JADA foundational science最新文献

{"title":"The receipt of the human papillomavirus vaccine’s influence on future human papillomavirus vaccine recommendations by medical and dental students","authors":"Ana Karina Mascarenhas BDS, MPH, DrPH ,&nbsp;Arati Kelekar MD ,&nbsp;Victoria C. Lucia PhD ,&nbsp;Nelia M. Afonso MD","doi":"10.1016/j.jfscie.2023.100029","DOIUrl":"https://doi.org/10.1016/j.jfscie.2023.100029","url":null,"abstract":"<div><h3>Background</h3><p>With a growing vaccine-hesitant population and with the increase in oral cancers, particularly in a younger population, there is a heightened need for dental and medical providers to advocate for vaccination, including the human papillomavirus (HPV) vaccine. This study aimed to assess HPV vaccine knowledge, personal immunization status, and attitudes and opinions of dental students (DSs) and medical students (MSs).</p></div><div><h3>Methods</h3><p>Students from 1 medical and 4 dental schools in the United States completed an anonymous online survey assessing knowledge and attitudes and opinions about the HPV vaccine, including personal HPV vaccine status and confidence in vaccine counseling.</p></div><div><h3>Results</h3><p>Seventy percent of the 453 students who completed the survey were vaccinated for HPV. Male students were significantly less likely to have received the HPV vaccine (odds ratio [OR], 0.37; 95% CI, 0.24 to 0.56). MSs were 1.75 times more likely to have received the HPV vaccine than DSs (95% CI, 1.16 to 2.63). Those who were vaccinated and those who were not vaccinated substantially differed in opinions and knowledge of the HPV vaccine. Vaccinated students were more than 5 times more likely to report they would recommend HPV vaccines to friends and family (OR, 5.22; 95% CI, 2.57 to 10.87), recommend HPV vaccines to patients (OR, 2.71; 95% CI, 1.39 to 5.26), and advocate for HPV vaccines (OR, 2.42; 95% CI, 1.24 to 4.70). In the linear regression model, age (<em>P</em> = .0204 and <em>P</em> &lt; .00003), profession (<em>P</em> &lt; .00001), and HPV vaccination status (<em>P</em> &lt; .00001) predicted HPV knowledge.</p></div><div><h3>Conclusions</h3><p>These findings show that MSs are more likely to be vaccinated. In addition, HPV-vaccinated people had better knowledge, attitudes, and opinions than those who were not vaccinated. Receipt of the HPV vaccine increased advocacy for the vaccine. Educating these professionals about the efficacy and impact of the HPV vaccine could increase their advocacy for the vaccine.</p></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"3 ","pages":"Article 100029"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772414X23000099/pdfft?md5=16ddafca1a92abea6a946dd5fff69f4e&pid=1-s2.0-S2772414X23000099-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139406011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of repeated activation on the heat output of electric pluggers","authors":"Anthony G. Fioretti DDS, MS ,&nbsp;Andrew D. Henning DMD, MS ,&nbsp;Susan E. Hinman DDS, MS ,&nbsp;Rodney V. Scott DDS, MS ,&nbsp;Nancy H. Osborne DDS, MS ,&nbsp;Nicholas J. Hamlin PhD, DDS, MS","doi":"10.1016/j.jfscie.2024.100032","DOIUrl":"https://doi.org/10.1016/j.jfscie.2024.100032","url":null,"abstract":"<div><h3>Background</h3><p>Electric pluggers that output accurate and reliable heat are required to thermoplasticize gutta-percha for endodontic obturation. This study aimed to evaluate the accuracy and reliability of heat output by Buchanan electronic pluggers (Kerr Endodontics) after repeated activation cycles.</p></div><div><h3>Methods</h3><p>The Elements Obturation Unit (Kerr Endodontics) was operated in downpack mode according to the manufacturer’s recommendations with a temperature of 200 °C and automatic cutoff after 4 seconds of continuous activation. Fifteen Buchanan Heat Pluggers were tested: 5 of each of sizes extra fine (XF) (0.04 taper), fine (F) (0.06 taper), and fine medium (FM) (0.08 taper). Pluggers were allowed to cool for 5 to 10 seconds between activations and were activated 25 times per day for 80 days, totaling 2,000 activations per plugger. A thermocouple and an electronic data logger were used to record a single peak temperature for each plugger at the final activation of each day.