Advances in medical sciences最新文献

{"title":"Evaluation of salusin-β in paediatric patients with chronic kidney disease or hypertension","authors":"Mirjam Močnik ,&nbsp;Sonja Golob Jančič ,&nbsp;Martina Filipič ,&nbsp;Evgenija Homšak ,&nbsp;Mateja Svetej ,&nbsp;Nataša Marčun Varda","doi":"10.1016/j.advms.2025.02.006","DOIUrl":"10.1016/j.advms.2025.02.006","url":null,"abstract":"<div><h3>Purpose</h3><div>Salusins are newly identified endogenous peptides implicated in the atherosclerotic process. Salusin-β, in particular, is recognized for its proatherogenic role. Given that atherosclerosis can commence in childhood, salusin-β holds promise as a potential biomarker for cardiovascular risk assessment. The objective of our study was to investigate salusin-β levels in children with early stages of chronic kidney disease (CKD) or hypertension (HTN), and compare them to healthy controls. Furthermore, we aimed to evaluate its association with obesity and pulse wave velocity (PWV), the latter being a well-established marker for determining arterial elasticity.</div></div><div><h3>Materials and methods</h3><div>This cross-sectional study involved 96 paediatric patients, including 46 with CKD and 50 with HTN, as well as 33 healthy controls. Anthropometric measurements, PWV assessments, serum salusin-β values, and basic laboratory investigations were conducted for all participants.</div></div><div><h3>Results</h3><div>Salusin-β levels were found to be elevated in patients with CKD (<em>p</em> ​= ​0.014), but not in patients with HTN when compared to healthy controls. When correlating salusin-β levels with PWV, a significant but weak correlation was observed (r ​= ​0.211, <em>p</em> ​= ​0.020).</div></div><div><h3>Conclusions</h3><div>Salusin-β levels were elevated in paediatric patients with CKD. Additionally, salusin-β levels correlated significantly with PWV. Obesity played a smaller role in these correlations, with significant correlations observed only after combining cardiovascular risk factors revealing certain associations between salusin-β levels and some cardiovascular variables, but with inconclusive findings and, in some instances, even contrary to anticipated outcomes.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 1","pages":"Pages 184-190"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of patients with severe asthma reported to be eligible or non-eligible for biologic therapy in Poland: Results from the international observational study RECOGNISE","authors":"Robert M. Mróz ,&nbsp;Łukasz Minarowski ,&nbsp;Jolanta Biegalska","doi":"10.1016/j.advms.2025.03.003","DOIUrl":"10.1016/j.advms.2025.03.003","url":null,"abstract":"<div><h3>Purpose</h3><div>To analyze characteristics of real-world patients with severe asthma in Poland and identify factors determining clinicians’ opinion on the eligibility for biologics.</div></div><div><h3>Methods</h3><div>In this retrospective, multi-national, single-visit study (NCT03629782), investigators were asked whether the patient might benefit from a referral for further clinical assessment and potentially biologic therapy. Asthma exacerbations and healthcare resource utilization (HCRU) in the last 12 months were documented by the investigators. Patient-reported outcomes included St George's Respiratory Questionnaire (SGRQ) and Asthma Control Questionnaire (ACQ-6).</div></div><div><h3>Results</h3><div>Of 1025 patients, 146 were enrolled in Poland. Investigators considered 77.4 ​% of patients eligible for biologics and 22.6 ​% non-eligible. Patients considered eligible were diagnosed at younger age than non-eligible (median 39 vs 45 years; p ​= ​0.0113) and more frequently had a history of atopy (46 ​% vs 21.2 ​%; p ​= ​0.0106). Eligible patients had a higher frequency (93.8 ​% vs 66.7 ​%, p ​&lt; ​0.0001) and number of exacerbations (median 2 vs 1, p ​= ​0.0003). Among eligible patients, 81.4 ​% and among non-eligible, 66.7 ​% had not well-controlled asthma; long-term oral corticosteroids were used by 46.0 ​% and 51.5 ​%, respectively. Short-term corticosteroid use was more frequent in biologics-eligible than in non-eligible patients (82.3 ​% vs 48.5 ​%, p ​&lt; ​0.0001). Patients eligible for biologics had a higher median SGRQ total score (64.7 vs 48.4; p ​= ​0.0075) and HRCU (63.7 ​% vs 9.1 ​%; p ​&lt; ​0.0001).