JADA foundational science最新文献

{"title":"Effect of the addition of thiourethane oligomers to experimental silanes and resin cement on the bond strength to glass ceramic","authors":"Anália Gabriella Borges Ferraz Facury DDS, MS ,&nbsp;Ana Rosa Costa DDS, MS, PhD ,&nbsp;Lincoln Pires Silva Borges DDS, PhD ,&nbsp;Fernanda Midori Tsuzuki DDS, PhD ,&nbsp;Américo Bortolazzo Correr DDS, PhD ,&nbsp;Carmem S. Pfeifer DDS, PhD ,&nbsp;Lourenço Correr-Sobrinho DDS, PhD","doi":"10.1016/j.jfscie.2026.100070","DOIUrl":"10.1016/j.jfscie.2026.100070","url":null,"abstract":"<div><h3>Background</h3><div>Despite advances in silane and resin cement formulations, the long-term stability of ceramic bonds remains susceptible to degradation, and strategies to enhance interfacial performance are still under investigation. This study aimed to evaluate the effect of incorporating thiourethane (TU) oligomers into silane or resin cement formulations on the microshear bond strength (μSBS) of ceramic restorations.</div></div><div><h3>Methods</h3><div>Experimental silanes and resin cements containing 0 or 20 wt% TU were formulated with dicyclohexylmethane-4,4′-diisocyanate and pentaerythritol-tetra-3-mercaptopropionate and applied to etched lithium disilicate ceramic plates. Nine combinations of silane and cement (10/group) were tested. μSBS was measured after 24 hours, 6 months, and 18 months of storage in water. Data were analyzed using 2-way analysis of variance and Tukey post hoc (α = 0.05).</div></div><div><h3>Results</h3><div>TU resin cement exhibited higher μSBS values than the commercial resin cement, particularly after 24 hours when combined with TU and methacrylate-based (MA) silanes, and after 6 months with the MA silane (<em>P</em> &lt; .05). When using the commercial silane, there was no difference in μSBS among the resin cements (<em>P</em> &gt; .05). However, the combinations of TU and MA silanes, along with TU and MA resin cements, exhibited significantly higher μSBS than other formulations (<em>P</em> &lt; .05). All groups showed a significant reduction in μSBS over time (<em>P</em> &lt; .05), with the TU resin cement maintaining higher values than the commercial resin cement.</div></div><div><h3>Conclusions</h3><div>The use of TU oligomers as silane or resin cement additives improves the μSBS of resin cement-ceramic interfaces, especially when TU silane is combined with TU resin cement (dicyclohexylmethane-4,4′-diisocyanate version). Water storage for 6 and 18 months significantly reduces μSBS across all groups.</div></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"5 ","pages":"Article 100070"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemistry, bioactivity, and future nanotechnology prospects of Azadirachta indica waste management","authors":"Raja Thandavamoorthy PhD","doi":"10.1016/j.jfscie.2026.100072","DOIUrl":"10.1016/j.jfscie.2026.100072","url":null,"abstract":"<div><h3>Objectives</h3><div>This review synthesizes evidence on the phytochemistry and bioactivity of <em>Azadirachta indica</em> (neem) twig–derived solvent extracts, with particular emphasis on their role as reducing and stabilizing agents in the green synthesis of nanoparticles for dental applications. The review critically evaluates the integration potential of nanoparticles produced from neem twigs traditionally used as chewing sticks into oral health care materials, focusing on antimicrobial and host-modulatory dental technologies.</div></div><div><h3>Search Strategy</h3><div>Search terms related to neem twigs, phytochemicals, antimicrobial activity, green nanoparticle synthesis, and dental applications were used.</div></div><div><h3>Citation Sources</h3><div>A literature search was performed across major scientific databases, including Scopus, Web of Science, PubMed, SpringerLink, ScienceDirect, and Wiley, covering studies published from January 1, 2020, through December 31, 2025, as most literature falls within this period.</div></div><div><h3>Study Selection Criteria</h3><div>Experimental, analytical, and review articles reporting the following were included: phytochemical characterization of neem twigs; antimicrobial, antibiofilm, or anti-inflammatory activity; green synthesis of nanoparticles using twig extracts; and dental or biomedical applications. Studies lacking primary data, using nontwig neem parts without dental relevance, or providing insufficient methodological detail were excluded.</div></div><div><h3>Data Elements Included</h3><div>Extracted data included phytochemical profiles, antimicrobial and antibiofilm outcomes, nanoparticle types (zinc oxide, silver, copper oxide, titanium oxide), synthesis conditions, characterization results, and applications in dental composites, adhesives, sealers, coatings, and preventive formulations.