ISRN cardiology最新文献_第5页

Novel m.15434C>A (p.230L>I) Mitochondrial Cytb Gene Missense Mutation Associated with Dilated Cardiomyopathy. 新型线粒体Cytb基因错义突变与扩张型心肌病相关。

ISRN cardiology Pub Date : 2012-01-01 DOI: 10.5402/2012/251723

Sinda Zarrouk Mahjoub, Sounira Mehri, Fatma Ourda, Josef Finsterer, Saïda Ben Arab

{"title":"Novel m.15434C>A (p.230L>I) Mitochondrial Cytb Gene Missense Mutation Associated with Dilated Cardiomyopathy.","authors":"Sinda Zarrouk Mahjoub, Sounira Mehri, Fatma Ourda, Josef Finsterer, Saïda Ben Arab","doi":"10.5402/2012/251723","DOIUrl":"https://doi.org/10.5402/2012/251723","url":null,"abstract":"Background. Previously it has been shown that various types of hypertrophic and dilative cardiomyopathy (hCMP, dCMP) can be attributed to disturbed mitochondrial oxidative energy metabolism. Several studies described mutations in mitochondrial DNA-located genes encoding for subunits of respiratory chain complexes, including the cytochrome b gene (MT-CYB), causing CMPs. Methods and Results. In the present study the MT-CYB gene was analysed in 30 patients with hCMP, 40 patients with dCMP, and 50 controls for alterations. Altogether, 27 MT-CYB variants were detected. Twenty-four of them were single nucleotide polymorphisms defining common haplogroups. The variant m.15434C>A was found in a single patient with severe dCMP and assessed as novel mutation, since it was not found in healthy controls or available data sets, and was nonhaplogroup associated with Phylotree. This variant altered an amino acid (L230I) with a high interspecific amino acid conservation index (CI = 97.7%) indicative of the functional importance of the residue. Conclusions. Though the L230I mutation seems to play a causative role for dCMP, prospective studies on yeast or transgenic mice models with defined mutation are warranted to study the pathogenetic impact of this mutation.","PeriodicalId":73519,"journal":{"name":"ISRN cardiology","volume":"2012 ","pages":"251723"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/251723","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9376256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Comparison of the effects of adenosine, inosine, and their combination as an adjunct to reperfusion in the treatment of acute myocardial infarction. 腺苷、肌苷及其联用辅助再灌注治疗急性心肌梗死的疗效比较。

ISRN cardiology Pub Date : 2012-01-01 DOI: 10.5402/2012/326809

Abdel Shafy, Vincent Molinié, Miguel Cortes-Morichetti, Vincent Hupertan, Nermine Lila, Juan C Chachques

{"title":"Comparison of the effects of adenosine, inosine, and their combination as an adjunct to reperfusion in the treatment of acute myocardial infarction.","authors":"Abdel Shafy, Vincent Molinié, Miguel Cortes-Morichetti, Vincent Hupertan, Nermine Lila, Juan C Chachques","doi":"10.5402/2012/326809","DOIUrl":"https://doi.org/10.5402/2012/326809","url":null,"abstract":"Adenosine and inosine are both key intracellular energy substrates for nucleotide synthesis by salvage pathways, especially during ischemic stress conditions. Additionally they both possess cell protective and cell repair properties. The objective of this study is to detect potential advantages of the combination of adenosine and inosine versus each drug alone, in terms of ventricular function, infarct size reduction and angiogenesis. Myocardial ischemia was created in rodents and treated with adenosine, inosine or their combination. Results of experiments showed that the combination of both drugs significantly reduced infarct size and improved myocardial angiogenesis and ventricular function. The two compounds, while chemically similar, use different intracellular pathways, allowing for complementary biological activities without overlapping. The drug combination at specific 1 : 5 adenosine : inosine dose ratio demonstrated positive cardiologic effects, deserving further evaluation as an adjunct to reperfusion techniques during and after acute coronary syndrome. The association of adenosine and inosine may contribute to reduce myocardial infarction morbidity and mortality rates.","PeriodicalId":73519,"journal":{"name":"ISRN cardiology","volume":"2012 ","pages":"326809"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/326809","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9728872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

