JADA foundational science最新文献

{"title":"The effect of allulose, sucralose, and xylitol on Streptococcus mutans acid production","authors":"John D. Ruby DMD, PhD ,&nbsp;Stephanie S. Momeni PhD, MBA ,&nbsp;Hui Wu PhD","doi":"10.1016/j.jfscie.2025.100052","DOIUrl":"10.1016/j.jfscie.2025.100052","url":null,"abstract":"<div><h3>Background</h3><div>Caries is a bacterial infection driven by a dysbiotic biofilm enriched and fueled by sugar. Frequent consumption of sugar can impart negative health effects, including caries; thus, there is increased interest in identifying less cariogenic sugar substitutes. In this study, the authors investigated the in vitro pH shift by <em>Streptococcus mutans</em> planktonic cells in the presence of various sugars and sugar substitutes.</div></div><div><h3>Methods</h3><div><em>S mutans</em> UA159 cells were suspended in a potassium chloride and magnesium chloride salt solution, and acidogenesis was determined by pH drop assay after the additions of sugars (sucrose, glucose, fructose) or sugar substitutes (allulose, sucralose, xylitol). The pH of <em>S mutans</em> cell suspensions was recorded at 10-minute intervals for 1 hour. Planktonic cells were then challenged with glucose and pH was monitored for an additional hour.</div></div><div><h3>Results</h3><div>All sugars resulted in an initial pH drop to 3.5. For xylitol and sucralose, the pH drop was minimal. Allulose initially dropped to a pH of 5.4 before leveling to 5.7. In subsequent glucose challenges, all <em>S mutans</em> cell suspensions with sugar substitutes dropped to pH 3.5.</div></div><div><h3>Conclusions</h3><div>Allulose, sucralose, and xylitol did not cause a pH drop as low as sugars, and were not considered cariogenic, except for allulose potentially causing root caries. Sugar substitutes were not able to prevent a pH drop to near 3.5 after the glucose challenge indicating these substitutes are not anticariogenic in the presence of glucose.</div></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"4 ","pages":"Article 100052"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation therapy","authors":"Praveen R. Arany BDS, MDS, MMSc, PhD","doi":"10.1016/j.jfscie.2025.100045","DOIUrl":"10.1016/j.jfscie.2025.100045","url":null,"abstract":"<div><h3>Objectives</h3><div>The use of low doses of photons (light) in biological tissues to modulate (inhibit or stimulate) responses is termed photobiomodulation (PBM). This nonthermal, noninvasive, and nonsurgical light treatment has been reported to reduce pain or inflammation, modulate immune responses, and promote tissue healing and regeneration. These fundamental pathophysiological responses underlie several oral and dental diseases, highlighting the broad scope of PBM interventions such as alleviating pain, discomfort, and swelling postsurgical procedures, including third-molar extractions, managing oncotherapy-associated mucositis and temporomandibular joint disorders, and promoting accelerated orthodontic tooth movements and implant osseointegration.</div></div><div><h3>Search Strategy, Citation Sources, and Data Elements</h3><div>This narrative review provides the state-of-the-art in the PBM field, including history, terminology, mechanisms, devices, safety, regulations, and policy. The primary emphasis of this work is to outline the advances in mechanistic insights and clinical dosing paradigms that enable the safe and effective use of this therapy.</div></div><div><h3>Overall Conclusions</h3><div>The importance of fundamental PBM education and training concepts focusing on light-tissue interactions, target tissue composition, evoked therapeutic biological responses, clinical diagnosis, and rationalized dose prescriptions is emphasized. Furthermore, several issues and logistical concerns should be addressed to enable the routine use of this innovative nonpharmacological treatment. A succinct version of this article is available as the American Dental Association Technical Report no. 189 Standards Committee on Dental Products Working Group 6.58.</div></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"4 ","pages":"Article 100045"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generative AI","authors":"Falk Schwendicke ,&nbsp;Sharanbir K. Sidhu ,&nbsp;Jack L. Ferracane ,&nbsp;Antonin Tichy ,&nbsp;Nicholas S. Jakubovics","doi":"10.1016/j.jfscie.2025.100056","DOIUrl":"10.1016/j.jfscie.2025.100056","url":null,"abstract":"<div><div>Generative artificial intelligence (AI) has the capability to generate new content—including text, code, imagery, video, and speech—based on human prompts and is entering dental and oral research. By retrieving, analyzing, summarizing, and contextualizing vast datasets, generative AI offers substantial potential to enhance scientific workflows. It can improve documentation, communication, and reproducibility while saving time and accelerating discovery. However, its integration into research brings significant ethical, societal, and scientific challenges. Concerns include embedded data biases, automation bias, overreliance, and error propagation, all requiring critical human oversight. Furthermore, generative AI raises complex issues around plagiarism, fraud, attribution, and