JADA foundational science最新文献

{"title":"Cleaning of dental handpieces","authors":"Ludger Schnieder PhD,&nbsp;Karen Seekamp-Schnieder PhD","doi":"10.1016/j.jfscie.2023.100030","DOIUrl":"https://doi.org/10.1016/j.jfscie.2023.100030","url":null,"abstract":"<div><h3>Background</h3><p>This work aimed to provide evidence for the importance of regular cleaning and care of dental handpieces. In addition, this study aimed to show that automated cleaning of dental tools may deliver superior results compared with manual cleaning.</p></div><div><h3>Methods</h3><p>Publicly available data from the US Food and Drug Administration’s (FDA’s) Manufacturer and User Facility Device Experience (MAUDE) database on incidents in the use of dental handpieces from the past 10 years were evaluated. The cleaning results of more than 4,830 instruments were also investigated and evaluated.</p></div><div><h3>Results</h3><p>By evaluating the manufacturer’s information on the incidents reported in the FDA’s MAUDE database, the connection between inadequate or no maintenance and care and the incidents was clearly shown. The evaluation of the results of manual cleaning compared with automated cleaning clearly shows that better results can be achieved through automated cleaning.</p></div><div><h3>Conclusions</h3><p>The evaluation of the FDA’s MAUDE database confirmed and emphasized the importance of cleaning and care for the safe and long-term use of dental tools. Comparing the data from manual cleaning and the usage of a device for automated cleaning of dental handpieces, it was shown that the establishment of a quality-controlled system for in-use testing of cleaning performance could provide valuable data for assessing the efficacy of different cleaning processes. Valuable feedback for the user can be derived this way. In addition, it was shown that automated cleaning of dental handpieces is a reasonable alternative and leads to clearly better results.</p></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"3 ","pages":"Article 100030"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772414X23000105/pdfft?md5=35a775d5aae60460cfa62da367d545d0&pid=1-s2.0-S2772414X23000105-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139999371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disruptive innovation events in dentistry","authors":"Jill Sirko PhD,&nbsp;Wenyuan Shi PhD","doi":"10.1016/j.jfscie.2024.100036","DOIUrl":"10.1016/j.jfscie.2024.100036","url":null,"abstract":"","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"3 ","pages":"Article 100036"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142573007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of scaling and root planing with and without minocycline hydrochloride microspheres on serum biomarkers and acute phase reactants","authors":"Michelle C. Arnett MS, RDH ,&nbsp;Massimo Costalonga DMD, PhD ,&nbsp;Phonsuda Chanthavisouk MDT, BSDH ,&nbsp;Michael D. Evans MS ,&nbsp;Danna R. Paulson MSDH, RDH, CCRP","doi":"10.1016/j.jfscie.2024.100040","DOIUrl":"10.1016/j.jfscie.2024.100040","url":null,"abstract":"<div><h3>Background</h3><div>This study tests the effects of scaling and root planing (SRP) vs SRP with minocycline hydrochloride microspheres (MMs) (SRP with MM) on serum biomarkers interleukin (IL)-1β, IL-6, tumor necrosis factor-α, and matrix metalloproteinase-8 and acute phase reactants hemoglobin A_1c (HbA_1c), high-sensitivity C-reactive proteins and haptoglobin (Hp) in patients with stage II-IV grade B periodontitis.</div></div><div><h3>Methods</h3><div>Seventy participants were randomized to receive SRP (n = 35) or SRP+MM (n = 35). Serum was collected at baseline (before SRP), 1-month reevaluation visit, and 3- and 6-month periodontal maintenance visits. MMs were delivered to pockets 5 mm or larger immediately after SRP and immediately after the 3-month periodontal maintenance visit. Serum for acute phase reactants only was collected at the 9- and 12-month posttreatment follow-up. All outcomes were summarized using estimated marginal means back-transformed to the original response scale with 95% CIs.</div></div><div><h3>Results</h3><div>At 6 months, no statistical significance was yielded in either group for IL-6 (<em>P</em> = .91), tumor necrosis factor-α (<em>P</em> = .34), or matrix metalloproteinase-8 (<em>P</em> = .34). IL-1β (<em>P</em> = .06) was slightly higher in the SRP-alone group, suggesting a clinical impact with the addition of MM. Acute phase reactants were not statistically significant for high-sensitivity C-reactive proteins (<em>P</em> = .59), HbA_1c (<em>P</em> = .46), or haptoglobin (<em>P</em> = .22) for either group. These outcomes continued at the 9- and 12-month posttreatment follow-up.