</div></div><div><h3>Conclusions</h3><div>In Poland, 3 in 4 patients with severe asthma are recognized by clinicians as potential candidates for biologics. However, eligibility is not associated with long-term oral corticosteroid use, highlighting the need to better inform the physicians about the benefits of biologic therapy.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 1","pages":"Pages 203-208"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conduction system optimized cardiac resynchronization therapy– exceptional modality of cardiac pacing in patients with severe heart failure. A hope for non-responders?","authors":"Jędrzej Michalik ,&nbsp;Maciej Sterliński ,&nbsp;Ewa Świerżyńska-Wodarska ,&nbsp;Aleksandra Klaus ,&nbsp;Marek Szołkiewicz","doi":"10.1016/j.advms.2025.02.008","DOIUrl":"10.1016/j.advms.2025.02.008","url":null,"abstract":"<div><div>For many years, the apex of the right ventricle (RV) seemed to be a sufficiently good site for ventricular pacing, effectively protecting both the health and life of patients with atrioventricular conduction disorders. However, the studies have demonstrated that this is not an optimal site, since it leads to electrical and mechanical interventricular asynchrony, which in some cases (15–20 ​%) results in the development of pacing-induced cardiomyopathy (PICM). The introduction of biventricular cardiac resynchronization therapy (BiV-CRT) into clinical practice was a real breakthrough in the development of modern electrotherapy, and conduction system pacing (CSP) has heralded even greater hopes. The CSP-optimized CRT is the most complex modality of CRT, involving the simultaneous pacing of His bundle or its left branch, and additionally, epicardial pacing of the left ventricle. This modality of pacing may represent the most optimal method for spreading the ventricle depolarization wave in severely damaged cardiac muscle and may represent a real hope for patients who do not adequately respond to other forms of CRT.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 1","pages":"Pages 197-202"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Column chart prediction model for ovarian cancer based on serum ovarian tumor related biomarkers and validation","authors":"Yuting Song ,&nbsp;Libo Liu ,&nbsp;Jie Gao ,&nbsp;Naibao Wu ,&nbsp;Jiwei Yin","doi":"10.1016/j.advms.2025.03.001","DOIUrl":"10.1016/j.advms.2025.03.001","url":null,"abstract":"<div><h3>Purpose</h3><div>The aim was to study the predictive model and validate serum ovarian tumor-related biomarkers for ovarian cancer histograms.</div></div><div><h3>Method</h3><div>We randomly selected 181 patients with ovarian tumors and 80 healthy individuals who underwent physical examinations from the hospital's medical record information system as the study participants. Clinical data and detection results of ovarian tumor-related markers such as serum carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), carbohydrate antigen 19-9 (CA19-9), and human epididymal protein (HE4) were collected from all study participants for analysis.</div></div><div><h3>Result</h3><div>Significant differences were found in serum CEA, CA125, CA19-9, and HE4 levels between healthy controls, benign ovarian tumors, and ovarian cancer (<em>P</em> ​&lt; ​0.05). Dysmenorrhea (present), family history (present), age at menarche, menstrual period, number of pregnancies, natural abortion frequency, number of induced abortions, CEA, CA125, CA19-9, HE4 were all influencing factors for the incidence of ovarian cancer (<em>P</em> ​&lt; ​0.05). The number of induced abortions, CEA, CA125, CA19-9, and HE4 were all independent risk factors for ovarian cancer, while the natural abortion frequency was a protective factor for ovarian cancer (<em>P</em> ​&lt; ​0.05). The constructed column chart prediction model had good discrimination and prediction accuracy for ovarian cancer, good clinical utility, and higher predictive performance for ovarian cancer than traditional ROMA models.