Advances in medical sciences最新文献

{"title":"The insight into house dust mites: which Dermatophagoides pteronyssinus proteins and cross-reactive allergens play pivotal role in sensitization among Polish patients with suspicion of allergy?","authors":"Magdalena Choina, Weronika Gromek, Danuta Kozłowska, Jakub Swadźba, Solomiya Pukalyak, Krzysztof Łangowski, Magdalena Wójtowicz, Bożena Cukrowska, Ryszard Kurzawa, Krzysztof Kowal, Emilia Majsiak","doi":"10.1016/j.advms.2026.04.003","DOIUrl":"https://doi.org/10.1016/j.advms.2026.04.003","url":null,"abstract":"<p><strong>Purpose: </strong>The profiles of house dust mite (HDM) sensitization may differ in various geographical regions, which could affect the course of allergic diseases. The identification of these discrepancies could help to introduce improved methods of HDM allergy management, more suited to the local needs. The study aimed to analyze the pattern of sensitization to Dermatophagoides pteronyssinus (DP) allergen components and allergens that may cross-react with the allergen components among Polish children and adults with suspicion of allergy.</p><p><strong>Methods: </strong>The sensitization to DP allergens and homologous proteins was assessed in 17,821 Polish individuals suspected of allergy. The specific immunoglobulins E (sIgE) were detected with the ALEX2® test between 2019 and 2023 in various laboratories across the country.</p><p><strong>Results: </strong>Almost 25% of the study participants had sIgE to any DP molecule (DP_m), and in this group, sIgE to Der p 2 was detected most frequently. The most common profile of sensitization was monosensitization to Der p 2. Polysensitization occurred in 61.3% of patients with sIgE to any DP_m. Among patients sensitized to Der p 23, 91.2% were co-sensitized to Der p 1 and/or Der p 2. The most common pattern of sensitization to tropomyosins included sIgE to all five proteins from the family.</p><p><strong>Conclusion: </strong>Major DP_ms, in various combinations, most frequently cause sensitization in the study group. Tropomyosin is a panallergen with high cross-reactivity potential, which was proved by the sensitization profile to tropomyosins in our study group.</p>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prothrombotic potential of diabetic patients with ischemic heart failure is associated with impaired left ventricular contractility and endothelial dysfunction","authors":"Karol Witold Nowak ,&nbsp;Aleksander Siniarski ,&nbsp;Alicia del Carmen Yika ,&nbsp;Aleksandra Karcinska ,&nbsp;Anna Matrejek ,&nbsp;Konrad Stepien ,&nbsp;Jadwiga Nessler ,&nbsp;Grzegorz Gajos ,&nbsp;Jaroslaw Zalewski","doi":"10.1016/j.advms.2026.01.003","DOIUrl":"10.1016/j.advms.2026.01.003","url":null,"abstract":"<div><h3>Purpose</h3><div>We sought to investigate whether left ventricular (LV) contractility and endothelial dysfunction in diabetic patients with ischemic heart failure (HF) are associated with enhanced thrombin generation and altered fibrin clot properties compared with individuals without HF.</div></div><div><h3>Materials and methods</h3><div>The study included 85 HF patients with type 2 diabetes (T2DM) and ischemic heart disease (IHD). Based on echocardiographic examination, 39 (45.9 %) patients were identified as having LV ejection fraction (LVEF) of &lt;40 % (HFrEF) while 46 patients (54.1 %) of ≥50 % (HFpEF). The control group (n = 43) consisted of diabetic and IHD participants without HF (non-HF). In all groups, endogenous thrombin potential (ETP), fibrin clot permeability (Ks), brachial artery flow-mediated dilation (FMD), and nitroglycerin-mediated dilatation (NMD) were assessed.</div></div><div><h3>Results</h3><div>HFrEF and HFpEF patients had less permeable fibrin clots than non-HF by 45.4 % and by 14.6 %, respectively (P &lt; 0.05 both). HFrEF patients had higher ETP by 14.4 % (P = 0.004), lower Ks by 16.9 % (P = 0.037) and lower NMD by 34.7 % (P = 0.001) without differences in FMD as compared with HFpEF. Multivariable analysis adjusted for fibrinogen levels showed that lower LVEF (β-coefficient −0.195, 95 % confidence interval [CI] for β-coefficient −0.385 to −0.015), reduced NMD (β-coefficient −0.230, 95 %CI -0.399 to −0.061), and increased total cholesterol level (β-coefficient 0.286, 95 %CI 0.108–0.464) influenced enhanced ETP in HF population.