</p></div><div><h3>Results</h3><p>There was no degradation in heat generation across 2,000 activations for any of the plugger sizes. Heat output for XF (0.04 taper) pluggers was significantly lower than for F (0.06 taper) and FM (0.08 taper) pluggers. Three of the 5 XF pluggers lost functionality before reaching 2,000 activations.</p></div><div><h3>Conclusions</h3><p>The heat output for F (0.06 taper) and FM (0.08 taper) pluggers was close to expected (temperatures) and did not degrade over 2,000 activations. All plugger sizes showed high variance in heat output. XF (0.04 taper) pluggers may be prone to lower temperature output than larger plugger sizes and prone to failure before 2,000 activations.</p></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"3 ","pages":"Article 100032"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772414X24000021/pdfft?md5=3177ab1c57fc5365128988b730757f63&pid=1-s2.0-S2772414X24000021-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140160027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The oral microbiome","authors":"Justin Merritt PhD ,&nbsp;Jack L. Ferracane PhD","doi":"10.1016/j.jfscie.2024.100042","DOIUrl":"10.1016/j.jfscie.2024.100042","url":null,"abstract":"","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"3 ","pages":"Article 100042"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relaxation mechanisms in low-stress polymer networks with alternative chemistries","authors":"Steven H. Lewis BS, MS,&nbsp;Ana Paula P. Fugolin DDS, MS, PhD,&nbsp;Anissa Bartolome BS,&nbsp;Carmem S. Pfeifer DDS, PhD","doi":"10.1016/j.jfscie.2024.100033","DOIUrl":"https://doi.org/10.1016/j.jfscie.2024.100033","url":null,"abstract":"<div><h3>Background</h3><p>Low-stress resin-based composites (RBCs) are available to the clinician, some using stress relaxation mechanisms on the basis of network reconfiguration, modulated photopolymerization, or chain transfer reactions. This study investigated those materials in terms of their overall stress relaxation and their relationship with polymerization kinetics and compared them with an experimental low-stress thiourethane (TU) material.</p></div><div><h3>Methods</h3><p>Experimental composites (bisphenol-A-diglycidyl dimethacrylate, urethane dimethacrylate, and triethylene glycol dimethacrylate [50:30:20 mass ratio]; 70% barium aluminosilicate filler; camphoroquinone, ethyl-4-dimethylaminobenzoate, and 2,6-di-tert-butyl-4-methylphenol [0.2:0.8:0.2% by mass]) with or without TU oligomer (synthesized in-house) and commercial composites (SureFil SDR Flow+ Posterior Bulk Fill Flowable Base [SDR Flow+] [Dentsply Sirona], Filtek Bulk Fill Posterior Restorative [3M ESPE], and Filtek Supreme Ultra Universal Restorative [3M ESPE]) were tested. Polymerization kinetics (near-infrared) and polymerization stress (Bioman) were evaluated during light-emitting diode photoactivation at 100 mW/cm² for 20 seconds. Stress relaxation was assessed using dynamic mechanical analysis. Data were analyzed with a 1-way analysis of variance and Tukey test (α = 0.05).</p></div><div><h3>Results</h3><p>The kinetic profiles of all materials differed substantially, including more than a 2-fold difference in the rate of polymerization between TU-modified composites and SDR Flow+. TU-modified RBCs also showed more than a 2-fold higher conversion at the onset of deceleration vs the experimental control and commercial materials. RBCs that used stress reduction mechanisms showed at least a 34% reduction in polymerization stress compared with the controls and significantly reduced the amount of early-onset stress buildup. SDR Flow+ and the TU-modified RBCs showed the greatest amount of viscoelastic stress relaxation postpolymerization.</p></div><div><h3>Conclusions</h3><p>The novel TU-modified materials showed similar or improved performance compared with commercial low-stress RBCs, showing that chain transfer may be a promising strategy for stress reduction, both during polymerization and after polymerization.