The intrinsic autonomic nervous system in atrial fibrillation: a review. 心房颤动的内在自主神经系统:综述。

ISRN cardiology Pub Date : 2012-01-01 DOI: 10.5402/2012/490674

Bo He, Benjamin J Scherlag, Hiroshi Nakagawa, Ralph Lazzara, Sunny S Po

{"title":"The intrinsic autonomic nervous system in atrial fibrillation: a review.","authors":"Bo He, Benjamin J Scherlag, Hiroshi Nakagawa, Ralph Lazzara, Sunny S Po","doi":"10.5402/2012/490674","DOIUrl":"https://doi.org/10.5402/2012/490674","url":null,"abstract":"The procedure of catheter ablation for the treatment of drug resistant atrial fibrillation (AF) has evolved but still relies on lesion sets intended to isolate areas of focal firing, mainly the myocardial sleeves of the pulmonary veins (PVs), from the rest of the atria. However the success rates for this procedure have varied inversely with the type of AF. At best success rates have been 20 to 30% below that of other catheter ablation procedures for Wolff-Parkinson-White syndrome, atrioventricular junctional re-entrant tachycardia and atrial flutter. Basic and clinical evidence has emerged suggesting a critical role of the ganglionated plexi (GP) at the PV-atrial junctions in the initiation and maintenance of the focal form of AF. At present the highest success rates have been obtained with the combination of PV isolation and GP ablation both as catheter ablation or minimally invasive surgical procedures. Various lines of evidence from earlier and more recent reports provide that both neurally based and myocardially based forms of AF can separately dominate or coexist within the context of atrial remodeling. Future studies are focusing on non-pharmacological, non-ablative approaches for the prevention and treatment of AF in order to avoid the substantive complications of both these regimens.","PeriodicalId":73519,"journal":{"name":"ISRN cardiology","volume":"2012 ","pages":"490674"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/490674","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9375097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse. 阿霉素和NRG-1/ erbb4缺乏影响基因表达谱:涉及小鼠蛋白稳态。

ISRN cardiology Pub Date : 2012-01-01 DOI: 10.5402/2012/745185

Cecilia Vasti, Henning Witt, Matilde Said, Patricia Sorroche, Hernán García-Rivello, Patricia Ruiz-Noppinger, Cecilia M Hertig

{"title":"Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse.","authors":"Cecilia Vasti, Henning Witt, Matilde Said, Patricia Sorroche, Hernán García-Rivello, Patricia Ruiz-Noppinger, Cecilia M Hertig","doi":"10.5402/2012/745185","DOIUrl":"https://doi.org/10.5402/2012/745185","url":null,"abstract":"The accumulating evidence demonstrates the essential role of neuregulin-1 signaling in the adult heart, and, moreover, indicates that an impaired neuregulin signaling exacerbates the doxorubicin-mediated cardiac toxicity. Despite this strong data, the specific cardiomyocyte targets of the active erbB2/erbB4 heterodimer remain unknown. In this paper, we examined pathways involved in cardiomyocyte damage as a result of the cardiac sensitization to anthracycline toxicity in the ventricular muscle-specific erbB4 knockout mouse. We performed morphological analyses to evaluate the ventricular remodeling and employed a cDNA microarray to assess the characteristic gene expression profile, verified data by real-time RT-PCR, and then grouped into functional categories and pathways. We confirm the upregulation of genes related to the classical signature of a hypertrophic response, implicating an erbB2-dependent mechanism in doxorubicin-treated erbB4-KO hearts. Our results indicate the remarkable downregulation of IGF-I/PI-3' kinase pathway and extends our current knowledge by uncovering an altered ubiquitin-proteasome system leading to cardiomyocyte autophagic vacuolization.","PeriodicalId":73519,"journal":{"name":"ISRN cardiology","volume":"2012 ","pages":"745185"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/745185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9432596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