</div></div><div><h3>Conclusions</h3><div>In diabetic patients with IHD, the diagnosis of HF is associated with more dense fibrin clots. HF patients with reduced versus preserved LVEF have shown enhanced thrombin generation and reduced clot permeability. Impairment of both LV systolic and vascular vasodilator function affected thrombin generation.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"71 1","pages":"Pages 19-26"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146045988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesothelin as a diagnostic biomarker in endometriosis: A cross-sectional study","authors":"Kamil Kiecka ,&nbsp;Aleksandra Zygula ,&nbsp;Anna Sankiewicz ,&nbsp;Mariusz Kuzmicki ,&nbsp;Slawomir Lawicki ,&nbsp;Michal Ciebiera ,&nbsp;Tadeusz Issat ,&nbsp;Jan Blaszczyk ,&nbsp;Krzysztof Cendrowski ,&nbsp;Ewa Gorodkiewicz ,&nbsp;Piotr Laudanski","doi":"10.1016/j.advms.2025.11.002","DOIUrl":"10.1016/j.advms.2025.11.002","url":null,"abstract":"<div><h3>Purpose</h3><div>Endometriosis is a prevalent gynecological condition often requiring invasive procedures for diagnosis. This study aimed to assess mesothelin (MSLN) as a potential non-invasive biomarker by analyzing its levels in peritoneal fluid (PF) and plasma.</div></div><div><h3>Materials/methods</h3><div>In a multicenter cross-sectional study, MSLN concentrations were measured using Surface Plasmon Resonance imaging (SPRi) biosensors in samples from women undergoing laparoscopy for pelvic pain or infertility.</div></div><div><h3>Results</h3><div>Significantly higher MSLN levels were observed in the PF of patients with endometriosis compared to controls (mean concentrations: 10.24 vs. 9.39 ​ng/mL, p ​= ​0.038). The elevation was particularly notable in patients with stage I and II endometriosis compared to the control group (mean concentrations: 10.83 vs. 9.39 ​ng/mL, p ​= ​0.049). No significant differences were observed in plasma.</div></div><div><h3>Conclusions</h3><div>Mesothelin in PF may be considered as a potential biomarker for endometriosis, especially in its early stages. Further studies are needed to confirm its diagnostic value.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"71 1","pages":"Pages 1-8"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145646923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Investigation of the effects of umbilical cord and adipose-derived mesenchymal stem cells on endoplasmic reticulum stress in cadmium-induced rat kidney” [Adv. Med. Sci. (2025 Oct) 70 (2) 284-290]","authors":"Bahar Kartal ,&nbsp;Uygar Saçik ,&nbsp;Güven Erbil","doi":"10.1016/j.advms.2025.12.001","DOIUrl":"10.1016/j.advms.2025.12.001","url":null,"abstract":"","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"71 1","pages":"Page 9"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145779815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial ischemia detected by SPECT/CT in patients with coronary artery aneurysm or ectasia. Insights from Coronary Artery Ectasia Database – Poland (CARED-POL)","authors":"Mateusz Podolec ,&nbsp;Konrad Stępień ,&nbsp;Sylwia Iwańczyk ,&nbsp;Julia Kościanek ,&nbsp;Anna Matrejek ,&nbsp;Karolina Gutkowska ,&nbsp;Alicia del Carmen Yika ,&nbsp;Paweł Matusik ,&nbsp;Katarzyna Holcman ,&nbsp;Magdalena Kostkiewicz ,&nbsp;Jadwiga Nessler ,&nbsp;Jarosław Zalewski","doi":"10.1016/j.advms.2026.02.004","DOIUrl":"10.1016/j.advms.2026.02.004","url":null,"abstract":"<div><h3>Purpose</h3><div>A high rate of coronary microcirculation dysfunction has been recently demonstrated in coronary artery aneurysm or ectasia (CAAE) in invasive assessment. We sought to analyse the diagnostic value of single-photon emission computed tomography (SPECT/CT) in patients with CAAE and to link it with their angiographic characteristics.