Advances in medical sciences最新文献

{"title":"The impacts of ribociclib on the post-treatment Tp-e interval and Tp-e/QTc ratio in breast cancer patients","authors":"Şükrü Çiriş ,&nbsp;Mustafa Seyyar ,&nbsp;İrfan Yaman ,&nbsp;Esra Polat","doi":"10.1016/j.advms.2026.03.002","DOIUrl":"10.1016/j.advms.2026.03.002","url":null,"abstract":"<div><h3>Purpose</h3><div>The study aimed to assess the impacts of ribociclib on the post-treatment Tp-e interval and Tp-e/QTc ratio in breast cancer patients.</div></div><div><h3>Materials/methods</h3><div>A retrospective study was carried out with 40 breast cancer patients between October 2023 and February 2024 to reveal the impacts of ribociclib therapy (either alone or in combination with letrozole) on the post-treatment Tp-e interval and Tp-e/QTc ratio. ECGs obtained before the start of the treatment and on the 21st day of the 3rd course were used in the evaluation.</div></div><div><h3>Results</h3><div>Patients' pre-treatment heart rate, WBC, AST, QRS (ms), Tp-e/QT, and Tp-e/JT values decreased after the treatment (p &lt; 0.05). Patients' pre-treatment QT, JT (ms), JTc(ms), Tp-e(ms), Tp-e/Qtc, and Tp-e/JTc values increased after the treatment (p &lt; 0.05). Patients' pre- and post-treatment ionized Ca/(Tpe/JTc) values showed statistically significant difference (p &lt; 0.01). The pre-treatment ionized Ca/(Tpe/JTc) values of patients decreased significantly after the treatment. The ionized Ca/(Tpe/QTc) values of patients differed statistically significantly before and after the treatment (p &lt; 0.01). Patients’ pre-treatment ionized Ca/(Tpe/QTc) values decreased significantly after the treatment.</div></div><div><h3>Conclusion</h3><div>The potential arrhythmogenic effects of ribociclib suggest that serum calcium (Ca), ionized calcium, QT, QTc, Tp-e interval, and Tp-e/QTc ratio may be monitored throughout the treatment period.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"71 1","pages":"Pages 83-87"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pooled granulocyte component–a worthy rival to the apheresis product?","authors":"Artur Szumowski ,&nbsp;Tomasz Wasiluk ,&nbsp;Magdalena Średzińska ,&nbsp;Kamila Rybińska ,&nbsp;Mateusz Dziemiańczuk ,&nbsp;Paulina Radziwon ,&nbsp;Michał Kuźma ,&nbsp;Piotr Radziwon","doi":"10.1016/j.advms.2026.01.002","DOIUrl":"10.1016/j.advms.2026.01.002","url":null,"abstract":"<div><h3>Purpose</h3><div>Granulocyte concentrates (GCs) are crucial in preventing and treating hazardous infections in neutropenic patients with hematological malignancies. Our study goal was to evaluate the impact of various collection and preparation methods on the quality of GCs.</div></div><div><h3>Materials and methods</h3><div>Our study included 30 GCs that were collected either by leukapheresis (group L), by standard buffy coat pooling (group S), or by using the Reveos system (group R). All studied GCs were irradiated with gamma rays and stored for 24 h at room temperature without agitation. Laboratory tests included the assessment of leukocyte (WBC), neutrophil, lymphocyte and monocyte counts, pH, cell viability, phagocytosis, and the expression of CD11b, CD62L, CD66b and CXCR4 molecules.</div></div><div><h3>Results</h3><div>We showed that GCs prepared using different methods differed primarily in terms of cell counts, cell viability, and the CD11b, CD62L and CXCR4 expression. We also observed that gamma irradiation expectedly reduced the lymphocyte count, whereas 24-h storage drastically reduced cell viability. An additional effect of the preparation method on GCs susceptibility to quality changes due to gamma rays and 24-h storage was noticed as well.</div></div><div><h3>Conclusions</h3><div>Our research indicates that apheresis-derived granulocytes and pooled GCs do not differ enough to not consider more frequent use of the latter in daily clinical practice. Moreover, we concluded that gamma irradiation does not worsen the quality of granulocyte components, and freshly collected GCs should be preferred.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"71 1","pages":"Pages 27-39"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between lipoprotein (a) and lipid profile and body composition in patients with high cardiovascular risk","authors":"Joanna Popiolek-Kalisz ,&nbsp;Pierre Sabouret","doi":"10.1016/j.advms.2026.02.006","DOIUrl":"10.1016/j.advms.2026.02.006","url":null,"abstract":"<div><h3>Purpose</h3><div>Dyslipidemia remains a major contributor to atherosclerosis and cardiovascular events. While low-density lipoprotein cholesterol (LDL-C) lowering is the primary treatment target, lipoprotein(a) [Lp(a)] has emerged as an independent, genetically determined risk factor, often unaffected by standard treatment. This study aimed to analyze the relationship between body composition parameters and lipid profile, including Lp(a).