CT Imaging of Coronary Stents: Past, Present, and Future. 冠状动脉支架的CT成像:过去，现在和未来。

ISRN cardiology Pub Date : 2012-01-01 DOI: 10.5402/2012/139823

Andreas H Mahnken

引用次数: 59

Persistent atrial fibrillation is associated with worse prognosis than paroxysmal atrial fibrillation in acute cerebral infarction. 急性脑梗死患者持续性房颤的预后较阵发性房颤差。

ISRN cardiology Pub Date : 2012-01-01 DOI: 10.5402/2012/650915

Halvor Naess, Ulrike Waje-Andreassen, Lars Thomassen

{"title":"Persistent atrial fibrillation is associated with worse prognosis than paroxysmal atrial fibrillation in acute cerebral infarction.","authors":"Halvor Naess, Ulrike Waje-Andreassen, Lars Thomassen","doi":"10.5402/2012/650915","DOIUrl":"https://doi.org/10.5402/2012/650915","url":null,"abstract":"Background and Purpose. We hypothesized that patients with persistent atrial fibrillation (AF) suffer from more severe cerebral infarction than patients with paroxysmal AF due to differences in clot structure and volume. Methods. This study includes consecutive patients with acute cerebral infarction and persistent or paroxysmal AF documented by ECG any time prior to stroke onset. The National Institute of Health Stroke Scale (NIHSS) was used to assess stroke severity on admission. Short-term outcome was determined by the modified Rankin scale (mRS) score, Barthel index, and NIHSS score 7 days after stroke onset. Risk factors were registered on admission. Eligible patients were treated with thrombolysis. Results. In total, 141 (52%) patients had paroxysmal AF, and 129 (48%) patients had persistent AF. NIHSS score on admission, mRS score at day 7, and mortality were significantly higher among patients with persistent AF. Thrombolysis was less effective in patients with persistent AF. Conclusions. Our study shows that patients with persistent AF and acute cerebral infarction have poorer short-term outcome than patients with paroxysmal AF. Differences in clot structure or clot volume may explain this.","PeriodicalId":73519,"journal":{"name":"ISRN cardiology","volume":"2012 ","pages":"650915"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/650915","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9375130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

The sweet spot: continued search for the glycemic threshold for macrovascular disease-a retrospective single center experience. 最佳点:继续寻找大血管疾病的血糖阈值-回顾性单中心经验。

ISRN cardiology Pub Date : 2012-01-01 DOI: 10.5402/2012/874706

Andrzej Boguszewski, Andrew Teklinski, Howard Rosman, Devang Desai, Sajid Ali, Susan Szpunar, Ruth Moore, James Maciejko

{"title":"The sweet spot: continued search for the glycemic threshold for macrovascular disease-a retrospective single center experience.","authors":"Andrzej Boguszewski, Andrew Teklinski, Howard Rosman, Devang Desai, Sajid Ali, Susan Szpunar, Ruth Moore, James Maciejko","doi":"10.5402/2012/874706","DOIUrl":"https://doi.org/10.5402/2012/874706","url":null,"abstract":"Background. Atherosclerotic cardiovascular disease (ASCVD) is a common complication of diabetes mellitus and impaired fasting glucose (IFG). We hypothesized that the relation of fasting glucose levels to ASCVD is linear, with the prevalence of clinical ASCVD beginning to increase even among individuals currently categorized as normoglycemic. Methods. Patient charts were retrospectively reviewed from our Dyslipidemic Preventive Cardiology Clinic. We evaluated the prevalence of ASCVD relative to fasting glucose levels in a cross-section of patients at high risk for ASCVD. Results. In 558 dyslipidemic patients, ASCVD prevalence increased with increasing fasting glucose levels. A significantly higher prevalence of ASCVD was observed among patients with fasting glucose levels between 90 and 99 mg/dL versus lower levels. As glucose levels increased from 90 to 125 mg/dL, the prevalence of ASCVD continued to rise in parallel. Logistic regression analysis with forward likelihood ratio stepwise selection indicated that individuals with fasting blood glucose of 90-99 mg/dL were 2.6 times more likely to have ASCVD than those with lower levels of fasting blood glucose. Conclusion. Our findings suggest that the current cutoff for impaired fasting glucose of 100 mg/dL may be somewhat conservative and that a level above 90 mg/dL may be more appropriate as an ASCVD risk factor, particularly in patients with a lipid disorder.","PeriodicalId":73519,"journal":{"name":"ISRN cardiology","volume":"2012 ","pages":"874706"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/874706","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9376732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac ion channelopathies and the sudden infant death syndrome. 心脏离子通道病变与婴儿猝死综合征