</div></div><div><h3>Overall Conclusions</h3><div>Neem twigs, rich in diverse bioactive phytochemicals, offer a sustainable platform for developing multifunctional nanomaterials with antimicrobial, antioxidant, and anti-inflammatory properties. Neem twig–mediated nanoparticles show strong potential for restorative, preventive, and implant dentistry, supporting eco-friendly and advanced oral health care solutions.</div></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"5 ","pages":"Article 100072"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyphenol-functionalized biomaterials for bone and dental tissue regeneration","authors":"Niaz Akbarnejad DDS ,&nbsp;Venkata Suresh Venkataiah MDS, PhD ,&nbsp;Deepak Mehta MDS, PhD ,&nbsp;Mohmed Isaqali Karobai MDS, PhD ,&nbsp;Michela Capoferri MSc ,&nbsp;Eloy Bejarano PhD ,&nbsp;Stella Helen Constantinidou DDS, MSc ,&nbsp;Salvatore Sauro BsC, PhD","doi":"10.1016/j.jfscie.2025.100067","DOIUrl":"10.1016/j.jfscie.2025.100067","url":null,"abstract":"<div><h3>Objectives</h3><div>Biomaterials are widely used in dental and bone regeneration, but often lack intrinsic bioactivity. This systematic review evaluated whether incorporating polyphenols into biomaterials enhances regenerative efficacy in bone and dental tissue applications.</div></div><div><h3>Search Strategy</h3><div>A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies published from January 2014 through December 2025 were identified through searches of PubMed, Scopus, Web of Science, and Embase. Eligible studies included preclinical in vivo and in vitro studies as well as early clinical reports.</div></div><div><h3>Citation Sources</h3><div>PubMed, Scopus, Web of Science, Embase.</div></div><div><h3>Study Selection Criteria</h3><div>Studies combining polyphenols and biomaterials for bone or dental tissue regeneration were included. Both preclinical and early-phase clinical studies were considered.</div></div><div><h3>Data Elements Included</h3><div>Outcomes assessed included osteogenic differentiation, collagen deposition, angiogenesis, and immunomodulation. The evidence primarily consists of preclinical studies, primarily in rodent models of defects, with some in vitro and early clinical studies. Polyphenols promote osteogenic differentiation, collagen formation, angiogenesis, and immune responses through various delivery methods, thus improving bone and periodontal repair.</div></div><div><h3>Overall Conclusions</h3><div>The integration of polyphenols into biomaterials holds promise for improving regenerative outcomes in bone and dental applications. However, evidence is mainly limited to preclinical studies with small sample sizes and diverse methodologies. Bias risk and the lack of standardized protocols hinder direct comparisons and prevent meta-analyses. Future research should aim to standardize experimental designs, improve compound stability and bioavailability, and conduct well-structured clinical trials to confirm the long-term safety, efficacy, and translational potential of these compounds.</div></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"5 ","pages":"Article 100067"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proinflammatory and anti-inflammatory cytokines in modulating bone remodeling during orthodontic tooth movement","authors":"Nisha Varughese MDS ,&nbsp;Karunya Krishnakumar MDS ,&nbsp;K. Hema Shree MDS ,&nbsp;Aravind Kumar Subramanian MOrth (RCS)Ed, PhD ,&nbsp;Ramya Ramadoss MDS, PhD","doi":"10.1016/j.jfscie.2025.100054","DOIUrl":"10.1016/j.jfscie.2025.100054","url":null,"abstract":"<div><h3>Objectives</h3><div>This systematic review and meta-analysis sought to assess the influence of proinflammatory (interleukin [IL]-1β, IL-6, tumor necrosis factor α) and anti-inflammatory (IL-10, IL-4, IL-1RA) cytokines on bone remodeling during orthodontic tooth movement. The aim was to clarify their dynamics over time and space and evaluate their potential as clinical biomarkers.</div></div><div><h3>Search Strategy</h3><div>The review adhered to the Preferred Reporting Items for Systematic reviews and Meta-analyses 2020 guidelines. A structured population, intervention, comparator, outcome framework directed the search. Medical Subject Heading terms alongside free-text key words were used in combination with Boolean operators across various databases (PubMed, Embase, Scopus, Cochrane Library, Web of Science) from 2000 through 2024. The reference lists of the included studies were examined manually to ensure thoroughness.