</div></div><div><h3>Materials and methods</h3><div>Clinically stable high cardiovascular risk patients (n = 207) receiving lipid-lowering pharmacotherapy were enrolled in this cross-sectional study. Anthropometric data and body composition were assessed using bioelectrical impedance analysis, including body mass index (BMI), fat mass (FM%) and fat-free mass percentage (FFM%). Lp(a) and lipid profile were measured. Patients were stratified by Lp(a) concentration: &lt;75 nmol/L, 75–125 nmol/L, and &gt;125 nmol/L.</div></div><div><h3>Results</h3><div>Lp(a) levels showed no significant association with body composition, age, and sex. In contrast, HDL-C was significantly inversely correlated with BMI (R = −0.25, p &lt; 0.001) and this relationship was independent of sex (β = −0.68, p &lt; 0.001), while triglycerides were positively correlated with FM% (R = 0.17, p = 0.02) and BMI (R = 0.28, p &lt; 0.001) and negatively with FFM% (R = −0.17, p = 0.02). LDL-C was not associated with body composition. No significant differences in lipid profile or body composition were observed across Lp(a) strata.</div></div><div><h3>Conclusions</h3><div>In high cardiovascular risk patients, Lp(a) appears unrelated to body composition, supporting its role as a non-modifiable, genetically driven risk factor. Conversely, despite pharmacotherapy, HDL-C and triglycerides demonstrated significant associations with body fat distribution. These findings suggest clinical role of body composition assessment in cardiovascular risk management, particularly in addressing residual risk beyond LDL-C.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"71 1","pages":"Pages 68-74"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can liver-associated parameters serve as prognostic factors in pancreatic cancer? – A retrospective analysis of a large-capacity centre","authors":"Marta Fudalej ,&nbsp;Anna Badowska-Kozakiewicz ,&nbsp;Andrzej Deptała","doi":"10.1016/j.advms.2026.02.001","DOIUrl":"10.1016/j.advms.2026.02.001","url":null,"abstract":"<div><h3>Purpose</h3><div>The study aimed to analyze pretreatment liver parameters among patients with pancreatic cancer (PC) and determine their prognostic value.</div></div><div><h3>Materials/methods</h3><div>A total of 310 patients with a confirmed PC diagnosis were screened for available liver parameters in routine blood sample analysis before the first round of chemotherapy. The assessed parameters included alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, alkaline phosphatase (ALP), and albumin. Two indices were calculated: AST/ALT and albumin/ALP ratios. Statistical analyses were performed utilizing appropriate tests.</div></div><div><h3>Results</h3><div>An elevated AST/ALT ratio was associated with more than a twofold increase in mortality risk (HR = 2.13, 95% CI 1.40–3.24, p &lt; 0.001); however, this association did not remain statistically significant after adjustment for age and disease stage in the multivariate analysis. The calculated AST/ALT ratio cut-off did not effectively distinguish between patients with different tumor characteristics. Therefore, stratification based on this ratio may not be informative in PC. Pretreatment albumin and total bilirubin levels significantly predicted mortality (albumin value &gt; 4.31 g/dL: HR = 0.49, 95% CI 0.30–0.80, p = 0.004, and total bilirubin &gt;0.77 mg/dL: HR = 2.30, 95% CI 1.67–3.17, p &lt; 0.001) and helped classify patients. Neither ALP alone nor the albumin/ALP ratio appeared to serve as a valuable prognostic factor.</div></div><div><h3>Conclusions</h3><div>Our study further confirmed that liver function can influence the prognosis of patients with PC. The exact values of liver parameters in clinical practice should be established through a large, prospective, multicenter study.