Interdisciplinary cardiovascular and thoracic surgery最新文献

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External stenting for saphenous vein grafts reduces early postoperative graft failure. 大隐静脉移植物外部支架可减少术后早期移植物失败。
Interdisciplinary cardiovascular and thoracic surgery Pub Date : 2024-06-05 DOI: 10.1093/icvts/ivae099
Stak Dushaj, Achim Häussler, Laura Rings, Vasileios Ntinopoulos, Nestoras Papadopoulos, Dragan Odavic, Hector Rodriguez Cetina Biefer, Omer Dzemali
{"title":"External stenting for saphenous vein grafts reduces early postoperative graft failure.","authors":"Stak Dushaj, Achim Häussler, Laura Rings, Vasileios Ntinopoulos, Nestoras Papadopoulos, Dragan Odavic, Hector Rodriguez Cetina Biefer, Omer Dzemali","doi":"10.1093/icvts/ivae099","DOIUrl":"10.1093/icvts/ivae099","url":null,"abstract":"<p><strong>Objectives: </strong>Multiple studies have shown that external stenting (ExSt) mitigates the progression of vein graft disease years after coronary artery bypass grafting (CABG). We used computed tomography to evaluate the effect of ExSt on perioperative vein graft patency.</p><p><strong>Methods: </strong>This study assessed graft patency rates of saphenous vein grafts (SVG) in consecutive patients with isolated coronary artery bypass grafting (CABG) between 2018 and 2021. Logistic regression analyses were conducted to compare the outcomes of supported and non-supported groups at both patient and graft levels, with age, EuroSCORE II, gender, diabetes and arterial grafts as covariates. Subgroup analyses were performed based on different covariates. The goal of the study was to provide valuable insights into the clinical outcomes of SVG in patients having CABG.</p><p><strong>Results: </strong>The study examined a total of 357 patients who met the inclusion criteria and evaluated 572 vein grafts. Of these, 150 patients (205 SVGs) received ExSt, whereas 207 patients (337 SVGs) did not receive ExSt. The study results indicated that the likelihood of overall SVG patency at discharge was higher in the stented group than in the non-stented group, both at the level of the grafts [93.8% vs 87.8%, odds ratio (OR) 2.1; 95% confidence interval (CI) 1.0-4.5; P = 0.05] and at the patient level (90.1% vs 83.5%, OR 1.8; 95% CI 0.9-3.6; P = 0.1). It is worth noting that the difference between the stented and non-stented groups was most significant in the subgroup that received 2 arterial grafts (96.5% vs 89.6%, OR 3.2; 95% CI 1.2-8.4; P = 0.02) and in the subgroup with a higher EuroSCORE II (median >1.1) (98.6% vs 88.6%, OR 8.8; 95% CI 1.1-72.7; P = 0.04).</p><p><strong>Conclusions: </strong>The ExSt is associated with improved perioperative SVG patency at both the graft and the patient levels. Moreover, SVGs to the right territory and high-risk patients appear to have an advantage using ExSt.</p>","PeriodicalId":73406,"journal":{"name":"Interdisciplinary cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11162150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141077365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of institutional variables on centre performance in long-term survival after heart transplant. 机构变量对心脏移植手术后长期存活率中心绩效的影响。
Interdisciplinary cardiovascular and thoracic surgery Pub Date : 2024-06-05 DOI: 10.1093/icvts/ivae111
Weston E McDonald, Khaled Shorbaji, Maxwell Kilcoyne, William Few, Brett Welch, Zubair Hashmi, Arman Kilic
{"title":"Impact of institutional variables on centre performance in long-term survival after heart transplant.","authors":"Weston E McDonald, Khaled Shorbaji, Maxwell Kilcoyne, William Few, Brett Welch, Zubair Hashmi, Arman Kilic","doi":"10.1093/icvts/ivae111","DOIUrl":"10.1093/icvts/ivae111","url":null,"abstract":"<p><strong>Objectives: </strong>The gold standard metric for centre-level performance in orthotopic heart transplantation (OHT) is 1-year post-OHT survival. However, it is unclear whether centre performance at 1 year is predictive of longer-term outcomes. This study evaluated factors impacting longer-term centre-level performance in OHT.</p><p><strong>Methods: </strong>Patients who underwent OHT in the USA between 2010 and 2021 were identified using the United Network of Organ Sharing data registry. The primary outcome was 5-year survival conditional on 1-year survival following OHT. Multivariable Cox proportional hazard models assessed the impact of centre-level 1-year survival rates on 5-year survival rates. Mixed-effect models were used to evaluate between-centre variability in outcomes.