</div></div><div><h3>Methods</h3><div>We analyzed 79 patients with CAAE without coronary artery disease who underwent coronary angiography assessed with quantitative coronary angiography (QCA). In all patients SPECT/CT with technetium agents was performed to assess the presence of reversible myocardial perfusion defect.</div></div><div><h3>Results</h3><div>The presence of reversible defect was found in 27 (34.2%) of the included patients. Patients with reversible defect were characterized by more frequent diabetes (55.6 vs 25%, P = 0.007). They were more often treated with insulin (14.8 vs 1.9%, P = 0.026) and non-insulin hypoglycemic drugs (40.7 vs 19.2%, P = 0.043). In patients with reversible defect there was a higher number of multiple CAAE (14.8 vs 5.8%, P = 0.044) without other significant differences in CAAE diameters. The percentage of reversible perfusion defect was inversely associated with distal reference diameter of CAAE (R = −0.342, P = 0.031). In the multivariable analysis, only diabetes was independently associated with presence of reversible perfusion defect (odds ratio [OR] 3.525, 95% confidence interval [CI] 1.240-10.019, P = 0.018).</div></div><div><h3>Conclusions</h3><div>As has been shown for the first time in a high percentage of CAAE patients without coronary artery disease, a reversible perfusion defect in SPECT/CT is observed, which may explain their high symptomaticity. Diabetes, but not CAAE diameters, is the independent predictor of reversible perfusion defect.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"71 1","pages":"Pages 88-94"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147300617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Canaloplasty ab externo: evaluation of its standalone benefits vs. combined with phacoemulsification in managing open-angle glaucoma","authors":"Jakub Błażowski,&nbsp;Anna Charytonowicz,&nbsp;Joanna Konopińska","doi":"10.1016/j.advms.2026.03.001","DOIUrl":"10.1016/j.advms.2026.03.001","url":null,"abstract":"<div><h3>Purpose</h3><div>This literature review was prepared in order to evaluate and compare the outcomes of canaloplasty (CP) performed externally (<em>ab externo</em>) and phacocanaloplasty (PCP) in glaucoma management in patients with coexisting cataracts.</div></div><div><h3>Methods</h3><div>A literature search was conducted using PubMed, Google Scholar, Scopus, Web of Science, and Embase. Two independent reviewers screened and evaluated the identified studies.</div></div><div><h3>Results</h3><div>A total of 6 papers were included into this review. The analysis involved 711 eyes treated with CP and 475 eyes treated with PCP, with surgical success defined as achieving intraocular pressure (IOP) of 21 mmHg either with medications (qualified success) or without medications (complete success). Both CP and PCP significantly reduced IOP and the need for medications, though PCP showed a higher cumulative surgical success rate than CP.</div></div><div><h3>Conclusions</h3><div>PCP offers improved outcomes compared to standalone CP.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"71 1","pages":"Pages 106-113"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subureteric injection in complex vesicoureteral reflux in pediatric patients: a retrospective observational study","authors":"Çiğdem Arslan Alıcı ,&nbsp;Baran Tokar","doi":"10.1016/j.advms.2026.01.001","DOIUrl":"10.1016/j.advms.2026.01.001","url":null,"abstract":"<div><h3>Purpose</h3><div>This study evaluated the effectiveness of subureteric injection (SUI) compared to ureteral reimplantation in treating vesicoureteral reflux (VUR) among children, focusing on whether SUI reduces the need for surgical interventions, especially in complex cases.