</div></div><div><h3>Citation Sources</h3><div>Searching electronic databases and conducting manual reference checks resulted in an initial collection of 85 studies of which 14 met the criteria for inclusion.</div></div><div><h3>Study Selection Criteria</h3><div>The studies eligible for inclusion measured cytokine levels (IL-1β, IL-10, IL-1RA, IL-4) in gingival crevicular fluid, saliva, or serum throughout orthodontic treatment. No age, sex, or appliance type restrictions were imposed on the participants. Both observational and interventional human studies were considered.</div></div><div><h3>Data Elements Included</h3><div>Data extraction included details such as authorship, methodology, biological fluid examined, cytokines investigated, detection technique (enzymed-linked immunosorbant assay, multiplex assay, polymerase chain reaction), sample size, and key outcomes. Quality assessment was conducted using the Newcastle-Ottawa Scale.</div></div><div><h3>Overall Conclusions</h3><div>Proinflammatory cytokines showed early peaks after the application of orthodontic force, triggering bone resorption at compression sites. In contrast, anti-inflammatory cytokines appeared later, facilitating repair and bone deposition at tension sites. IL-1β levels were positively correlated with the rate of tooth movement, while lower levels of IL-1RA were associated with quicker distal displacement. Although the pooled results from the meta-analysis did not show statistically significant differences, consistent trends supported the regulatory role of cytokines in orthodontic tooth movement. Future investigations should focus on larger, multicenter studies using standardized protocols to confirm the reliability of cytokines as biomarkers for precise orthodontic treatments.</div></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"4 ","pages":"Article 100054"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presurgical orthodontic treatment with ultraearly application of premaxilla-guiding nasoalveolar molding in feeding neonates","authors":"Keiichiro Watanabe DDS, PhD ,&nbsp;Kaoru Yoshinaga DDS, PhD ,&nbsp;Sooha Matsuki DDS, PhD ,&nbsp;Shunsuke Mima MD, PhD ,&nbsp;Hiroyuki Yamasaki MD, PhD ,&nbsp;Kazuhide Mineda MD, PhD ,&nbsp;Masashi Suzue MD, PhD ,&nbsp;Ryuji Nakagawa MD, PhD ,&nbsp;Kenichi Suga MD, PhD ,&nbsp;Takashi Kaji MD, PhD ,&nbsp;Ichiro Hashimoto MD, PhD ,&nbsp;Eiji Tanaka DDS, PhD","doi":"10.1016/j.jfscie.2025.100055","DOIUrl":"10.1016/j.jfscie.2025.100055","url":null,"abstract":"<div><h3>Background</h3><div>The objective of this study was to present 3 cases of bilateral cleft lip and palate in which early application of premaxilla-guiding nasoalveolar molding (PG-NAM) achieved proper premaxillary alignment, columella, and upper lip lengthening by 2 months of age.</div></div><div><h3>Methods</h3><div>Patients with bilateral cleft lip and palate were referred shortly after birth for intraoral scanning, which enables the creation of a 3-dimensional–printed jaw model. Using the jaw model, the Hotz plate was designed as a feeding plate. One week after birth, a nasal stent was applied to the Hotz plate. Once the stent was in place, 2 elastic lip tapes were used to prevent premaxillary collapse.</div></div><div><h3>Results</h3><div>In all 3 cases, premaxillary alignment was completed within 1 through 2 months of appliance placement, and nasal septal curvature was observed after posterior premaxillary movement; however, at the time of palatoplasty, the nasal septum was straightened in all cases.</div></div><div><h3>Conclusions</h3><div>These findings suggest ultraearly application of PG-NAM achieves appropriate premaxillary alignment, columella, and upper lip lengthening by 2 months of age, allowing for smooth surgical interventions.</div></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"4 ","pages":"Article 100055"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradable polymeric ion–releasing fillers","authors":"Hannah Reynolds BS ,&nbsp;Bryanna Bravo BS ,&nbsp;Germelle Fulford MS ,&nbsp;Ana Martinez BS ,&nbsp;Mark A. Latta MS, DMD ,&nbsp;Stephen M. Gross BS, PhD","doi":"10.1016/j.jfscie.2025.100047","DOIUrl":"10.1016/j.jfscie.2025.100047","url":null,"abstract":"<div><h3>Background</h3><div>Dentists spend considerable time treating issues stemming from caries, especially recurrent caries. European Union regulations require microplastics to be biodegradable. The goal of this research is to develop biodegradable, ion-releasing fillers that could be incorporated into dental materials that aid in remineralization of teeth.