reproducibility, compounded by the potential for AI “hallucinations” or fabricated content. Addressing these concerns demands transparency, robust verification processes, ethical compliance, and clear documentation distinguishing synthetic from real-world data. Several scientific and regulatory bodies have published guidelines to support responsible AI use. Recommendations relevant to scientists in dental, oral, and craniofacial research include transparent disclosure of AI tools and methods, thorough verification of AI outputs, ethical oversight, and active monitoring. Scientists are urged to work collaboratively with stakeholders to enforce these principles and engage the public in the evolving discourse. The risk of misuse, particularly through fraudulent AI-generated publications, is growing. Paper mills exploiting generative AI can produce fabricated or manipulated articles, which may mislead the scientific community and distort evidence bases. Coordinated action, involving journals, institutions, and ethics bodies, is essential to combat these threats. As generative AI continues to evolve, adaptive and harmonized guidelines wil be necessary to safeguard scientific integrity. Researchers, reviewers, and editors must play a proactive role in ensuring that AI serves to advance—not undermine—the quality and trustworthiness of dental and oral science.</div></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"4 ","pages":"Article 100056"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145361832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental plaque","authors":"Jessica L. Mark Welch PhD,&nbsp;Gary G. Borisy PhD","doi":"10.1016/j.jfscie.2025.100051","DOIUrl":"10.1016/j.jfscie.2025.100051","url":null,"abstract":"","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"4 ","pages":"Article 100051"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current basic and preclinical research for treatment of radiation therapy–induced hyposalivation","authors":"Olga J. Baker DDS, PhD ,&nbsp;Harim Tavares dos Santos DDS, PhD ,&nbsp;Kihoon Nam PhD","doi":"10.1016/j.jfscie.2025.100046","DOIUrl":"10.1016/j.jfscie.2025.100046","url":null,"abstract":"<div><h3>Objectives</h3><div>Patients receiving radiation therapy (RT) for head and neck cancer experience hyposalivation, a condition that results in loss of oral health and significantly decreases the quality of life of millions of patients worldwide. Treatments include saliva substitutes and secretory agonists that provide only temporary relief and can result in significant adverse effects. To find more permanent and clinically viable solutions, alternative strategies are being developed that may restore salivary gland function in patients with head and neck cancer. This review provides an overview and basic interpretation of research for the treatment of RT-induced hyposalivation.</div></div><div><h3>Search Strategy</h3><div>The authors critique and synthesize a broad group of approaches that promote secretory function in an irradiated salivary gland.</div></div><div><h3>Citation Sources</h3><div>Three databases (PubMed, MEDLINE, Google Scholar) were searched for relevant peer-reviewed articles published from January 2000 through July 2024.</div></div><div><h3>Study Selection Criteria</h3><div>The authors selected research constituting a continuum from the most to least studied approaches to treating RT-induced hyposalivation with the goal of facilitating future work in the field.</div></div><div><h3>Data Elements Included</h3><div>The RT-induced hyposalivation treatments were categorized into post- and pre-RT headings, with approaches further distinguished according to their therapeutic goal, modality, and research stage, as well as with regard to their general pros and cons.</div></div><div><h3>Overall Conclusion</h3><div>A summary of the research approaches used to treat RT-induced hyposalivation has been created to encourage the development of improved treatments.</div></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"4 ","pages":"Article 100046"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The future of endodontic diagnosis","authors":"Marie Mora DDS, MS ,&nbsp;Juan Pacheco-Yanes DDS, MS, PhD ,&nbsp;Asgeir Sigurdsson DDS, MS","doi":"10.1016/j.jfscie.2025.100050","DOIUrl":"10.1016/j.jfscie.2025.100050","url":null,"abstract":"<div><h3>Objectives</h3><div>Innovative methods for pulpal diagnosis are becoming increasingly important in endodontics, as traditional diagnostic techniques often lack the precision and reliability needed for confident decision making. Molecular diagnostic approaches, like biomarker analysis and advanced sampling methods, represent a step forward in clinical practice. This narrative review aims to identify key biomarkers associated with pulpal inflammation, compare published cutoff points for these biomarkers, and briefly review molecular methods and sampling techniques.</div></div><div><h3>Search Strategy</h3><div>This study is a narrative review of literature identified by a web-based search on PubMed. Original scientific articles, such as clinical studies, reviews, and case reports, were included.