</div></div><div><h3>Method</h3><div>We retrospectively analysed 132 children diagnosed with VUR. We divided the patients into two groups: Group 1 - only VUR cases (n = 65) and Group 2 - complex cases (n = 67). We diagnosed VUR and complex pathologies by voiding cystourethrography (VCUG) and cystoscopic examination. VUR was graded according to the International Reflux Study Committee classification system. SUI and intravesical ureteroneocystostomy (UNC) were used as surgical treatment methods.</div></div><div><h3>Results</h3><div>In Group 2, complex pathologies included duplex renal collecting systems (1.6 %), bladder diverticulum (11.4 %), bladder trabeculation (27.8 %), and posterior urethral valves (18 %). SUI was performed in 48.5 % of patients, with 22.7 % requiring reimplantation after SUI, while 28.8 % underwent direct reimplantation. Success rates of SUI (65.6 %) and reimplantation (70.6 %) were similar (p = 0.68), though lower in children aged 0–2 years with high-grade VUR (45 % for Grade 5) and renal scarring (48 %). Mean recurrence times were 8.4 ± 3.2 months for SUI and 9.1 ± 3.8 months for reimplantation.</div></div><div><h3>Conclusions</h3><div>The success of SUI and ureteral reimplantation was comparable in both simple and complex cases, suggesting SUI is a viable first-line option, particularly in patients older than 2 years with low-grade reflux. However, further studies are needed to confirm these findings.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"71 1","pages":"Pages 40-45"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146002837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impacts of ribociclib on the post-treatment Tp-e interval and Tp-e/QTc ratio in breast cancer patients","authors":"Şükrü Çiriş ,&nbsp;Mustafa Seyyar ,&nbsp;İrfan Yaman ,&nbsp;Esra Polat","doi":"10.1016/j.advms.2026.03.002","DOIUrl":"10.1016/j.advms.2026.03.002","url":null,"abstract":"<div><h3>Purpose</h3><div>The study aimed to assess the impacts of ribociclib on the post-treatment Tp-e interval and Tp-e/QTc ratio in breast cancer patients.</div></div><div><h3>Materials/methods</h3><div>A retrospective study was carried out with 40 breast cancer patients between October 2023 and February 2024 to reveal the impacts of ribociclib therapy (either alone or in combination with letrozole) on the post-treatment Tp-e interval and Tp-e/QTc ratio. ECGs obtained before the start of the treatment and on the 21st day of the 3rd course were used in the evaluation.</div></div><div><h3>Results</h3><div>Patients' pre-treatment heart rate, WBC, AST, QRS (ms), Tp-e/QT, and Tp-e/JT values decreased after the treatment (p &lt; 0.05). Patients' pre-treatment QT, JT (ms), JTc(ms), Tp-e(ms), Tp-e/Qtc, and Tp-e/JTc values increased after the treatment (p &lt; 0.05). Patients' pre- and post-treatment ionized Ca/(Tpe/JTc) values showed statistically significant difference (p &lt; 0.01). The pre-treatment ionized Ca/(Tpe/JTc) values of patients decreased significantly after the treatment. The ionized Ca/(Tpe/QTc) values of patients differed statistically significantly before and after the treatment (p &lt; 0.01). Patients’ pre-treatment ionized Ca/(Tpe/QTc) values decreased significantly after the treatment.</div></div><div><h3>Conclusion</h3><div>The potential arrhythmogenic effects of ribociclib suggest that serum calcium (Ca), ionized calcium, QT, QTc, Tp-e interval, and Tp-e/QTc ratio may be monitored throughout the treatment period.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"71 1","pages":"Pages 83-87"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pooled granulocyte component–a worthy rival to the apheresis product?","authors":"Artur Szumowski ,&nbsp;Tomasz Wasiluk ,&nbsp;Magdalena Średzińska ,&nbsp;Kamila Rybińska ,&nbsp;Mateusz Dziemiańczuk ,&nbsp;Paulina Radziwon ,&nbsp;Michał Kuźma ,&nbsp;Piotr Radziwon","doi":"10.1016/j.advms.2026.01.002","DOIUrl":"10.1016/j.advms.2026.01.002","url":null,"abstract":"<div><h3>Purpose</h3><div>Granulocyte concentrates (GCs) are crucial in preventing and treating hazardous infections in neutropenic patients with hematological malignancies. Our study goal was to evaluate the impact of various collection and preparation methods on the quality of GCs.