ISRN cardiology Pub Date : 2012-01-01 DOI: 10.5402/2012/846171

Ronald Wilders

{"title":"Cardiac ion channelopathies and the sudden infant death syndrome.","authors":"Ronald Wilders","doi":"10.5402/2012/846171","DOIUrl":"https://doi.org/10.5402/2012/846171","url":null,"abstract":"The sudden infant death syndrome (SIDS) causes the sudden death of an apparently healthy infant, which remains unexplained despite a thorough investigation, including the performance of a complete autopsy. The triple risk model for the pathogenesis of SIDS points to the coincidence of a vulnerable infant, a critical developmental period, and an exogenous stressor. Primary electrical diseases of the heart, which may cause lethal arrhythmias as a result of dysfunctioning cardiac ion channels (\"cardiac ion channelopathies\") and are not detectable during a standard postmortem examination, may create the vulnerable infant and thus contribute to SIDS. Evidence comes from clinical correlations between the long QT syndrome and SIDS as well as genetic analyses in cohorts of SIDS victims (\"molecular autopsy\"), which have revealed a large number of mutations in ion channel-related genes linked to inheritable arrhythmogenic syndromes, in particular the long QT syndrome, the short QT syndrome, the Brugada syndrome, and catecholaminergic polymorphic ventricular tachycardia. Combining data from population-based cohort studies, it can be concluded that at least one out of five SIDS victims carries a mutation in a cardiac ion channel-related gene and that the majority of these mutations are of a known malignant phenotype.","PeriodicalId":73519,"journal":{"name":"ISRN cardiology","volume":"2012 ","pages":"846171"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/846171","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9375520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44

Minimally invasive surgical therapies for atrial fibrillation. 心房颤动的微创手术治疗。

ISRN cardiology Pub Date : 2012-01-01 DOI: 10.5402/2012/606324

Yoshitsugu Nakamura, Bob Kiaii, Michael W A Chu

引用次数: 11

Physical activity, health benefits, and mortality risk. 体育锻炼、健康益处和死亡风险。

ISRN cardiology Pub Date : 2012-01-01 DOI: 10.5402/2012/718789

Peter Kokkinos

{"title":"Physical activity, health benefits, and mortality risk.","authors":"Peter Kokkinos","doi":"10.5402/2012/718789","DOIUrl":"https://doi.org/10.5402/2012/718789","url":null,"abstract":"A plethora of epidemiologic evidence from large studies supports unequivocally an inverse, independent, and graded association between volume of physical activity, health, and cardiovascular and overall mortality. This association is evident in apparently healthy individuals, patients with hypertension, type 2 diabetes mellitus, and cardiovascular disease, regardless of body weight. Moreover, the degree of risk associated with physical inactivity is similar to, and in some cases even stronger than, the more traditional cardiovascular risk factors. The exercise-induced health benefits are in part related to favorable modulations of cardiovascular risk factors observed by increased physical activity or structured exercise programs. Although the independent contribution of the exercise components, intensity, duration, and frequency to the reduction of mortality risk is not clear, it is well accepted that an exercise volume threshold defined at caloric expenditure of approximately 1,000 Kcal per week appears to be necessary for significant reduction in mortality risk. Further reductions in risk are observed with higher volumes of energy expenditure. Physical exertion is also associated with a relatively low and transient increase in risk for cardiac events. This risk is significantly higher for older and sedentary individuals. Therefore, such individuals should consult their physician prior to engaging in exercise.\"Walking is man's best medicine\"Hippocrates.","PeriodicalId":73519,"journal":{"name":"ISRN cardiology","volume":"2012 ","pages":"718789"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/718789","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9380973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 233