</div></div><div><h3>Conclusions</h3><div>SRP alone and SRP+MM minimally reduced levels of cytokine biomarkers and acute phase reactants in self-reported systemically healthy patients with advanced stages of periodontitis. Thresholds for resolution of local clinical inflammation may not have been achieved in this study to result in a reduction of systemic inflammation.</div></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"3 ","pages":"Article 100040"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142654050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of human papillomavirus infection in oral mucosal diseases","authors":"Paolo Junior Fantozzi DDS ,&nbsp;Umberto Romeo DDS ,&nbsp;Gianluca Tenore DDS, PhD ,&nbsp;Gaspare Palaia DDS, PhD ,&nbsp;Chiara Ciolfi DDS ,&nbsp;Alessandra Pierangeli PhD ,&nbsp;Cira Rosaria Tiziana Di Gioia MD, PhD ,&nbsp;Alessandro Villa DDS, PhD, MPH","doi":"10.1016/j.jfscie.2024.100031","DOIUrl":"https://doi.org/10.1016/j.jfscie.2024.100031","url":null,"abstract":"<div><h3>Background</h3><p>Human papillomavirus (HPV) infection accounts for more than 70% of oropharyngeal cancers but only a small proportion of oral cavity cancers. This study aimed to investigate the presence of HPV DNA in oral diseases to understand better the possible correlation between oral lesions and HPV infections.</p></div><div><h3>Methods</h3><p>This was a cross-sectional study of 99 adult patients seen for the evaluation of oral diseases. All patients received an oral biopsy and histopathologic examination and a brush biopsy for HPV-DNA detection and genotyping by real-time polymerase chain reaction. Immunohistochemistry was used to assess p16INK4a expression.</p></div><div><h3>Results</h3><p>HPV was identified in 15 of 99 (15.2%) patients (males, 66.6%). Patients with oral leukoplakia (OL) (46.6%), followed by patients with oral lichen planus (OLP) (33.3%) had the highest rate of HPV infection, with a predilection for the buccal mucosa (17.5%). Most patients with high-risk HPV infections had OLP (4/10, 40.0%), whereas most of the patients with low-risk HPV infections had nonreactive epithelial hyperkeratosis (3/6, 50.0%). Among all benign lesions, 19.0% were positive for any HPV infection. One patient with OL showing mild epithelial dysplasia had a positive p16INK4a expression.</p></div><div><h3>Conclusions</h3><p>The highest rate of HPV infection was in male patients, patients with OL and OLP, and conditions affecting the buccal mucosa. Larger studies are needed to elucidate the role of HPV in the development of these conditions.</p></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"3 ","pages":"Article 100031"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772414X2400001X/pdfft?md5=4e7645c8b5dbc1b14aae1d459d4c1171&pid=1-s2.0-S2772414X2400001X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140555056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A combination treatment of low-dose dexamethasone and aspirin-triggered resolvin D1 reduces Sjögren syndrome–like features in a mouse model","authors":"Harim Tavares dos Santos DDS, PhD ,&nbsp;Frank Maslow BS ,&nbsp;Kihoon Nam PhD ,&nbsp;Bryan Trump DDS ,&nbsp;Gary A. Weisman PhD ,&nbsp;Olga J. Baker DDS, PhD","doi":"10.1016/j.jfscie.2022.100016","DOIUrl":"10.1016/j.jfscie.2022.100016","url":null,"abstract":"<div><h3>Background</h3><p>Sjögren syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration and diminished secretory function of the salivary glands. Dexamethasone (DEX) resolves dry mouth and lymphocytic infiltration; however, this treatment is difficult to maintain because of multiple adverse effects (eg, osteoporosis and skin thinning); likewise, aspirin-triggered resolvin D1 (AT-RvD1) increases saliva secretion but cannot eliminate lymphocytic infiltration. Previous studies showed that a combination of low-dose DEX with AT-RvD1 before disease onset prevents SS-like features in a mouse model; however, this is not clinically practical because there are no reliable indicators of SS before disease onset. Therefore, the authors applied the combined treatment at disease onset to show its efficacy and comparative lack of adverse effects, so that it may reasonably be maintained over a patient’s lifetime.</p></div><div><h3>Methods</h3><p>NOD/ShiLtJ mice were treated with ethanol (vehicle control), high-dose DEX alone, AT-RvD1 alone, or a combination of low-dose DEX with AT-RvD1 at disease onset for 8 weeks. Then saliva flow rates were measured, and submandibular glands were harvested for histologic analyses.</p></div><div><h3>Results</h3><p>A combined treatment of low-dose DEX with AT-RvD1 significantly decreased mast cell degranulation and lymphocytic infiltration, increased saliva secretion, and restored apical aquaporin-5 expression in submandibular glands of NOD/ShiLtJ mice.</p></div><div><h3>Conclusions</h3><p>Low-dose DEX combined with AT-RvD1 reduces the severity of SS-like manifestation and prevents the development of advanced and potentially irreversible damage, all in a form that can reasonably be administered indefinitely without the need to cease treatment because of secondary effects.