</div></div><div><h3>Results</h3><div>Several biomarkers have been associated with pulp inflammation and have been reported as statistically significant, including interleukin 1, 6, and 8; tumor necrosis factor-α; vascular endothelial growth factor; fibrocyte growth factor acidic; and matrix metalloproteinases 8 and 9. Although some cutoff points for these biomarkers have been identified, further research is necessary to refine their clinical applicability. Various sample collection methods, such as gingival crevicular fluid, dentinal fluid, pulpal tissue, and pulpal blood, have been used. Among the analytical techniques, enzyme-linked immunosorbent assay and Luminex protein assays have proven to be the most accurate, sensitive, and specific for evaluating pulpal inflammation.</div></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"4 ","pages":"Article 100050"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An introduction to antibacterial materials in composite restorations","authors":"Devatha P. Nair MS, PhD ,&nbsp;Sarah Asby MS ,&nbsp;Fernanda S. de Lucena DDS, MS, PhD ,&nbsp;Carmem S. Pfeifer DDS, PhD","doi":"10.1016/j.jfscie.2024.100038","DOIUrl":"10.1016/j.jfscie.2024.100038","url":null,"abstract":"<div><div>The longevity of direct esthetic restorations is severely compromised because of, among other things, a loss of function that comes from their susceptibility to biofilm-mediated secondary caries, with <em>Streptococcus mutans</em> being the most prevalent associated pathogen. Strategies to combat biofilms range from dental compounds that can disrupt multispecies biofilms in the oral cavity to approaches that specifically target caries-causing bacteria such as <em>S mutans</em>. One strategy is to include those antibacterial compounds directly in the material so they can be available long-term in the oral cavity and localized at the margin of the restorations, in which many of the failures initiate. Many antibacterial compounds have already been proposed for use in dental materials, including but not limited to phenolic compounds, antimicrobial peptides, quaternary ammonium compounds, and nanoparticles. In general, the goal of incorporating them directly into the material is to increase their availability in the oral cavity past the fleeting effect they would otherwise have in mouth rinses. This review focuses specifically on natural compounds, of which polyphenols are the most abundant category. The authors examined attempts at using these either as pretreatment or incorporated directly into restorative material as a step toward fulfilling a long-recognized need for restorations that can combat or prevent secondary caries formation. Repeatedly restoring failed restorations comes with the loss of more tooth structure along with increasingly complex and costly dental procedures, which is detrimental to not only oral health but also systemic health.</div></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"3 ","pages":"Article 100038"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of silver diamine fluoride on nicotine-induced Streptococcus mutans biofilm","authors":"Marwa M. Elsharkasi BDS, MSD, ABOD ,&nbsp;George J. Eckert MAS ,&nbsp;Richard L. Gregory PhD","doi":"10.1016/j.jfscie.2024.100039","DOIUrl":"10.1016/j.jfscie.2024.100039","url":null,"abstract":"<div><h3>Background</h3><div>Silver diamine fluoride (SDF) reagent is used to prevent and arrest caries lesions. However, the mechanism of its action is not fully reported. The antimicrobial effect of SDF was determined on an established nicotine-induced <em>Streptococcus mutans</em> biofilm by measuring colony-forming units (CFUs), different application times, and extracellular polysaccharide (EPS) synthesis.</div></div><div><h3>Methods</h3><div><em>S mutans</em> biofilm was established with and without 2 mg/mL of nicotine in tryptic soy broth supplemented with sucrose. Nicotine and nonnicotine-induced biofilm groups were treated with 38% SDF for 1 minute. Non-SDF-treated groups were used as a control. The biofilm was plated on blood agar plates, and CFUs were determined. In addition, different SDF application times (30 seconds and 1, 2, and 3 minutes) were tested. For EPS production, <em>S mutans</em> were incubated with and without nicotine in tryptic soy broth supplemented with sucrose. SDF groups were treated with SDF for 1 minute. A phenol-sulfuric acid assay was used to measure the total carbohydrate produced.</div></div><div><h3>Results</h3><div>There was a significant effect of SDF on reducing CFUs for both nicotine and nonnicotine groups. The different application times of SDF reduced CFUs for all tested groups. EPS production was significantly reduced with the SDF application.</div></div><div><h3>Conclusions</h3><div>The use of SDF with different application times disrupted established <em>S mutans</em> biofilms. In addition, EPS production was reduced by the application of SDF. This confirms the ability of a shorter SDF treatment time to be effective and suggests a possible mechanism of action for the inhibition of caries development.