Atherosclerosis in the context of hemostasis and neovascularization – Current state of knowledge

IF 2.6 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in medical sciences Pub Date : 2025-09-08 DOI:10.1016/j.advms.2025.09.002

Urszula Jakobsche-Policht , Agnieszka Bronowicka-Szydełko , Rajmund Adamiec , Dorota Bednarska-Chabowska , Emilia Królewicz , Łukasz Lewandowski , Kinga Gostomska-Pampuch , Arkadiusz Derkacz , Katarzyna Budrewicz , Ewa Grzebyk , Maciej Nowak , Daria Dolińska , Paulina Matlak , Julia Sobczyńska , Maciej Ziomek , Maciej Tota , Wojciech Stach , Dominik Fidorowicz , Katarzyna Madziarska

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Abstract

Atherosclerosis is a progressive process resulting from endothelial dysfunction, primarily caused by damage to the integrity of the glycocalyx. Its pathogenesis is complex and involves numerous biomechanical and biochemical factors, such as blood pressure, shear forces, lipid metabolism disorders, monocyte migration and their transformation into macrophages, immune response, lipid accumulation, neovascularization, and activation of coagulation. Recently, the possibility of atherosclerosis regression has been confirmed, although the mechanisms behind the reversal of changes remain unknown. This review presents current knowledge on the pathogenesis of atherosclerosis, with particular emphasis on pro-atherogenic processes in the glycocalyx and endothelium, especially those related to hemostasis, neovascularization, and epigenetic changes.

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动脉粥样硬化在止血和新生血管的背景下-目前的知识状况。

动脉粥样硬化是由内皮功能障碍引起的进行性过程，主要由糖萼完整性受损引起。其发病机制复杂，涉及众多生物力学和生化因素，如血压、剪切力、脂质代谢紊乱、单核细胞迁移及其向巨噬细胞的转化、免疫反应、脂质积累、新生血管形成和凝血激活等。最近，动脉粥样硬化消退的可能性已被证实，尽管逆转变化背后的机制尚不清楚。本文综述了动脉粥样硬化发病机制的最新知识，特别强调了糖萼和内皮的促动脉粥样硬化过程，特别是与止血、新生血管和表观遗传改变有关的过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in medical sciences 医学-医学：研究与实验

CiteScore

5.00

自引率

0.00%

发文量

审稿时长

25 days

期刊介绍： Advances in Medical Sciences is an international, peer-reviewed journal that welcomes original research articles and reviews on current advances in life sciences, preclinical and clinical medicine, and related disciplines. The Journal’s primary aim is to make every effort to contribute to progress in medical sciences. The strive is to bridge laboratory and clinical settings with cutting edge research findings and new developments. Advances in Medical Sciences publishes articles which bring novel insights into diagnostic and molecular imaging, offering essential prior knowledge for diagnosis and treatment indispensable in all areas of medical sciences. It also publishes articles on pathological sciences giving foundation knowledge on the overall study of human diseases. Through its publications Advances in Medical Sciences also stresses the importance of pharmaceutical sciences as a rapidly and ever expanding area of research on drug design, development, action and evaluation contributing significantly to a variety of scientific disciplines. The journal welcomes submissions from the following disciplines: General and internal medicine, Cancer research, Genetics, Endocrinology, Gastroenterology, Cardiology and Cardiovascular Medicine, Immunology and Allergy, Pathology and Forensic Medicine, Cell and molecular Biology, Haematology, Biochemistry, Clinical and Experimental Pathology.