Advances in medical sciences最新文献

{"title":"Sex-Based Differences in Patients with Acute Pulmonary Embolism Managed by a Pulmonary Embolism Response Team: a Multicenter, Retrospective Cohort Study.","authors":"Grzegorz Procyk, Paweł Kurzyna, Karolina Jasińska-Gniadzik, Julia Maria Smyk, Marcin Wasilewski, Rafał Wolański, Piotr Szwed, Dominika Rymaszewska, Dominika Zajkowska, Katarzyna Wrona, Szymon Darocha, Marta Banaszkiewicz, Michał Florczyk, Dariusz Zieliński, Krzysztof Wróbel, Marcin Grabowski, Grzegorz Opolski, Adam Torbicki, Marcin Kurzyna, Aleksandra Gąsecka, Arkadiusz Pietrasik","doi":"10.1016/j.advms.2025.09.003","DOIUrl":"https://doi.org/10.1016/j.advms.2025.09.003","url":null,"abstract":"<p><strong>Purpose: </strong>Pulmonary embolism (PE) is the third most frequent acute cardiovascular condition worldwide. PE response teams (PERTs) were proposed recently to facilitate treatment implementation in PE patients. There is limited data regarding the characteristics of patients consulted by PERTs. We aimed to analyze sex-related differences in baseline characteristics, applied treatment, and prognosis of acute PE patients consulted by a local PERT. We did not seek to assess the influence of PERT on potential differences.</p><p><strong>Materials and methods: </strong>The study included 235 patients diagnosed with PE in the three participating hospitals between September 2017 and December 2021. Clinical and treatment data were obtained from medical records.</p><p><strong>Results: </strong>We found that women were older than men (median [IQR]: 66.0 [49.5-77.0] vs. 58.5 [49.0-69.3] years, P=0.02). Cough was more prevalent in men (23.0% vs. 7.3%, P=0.001). Smoking was more frequent in men (32.5% vs. 15.6%, P=0.004), whereas hormonal therapy was more frequent in women (11.0% vs. 0.8%, P=0.001). Hospitalized women required intubation more often than men (16.5% vs. 6.3%, P=0.02). Proximal deep vein thrombosis was more common in men (46.8% vs. 33.9%, P=0.047). Low molecular weight heparins were more often used in men (82.5% vs. 66.1%, P=0.004).</p><p><strong>Conclusions: </strong>Most analyzed parameters did not differ between the sexes in acute PE patients treated by a PERT. Differences in risk factors are associated with well-established sex-related differences, with smoking more often reported in men and hormonal therapy more common in women. Notably, the survival rate was comparable for women and men.</p>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of FKBP5 gene polymorphism with insomnia symptoms in the depressive episodes of stress-related bipolar disorder.","authors":"Ovinuchi Ejiohuo, Karolina Bilska, Karolina Gattner, Łukasz Mech, Dominik Spalek, Maria Skibińska, Monika Dmitrzak-Węglarz, Paweł Kapelski, Beata Narożna, Bartłomiej Budziński, Aleksandra Szczepankiewicz, Joanna Pawlak","doi":"10.1016/j.advms.2025.09.004","DOIUrl":"https://doi.org/10.1016/j.advms.2025.09.004","url":null,"abstract":"<p><strong>Purpose: </strong>Stress-related bipolar disorder (BP) arises from complex genetic, environmental, and clinical interactions. While FKBP5(key stress response regulator) is linked to mood disorders, its role in insomnia during depressive episodes remains unclear. This study explores the association between FKBP5 polymorphisms and insomnia symptoms occurring during the depressive episodes of BP.</p><p><strong>Materials and methods: </strong>A total of 347 individuals with BP (42% male, 58% female; 78% insomnia symptoms) were assessed using the SCID, OPCRIT, and TaqMan genotyping for eight FKBP5 polymorphisms. Participants were grouped based on the presence/absence of a stressor before the first episode. Statistical analyses (ANCOVA and Chi-square with pairwise post hoc tests) were performed using Statistica 13.3 and R. Functional annotation of significantly associated variants was conducted using Ensembl VEP, RegulomeDB, HaploReg, and SNPnexus.</p><p><strong>Results: </strong>FKBP5 rs755658 polymorphism may be associated with insomnia symptoms in individuals with stressors, with CT/CC genotypes showing a higher likelihood of symptoms (p = 0.03; BH-adjusted p = 0.22, below the 0.25 threshold) compared to the TT. Seven polymorphisms were significantly associated with BP subtypes in those without stressors, suggesting genetic influence. The rs755658 variant is predicted to affect gene expression, transcription factor binding, and post-transcriptional regulation.