</div></div><div><h3>Conclusion</h3><div>The ovarian cancer column chart prediction model based on serum ovarian tumor related markers has good discrimination and prediction accuracy for ovarian cancer, with high clinical utility. Future research may need to incorporate more serum markers related to ovarian cancer to further improve the performance of predictive models.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 1","pages":"Pages 209-218"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trimethylamine N-oxide as a potential prognostic biomarker for mortality in patients with COVID-19 disease","authors":"Zinnet Şevval Aksoyalp ,&nbsp;Betül Rabia Erdoğan ,&nbsp;Saliha Aksun ,&nbsp;Melih Kaan Sözmen ,&nbsp;Murat Aksun ,&nbsp;Cüneyt Kemal Buharalıoğlu ,&nbsp;Nagihan Altıncı-Karahan ,&nbsp;Nergiz Hacer Turgut ,&nbsp;Tijen Kaya-Temiz","doi":"10.1016/j.advms.2025.02.002","DOIUrl":"10.1016/j.advms.2025.02.002","url":null,"abstract":"<div><h3>Purpose</h3><div>Trimethylamine N-oxide (TMAO) is suggested as a biomarker for inflammatory and cardiovascular diseases which are identified as risk factors for severe cases of coronavirus disease 2019 (COVID-19). Our primary aim was to assess prognostic potential of serum TMAO levels in predicting COVID-19-related mortality. The secondary aim was to examine the potential of various biochemical parameters, particularly those associated with inflammation or thrombosis, as predictors of mortality.</div></div><div><h3>Patients and methods</h3><div>In this prospective and single-centre study, COVID-19 patients were categorized as death (group 1) or discharged (group 2) based on their in-hospital mortality status. The characteristics of participants were documented, and clinical data, including TMAO, angiotensin-converting enzyme-2 (ACE2), and neutrophil to lymphocyte ratio (NLR), were determined. The association of these independent variables with the COVID-19-related mortality, was assessed by calculation of crude odds ratios (OR) in bivariate and logistic regression analysis. Receiver operation characteristic (ROC) analysis was used for cut-off values.</div></div><div><h3>Results</h3><div>The serum levels of TMAO, ACE2 and NLR were markedly higher in group 1 on the days of hospital admission (<em>p</em> ​&lt; ​0.05, <em>p</em> ​&lt; ​0.05, and <em>p</em> ​&lt; ​0.01, respectively). Serum TMAO levels (OR 1.422; 95 ​% CI [1.067–1.894]; <em>p</em> ​= ​0.016) and NLR (OR 1.166; 95 ​% CI [1.012–1.343]; <em>p</em> ​= ​0.033) were determined as independent predictors for COVID-19-related mortality with after multivariate logistic regression analysis. The optimal cut-off values were detected as 7.9 ​ng/ml for TMAO (71 ​% sensitivity, 68 ​% specificity, AUC ​= ​0.701).</div></div><div><h3>Conclusions</h3><div>The findings of this initial study indicate that serum TMAO levels and NLR may be useful in predicting mortality in the early stages of COVID-19.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 1","pages":"Pages 174-183"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants and dynamics of the seroprevalence of anti-SARS-CoV-2 antibodies in Poland","authors":"Justyna Adamczuk ,&nbsp;Karol Adam Kamiński ,&nbsp;Sebastian Sołomacha ,&nbsp;Małgorzata Kazberuk ,&nbsp;Magdalena Chlabicz ,&nbsp;Piotr Czupryna ,&nbsp;Justyna Dunaj-Małyszko ,&nbsp;Anna Citko ,&nbsp;Paweł Sowa ,&nbsp;Marlena Dubatówka ,&nbsp;Magda Łapińska ,&nbsp;Łukasz Kiszkiel ,&nbsp;Łukasz Szczerbiński ,&nbsp;Piotr Paweł Laskowski ,&nbsp;Maciej Alimowski ,&nbsp;Anna Moniuszko-Malinowska","doi":"10.1016/j.advms.2025.03.002","DOIUrl":"10.1016/j.advms.2025.03.002","url":null,"abstract":"<div><h3>Purpose</h3><div>In the present study, we aimed to assess the anti-SARS-CoV-2 antibodies in population and in convalescents 6 months after infection with COVID-19.</div></div><div><h3>Patients and methods</h3><div>The study population consisted of 2 groups, i.e. group I: 232 post-COVID-19 patients, and group II: 544 patients from a population cohort.</div><div>Detection of anti-N antibodies was performed with Elecsys Anti-SARS-CoV-2 and anti-S antibodies with LIAISON SARS-CoV-2 S1/S2 IgG tests.