</div></div><div><h3>Methods</h3><div>Polymeric ion–releasing fillers (PIRFs) that released calcium from a dental composite were prepared. These fillers were synthesized from a biodegradable polymer obtained from a renewable resource (alginate) and are capable of releasing calcium ions. Synthetic variables included the concentration of reactants, emulsifying agents, and applied shear rate. PIRFs were incorporated into dental formulations and categorized by scanning electron microscopy, ion release, degree of conversion, depth of cure, and viscosity measurements.</div></div><div><h3>Results</h3><div>Scanning electron microscopic images confirmed the successful isolation of the PIRFs from synthesis and subsequent mixing into a bisphenol A glycidyl methacrylate and triethylene glycol dimethacrylate continuous phase that was converted into a dental composite. The degree of conversion and depth of cure measurements were consistent with those of a typical dental material, showing the viability of adding PIRFs to dental composites. The effect of mixing the PIRFs on the viscosity of the continuous phase was measured. The addition of up to 5 wt/wt% of these fillers did not significantly increase viscosity, allowing for inclusion into a wide array of dental materials. Incorporation led to pseudoplastic behavior, in which the viscosity decreased with increased shear rate. The incorporation of PIRFs leads to rheopectic behavior at low shear rates and thixotropic behavior at higher rates.</div></div><div><h3>Conclusions</h3><div>Biodegradable PIRFs are a promising approach to help prevent caries.</div></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"4 ","pages":"Article 100047"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial dark matter and the future of dentistry","authors":"Jill Sirko PhD,&nbsp;Batbileg Bor PhD,&nbsp;Xuesong He DDS, PhD","doi":"10.1016/j.jfscie.2024.100043","DOIUrl":"10.1016/j.jfscie.2024.100043","url":null,"abstract":"","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"4 ","pages":"Article 100043"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143158177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of platelet-rich fibrin in maintaining vascularity for intentionally replanted teeth","authors":"Elisabeth L. Easley-Perez DMD, MPH, MS ,&nbsp;Joseph B. Bavitz DMD ,&nbsp;Lynette M. Smith PhD ,&nbsp;Peter J. Giannini DDS, MS","doi":"10.1016/j.jfscie.2025.100048","DOIUrl":"10.1016/j.jfscie.2025.100048","url":null,"abstract":"<div><h3>Background</h3><div>A primary goal for a mature tooth autotransplant is preserving tooth vitality. Platelet-rich fibrin (PRF) has characteristics that may improve the success of autotransplanted mature teeth by decreasing harmful inflammation and boosting vascular growth. This prospective human trial aimed to evaluate the effectiveness of PRF on vitality in a mature tooth replantation model.</div></div><div><h3>Methods</h3><div>This double-blind, randomized controlled trial included 18 participants with 70 single-rooted vital teeth planned for prosthetic extraction. Experimental teeth were extracted and apicoectomized to increase vascular growth. PRF was condensed into the canals before teeth were replanted in their respective sockets. In the same patient, control teeth received identical treatment without PRF. Teeth were splinted and monitored for 3 through 11 months before final vitality testing, extraction, and histologic analysis of pulpal tissue.</div></div><div><h3>Results</h3><div>Comparison of vitality testing did not yield statistically significant differences between experimental and control teeth. In addition, histologic evaluation of infiltrate type and health of pulp did not reveal any benefit from the addition of PRF. Out-of-mouth time marginally differed between experimental and control groups (mean difference, 0.26 [95% CI, −0.50 to −0.020]; <em>P</em> = .04) but did not affect vitality testing (<em>P</em> = .86). Inflammation state of the recipient site is believed to have confounded final results.</div></div><div><h3>Conclusions</h3><div>PRF applied to the periapical region did not improve the chances of vitality retention after extraction and replantation; however, it is possible site inflammation may have affected vitality results and confounded the effects of PRF.</div></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"4 ","pages":"Article 100048"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144296828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing dentist and chatbot answers to dental questions for quality and empathy","authors":"Erin E. Maruska DMD, MPH ,&nbsp;Amira Elgreatly BDS, MS ,&nbsp;William Madaio DMD ,&nbsp;Klud Razoky BDS, NZDREX ,&nbsp;Curt Bay PhD ,&nbsp;Ahmed Mahrous BDS, MS","doi":"10.1016/j.jfscie.2025.100044","DOIUrl":"10.1016/j.jfscie.2025.100044","url":null,"abstract":"<div><h3>Background</h3><div>Integration of large language models (LLMs) into health care, particularly in patient communication, is a growing trend. This study evaluated the effectiveness of LLM chatbots in addressing dental patient queries compared with responses from human dentists on a public online forum.