</div></div><div><h3>Materials and methods</h3><div>Our study included 30 GCs that were collected either by leukapheresis (group L), by standard buffy coat pooling (group S), or by using the Reveos system (group R). All studied GCs were irradiated with gamma rays and stored for 24 h at room temperature without agitation. Laboratory tests included the assessment of leukocyte (WBC), neutrophil, lymphocyte and monocyte counts, pH, cell viability, phagocytosis, and the expression of CD11b, CD62L, CD66b and CXCR4 molecules.</div></div><div><h3>Results</h3><div>We showed that GCs prepared using different methods differed primarily in terms of cell counts, cell viability, and the CD11b, CD62L and CXCR4 expression. We also observed that gamma irradiation expectedly reduced the lymphocyte count, whereas 24-h storage drastically reduced cell viability. An additional effect of the preparation method on GCs susceptibility to quality changes due to gamma rays and 24-h storage was noticed as well.</div></div><div><h3>Conclusions</h3><div>Our research indicates that apheresis-derived granulocytes and pooled GCs do not differ enough to not consider more frequent use of the latter in daily clinical practice. Moreover, we concluded that gamma irradiation does not worsen the quality of granulocyte components, and freshly collected GCs should be preferred.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"71 1","pages":"Pages 27-39"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between lipoprotein (a) and lipid profile and body composition in patients with high cardiovascular risk","authors":"Joanna Popiolek-Kalisz ,&nbsp;Pierre Sabouret","doi":"10.1016/j.advms.2026.02.006","DOIUrl":"10.1016/j.advms.2026.02.006","url":null,"abstract":"<div><h3>Purpose</h3><div>Dyslipidemia remains a major contributor to atherosclerosis and cardiovascular events. While low-density lipoprotein cholesterol (LDL-C) lowering is the primary treatment target, lipoprotein(a) [Lp(a)] has emerged as an independent, genetically determined risk factor, often unaffected by standard treatment. This study aimed to analyze the relationship between body composition parameters and lipid profile, including Lp(a).</div></div><div><h3>Materials and methods</h3><div>Clinically stable high cardiovascular risk patients (n = 207) receiving lipid-lowering pharmacotherapy were enrolled in this cross-sectional study. Anthropometric data and body composition were assessed using bioelectrical impedance analysis, including body mass index (BMI), fat mass (FM%) and fat-free mass percentage (FFM%). Lp(a) and lipid profile were measured. Patients were stratified by Lp(a) concentration: &lt;75 nmol/L, 75–125 nmol/L, and &gt;125 nmol/L.</div></div><div><h3>Results</h3><div>Lp(a) levels showed no significant association with body composition, age, and sex. In contrast, HDL-C was significantly inversely correlated with BMI (R = −0.25, p &lt; 0.001) and this relationship was independent of sex (β = −0.68, p &lt; 0.001), while triglycerides were positively correlated with FM% (R = 0.17, p = 0.02) and BMI (R = 0.28, p &lt; 0.001) and negatively with FFM% (R = −0.17, p = 0.02). LDL-C was not associated with body composition. No significant differences in lipid profile or body composition were observed across Lp(a) strata.</div></div><div><h3>Conclusions</h3><div>In high cardiovascular risk patients, Lp(a) appears unrelated to body composition, supporting its role as a non-modifiable, genetically driven risk factor. Conversely, despite pharmacotherapy, HDL-C and triglycerides demonstrated significant associations with body fat distribution. These findings suggest clinical role of body composition assessment in cardiovascular risk management, particularly in addressing residual risk beyond LDL-C.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"71 1","pages":"Pages 68-74"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}