</p><p><strong>Results: </strong>Centre-level risk-adjusted 5-year mortality conditional on 1-year survival was not associated with centre-level 1-year survival rates [hazard ratio: 0.99 (0.97-1.01, P = 0.198)]. Predictors of 5-year mortality conditional on 1-year survival included black recipient race, pre-OHT serum creatinine, diabetes and donor age. In mixed-effect modelling, there was substantial variability between centres in 5-year mortality rates conditional on 1-year survival, a finding that persisted after controlling for recipient, donor and institutional factors (P < 0.001). In a crude analysis using Kaplan-Meier, the 5-year survival conditional on 1-year survival was: low volume: 86.5%, intermediate volume: 87.5%, high volume: 86.7% (log-rank P = 0.52). These measured variables only accounted for 21.4% of the between-centre variability in 5-year mortality conditional on 1-year survival.</p><p><strong>Conclusions: </strong>Centre-level risk-adjusted 1-year outcomes do not correlate with outcomes in the 1- to 5-year period following OHT. Further research is needed to determine what unmeasured centre-level factors contribute to longer-term outcomes in OHT.</p>","PeriodicalId":73406,"journal":{"name":"Interdisciplinary cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141319087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictors of long-term success after successful explantation of continuous flow left ventricular assist device support. 持续流左心室辅助装置支持成功拆卸后长期成功的预测因素。
Interdisciplinary cardiovascular and thoracic surgery Pub Date : 2024-06-05 DOI: 10.1093/icvts/ivae091
Takayuki Gyoten, Eisuke Amiya, Akihito Saito, Minoru Ono
{"title":"Predictors of long-term success after successful explantation of continuous flow left ventricular assist device support.","authors":"Takayuki Gyoten, Eisuke Amiya, Akihito Saito, Minoru Ono","doi":"10.1093/icvts/ivae091","DOIUrl":"10.1093/icvts/ivae091","url":null,"abstract":"<p><strong>Objectives: </strong>Predictors and evaluations of continuous flow left ventricular assist device (cf-LVAD) explantation in recovered patients remain under discussion due to lack of evidence on long-term safety and efficacy. This study summarized our experiences regarding cf-LVAD explantation in non-ischaemic dilated cardiomyopathy patients and estimated a predictor for sufficient myocardial recovery allowing left ventricular assist device explant.</p><p><strong>Methods: </strong>We retrospectively identified 135 adult patients with cf-LVAD therapy as bridge to heart transplant due to non-ischaemic dilated cardiomyopathy. Of those, 13 patients underwent device explantation (recovery group) after myocardial recovery. Twelve (92%) of the explanted patients were evaluated using our weaning protocol and underwent surgical explantation. Meanwhile, the remaining 122 continued with cf-LVAD therapy (non-recovery group).</p><p><strong>Results: </strong>Multivariate logistic regression analysis revealed time interval between the first heart failure event and cf-LVAD implantation as an independent predictor for successful explantation. The optimal time interval cutoff value to predict cf-LVAD explantation was 7 months, with a sensitivity of 91.0% and specificity of 84.6%. Echocardiography in patients with successful cf-LVAD explantation showed significant improvement of left ventricular function and dimensions at 6 months postoperatively. The 13 explanted patients are currently alive at a median of 30 (interquartile range; 18-58) months after explantation. The survival rate free from rehospitalization due to heart failure following explantation was 100%. Left ventricular function and remodelling after explantation were also preserved.</p><p><strong>Conclusions: </strong>In non-ischaemic dilated cardiomyopathy patients with a short interval between the first heart failure event and cf-LVAD therapy, left ventricular myocardium may recover in an early phase after device implantation.</p>","PeriodicalId":73406,"journal":{"name":"Interdisciplinary cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First experiences with automated annular suturing device in totally endoscopic aortic and mitral valve replacement. 在全内窥镜主动脉瓣和二尖瓣置换术中首次使用自动瓣环缝合装置的经验。
Interdisciplinary cardiovascular and thoracic surgery Pub Date : 2024-06-05 DOI: 10.1093/icvts/ivae112
Ali El-Sayed Ahmad, Saad Salamate, Nermir Granov, Ali Bayram, Sami Sirat, Mirko Doss, Miriam Silaschi, Ömür Akhavuz, Farhad Bakhtiary
