肺栓塞反应小组处理急性肺栓塞患者的性别差异：一项多中心、回顾性队列研究。

IF 2.6 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in medical sciences Pub Date : 2025-09-11 DOI:10.1016/j.advms.2025.09.003

Grzegorz Procyk , Paweł Kurzyna , Karolina Jasińska-Gniadzik , Julia Maria Smyk , Marcin Wasilewski , Rafał Wolański , Piotr Szwed , Dominika Rymaszewska , Dominika Zajkowska , Katarzyna Wrona , Szymon Darocha , Marta Banaszkiewicz , Michał Florczyk , Dariusz Zieliński , Krzysztof Wróbel , Marcin Grabowski , Grzegorz Opolski , Adam Torbicki , Marcin Kurzyna , Aleksandra Gąsecka , Arkadiusz Pietrasik

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引用次数: 0

摘要

目的：肺栓塞（PE）是全球第三大最常见的急性心血管疾病。最近提出了PE反应小组（PERTs），以促进PE患者的治疗实施。关于pert咨询的患者特征的数据有限。我们的目的是分析在当地PERT咨询的急性PE患者的基线特征、应用治疗和预后方面的性别相关差异。我们没有试图评估PERT对潜在差异的影响。材料与方法：研究纳入了2017年9月至2021年12月在三家参与医院诊断为PE的235例患者。临床和治疗资料来源于医疗记录。结果：我们发现女性比男性年龄大（中位[IQR]: 66.0[49.5-77.0]比58.5[49.0-69.3]岁，P=0.02）。咳嗽在男性中更为普遍（23.0%比7.3%，P=0.001）。吸烟在男性中更常见（32.5%比15.6%，P=0.004），而激素治疗在女性中更常见（11.0%比0.8%，P=0.001）。住院女性比男性更需要插管（16.5%比6.3%，P=0.02）。近端深静脉血栓在男性中更为常见（46.8%比33.9%，P=0.047）。低分子量肝素在男性中使用较多（82.5%比66.1%，P=0.004）。结论：在接受PERT治疗的急性PE患者中，大多数分析参数在性别之间没有差异。危险因素的差异与已确立的性别差异有关，吸烟在男性中更为常见，激素治疗在女性中更为常见。值得注意的是，女性和男性的存活率相当。

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Sex-based differences in patients with acute pulmonary embolism managed by a pulmonary embolism response team: a multicenter, retrospective cohort study

Purpose

Pulmonary embolism (PE) is the third most frequent acute cardiovascular condition worldwide. PE response teams (PERTs) were proposed recently to facilitate treatment implementation in PE patients. There is limited data regarding the characteristics of patients consulted by PERTs. We aimed to analyze sex-related differences in baseline characteristics, applied treatment, and prognosis of acute PE patients consulted by a local PERT. We did not seek to assess the influence of PERT on potential differences.

Materials and methods

The study included 235 patients diagnosed with PE in the three participating hospitals between September 2017 and December 2021. Clinical and treatment data were obtained from medical records.

Results

We found that women were older than men (median [IQR]: 66.0 [49.5–77.0] vs. 58.5 [49.0–69.3] years, P = 0.02). Cough was more prevalent in men (23.0 % vs. 7.3 %, P = 0.001). Smoking was more frequent in men (32.5 % vs. 15.6 %, P = 0.004), whereas hormonal therapy was more frequent in women (11.0 % vs. 0.8 %, P = 0.001). Hospitalized women required intubation more often than men (16.5 % vs. 6.3 %, P = 0.02). Proximal deep vein thrombosis was more common in men (46.8 % vs. 33.9 %, P = 0.047). Low molecular weight heparins were more often used in men (82.5 % vs. 66.1 %, P = 0.004).

Conclusions

Most analyzed parameters did not differ between the sexes in acute PE patients treated by a PERT. Differences in risk factors are associated with well-established sex-related differences, with smoking more often reported in men and hormonal therapy more common in women. Notably, the survival rate was comparable for women and men.

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来源期刊

Advances in medical sciences 医学-医学：研究与实验

CiteScore

5.00

自引率

0.00%

发文量

审稿时长

25 days

期刊介绍： Advances in Medical Sciences is an international, peer-reviewed journal that welcomes original research articles and reviews on current advances in life sciences, preclinical and clinical medicine, and related disciplines. The Journal’s primary aim is to make every effort to contribute to progress in medical sciences. The strive is to bridge laboratory and clinical settings with cutting edge research findings and new developments. Advances in Medical Sciences publishes articles which bring novel insights into diagnostic and molecular imaging, offering essential prior knowledge for diagnosis and treatment indispensable in all areas of medical sciences. It also publishes articles on pathological sciences giving foundation knowledge on the overall study of human diseases. Through its publications Advances in Medical Sciences also stresses the importance of pharmaceutical sciences as a rapidly and ever expanding area of research on drug design, development, action and evaluation contributing significantly to a variety of scientific disciplines. The journal welcomes submissions from the following disciplines: General and internal medicine, Cancer research, Genetics, Endocrinology, Gastroenterology, Cardiology and Cardiovascular Medicine, Immunology and Allergy, Pathology and Forensic Medicine, Cell and molecular Biology, Haematology, Biochemistry, Clinical and Experimental Pathology.