</p><p><strong>Conclusions: </strong>These findings suggest that FKBP5 genetic variants may affect sleep disturbances with a stressor present, highlighting their role in stress regulation and insomnia during depressive episodes in BP. Given the study's exploratory nature, findings should be interpreted cautiously and validated in larger, independent samples. Future studies should investigate the underlying mechanisms and therapeutic implications.</p>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atherosclerosis in the Context of Hemostasis and Neovascularization - Current State of Knowledge.","authors":"Urszula Jakobsche-Policht, Agnieszka Bronowicka-Szydełko, Rajmund Adamiec, Dorota Bednarska-Chabowska, Emilia Królewicz, Łukasz Lewandowski, Kinga Gostomska-Pampuch, Arkadiusz Derkacz, Katarzyna Budrewicz, Ewa Grzebyk, Maciej Nowak, Daria Dolińska, Paulina Matlak, Julia Sobczyńska, Maciej Ziomek, Maciej Tota, Wojciech Stach, Dominik Fidorowicz, Katarzyna Madziarska","doi":"10.1016/j.advms.2025.09.002","DOIUrl":"https://doi.org/10.1016/j.advms.2025.09.002","url":null,"abstract":"<p><p>Atherosclerosis is a progressive process resulting from endothelial dysfunction, primarily caused by damage to the integrity of the glycocalyx. Its pathogenesis is complex and involves numerous biomechanical and biochemical factors, such as blood pressure, shear forces, lipid metabolism disorders, monocyte migration and their transformation into macrophages, immune response, lipid accumulation, neovascularization, and activation of coagulation. Recently, the possibility of atherosclerosis regression has been confirmed, although the mechanisms behind the reversal of changes remain unknown. This review presents current knowledge on the pathogenesis of atherosclerosis, with particular emphasis on pro-atherogenic processes in the glycocalyx and endothelium, especially those related to hemostasis, neovascularization, and epigenetic changes.</p>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ropivacaine and lidocaine at clinically relevant concentrations suppress proliferation and migration of ovarian cancer cells and induce morphological alterations","authors":"Jane M. Hayden ,&nbsp;Andreas Tinnert ,&nbsp;Kersti Alm ,&nbsp;Jonatan Oras ,&nbsp;Linda Block ,&nbsp;Anil Gupta ,&nbsp;Sven-Egron Thörn ,&nbsp;Stina Oredsson","doi":"10.1016/j.advms.2025.08.003","DOIUrl":"10.1016/j.advms.2025.08.003","url":null,"abstract":"<div><h3>Purpose</h3><div>Ovarian cancer ranks as a gynecological malignancy with poor prognosis, specifically if detected late. Primary treatment includes cytoreductive surgery and adjuvant chemotherapy with curative intent. Local anesthetics (LA) administered in the perioperative period may potentially impact patient outcome by several mechanisms. The beneficial impact of LA has been attributed, among other factors, to the drug's inhibitory effect on cancer cells. The primary aim of the study was to evaluate the effect of clinically relevant concentrations of ropivacaine and lidocaine on ovarian cancer cell lines.</div></div><div><h3>Method</h3><div>Three ovarian cancer cell lines (SKOV-3, SW-626 and CA-OV-3) were treated with 1, 10, 100, or 1000 ​μM of the two LAs. Cell function and morphology were assessed in the following ways: cell counting, phase-contrast and holographic microscopy, a conventional MTT assay for dose response testing, wound healing assay for migration, and cancer stem cell (CSC) identification by aldehyde dehydrogenase.</div></div><div><h3>Results</h3><div>Both ropivacaine and lidocaine significantly reduced cell number, altered morphology, suppressed migration, and decreased the population of CSCs in a concentration-dependent manner.</div></div><div><h3>Conclusion</h3><div>LAs exert a direct inhibitory effect on ovarian cancer cell lines <em>in vitro</em>, suggesting their potential benefits in perioperative management for patients undergoing surgery. Clinical studies using LA during ovarian cancer surgery are needed.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 2","pages":"Pages 326-334"},"PeriodicalIF":2.6,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive assessment of triclosan-induced toxicity: impacts on zebrafish development, mammalian cell viability and microbial activity.","authors":"Piotr Stachurski, Łukasz Kurach, Maryna Khalavka, Maja Ptasiewicz, Wojciech Świątkowski, Renata Żelazowska, Agnieszka Magryś","doi":"10.1016/j.advms.2025.09.001","DOIUrl":"https://doi.org/10.1016/j.advms.2025.09.001","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the study was to evaluate the toxicity of triclosan in the Danio rerio model and mammalian cells, as well as to assess its antimicrobial and antibiofilm activity against selected bacterial pathogens.