</p></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"3 ","pages":"Article 100033"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772414X24000033/pdfft?md5=fe849c9ccb34e08cda9da7e3b7657d3e&pid=1-s2.0-S2772414X24000033-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140351147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted enamel remineralization with mineral-loaded starch particles","authors":"Nathan A. Jones PhD ,&nbsp;Li-Chi Pan MEng ,&nbsp;Susan E. Flannagan MS ,&nbsp;Kai A. Jones MD ,&nbsp;Lyudmila Lukashova MS ,&nbsp;Lucas Wightman BEng ,&nbsp;Sywe-Ren Chang MS ,&nbsp;Glenn Jones MD ,&nbsp;Livia M.A. Tenuta DDS, PhD ,&nbsp;Carlos González-Cabezas DDS, PhD ,&nbsp;Brian H. Clarkson DDS, PhD ,&nbsp;Wendy Bloembergen MD ,&nbsp;Steven Bloembergen PhD","doi":"10.1016/j.jfscie.2024.100041","DOIUrl":"10.1016/j.jfscie.2024.100041","url":null,"abstract":"<div><h3>Background</h3><div>Noninvasive caries treatments work topically, which may limit efficacy. The authors hypothesized that an alternative approach using mineral-loaded particles designed to target the subsurface of noncavitated caries lesions could be advantageous. This study shows in vitro proof-of-concept.</div></div><div><h3>Methods</h3><div>Mineral-loaded cationic starch (MLCS) particles were prepared, containing calcium, phosphate, and fluoride to provide fluoride-plus (FP) and fluoride-free (FF) alternatives. Particles were characterized for mineral loading and release. MLCS-FP and -FF treatments vs 1,000 ppm fluoride and deionized water controls were evaluated on natural smooth-surface caries lesions (n = 15 per group) after a 20-day protocol with immersion in artificial saliva with amylase and acid challenge. Treatment efficacy was assessed by microcomputed tomography, labeled fluorescence imaging, and blinded qualitative visual assessment.</div></div><div><h3>Results</h3><div>In aqueous suspension and absent amylase, particles showed sustained mineral ion release. The tomographic evaluation found significant (multivariable regression analysis, <em>P</em> &lt; .05) restoration of lesion mineral density by MLCS-FP and MLCS-FF (42.9% and 38.6%, respectively) vs fluoride and negative controls (7.4% and −18%, respectively), particularly for the lesion subsurface (13.8% [13.0%], 15.9% [9.4%], −2.2% [7.3%], and −1.8% [4.0%] relative hydroxyapatite density for 0.25 through 0.45 μm lesion depth for FP, FF, fluoride, and deionized water, respectively). Visually reduced white opacity (Fisher exact test, <em>P</em> = .038, MLCS-FF vs fluoride) and labeled fluorescence (analysis of variance, <em>P</em> &lt; .05 for MLCS-FF [75.4%], MLCS-FP [75.7%], fluoride [64.1%] vs negative control [−0.2%]) were observed.</div></div><div><h3>Conclusions</h3><div>These foundational studies show the potential of mineral-loaded starch particles to remineralize enamel as a new approach to treating early caries by subsurface targeted mineral delivery. The in vitro study results indicated that targeted particles improved treatment efficacy, with the data supporting the superiority of MLCS-FP and FF formulations over control conditions for subsurface remineralization and visual esthetic.</div></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"3 ","pages":"Article 100041"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of flow cytometry to analyze microbial quality of dental unit water","authors":"Clifton M. Carey PhD ,&nbsp;Shannon E. Mills DDS ,&nbsp;Richard Vigil MS ,&nbsp;Madison Aungst BS, DDS ,&nbsp;Lacey Favazzo PhD","doi":"10.1016/j.jfscie.2024.100037","DOIUrl":"10.1016/j.jfscie.2024.100037","url":null,"abstract":"<div><h3>Background</h3><div>Dental unit waterline (DUWL) safety is vital for dental practitioners. Unfortunately, the standard heterotrophic plate count (HPC) methods commonly used to identify bacterial contamination dramatically underestimate planktonic bacteria counts. Flow cytometry (FCM) directly counts bacterial cells using laser-activated fluorescence, providing more reliable and timely results.</div></div><div><h3>Methods</h3><div>Approximately 1,700 DUWL samples were measured by both HPC and FCM methods. HPC samples were plated on R2A agar within 8 hours of receipt, incubated at 25 °C for 7 days, and reported as colony-forming units (CFU)/mL. FCM samples were treated with SYBR Green I fluorescent stain, analyzed and reported as high nucleic acid (HNA) and low nucleic acid (LNA) cell counts. An empirical algorithm was developed using HNA and LNA cell counts compared with the recommended action limit for the Centers for Disease Control and Prevention’s greater than 500 CFU/mL pass or fail.