</div></div><div><h3>Results</h3><div>After the Omicron wave, gradual increase in the prevalence of the analyzed antibodies was observed in the general population - up to 92.5 ​% of anti-S and 69.7 ​% of anti-N antibodies. In the COVID-19 convalescents, 6 months after infection, 4.3 ​% and 3.7 ​% did not generate significant titers of anti-S and anti-N antibodies, respectively. Among patients, who were vaccinated, 1 ​% did not generate anti-S antibodies. The median age of non-responders was higher than that of responders. Sex did not influence the results. Comparison of anti-N and anti-S antibodies 6 months after infection in the whole group showed higher anti-N titer in patients who suffered from the disease than in the general population. In the general population, 17.4 ​% of participants had anti-N antibodies, and 9 ​% had anti-S antibodies, despite no prior vaccination or history of COVID-19.</div></div><div><h3>Conclusions</h3><div>High prevalence of anti-N antibodies in patients reporting no history of COVID-19 during last wave, even after official end of the pandemic suggests high prevalence of SARS-CoV-2 in the environment and frequent asymptomatic or unspecific COVID-19, what is of high importance from the public health perspective.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 1","pages":"Pages 219-228"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Genome-engineering technologies for modeling and treatment of cystic fibrosis” [Adv Med Sci (2023 Sept) 68(1) 111–120]","authors":"Michał Dębczyński ,&nbsp;Damian Mojsak ,&nbsp;Łukasz Minarowski ,&nbsp;Monika Maciejewska ,&nbsp;Paweł Lisowski ,&nbsp;Robert M. Mróz","doi":"10.1016/j.advms.2025.01.009","DOIUrl":"10.1016/j.advms.2025.01.009","url":null,"abstract":"","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 1","pages":"Page 229"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High levels of soluble neuropilin −1 in critically ill multiple trauma/surgical patients","authors":"Charikleia S. Vrettou,&nbsp;Chrysi Keskinidou ,&nbsp;Alice G. Vassiliou ,&nbsp;Georgios Poupouzas,&nbsp;Edison Jahaj,&nbsp;Vassilios Issaris,&nbsp;Evangelia Theodorou,&nbsp;Asimenia Halioti,&nbsp;Vassiliki Giannopoulou,&nbsp;Nikolaos S. Lotsios,&nbsp;Anastasia Kotanidou,&nbsp;Ioanna Dimopoulou","doi":"10.1016/j.advms.2025.02.007","DOIUrl":"10.1016/j.advms.2025.02.007","url":null,"abstract":"<div><h3>Purpose</h3><div>Critically ill trauma/surgical patients may experience excessive inflammation, immune and coagulation dysregulation, leading to multiple organ failure (MOF), carrying high mortality rates. Neuropilin-1 (NRP-1) and its soluble isoform (sNRP-1) are implicated in immune response regulation, inflammation, and vascular permeability. This study aimed to investigate the possible role of sNRP-1 in trauma/surgical patients in the intensive care unit (ICU).</div></div><div><h3>Patients and methods</h3><div>This prospective observational study was conducted in a 31-bed ICU and included 81 patients, 43 of whom were trauma/surgical patients and 38 of whom were matched medical patients, comprising the control group. sNRP-1, interleukin (IL)-6, IL-8, and IL-10 levels were measured on admission to the ICU (within 48 ​h).</div></div><div><h3>Results</h3><div>Trauma/surgical patients had significantly higher sNRP-1 (p ​= ​0.027), IL-6, IL-8, and IL-10 levels (p ​&lt; ​0.05) compared to medical patients. In the entire cohort, sNRP-1 correlated positively with the international normalized ratio (INR) (p ​= ​0.017), the activated partial thromboplastin time (p ​= ​0.026), fibrinogen (p ​= ​0.027), alanine aminotransferase (p ​= ​0.024), and C-reactive protein (p ​= ​0.004). Moreover, sNRP-1 correlated negatively with total protein (p ​= ​0.035), albumin (p ​= ​0.005), and platelets (p ​= ​0.033).</div></div><div><h3>Conclusion</h3><div>sNRP-1 levels were elevated in critically ill trauma/surgical patients compared to matched medical ICU patients. Further research is needed to elucidate the exact role of sNRP-1 in these patients' pathophysiology.