</p><p><strong>Methods: </strong>Triclosan toxicity was assessed in Danio rerio embryos in accordance with OECD Test Guideline 236: Fish Embryo Acute Toxicity (FET) Test. Cytotoxicity was evaluated in vitro using the MTT assay on human dermal fibroblasts (BJ) and rat cardiomyoblasts (H9c2). Antimicrobial activity was assessed via broth microdilution method following EUCAST guidelines and antibiofilm effects were evaluated through minimum biofilm inhibitory concentration (MBIC) assays for each tested strain.</p><p><strong>Results: </strong>Triclosan exhibited toxicity towards Danio rerio, reducing their survival rate, heart rate, and locomotor activity. In vitro tests revealed cytotoxicity (LC₅₀ = 28.44 μg/mL for BJ cells and 25.36 μg/mL for H9c2 cells). Antimicrobial tests demonstrated MIC values ranging from 0.24 μg/mL (Lactobacillus acidophilus) to 3.9 μg/mL (Enterococcus faecalis), with corresponding MBC values up to 7.8 μg/mL. MBIC values ranged from 0.03 to 0.12 μg/mL, confirming potent antibiofilm activity.</p><p><strong>Conclusions: </strong>Triclosan demonstrates high antimicrobial efficacy and inhibits bacterial biofilm formation. However, its toxicity towards aquatic organisms, including Danio rerio, and its cytotoxic effects on mammalian cells raise concerns.</p>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of the C2HEST score in predicting the clinical outcomes of COVID-19 in obese and non-obese cohorts - subanalysis of the COLOS Study","authors":"Piotr Rola ,&nbsp;Olgierd Dróżdż ,&nbsp;Adrian Doroszko ,&nbsp;Małgorzata Trocha ,&nbsp;Krzysztof Kujawa ,&nbsp;Agnieszka Bronowicka-Szydełko ,&nbsp;Agnieszka Matera-Witkiewicz ,&nbsp;Dorota Bednarska-Chabowska ,&nbsp;Maciej Rabczyński ,&nbsp;Edwin Kuźnik ,&nbsp;Marcin Madziarski ,&nbsp;Jędrzej Machowiak ,&nbsp;Rafał Małecki ,&nbsp;Michał Tkaczyszyn ,&nbsp;Joanna Adamiec-Mroczek ,&nbsp;Janusz Sokołowski ,&nbsp;Jarosław Nowak ,&nbsp;Ewa A. Jankowska ,&nbsp;Katarzyna Madziarska","doi":"10.1016/j.advms.2025.08.002","DOIUrl":"10.1016/j.advms.2025.08.002","url":null,"abstract":"<div><h3>Purpose</h3><div>Cardiovascular risk factors, particularly obesity, are strong predictors of poor COVID-19 outcomes, though prognosis remains uncertain for overweight individuals. Identifying new tools to assess obesity's impact on COVID-19 severity is vital for early risk stratification. We evaluated the C₂HEST-score system's ability to predict unfavorable outcomes in hospitalized COVID-19 patients.</div></div><div><h3>Material and methods</h3><div>Consecutive 2183 patients hospitalized due to confirmed COVID-19 were enrolled to this study. Based on the physical examination and past medical history, 332 carefully selected patients were assigned to one of two of the study cohorts, i.e. obese (n ​= ​191) vs. non-obese (n ​= ​141), and allocated to different risk-strata based on the C₂HEST score result.</div></div><div><h3>Results</h3><div>A total of 52 in-hospital deaths (27.2 ​%) were reported in the obese cohort, while in the non-obese cohort the in-hospital mortality rate was 17 ​% (24 reported cases). The in-hospital, 3-month and 6-month mortality were the highest in the high-risk C₂HEST stratum in both study cohorts, reaching respectively 47.62 ​%, 57.14 ​%, and 57.14 ​% in the obese and 63.64 ​%, 72.73 ​%, and 88.89 ​% in the non-obese cohorts. Among patients with the high-risk C₂HEST-score, non-obese individuals were more likely to experience myocardial injury and acute heart failure, whereas obese individuals were more prone to develop acute kidney injury.</div></div><div><h3>Conclusions</h3><div>This study shows the usefulness and performance of the C₂HEST-score in predicting the adverse outcomes of COVID-19 in hospitalized patients with obesity. In the cohort with normal body mass, the C₂HEST score revealed to be far more precise in the risk prediction.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 2","pages":"Pages 318-325"},"PeriodicalIF":2.