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"71 1","pages":"Pages 46-55"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146163484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the prognostic value of Wnt signaling pathways in non-small cell lung cancer patients","authors":"Joanna Pancewicz ,&nbsp;Paweł Golec ,&nbsp;Anetta Sulewska ,&nbsp;Radoslaw Charkiewicz ,&nbsp;Wieslawa Niklinska ,&nbsp;Piotr Michal Chodorowski ,&nbsp;Miroslaw Kozlowski","doi":"10.1016/j.advms.2025.12.002","DOIUrl":"10.1016/j.advms.2025.12.002","url":null,"abstract":"<div><h3>Purpose</h3><div>The Wnt/β-catenin signaling pathway is frequently deregulated in various malignancies, including non-small cell lung cancer (NSCLC). This study aimed to evaluate the expression levels of genes encoding ligands that are typically associated with the non-canonical Wnt/β-catenin pathways, specifically, <em>WNT-4</em>, <em>WNT-5A</em>, <em>WNT-7A</em>, <em>WNT-11</em>, and <em>WNT-16</em> in NSCLC.</div></div><div><h3>Materials and methods</h3><div>The analysis was conducted on 80 matched pairs of tumor and adjacent non-cancerous lung tissues. Quantitative gene expression analysis was performed using real-time polymerase chain reaction (qPCR).</div></div><div><h3>Results</h3><div>The results revealed a consistent reduction in the expression of all investigated genes across NSCLC samples and their respective histological subtypes. Notably, elevated <em>WNT-7A</em> gene expression was observed between clinical early (IA) and intermediate IIA stages of NSCLC.</div></div><div><h3>Conclusions</h3><div>These findings suggest that alterations in the expression of non-canonical Wnt/β-catenin pathway ligands are integral to lung carcinogenesis and may play a critical role in the development of NSCLC. The observed changes in <em>WNT-7A</em> expression between IA and IIA stages of NSCLC further indicate its potential involvement in tumor progression.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"71 1","pages":"Pages 10-18"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145832099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of fluoxetine on innate immunity and melanoma metastasis in mice","authors":"Beata Grygier ,&nbsp;Elzbieta Kolaczkowska ,&nbsp;Monika Leśkiewicz ,&nbsp;Katarzyna Curzytek ,&nbsp;Michael Maes ,&nbsp;Marta Kubera","doi":"10.1016/j.advms.2026.03.003","DOIUrl":"10.1016/j.advms.2026.03.003","url":null,"abstract":"<div><h3>Purpose</h3><div>Fluoxetine, a selective serotonin reuptake inhibitor, is widely used for the treatment of depressive symptoms in cancer patients. However, there is conflicting evidence regarding its effects on immunity and cancer. The present study aimed to clarify the effect of fluoxetine administration before or after the initiation of B16F10 melanoma lung metastasis formation on cancer development.</div></div><div><h3>Methods</h3><div>In the present study, we used an experimental tumoral model of lung metastasis formation by melanoma B16F10 cells in C57BL/6J mice. Fluoxetine was administered 14 days before or 14 days after tumor cell injection. We assessed the mice's behavior in the forced swimming test, the formation of lung metastases, the proliferative and metabolic activity of splenocytes, and the activity of metalloproteinases.</div></div><div><h3>Results</h3><div>Results showed that repeated daily fluoxetine administration (10 mg/kg) after injection of tumor cells: 1) decreased the number of metastasis in the lungs; 2) decreased immobility time in forced swimming test; 3) increased proliferative and metabolic activity of splenocytes, 4) decreased ability of splenocytes to produce metalloproteinase 9 (MMP-9) whereas fluoxetine administration before injection of tumor cells induced opposite effect.</div></div><div><h3>Conclusion</h3><div>Obtained data confirm the inhibitory effect of fluoxetine on melanoma growth, but only when this antidepressant is given to animals that already struggle with melanoma development. Fluoxetine administration before cancer development accelerates its progress and induces unbeneficial changes in immunity and metalloproteinase levels in comparison to saline-pretreated mice.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"71 1","pages":"Pages 95-105"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body weight as a confounder inversely correlating with wound closure. A retrospective analysis of observations in normal-weight mice","authors":"Paulina Słonimska ,&nbsp;Jakub Baczyński-Keller ,&nbsp;Piotr Sass ,&nbsp;Paweł Sosnowski ,&nbsp;Rafał Płatek ,&nbsp;Paweł Sachadyn","doi":"10.1016/j.advms.2026.04.002","DOIUrl":"10.1016/j.advms.2026.04.002","url":null,"abstract":"<div><h3>Purpose</h3><div>The impact of body weight on wound healing is well established in obesity but remains an unexplored aspect in normal-weight organisms. The extensive data we gathered using murine wound models provided a unique opportunity to address this question by retrospective data analysis.