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 1","pages":"Pages 191-196"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical determinants and long-term survival in heart failure with supra-normal ejection fraction. Insights from LECRA-HF registry","authors":"Konrad Stępień ,&nbsp;Karolina Eliasz ,&nbsp;Karol Nowak ,&nbsp;Aleksandra Karcińska ,&nbsp;Natalia Kachnic ,&nbsp;Alicia del Carmen Yika ,&nbsp;Michael Platschek ,&nbsp;Krzysztof Krawczyk ,&nbsp;Aleksander Siniarski ,&nbsp;Jarosław Zalewski ,&nbsp;Jadwiga Nessler","doi":"10.1016/j.advms.2025.02.005","DOIUrl":"10.1016/j.advms.2025.02.005","url":null,"abstract":"<div><h3>Purpose</h3><div>Heart failure with supra-normal ejection fraction (HFsnEF), defined as HF with left ventricular ejection fraction (LVEF) ​&gt; ​65 ​%, constitutes a novel HF category. However, its clinical characteristics and long-term outcomes remain insufficiently elucidated. We sought to characterize Polish HFsnEF patients and provide their long-term mortality.</div></div><div><h3>Material and methods</h3><div>Of 1186 patients enrolled in the single-center Lesser Poland Cracovian Heart Failure (LECRA-HF) registry between years 2009 and 2019, 261 (22 ​%) were classified as HF with LVEF ≥50 ​%. Of them, 40 (15.3 ​%) were classified as HFsnEF, and the remaining 221 (84.7 ​%) as HF with preserved EF (HFpEF). Baseline characteristics, prior cardiovascular treatment, laboratory and echocardiographic measurements have been collected during index hospitalization. The long-term follow-up of all-cause mortality was obtained from the National Death Registry.</div></div><div><h3>Results</h3><div>HFsnEF patients were less frequently hypertensive (75 vs 88.2 ​%, P ​= ​0.026) and they were less often treated with mineralocorticoid receptor antagonists (25 vs 46.2 ​%, P ​= ​0.013) and loop diuretics (60 vs 76 ​%, P ​= ​0.017). The Kaplan-Meier analysis showed that all-cause mortality is higher in HFsnEF than in HFpEF (65 vs 55.2 ​%, P ​= ​0.044). The independent predictors of long-term mortality were age and HFsnEF diagnosis (hazard ratio [HR] 1.037, 95 ​% confidence interval [CI] 1.018–1.056; HR 1.665, 95 ​% CI 1.063–2.608, respectively).</div></div><div><h3>Conclusions</h3><div>Our findings indicate that every 7th Polish patient admitted with HFpEF could be classified as HFsnEF. Baseline characteristics of HFsnEF patients are not significantly different from HFpEF. Simultaneously, in the longest follow-up to date, HFsnEF diagnosis is associated with lower long-term survival.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 1","pages":"Pages 166-171"},"PeriodicalIF":2.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal stem cells versus mesenchymal stem cells-derived exosomes as potential autophagy pathway modulators in a diabetic model","authors":"Fatma Y. Meligy ,&nbsp;Hanan Sharaf El-Deen Mohammed ,&nbsp;Amal T. Abou Elghait ,&nbsp;Heba K. Mohamed ,&nbsp;Israa El-Sayed Mohamed Ashry ,&nbsp;Ayat Abdel-Rahman Sayed ,&nbsp;Ola A. Hussein ,&nbsp;Ahmed Salman ,&nbsp;Tarek Atia ,&nbsp;Abir S. Mohamed ,&nbsp;Nour H. Behnsawy ,&nbsp;Safy Salah Gaber ,&nbsp;Hader I. Sakr ,&nbsp;Salwa Fares Ahmed","doi":"10.1016/j.advms.2025.02.004","DOIUrl":"10.1016/j.advms.2025.02.004","url":null,"abstract":"<div><h3>Purpose</h3><div>This work compared the potential effects of bone marrow mesenchymal stem cells (BM-MSCs) with BM-MSCs-derived exosomes against impaired autophagy in streptozotocin (STZ)-induced diabetic rats.</div></div><div><h3>Materials and methods</h3><div>Three days after STZ injection, a single dose of (3 ​× ​10^6) BM- MSCs or BM-MSCs-derived exosomes (80 μg/rat) was administered to evaluate their effects against nondiabetic and diabetic control rats. We assessed pancreatic structure via light and electron microscopy and evaluated its staining for insulin and the autophagy marker P62 immunohistochemically. Moreover, autophagy marker LC3 gene expression was examined by PCR.</div></div><div><h3>Results</h3><div>Both BM-MSCs and BM-MSCs derived exosomes showed histological restoration of pancreatic tissues. Both treatments markedly increased the amount of insulin and significantly decreased the autophagy markers P62 and LC3.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that both BM-MSCs and BM-MSCs-derived exosomes provides a potential alternative to modulate diabetes mellitus.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 1","pages":"Pages 152-165"},"PeriodicalIF":2.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}