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental evaluation of selected mechanical properties of anterior cruciate ligament and posterior cruciate ligament complex","authors":"Piotr Prochor,&nbsp;Julia Jagodyńska,&nbsp;Anita Gryko","doi":"10.1016/j.advms.2025.08.001","DOIUrl":"10.1016/j.advms.2025.08.001","url":null,"abstract":"<div><h3>Purpose</h3><div>Ligaments are fibrous connective tissues that transmit force from bone to bone. One of the most important ligaments in the human body is the knee-joint ligament, which is exposed to large and dynamic forces during daily activities. Owing to their frequent injuries, cruciate ligaments are among the most studied in the current literature. Thus far, research has focused mainly on the study of individual ligament structures and less frequently on analysing entire bone-ligament systems. Therefore, this study examines the mechanical properties of the entire cruciate ligament system.</div></div><div><h3>Materials and methods</h3><div>Tensile tests were conducted on 18 porcine forelimb knee joints. The joints were mounted on a holder, ensuring freedom of the ligament positioning during the examination. The test consisted of three stages: preconditioning (stage 1), relaxation (stage 2), and breaking (stage 3).</div></div><div><h3>Results</h3><div>In stage 1, the tissue showed a decrease in reaction force with subsequent conditioning cycles, with a slower decrease at lower tensile velocities. The dissipated energy and stiffness decreased with each cycle, but increased at higher tensile velocities. In stage 2, an increase in stiffness was observed with the elongation of the structure. In stage 3, injuries mainly occurred in the bone fragments and attachments rather than in the ligament structures.</div></div><div><h3>Conclusions</h3><div>The testing stage and tensile velocity influenced the mechanical response of the tissue. The obtained results are important for a better understanding of the mechanism of intra-articular periarticular injuries.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 2","pages":"Pages 308-317"},"PeriodicalIF":2.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the effects of umbilical cord and adipose-derived mesenchymal stem cells on endoplasmic reticulum stress in cadmium-induced rat kidney","authors":"Bahar Kartal ,&nbsp;Uygar Saçik ,&nbsp;Güven Erbil","doi":"10.1016/j.advms.2025.07.002","DOIUrl":"10.1016/j.advms.2025.07.002","url":null,"abstract":"<div><h3>Purpose</h3><div>The hazardous heavy metal cadmium (Cd) has the potential to cause long-term kidney damage, mostly dependent on autophagy. Endoplasmic reticulum (ER) stress has been recognized as a primary source of Cd-induced toxicity. The ER chaperone GRP78 binds ER stress sensors, keeping them dormant. Exposure to Cd increases ER stress, a well-known inducer of autophagy. Adipose-derived mesenchymal stem cells (AD-MSC) are potentially useful tissue engineering and cellular treatment tools. Various disorders are treated with human umbilical cord MSCs (HUC-MSCs). They possess several unique qualities that are necessary for their therapeutic uses. The study aimed to investigate the effects of AD-MSCs and HUC-MSCs on Cd-induced nephrotoxicity.</div></div><div><h3>Methods</h3><div>The study used 36 male Wistar albino rats that were divided into six groups: control, AD-MSC, HUC-MSC, Cd, Cd ​+ ​AD-MSC, and Cd ​+ ​HUC-MSC. Hematoxylin and eosin (H&amp;E) were used to stain the renal tissues in preparation for a histological analysis. Furthermore, the ER stress level was assessed by measuring GRP78 immunoexpression. Additionally, LC3B and Beclin-1 immunostaining were used to determine the autophagy.</div></div><div><h3>Results</h3><div>The histopathological results showed that the glomerular structure, proximal and distal tubules were disrupted in rat kidneys from the Cd group. Treatment with AD-MSCs and HUC-MSCs restored renal histological damage caused by Cd. Additionally, in Cd-induced renal tissues, there was an increase in the immunoexpression of the autophagic sensors LC3B and Beclin-1 and the ER stress indicator GRP78.</div></div><div><h3>Conclusion</h3><div>MSCs enabled Cd-damaged kidney tissues to regain an almost healthy histological structure.