</div></div><div><h3>Materials/methods</h3><div>Wound closure data were obtained in two models: a 2-mm ear pinna punch and a 6-mm dorsal skin excision, in 8-10-weeks-old BALB/c strain females, exclusively from control experiments in which animals received vehicle alone. The analyses included 132 mice examined in the ear pinna and 58 in the dorsal skin models, with weights ranging from 15.6 to 25.9 g, with a mean of approximately 20 g at the beginning of the experiments.</div></div><div><h3>Results</h3><div>Linear regression models revealed inverse and statistically significant correlations between body weight and wound closure in the ear pinna (R = −0.185, slope = 0.0209, <em>p</em> = 2.52E-03) and dorsal skin (R = −0.266, slope = 0.0260, <em>p</em> = 4.08E-03). The correlations were consistent with significant differences in mean wound closure between extreme quartiles in the ear pinna (62.6% vs. 53.6%, <em>p</em> = 5.79E-03) and the dorsal skin model (81.4% vs 68.4%, <em>p</em> = 1.40E-03).</div></div><div><h3>Conclusions</h3><div>Our retrospective study provides a methodological clue that body weight should be included in wound healing experiment designs and data interpretation. The finding delineates a promising research model for skin wound healing and tissue regeneration research. Such a model could involve omics comparisons between animals with lower and higher body weights to identify molecular signatures of improved wound healing within physiological norms, as well as molecular factors promoting tissue regeneration.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"71 1","pages":"Pages 167-174"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital and artificial intelligence literacy in inflammatory rheumatic and degenerative joint diseases","authors":"Gülseren Demir Karakılıç ,&nbsp;Özlem Balbaloğlu ,&nbsp;Şemsinnur Göçer","doi":"10.1016/j.advms.2026.03.004","DOIUrl":"10.1016/j.advms.2026.03.004","url":null,"abstract":"<div><h3>Purpose</h3><div>The development of digital technologies and artificial intelligence (AI) in healthcare has highlighted the need for patients to improve digital competencies such as e-Health literacy (eHL) and AI literacy (AIL). However, these skills remain largely unexamined in populations with chronic rheumatic and degenerative joint diseases. In particular, comparative data examining both eHL and AIL across different rheumatic disease groups remain limited. This interdisciplinary study aimed to jointly assess eHL and AIL in individuals with inflammatory rheumatic diseases (IRD) and knee osteoarthritis (OA) compared with healthy controls, and to examine sociodemographic and psychological correlates of eHL.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted with 201 participants divided equally into three groups: patients with IRD (rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis), patients with knee OA, and healthy individuals. Standardized clinical, psychological, and digital literacy assessments including eHL Scale and AIL Scale were administered through structured face-to-face interviews. Trial registration is available at <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span>, identifier: NCT07054749, registration date: December 25, 2024.</div></div><div><h3>Results</h3><div>Patients with IRD demonstrated significantly higher eHL and AIL levels than knee OA and healthy groups. Higher literacy was associated with better healthcare engagement and inversely related to anxiety and functional disability. Digital competency was associated with education level and patterns of healthcare engagement across disease groups.</div></div><div><h3>Conclusions</h3><div>These findings suggest potential relevance of integrating eHL and AIL considerations into clinical practice. Strengthening eHL and AIL competencies may be associated with greater patient autonomy and may support adaptation to AI-supported healthcare delivery.