</p></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"2 ","pages":"Article 100016"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6b/14/nihms-1926175.PMC10448398.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10459157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey of the mechanical and physical behaviors of yttria-stabilized zirconia from multiple dental laboratories","authors":"Yifeng Liao PhD ,&nbsp;Max Gruber BSE ,&nbsp;Henry Lukic BSE ,&nbsp;Jim McLees CDT ,&nbsp;Si Chen PhD ,&nbsp;Alan Boghosian DDS ,&nbsp;Spiro Megremis MS, PhD","doi":"10.1016/j.jfscie.2022.100018","DOIUrl":"https://doi.org/10.1016/j.jfscie.2022.100018","url":null,"abstract":"","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"2 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49783713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the transparent surface layer formed at the surfaces of arrested enamel caries lesions with tomographic imaging methods","authors":"Nai-Yuan N. Chang DDS, PhD ,&nbsp;Morgan Ng BS ,&nbsp;Tina Dillas BS ,&nbsp;Yi-Ching Ho DDS, PhD ,&nbsp;Yihua Zhu MS ,&nbsp;Daniel Fried PhD","doi":"10.1016/j.jfscie.2023.100025","DOIUrl":"https://doi.org/10.1016/j.jfscie.2023.100025","url":null,"abstract":"","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"2 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49783717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive dental materials","authors":"Jack L. Ferracane PhD ,&nbsp;Sharanbir K. Sidhu BDS, MSc, PhD ,&nbsp;Mary Anne S. Melo DDS, MSc, PhD, FADM ,&nbsp;In-Sung Luke Yeo DDS, MSD, PhD ,&nbsp;Anibal Diogenes DDS, MS, PhD ,&nbsp;Brian W. Darvell DSc","doi":"10.1016/j.jfscie.2023.100022","DOIUrl":"https://doi.org/10.1016/j.jfscie.2023.100022","url":null,"abstract":"","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"2 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49783716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In silico study of hyposalivation and sugar exposure on biofilm dysbiosis","authors":"David Head PhD ,&nbsp;Philip D. Marsh PhD ,&nbsp;Deirde Devine PhD ,&nbsp;Livia M.A. Tenuta DDS, MS, PhD","doi":"10.1016/j.jfscie.2022.100019","DOIUrl":"10.1016/j.jfscie.2022.100019","url":null,"abstract":"<div><h3>Background</h3><p>Dental caries develops under actively sugar-fermenting dental biofilms, but the most successful control methods available only target mineral loss. Reduced salivary flow rates (hyposalivation) significantly exacerbate caries progression by lessening sugar and acid clearance near tooth surfaces. Maintaining dental biofilm symbiosis (health) under hyposalivation requires knowledge of the impact of acid inhibition under given dietary regimens.</p></div><div><h3>Methods</h3><p>An individual-based mathematical model was used to predict biofilm dysbiosis under normal or hyposalivatory conditions by regulating the frequency of sugar intake and inhibiting microbial glycolysis, reducing the acid challenge to the tooth mineral. The impact of pH-dependent (stronger inhibition at lower pH [eg, fluoride]) and pH-independent (general percentage reduction in acid production) strategies on pH near the tooth surface during sugar intake, and the corresponding compositional changes in the biofilm, were quantified.</p></div><div><h3>Results</h3><p>Under normal saliva flow, reducing the frequency of sugar intake and increasing the inhibition of acid production by pH-dependent or pH-independent strategies could prevent bacterial dysbiosis and prevent the biofilm from having a caries-associated (dysbiotic) to a health-associated (symbiotic) composition. However, under hyposalivatory conditions, dysbiosis occurred beyond 2 sugar intakes per day, and the degree of inhibition of glycolysis required to prevent dysbiosis was not feasible with available therapeutics.</p></div><div><h3>Conclusions</h3><p>Model data predict that to counteract the drastic effect of hyposalivation on biofilm dysbiosis, it will be essential to significantly reduce the frequency of fermentable sugar intake and any direct inhibition of bacterial metabolism.</p></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"2 ","pages":"Article 100019"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46203290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular systems architecture of host-microbiome interactions in periodontitis","authors":"V.A. Shiva Ayyadurai PhD ,&nbsp;Prabhakar Deonikar PhD ,&nbsp;Philip Stashenko DMD, PhD","doi":"10.1016/j.jfscie.2023.100026","DOIUrl":"https://doi.org/10.1016/j.jfscie.2023.100026","url":null,"abstract":"","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"2 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49783718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}