Novel factors of cisplatin resistance in epithelial ovarian tumours

IF 2.5 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Pavol Harvanik , Martina Šemeláková , Zuzana Solárová , Peter Solár
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引用次数: 0

Abstract

Ovarian tumours are these days one of the biggest oncogynecological problems. In addition to surgery, the treatment of ovarian cancer includes also chemotherapy in which platinum preparations are one of the most used chemotherapeutic drugs. The principle of antineoplastic effects of cisplatin (cis-diamminedichloroplatinum(II), CDDP) is its binding to the DNA and the formation of adducts. While DNA adducts induce the process of apoptosis, or inhibit the process of DNA replication, which prevents further division of tumour cells, various molecular mechanisms can reverse this process. On the other hand, with increasing scientific knowledge, it is becoming clearer that chemotherapy resistance is a very complex process. In this regard, factors and the amount of their expression may regulate the effect of resistance to chemotherapy. This review focuses on new molecular mechanisms and factors such as mitochondrial dynamics, epithelial-mesenchymal transition (EMT), cluster of differentiation, exosomes and others, that could be involved in the emergence of CDDP resistance.
卵巢上皮性肿瘤顺铂耐药的新因素。
卵巢肿瘤是当今最大的妇科肿瘤问题之一。除手术外,卵巢癌的治疗还包括化疗,其中铂制剂是最常用的化疗药物之一。顺铂(顺-二胺二氯铂,CDDP)抗肿瘤作用的原理是其与DNA结合并形成加合物。DNA加合物可以诱导细胞凋亡过程,或抑制DNA复制过程,从而阻止肿瘤细胞进一步分裂,但多种分子机制可以逆转这一过程。另一方面,随着科学知识的增加,化疗耐药是一个非常复杂的过程,这一点越来越清楚。在这方面,因子及其表达量可能调节化疗耐药的效果。本文综述了可能参与CDDP耐药产生的线粒体动力学、上皮-间质转化(EMT)、分化簇、外泌体等新的分子机制和因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advances in medical sciences
Advances in medical sciences 医学-医学:研究与实验
CiteScore
5.00
自引率
0.00%
发文量
53
审稿时长
25 days
期刊介绍: Advances in Medical Sciences is an international, peer-reviewed journal that welcomes original research articles and reviews on current advances in life sciences, preclinical and clinical medicine, and related disciplines. The Journal’s primary aim is to make every effort to contribute to progress in medical sciences. The strive is to bridge laboratory and clinical settings with cutting edge research findings and new developments. Advances in Medical Sciences publishes articles which bring novel insights into diagnostic and molecular imaging, offering essential prior knowledge for diagnosis and treatment indispensable in all areas of medical sciences. It also publishes articles on pathological sciences giving foundation knowledge on the overall study of human diseases. Through its publications Advances in Medical Sciences also stresses the importance of pharmaceutical sciences as a rapidly and ever expanding area of research on drug design, development, action and evaluation contributing significantly to a variety of scientific disciplines. The journal welcomes submissions from the following disciplines: General and internal medicine, Cancer research, Genetics, Endocrinology, Gastroenterology, Cardiology and Cardiovascular Medicine, Immunology and Allergy, Pathology and Forensic Medicine, Cell and molecular Biology, Haematology, Biochemistry, Clinical and Experimental Pathology.
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