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"71 1","pages":"Pages 114-121"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between baseline sodium level, fluid therapy and outcomes in patients with coronavirus disease 2019","authors":"Maciej Niczewski ,&nbsp;Maciej Dyrbuś ,&nbsp;Szymon Gawęda ,&nbsp;Anna Danel ,&nbsp;Mikołaj Rycerski ,&nbsp;Aleksandra Oraczewska ,&nbsp;Agata Stanek ,&nbsp;Jan Duława ,&nbsp;Szymon Skoczyński","doi":"10.1016/j.advms.2026.04.001","DOIUrl":"10.1016/j.advms.2026.04.001","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to determine a correlation between baseline sodium levels, laboratory test results, and clinical condition as well as the association between sodium level changes during treatment and prognosis of patients with COVID-19.</div></div><div><h3>Materials and methods</h3><div>Our retrospective analysis included 1673 patients hospitalized due to COVID-19 at the Temporary Hospital in Pyrzowice. The patients were treated in accordance with the hospital's treatment protocol, including standard fluid therapy regimen adjusted to oxygen support. The analysis considered data on comorbidities, laboratory tests results, blood gas analysis and computed tomography. The endpoints were the need for treatment in the intensive care unit, length of hospital stay, in-hospital mortality, and long-term mortality.</div></div><div><h3>Results</h3><div>Abnormal sodium levels were found in 35.7% (597) of patients. This correlated with comorbidities and abnormal laboratory test results. Baseline sodium imbalance correlated with longer hospitalization and increased in-hospital and long-term mortality rates. Significant sodium level changes (≥6 mmol/L) were observed in 148 patients which correlated with higher in-hospital and long-term mortality rates.</div></div><div><h3>Conclusions</h3><div>Baseline sodium imbalances and significant sodium level changes during treatment are associated with worse prognosis of COVID-19. According to our best knowledge there are no prospective randomized studies which would compare different fluid strategies in COVID-19 patients. Further prospective studies comparing different fluid therapy strategies and different compositions of fluids should be conducted.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"71 1","pages":"Pages 159-166"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of an artificial intelligence–enhanced pulse oximeter for atrial fibrillation detection: a real-world population study","authors":"Chun-Chien Chao ,&nbsp;Hui-An Lin ,&nbsp;Sen-Kuang Hou ,&nbsp;Shu-Cheng Kuo ,&nbsp;Kuo-Yuan Chang ,&nbsp;Wei-Fong Kao ,&nbsp;Sheng-Feng Lin","doi":"10.1016/j.advms.2026.03.005","DOIUrl":"10.1016/j.advms.2026.03.005","url":null,"abstract":"<div><h3>Purpose</h3><div>Fingertip-based photoplethysmographic (PPG) devices offer a noninvasive method for at-home atrial fibrillation (AF) screening. In this study, we evaluated the accuracy of a fingertip pulse oximeter enhanced with a supervised artificial intelligence (AI) algorithm in diagnosing AF in a real-world setting.</div></div><div><h3>Materials and methods</h3><div>This prospective, multicenter study included 401 individuals who underwent concurrent assessment using an AI-enhanced fingertip pulse oximeter and standard 12-lead electrocardiography (ECG), with expert-interpreted ECG serving as the diagnostic reference standard. The oximeter measured pulse rate, oxygen saturation, perfusion index (PI; a PPG-derived indicator of peripheral perfusion), and PPG waveforms, which were analyzed with an embedded AI module to classify heart rhythm as “normal,” “irregular,” or “possible AF.”</div></div><div><h3>Results</h3><div>When benchmarked against expert-interpreted ECG, the AI-enhanced pulse oximeter demonstrated high diagnostic performance for AF detection, with a sensitivity of 96.7%, specificity of 90.5%, positive predictive value of 91.9%, and negative predictive value of 96.1%. AF detection rates derived from the AI-enhanced pulse oximeter were consistent with those identified by computer-read 12-lead ECG (55.4% vs. 52.6%, <em>p</em> = 0.436). Diagnostic performance remained high across all clinical subgroups, with a minor decrease observed among individuals with a perfusion index value of ≤1%. No severe device-related adverse events were reported.</div></div><div><h3>Conclusions</h3><div>The portable, site-less design of this fingertip-based PPG device incorporating an AI algorithm supports its scalability for remote, real-time rhythm monitoring and population-level AF screening.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"71 1","pages":"Pages 122-129"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147525297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}