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 2","pages":"Pages 284-290"},"PeriodicalIF":2.6,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QT variability and myocardial repolarization in sleep apnea: implications for cardiac risk","authors":"Aleksandra Jarecka-Dobroń ,&nbsp;Wojciech Braksator ,&nbsp;Paweł Chrom","doi":"10.1016/j.advms.2025.07.004","DOIUrl":"10.1016/j.advms.2025.07.004","url":null,"abstract":"<div><h3>Purpose</h3><div>Due to the increased risk of sudden cardiac death, we decided to assess ECG parameters related to the stability of the myocardial repolarization period, i.e. the corrected QT interval (QTc) and derivatives describing its variability (QTV and QTVi).</div></div><div><h3>Methods</h3><div>Healthy volunteers (n ​= ​187) with visceral obesity, aged 35–65 years, were included. Each participant underwent Holter-ECG and polygraphy simultaneously. According to the severity of breathing disorders during sleep the cohort was divided into 3 groups: Respiratory Event Index (REI) 5–14/hour, REI 15–30/hour, REI ≥ 30/hour. The values of QT parameters were compared between obstructive sleep apnea (OSA)-positive and -negative group as well as among OSA positive group (depending on the OSA severity degree).</div></div><div><h3>Results</h3><div>We enrolled 121 patients, mean age 47.57 ​± ​9.36 (47 ​% female), mean BMI 32.18 ​± ​5.98 ​kg/m², 70 (58 ​%) of them were diagnosed with OSA, mean REI 26.79 ​± ​25.66/hour. In OSA group, QTV and QTVi were higher (p ​&lt; ​0.001) however QTc max was not significantly longer (p ​= ​0.06).</div><div>Furthermore, we found significantly increased QTc max and QTVi in OSA positive patients during respiratory events compared to normal breathing (p ​= ​0.02 and p ​= ​0.008, respectively). Additionally, we found a positive correlation between REI and QTc max (p ​= ​0.004, R ​= ​0.22). Parameters related to hypoxia (oxygen desaturation index 4 ​%, time with SpO2 &lt;90 ​%, SpO2 min, SpO2 mean) also presented a positive correlation with QTc max. Variables were not dependent on age or BMI.</div></div><div><h3>Conclusions</h3><div>Repolarization of cardiomyocytes is impaired in patients with OSA. The severity of impairment is positively correlated with the severity of sleep-related breathing disorders and hypoxemia.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 2","pages":"Pages 301-307"},"PeriodicalIF":2.6,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of hepatitis D virus in chronic hepatitis B patients: findings from Poland","authors":"Dorota Zarębska-Michaluk ,&nbsp;Michał Brzdęk ,&nbsp;Krystyna Dobrowolska ,&nbsp;Diana Martonik ,&nbsp;Anna Parfieniuk-Kowerda ,&nbsp;Jakub Janczura ,&nbsp;Kinga Brzdęk ,&nbsp;Robert Pleśniak ,&nbsp;Agnes Piszcz ,&nbsp;Robert Flisiak","doi":"10.1016/j.advms.2025.07.003","DOIUrl":"10.1016/j.advms.2025.07.003","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to determine the prevalence of hepatitis B/hepatitis D virus (HBV/HDV) co-infections in eastern Poland.</div></div><div><h3>Materials/methods</h3><div>We included consecutive patients with chronic hepatitis B treated with nucleos(t)ide analogues (NA) in the study, in whom we performed anti-HDV assays verified by molecular testing.</div></div><div><h3>Results</h3><div>The analysed population consisted of 398 patients, predominantly male with a median age of 50 years, 58.3 ​% of whom had comorbidities. Forty-three patients (10.8 ​%) were diagnosed with cirrhosis. Patients were treated with entecavir, tenofovir, or lamivudine for a median of 5 years. At the start of treatment, the median viral load was 5110 IU/ml, and 98 ​% of patients achieved viral eradication during the therapy. In the study population, anti-HDV antibodies were detected in 6 patients (1.5 ​%), 3 men and 3 women, of whom in 1 (0.25 ​%) the presence of genetic material of the HDV was confirmed by molecular testing.</div><div>Among anti-HDV-positive patients, 3 (50 ​%) had cirrhosis, 1 of them underwent liver transplantation, and 2 had extrahepatic malignancy. All of them were negative for hepatitis B virus envelope (HBe) antigen and had antibodies to HBe antigen present at the beginning of antiviral treatment. All anti-HDV-positive patients achieved viral clearance during the therapy.</div></div><div><h3>Conclusion</h3><div>In a population of almost four hundred patients infected with HBV, we observed a low prevalence of anti-HDV antibodies of 1.5 ​% and HDV replication of only 0.25 ​%. Half of the 6 patients with serologic evidence of co-infection had cirrhosis, so HDV likely played a role in disease progression.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 2","pages":"Pages 277-283"},"PeriodicalIF":2.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}