{"title":"First experiences with automated annular suturing device in totally endoscopic aortic and mitral valve replacement.","authors":"Ali El-Sayed Ahmad, Saad Salamate, Nermir Granov, Ali Bayram, Sami Sirat, Mirko Doss, Miriam Silaschi, Ömür Akhavuz, Farhad Bakhtiary","doi":"10.1093/icvts/ivae112","DOIUrl":"10.1093/icvts/ivae112","url":null,"abstract":"<p><strong>Objectives: </strong>To overcome some of the challenges of endoscopic minimally invasive valve surgery, an automated annular suturing device has been used in aortic and mitral valve replacement surgeries. The current study investigates early clinical outcomes of patients who received aortic or mitral valve replacement with the help of the RAM® device as first experiences in minimally invasive valve surgery.</p><p><strong>Methods: </strong>Between September 2020 and June 2023, 66 consecutive patients (mean age 61.8 ± 11 years) underwent endoscopic minimally invasive aortic or mitral valve replacement through right anterior mini-thoracotomy at 2 cardiac surgery referral centres in Germany. The RAM® device was used in all Patients. 3.5 and 5.0 sizes were used in 16.7% and 83.3% of patients, respectively. Aortic, mitral and double valve surgery was performed in 81.8%, 15.2% and 1.5% of patients, respectively. Clinical data were prospectively entered into our institutional database.</p><p><strong>Results: </strong>Cardiopulmonary bypass time and cross-clamping time were 97.9 ± 20.9 and 66 ± 15.7 min, respectively. Intensive care unit and hospital stays were 1 [1-2] and 9 [7-13] days, respectively. No paravalvular leak and no other intraoperative complications occurred. 30-day and in-hospital mortality were zero. Conversion to sternotomy occurred in 1 (1.5%) patient due to bleeding.</p><p><strong>Conclusions: </strong>The usage of the RAM® device is a safe, feasible and effective approach to the endoscopic implantation of aortic or mitral valves and yield excellent early outcomes. Larger size studies are needed to evaluate the efficacy and safety of RAM® device.</p>","PeriodicalId":73406,"journal":{"name":"Interdisciplinary cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11198731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robotically assisted internal mammary artery harvesting-will single-port systems be useful? 机器人辅助乳内动脉采集--单孔系统是否有用?
Interdisciplinary cardiovascular and thoracic surgery Pub Date : 2024-06-05 DOI: 10.1093/icvts/ivae107
Johannes Bonatti
{"title":"Robotically assisted internal mammary artery harvesting-will single-port systems be useful?","authors":"Johannes Bonatti","doi":"10.1093/icvts/ivae107","DOIUrl":"10.1093/icvts/ivae107","url":null,"abstract":"","PeriodicalId":73406,"journal":{"name":"Interdisciplinary cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11165269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Re-appraisal of bronchus-first right upper lobectomy as an alternative routine procedure. 重新评估支气管先行右上叶切除术作为常规手术的替代方案。
Interdisciplinary cardiovascular and thoracic surgery Pub Date : 2024-06-05 DOI: 10.1093/icvts/ivae114
Takahiro Utsumi, Haruaki Hino, Natsumi Maru, Hiroshi Matsui, Yohei Taniguchi, Tomohito Saito, Tomohiro Murakawa
{"title":"Re-appraisal of bronchus-first right upper lobectomy as an alternative routine procedure.","authors":"Takahiro Utsumi, Haruaki Hino, Natsumi Maru, Hiroshi Matsui, Yohei Taniguchi, Tomohito Saito, Tomohiro Murakawa","doi":"10.1093/icvts/ivae114","DOIUrl":"10.1093/icvts/ivae114","url":null,"abstract":"<p><strong>Objectives: </strong>Postoperative air leakage is a major complication of lung resection, particularly right upper lobectomy. However, various surgical procedures can reduce postoperative complications and shorten the drainage period. The current study aimed to analyse the utility of bronchus-first right upper lobectomy as an alternative routine procedure.</p><p><strong>Methods: </strong>We retrospectively analysed the data of 225 (53.7%) patients who underwent bronchus-first right upper lobectomy and 194 (46.3%) patients who underwent the conventional bronchus-last right upper lobectomy at our institution from 2015 to 2022. In patients with incomplete fissures who underwent bronchus-first right upper lobectomy, the bronchus was dissected 1st, followed by the pulmonary artery and vein, and then, the interlobar fissure was divided. We compared the outcomes of 2 procedures and analysed the surgical utility of bronchus-first right upper lobectomy.</p><p><strong>Results: </strong>The surgical outcomes and postoperative morbidity comparing bronchus-first and bronchus-last procedure were as follows: median operation time (min) 103/126 (P < 0.001), median bleeding amount (ml) 28/55 (P = 0.003), incomplete lobulation rate (%) 35.1/24.2 (P = 0.02), incidence of prolonged air leakage (%) 2.2/3.1 (P = 0.76) and rate of fellow surgeon's operation (%) 28.0/4.6 (P < 0.001). The procedure was associated with a decreased incidence of prolonged air leakage. The 4-year overall survival rates did not significantly differ between the 2 groups (P = 0.24).