</div></div><div><h3>Results</h3><div>An FCM threshold limit that included both HNA 250 or greater and LNA 750 or greater cell counts was derived by pairing FCM data with R2A samples dichotomized as passing (≤ 500 CFU/mL) or failing (&gt; 500 CFU/mL) to establish corresponding pass or fail criteria that would minimize false pass and false fail compared with R2A results. 1,388 (81.6%) of samples passed the R2A limit of 500 CFU/mL or fewer, whereas 1,427 (83.9%) FCM samples passed the proposed HNA 250 or fewer and LNA 750 or fewer criteria.</div></div><div><h3>Conclusions</h3><div>The data show that FCM analysis and the proposed threshold criteria can be used as a powerful adjunctive tool for monitoring DUWL contamination, which includes greater accuracy and the ability to analyze samples immediately on receipt.</div></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"3 ","pages":"Article 100037"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142326573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cleaning of dental handpieces","authors":"Ludger Schnieder PhD,&nbsp;Karen Seekamp-Schnieder PhD","doi":"10.1016/j.jfscie.2023.100030","DOIUrl":"https://doi.org/10.1016/j.jfscie.2023.100030","url":null,"abstract":"<div><h3>Background</h3><p>This work aimed to provide evidence for the importance of regular cleaning and care of dental handpieces. In addition, this study aimed to show that automated cleaning of dental tools may deliver superior results compared with manual cleaning.</p></div><div><h3>Methods</h3><p>Publicly available data from the US Food and Drug Administration’s (FDA’s) Manufacturer and User Facility Device Experience (MAUDE) database on incidents in the use of dental handpieces from the past 10 years were evaluated. The cleaning results of more than 4,830 instruments were also investigated and evaluated.</p></div><div><h3>Results</h3><p>By evaluating the manufacturer’s information on the incidents reported in the FDA’s MAUDE database, the connection between inadequate or no maintenance and care and the incidents was clearly shown. The evaluation of the results of manual cleaning compared with automated cleaning clearly shows that better results can be achieved through automated cleaning.</p></div><div><h3>Conclusions</h3><p>The evaluation of the FDA’s MAUDE database confirmed and emphasized the importance of cleaning and care for the safe and long-term use of dental tools. Comparing the data from manual cleaning and the usage of a device for automated cleaning of dental handpieces, it was shown that the establishment of a quality-controlled system for in-use testing of cleaning performance could provide valuable data for assessing the efficacy of different cleaning processes. Valuable feedback for the user can be derived this way. In addition, it was shown that automated cleaning of dental handpieces is a reasonable alternative and leads to clearly better results.</p></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"3 ","pages":"Article 100030"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772414X23000105/pdfft?md5=35a775d5aae60460cfa62da367d545d0&pid=1-s2.0-S2772414X23000105-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139999371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disruptive innovation events in dentistry","authors":"Jill Sirko PhD,&nbsp;Wenyuan Shi PhD","doi":"10.1016/j.jfscie.2024.100036","DOIUrl":"10.1016/j.jfscie.2024.100036","url":null,"abstract":"","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"3 ","pages":"Article 100036"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142573007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of human papillomavirus infection in oral mucosal diseases","authors":"Paolo Junior Fantozzi DDS ,&nbsp;Umberto Romeo DDS ,&nbsp;Gianluca Tenore DDS, PhD ,&nbsp;Gaspare Palaia DDS, PhD ,&nbsp;Chiara Ciolfi DDS ,&nbsp;Alessandra Pierangeli PhD ,&nbsp;Cira Rosaria Tiziana Di Gioia MD, PhD ,&nbsp;Alessandro Villa DDS, PhD, MPH","doi":"10.1016/j.jfscie.2024.100031","DOIUrl":"https://doi.org/10.1016/j.jfscie.2024.100031","url":null,"abstract":"<div><h3>Background</h3><p>Human papillomavirus (HPV) infection accounts for more than 70% of oropharyngeal cancers but only a small proportion of oral cavity cancers. This study aimed to investigate the presence of HPV DNA in oral diseases to understand better the possible correlation between oral lesions and HPV infections.