</div></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"3 ","pages":"Article 100039"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The receipt of the human papillomavirus vaccine’s influence on future human papillomavirus vaccine recommendations by medical and dental students","authors":"Ana Karina Mascarenhas BDS, MPH, DrPH ,&nbsp;Arati Kelekar MD ,&nbsp;Victoria C. Lucia PhD ,&nbsp;Nelia M. Afonso MD","doi":"10.1016/j.jfscie.2023.100029","DOIUrl":"https://doi.org/10.1016/j.jfscie.2023.100029","url":null,"abstract":"<div><h3>Background</h3><p>With a growing vaccine-hesitant population and with the increase in oral cancers, particularly in a younger population, there is a heightened need for dental and medical providers to advocate for vaccination, including the human papillomavirus (HPV) vaccine. This study aimed to assess HPV vaccine knowledge, personal immunization status, and attitudes and opinions of dental students (DSs) and medical students (MSs).</p></div><div><h3>Methods</h3><p>Students from 1 medical and 4 dental schools in the United States completed an anonymous online survey assessing knowledge and attitudes and opinions about the HPV vaccine, including personal HPV vaccine status and confidence in vaccine counseling.</p></div><div><h3>Results</h3><p>Seventy percent of the 453 students who completed the survey were vaccinated for HPV. Male students were significantly less likely to have received the HPV vaccine (odds ratio [OR], 0.37; 95% CI, 0.24 to 0.56). MSs were 1.75 times more likely to have received the HPV vaccine than DSs (95% CI, 1.16 to 2.63). Those who were vaccinated and those who were not vaccinated substantially differed in opinions and knowledge of the HPV vaccine. Vaccinated students were more than 5 times more likely to report they would recommend HPV vaccines to friends and family (OR, 5.22; 95% CI, 2.57 to 10.87), recommend HPV vaccines to patients (OR, 2.71; 95% CI, 1.39 to 5.26), and advocate for HPV vaccines (OR, 2.42; 95% CI, 1.24 to 4.70). In the linear regression model, age (<em>P</em> = .0204 and <em>P</em> &lt; .00003), profession (<em>P</em> &lt; .00001), and HPV vaccination status (<em>P</em> &lt; .00001) predicted HPV knowledge.</p></div><div><h3>Conclusions</h3><p>These findings show that MSs are more likely to be vaccinated. In addition, HPV-vaccinated people had better knowledge, attitudes, and opinions than those who were not vaccinated. Receipt of the HPV vaccine increased advocacy for the vaccine. Educating these professionals about the efficacy and impact of the HPV vaccine could increase their advocacy for the vaccine.</p></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"3 ","pages":"Article 100029"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772414X23000099/pdfft?md5=16ddafca1a92abea6a946dd5fff69f4e&pid=1-s2.0-S2772414X23000099-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139406011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of repeated activation on the heat output of electric pluggers","authors":"Anthony G. Fioretti DDS, MS ,&nbsp;Andrew D. Henning DMD, MS ,&nbsp;Susan E. Hinman DDS, MS ,&nbsp;Rodney V. Scott DDS, MS ,&nbsp;Nancy H. Osborne DDS, MS ,&nbsp;Nicholas J. Hamlin PhD, DDS, MS","doi":"10.1016/j.jfscie.2024.100032","DOIUrl":"https://doi.org/10.1016/j.jfscie.2024.100032","url":null,"abstract":"<div><h3>Background</h3><p>Electric pluggers that output accurate and reliable heat are required to thermoplasticize gutta-percha for endodontic obturation. This study aimed to evaluate the accuracy and reliability of heat output by Buchanan electronic pluggers (Kerr Endodontics) after repeated activation cycles.</p></div><div><h3>Methods</h3><p>The Elements Obturation Unit (Kerr Endodontics) was operated in downpack mode according to the manufacturer’s recommendations with a temperature of 200 °C and automatic cutoff after 4 seconds of continuous activation. Fifteen Buchanan Heat Pluggers were tested: 5 of each of sizes extra fine (XF) (0.04 taper), fine (F) (0.06 taper), and fine medium (FM) (0.08 taper). Pluggers were allowed to cool for 5 to 10 seconds between activations and were activated 25 times per day for 80 days, totaling 2,000 activations per plugger. A thermocouple and an electronic data logger were used to record a single peak temperature for each plugger at the final activation of each day.</p></div><div><h3>Results</h3><p>There was no degradation in heat generation across 2,000 activations for any of the plugger sizes. Heat output for XF (0.04 taper) pluggers was significantly lower than for F (0.06 taper) and FM (0.08 taper) pluggers. Three of the 5 XF pluggers lost functionality before reaching 2,000 activations.</p></div><div><h3>Conclusions</h3><p>The heat output for F (0.06 taper) and FM (0.08 taper) pluggers was close to expected (temperatures) and did not degrade over 2,000 activations. All plugger sizes showed high variance in heat output. XF (0.04 taper) pluggers may be prone to lower temperature output than larger plugger sizes and prone to failure before 2,000 activations.</p></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"3 ","pages":"Article 100032"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772414X24000021/pdfft?md5=3177ab1c57fc5365128988b730757f63&pid=1-s2.0-S2772414X24000021-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140160027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}