruct big bony defects within the head and neck region remains a serious surgical challenge. The goal of mandibular reconstruction is to revive facial kind and performance, implying repair of mandibular continuity, and muscle attachments. Free-flap reconstruction of oncological mandibular defects has become the fashionable common place of care. Here we are presenting a case of young female having central giant cell granuloma (CGCG) of the mandible in which reconstruction of the defect was done with free fibula flap, which was planned digitally to simulate the anatomy of mandible for better esthetic outcomes.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"27 3","pages":"283-286"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fracture Resistance and Surface Roughness of Zirconia Crowns Veneered by Layering, Press-on, and CAD-on Methods.","authors":"Mina Mohaghegh, Dorsa Pourzarabi, Masumeh Taghva, Reza Derafshi","doi":"10.30476/dentjods.2025.105198.2579","DOIUrl":"10.30476/dentjods.2025.105198.2579","url":null,"abstract":"<p><strong>Background: </strong>Various strategies are used for ceramic veneering on zirconia copings. Veneering techniques may influence the fracture resistance and surface roughness of zirconia crowns and controversial results are present in literature concerning these techniques.</p><p><strong>Purpose: </strong>The aim of the present study was to investigate the effects of layering, press-on, and CAD-on techniques on the fracture resistance and surface roughness of zirconia crowns after aging.</p><p><strong>Materials and method: </strong>In this <i>in vitro</i> study, 30 brass dies were milled and scanned. Coping was designed for all of them, milled from a zirconia block, and sintered. Porcelain veneering was done through layering, press-on, and CAD-on methods (n=10 per group), and aged in autoclave. Surface roughness was measured before and after aging. Fracture resistance was tested, and the failure pattern was checked by scanning electron microscopy (200-500×). The independent t-test and post-hoc test were used to compare the fracture resistance among the three groups. The surface roughness before and after aging was investigated using one-way ANOVA and ANCOVA. The data on failure patterns were analyzed using the chi-square test.</p><p><strong>Results: </strong>The mean fracture resistance in the CAD-on group (4442.19±1580.62 N) was higher than in layering (3225.63±1266.08 N) and press-on groups (2652.42±1320.02 N). The press-on group exhibited the highest surface roughness both before (2.97±0.26μm) and after aging (3.33±0.83μm). The most common failure patterns were adhesive pattern in the CAD-on group and cohesive pattern in layering and press-on groups.</p><p><strong>Conclusion: </strong>The three veneering techniques had clinically acceptable fracture resistance and surface roughness. The highest fracture resistance was found in the CAD-on group, followed by the layering and press-on groups. The lowest surface roughness was observed in the layering group, followed by CAD-on and press-on groups. Techniques with higher fracture resistance can be considered in patients with high force factors such as bruxism, clenching, and long span bridges.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"27 3","pages":"210-217"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teledentistry: Applications Across Dental Specialties: A Systematic Review and Meta-Analysis.","authors":"Aryan Tabibnia, Pooya Omidi, Saba Amini, Sam Shahbod, Arezoo Alaee, Kimia Ghods","doi":"10.30476/dentjods.2025.106873.2726","DOIUrl":"10.30476/dentjods.2025.106873.2726","url":null,"abstract":"<p><strong>Background: </strong>Teledentistry is the use of digital communication technologies to provide remote dental care, which offers innovative solutions to enhance access, efficiency, and patient outcomes.</p><p><strong>Purpose: </strong>This article evaluates the diagnostic accuracy of teledentistry compared to in-person gold-standard examinations, primarily in restorative dentistry.</p><p><strong>Materials and method: </strong>A systematic search of literature was conducted on PubMed, Google Scholar, Embase, and Scopus databases, covering studies from 2015 and 2024. Due to methodological heterogeneity and limited comparable studies, meta-analysis was only feasible for the field of restorative dentistry, and other specialties were analyzed descriptively. Furthermore, the Newcastle-Ottawa Scale was used to assess bias, which manifested a moderate-to-low risk of bias.</p><p><strong>Results: </strong>The results of 4 studies in restorative dentistry demonstrated a moderate sensitivity of 77.2% (95% CI 62.5-87.4%) and a high specificity of 89.1% (95% CI 70.5-96.5%). While significant heterogeneity persisted (I² = 68% for sensitivity and 92% for specificity), sensitivity analyses confirmed robust pooled estimates unaffected by individual study removal. This was attributable to methodological variations in diagnostic thresholds and image capture protocols despite uniform smartphone photography. On the other hand, descriptive analysis of studies in other fields revealed variable diagnostic accuracy, with teledentistry showing promise in orthodontics and prosthodontics but limitations in endodontics.</p><p><strong>Conclusion: </strong> The findings suggest teledentistry as a useful diagnostic tool in restorative dentistry, though it is not yet a complete substitute for in-person examinations. However, the generalizability of these findings to other dental specialties remains low due to the lack of an adequate number of relevant studies. Moreover, insufficient data exist to support the positive role of artificial intelligence (AI) in combination with tele-dentistry. Therefore, future work should prioritize standardized AI-tele-dentistry validation and expand research across diverse specialties to strengthen evidence.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"27 3","pages":"195-209"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Atypical Root Canal Configuration of Maxillary Second Molar: A Case Report.","authors":"Ali Rezaei Nejad, Yasamin Ghahramani, Fahime Alimardani, Hasti Hosseini","doi":"10.30476/dentjods.2025.107040.2714","DOIUrl":"10.30476/dentjods.2025.107040.2714","url":null,"abstract":"<p><p>The main goals of root canal therapy are to relieve pain, eliminate infections from the root canal system, and prevent future infection. The maxillary second molars typically present with three roots and contain three to four canals; however, anatomical variations frequently observed. Failure to identify these variations can complicate the procedure, emphasizing the importance of precise radiographic assessment. Cone beam computed tomography (CBCT) has demonstrated superior effectiveness compared to conventional radiography in assessing root canal morphology. This paper reports a maxillary second molar with unusual root morphology having two palatal roots. CBCT confirmed this diagnosis.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"27 3","pages":"287-291"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}