</p></div><div><h3>Methods</h3><p>This was a cross-sectional study of 99 adult patients seen for the evaluation of oral diseases. All patients received an oral biopsy and histopathologic examination and a brush biopsy for HPV-DNA detection and genotyping by real-time polymerase chain reaction. Immunohistochemistry was used to assess p16INK4a expression.</p></div><div><h3>Results</h3><p>HPV was identified in 15 of 99 (15.2%) patients (males, 66.6%). Patients with oral leukoplakia (OL) (46.6%), followed by patients with oral lichen planus (OLP) (33.3%) had the highest rate of HPV infection, with a predilection for the buccal mucosa (17.5%). Most patients with high-risk HPV infections had OLP (4/10, 40.0%), whereas most of the patients with low-risk HPV infections had nonreactive epithelial hyperkeratosis (3/6, 50.0%). Among all benign lesions, 19.0% were positive for any HPV infection. One patient with OL showing mild epithelial dysplasia had a positive p16INK4a expression.</p></div><div><h3>Conclusions</h3><p>The highest rate of HPV infection was in male patients, patients with OL and OLP, and conditions affecting the buccal mucosa. Larger studies are needed to elucidate the role of HPV in the development of these conditions.</p></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"3 ","pages":"Article 100031"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772414X2400001X/pdfft?md5=4e7645c8b5dbc1b14aae1d459d4c1171&pid=1-s2.0-S2772414X2400001X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140555056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of scaling and root planing with and without minocycline hydrochloride microspheres on serum biomarkers and acute phase reactants","authors":"Michelle C. Arnett MS, RDH ,&nbsp;Massimo Costalonga DMD, PhD ,&nbsp;Phonsuda Chanthavisouk MDT, BSDH ,&nbsp;Michael D. Evans MS ,&nbsp;Danna R. Paulson MSDH, RDH, CCRP","doi":"10.1016/j.jfscie.2024.100040","DOIUrl":"10.1016/j.jfscie.2024.100040","url":null,"abstract":"<div><h3>Background</h3><div>This study tests the effects of scaling and root planing (SRP) vs SRP with minocycline hydrochloride microspheres (MMs) (SRP with MM) on serum biomarkers interleukin (IL)-1β, IL-6, tumor necrosis factor-α, and matrix metalloproteinase-8 and acute phase reactants hemoglobin A_1c (HbA_1c), high-sensitivity C-reactive proteins and haptoglobin (Hp) in patients with stage II-IV grade B periodontitis.</div></div><div><h3>Methods</h3><div>Seventy participants were randomized to receive SRP (n = 35) or SRP+MM (n = 35). Serum was collected at baseline (before SRP), 1-month reevaluation visit, and 3- and 6-month periodontal maintenance visits. MMs were delivered to pockets 5 mm or larger immediately after SRP and immediately after the 3-month periodontal maintenance visit. Serum for acute phase reactants only was collected at the 9- and 12-month posttreatment follow-up. All outcomes were summarized using estimated marginal means back-transformed to the original response scale with 95% CIs.</div></div><div><h3>Results</h3><div>At 6 months, no statistical significance was yielded in either group for IL-6 (<em>P</em> = .91), tumor necrosis factor-α (<em>P</em> = .34), or matrix metalloproteinase-8 (<em>P</em> = .34). IL-1β (<em>P</em> = .06) was slightly higher in the SRP-alone group, suggesting a clinical impact with the addition of MM. Acute phase reactants were not statistically significant for high-sensitivity C-reactive proteins (<em>P</em> = .59), HbA_1c (<em>P</em> = .46), or haptoglobin (<em>P</em> = .22) for either group. These outcomes continued at the 9- and 12-month posttreatment follow-up.</div></div><div><h3>Conclusions</h3><div>SRP alone and SRP+MM minimally reduced levels of cytokine biomarkers and acute phase reactants in self-reported systemically healthy patients with advanced stages of periodontitis. Thresholds for resolution of local clinical inflammation may not have been achieved in this study to result in a reduction of systemic inflammation.</div></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"3 ","pages":"Article 100040"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142654050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}