</div></div><div><h3>Methods</h3><div>In January 2024, 20 patient questions and responses were randomly sampled from Reddit’s dental advice community. We assessed the quality and empathy of ChatGPT-generated responses (Version GPT-3.5, OpenAI) by 9 blinded dentists. The dentists were selected from a dental faculty pool familiar with reading and assessing written communication. The evaluators rated the information quality of the responses on a Likert scale (very poor, 1; poor, 2; acceptable, 3; good, 4; very good, 5) and empathy (not empathetic, 1; slightly empathetic, 2; moderately empathetic, 3; empathetic, 4; very empathetic, 5). Subsequently, they selected the best response (dentist or artificial intelligence). Nine blinded dentists rated 20 responses to the online inquiries, providing 180 potential responses.</div></div><div><h3>Results</h3><div>The results indicated that the LLM chatbots’ responses were rated as higher quality and exhibited higher levels of empathy than human responses. Among 179 responses (1 was missing) to the question about whether the response was better from ChatGPT or the dentist, 167 (93.3%) responses indicated ChatGPT and 12 (6.7%) indicated dentist (<em>P</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>Although subjective variations in assessing quality and empathy may exist, this study suggests that LLM chatbot responses show higher quality and empathy than online dentist responses. The use of LLM chatbots by dentists can enhance patient communication in dental practice owing to their efficiency, empathy, and quality. Further research is needed to determine the full potential of artificial intelligence in dentistry.</div></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"4 ","pages":"Article 100044"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of regenerating toothpastes on abrasion of eroded enamel and dentin","authors":"Mariele Vertuan PhD ,&nbsp;Eduardo Lista Francisco ,&nbsp;Monique Malta Francese MSc ,&nbsp;Júlia França da Silva DDS ,&nbsp;Ana Carolina Magalhães PhD","doi":"10.1016/j.jfscie.2025.100053","DOIUrl":"10.1016/j.jfscie.2025.100053","url":null,"abstract":"<div><h3>Background</h3><div>This in vitro study evaluated the effect of self-declared enamel regenerating toothpastes on advanced erosive tooth lesions.</div></div><div><h3>Methods</h3><div>A total of 48 bovine crown and root samples were allocated into the toothpastes: Elmex Erosion Protection (GABA International AG, 1,400 ppm F; pH, 4.69) (positive control); Dentalclean Regenerator Sensitive (Dentalclean, 1,450 ppm F; pH, 4.97); Sensodyne Repair &amp; Protect (GlaxoSmithKline) (1,426 ppm F; pH, 9.78) and erosion only (no abrasion) (negative control) (n = 12). All samples were subjected to erosive pH cycles (4× 90 seconds/day in 0.1% citric acid, pH 2.5). Groups 1 through 3 underwent abrasive challenges (2× 15 seconds/day abrasion + 45-second treatment) using toothpaste slurries and a brushing machine over 7 days. Between erosive and abrasive challenges, samples were immersed in artificial saliva. Wear was quantified using contact profilometry (in micrometers) to compare the initial and final profiles. Data were statistically compared using analysis of variance and Tukey test (<em>P</em> &lt; .05).</div></div><div><h3>Results</h3><div>Brushing with Dentalclean (3.67 [0.47] μm) induced the greatest enamel wear (SD), followed by Sensodyne (2.99 [0.56] μm). Both were significantly different (SD) from Elmex (1.85 [0.38] μm) (<em>P</em> &lt; .0001), which did not differ from erosion only (1.98 [0.57] μm). For dentin, brushing with Dentalclean (2.95 [0.60] μm) induced the greatest wear (SD), which was similar to that induced by erosion alone (2.87 [0.55] μm). In contrast, Elmex presented the lowest wear (SD) (1.26 [0.35] μm), similarly to Sensodyne (1.27 [0.58] μm).</div></div><div><h3>Conclusions</h3><div>Self-declared enamel regenerating toothpastes potentiate advanced erosive lesions. However, for dentin, Sensodyne toothpaste showed a similar result to the positive control.</div></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"4 ","pages":"Article 100053"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144830398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}