抗核抗体（ANA）在脊椎关节病中的患病率及临床相关性。

IF 2.6 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in medical sciences Pub Date : 2025-10-01 DOI:10.1016/j.advms.2025.09.005

Adrianna Błahuszewska-Omyła , Emilia Frąckiel , Marek Bielecki , Ewa Gińdzieńska- Sieśkiewicz , Natalia Szymańska , Otylia Kowal-Bielecka

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引用次数: 0

摘要

目的：脊椎关节病（SpA）是一种广泛而多样的疾病，具有高度可变的临床表现。由于这种广泛的症状及其与其他疾病实体的频繁重叠，SpA提出了许多诊断和治疗挑战。此外，SpA的发病机制尚不清楚。虽然目前流行的假设认为是一种自身炎症机制，但不排除自身免疫过程的参与。为了探索这种可能性，本研究旨在评估SpA患者中抗核抗体（ANA）的存在及其临床相关性。患者和方法：分析包括117例不同形式SpA的连续患者，即强直性脊柱炎（n = 52），银屑病关节炎（n = 34）和非影像学SpA （n = 31）。他们接受了临床评估，并从每个人身上收集血清样本进行间接免疫荧光检测。结果：46%的SpA患者存在ANA。ANA与特定SpA的诊断或临床症状之间没有统计学意义的关联。有趣的是，ANA的最高患病率（63%）出现在女性非影像学脊柱关节病患者中，最低患病率（38%）出现在男性强直性脊柱炎患者中，但差异没有达到统计学意义。结论：我们的研究结果提示，ANA在SpA患者中较为常见，尤其是在早期非影像学的SpA患者中，这可能具有临床意义。然而，需要进一步的研究，涉及更大的人群，来阐明ANA在SpA患者中存在的意义。

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Prevalence and clinical associations of antinuclear antibodies (ANA) in spondyloarthropathies

Purpose

Spondyloarthropathies (SpA) are a broad and diverse group of diseases with highly variable clinical manifestations. Due to this wide range of symptoms and their frequent overlap with other disease entities, SpA present numerous diagnostic and therapeutic challenges. Moreover, the pathogenesis of SpA remains unexplained. While the currently prevailing hypothesis suggests an autoinflammatory mechanism, the involvement of autoimmune processes has not been ruled out. To explore this possibility, the present study aimed to assess the presence of antinuclear antibodies (ANA) and their clinical associations in patients with SpA.

Patients and methods

The analysis included 117 consecutive patients with different forms of SpA, i.e., ankylosing spondylitis (n = 52), psoriatic arthritis (n = 34), and non-radiographic SpA (n = 31). They underwent clinical evaluation, and serum samples were collected from each for ANA testing using indirect immunofluorescence.

Results

ANA were found in 46 % of patients with SpA. No statistically significant association was found between ANA and diagnosis of specific SpA or clinical symptoms. Interestingly, the highest prevalence of ANA (63 %) was found in women with non-radiographic spondyloarthropathy and the lowest (38 %) in males with ankylosing spondylitis, however, the difference did not reach statistical significance.

Conclusion

The results of our study suggest that ANA are frequent in patients with SpA, in particular in women with early, non-radiographic SpA which may be of clinical significance. However, further studies, involving larger populations, are necessary to clarify the significance of ANA presence in SpA patients.

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来源期刊

Advances in medical sciences 医学-医学：研究与实验

CiteScore

5.00

自引率

0.00%

发文量

审稿时长

25 days

期刊介绍： Advances in Medical Sciences is an international, peer-reviewed journal that welcomes original research articles and reviews on current advances in life sciences, preclinical and clinical medicine, and related disciplines. The Journal’s primary aim is to make every effort to contribute to progress in medical sciences. The strive is to bridge laboratory and clinical settings with cutting edge research findings and new developments. Advances in Medical Sciences publishes articles which bring novel insights into diagnostic and molecular imaging, offering essential prior knowledge for diagnosis and treatment indispensable in all areas of medical sciences. It also publishes articles on pathological sciences giving foundation knowledge on the overall study of human diseases. Through its publications Advances in Medical Sciences also stresses the importance of pharmaceutical sciences as a rapidly and ever expanding area of research on drug design, development, action and evaluation contributing significantly to a variety of scientific disciplines. The journal welcomes submissions from the following disciplines: General and internal medicine, Cancer research, Genetics, Endocrinology, Gastroenterology, Cardiology and Cardiovascular Medicine, Immunology and Allergy, Pathology and Forensic Medicine, Cell and molecular Biology, Haematology, Biochemistry, Clinical and Experimental Pathology.