</p><p><strong>Conclusions: </strong>Bronchus-first right upper lobectomy can prevent postoperative air leakage in patients with incomplete fissure. Additionally, as an alternative routine procedure, it is associated with a shorter surgical duration and a lower volume of blood loss regardless of interlobar fissure and operator's experience.</p>","PeriodicalId":73406,"journal":{"name":"Interdisciplinary cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141447766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patterns of collateral arteries to the spinal cord after thoraco-abdominal aortic aneurysm repair. 胸腹主动脉瘤修复术后脊髓侧支动脉的模式。
Interdisciplinary cardiovascular and thoracic surgery Pub Date : 2024-06-05 DOI: 10.1093/icvts/ivae087
Daiki Saitoh, Yuya Yamazaki, Tatsunori Tsuji, Naoya Sakoda, Kazuki Yakuwa, Azuma Tabayashi, Junichi Koizumi, Satoshi Ohsawa, Hajime Kin
{"title":"Patterns of collateral arteries to the spinal cord after thoraco-abdominal aortic aneurysm repair.","authors":"Daiki Saitoh, Yuya Yamazaki, Tatsunori Tsuji, Naoya Sakoda, Kazuki Yakuwa, Azuma Tabayashi, Junichi Koizumi, Satoshi Ohsawa, Hajime Kin","doi":"10.1093/icvts/ivae087","DOIUrl":"10.1093/icvts/ivae087","url":null,"abstract":"<p><strong>Objectives: </strong>Our goal was to evaluate postoperative patterns of collateral arteries to the spinal cord during occlusion of the segmental arteries supplying the artery of Adamkiewicz (AKA).</p><p><strong>Methods: </strong>Between April 2011 and December 2022, a total of 179 patients underwent thoraco-abdominal aortic aneurysm repair; 141 had an identifiable AKA on preoperative multidetector computed tomography scans, 40 underwent thoraco-abdominal aortic aneurysm replacement (TAAR) and 101 underwent thoracic endovascular aortic repair (TEVAR). New postoperative collateral blood pathways invisible on preoperative contrast-enhanced computed tomography scans were identified in 42 patients (10 patients who had TAAR vs 32 patients who had TEVAR) who underwent preoperative and postoperative multidetector computed tomography scanning for AKA identification.</p><p><strong>Results: </strong>The thoracodorsal and segmental arteries were the main collateral pathways in both groups. Th9-initiated collaterals were the most common. Collaterals from the internal thoracic artery were observed in the TEVAR group but not in the TAAR group. One patient in the TEVAR group experienced postoperative paraparesis, which was not observed in the TAAR group. Postoperative paraplegia was more common in the non-Th9-origin group, but this difference was not significant.</p><p><strong>Conclusions: </strong>Thoracodorsal and segmental arteries may be important collateral pathways after TEVAR and TAAR. For thoracodorsal arteries, preserving the thoracodorsal muscle during the approach would be crucial; for segmental arteries, minimizing the area to be replaced or covered would be paramount. An AKA not initiated at the Th9 level poses a high risk of postoperative paraplegia.</p>","PeriodicalId":73406,"journal":{"name":"Interdisciplinary cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11193310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extended-sleeve resection for endoluminal recurrence of B3 thymoma: does aerogenous spread really exist? 针对 B3 胸腺瘤腔内复发的扩大袖状切除术:真的存在气源性扩散吗?
Interdisciplinary cardiovascular and thoracic surgery Pub Date : 2024-06-05 DOI: 10.1093/icvts/ivae105
Simone Tombelli, Stefano Bongiolatti, Valeria Pasini, Luca Voltolini
{"title":"Extended-sleeve resection for endoluminal recurrence of B3 thymoma: does aerogenous spread really exist?","authors":"Simone Tombelli, Stefano Bongiolatti, Valeria Pasini, Luca Voltolini","doi":"10.1093/icvts/ivae105","DOIUrl":"10.1093/icvts/ivae105","url":null,"abstract":"<p><p>Thymomas are a variant of thymic epithelial tumours. They are considered malignant due to their tendency to local invasion and they showed lower metastatic behaviour. Distal metastasis is rare and an endobronchial mass is a rare presentation. First-line treatment for early-stage thymomas is surgery; for Masaoka-Koga stage III, neoadjuvant or adjuvant chemoradiation therapy should be considered in association with surgery after Multidisciplinary Tumour Board evaluation. We report a rare case of radical resection with type A extended-sleeve lobectomy in a 63-year-old woman who was affected by endobronchial recurrence of B3 thymoma, 31 months after complete and radical thymectomy.</p>","PeriodicalId":73406,"journal":{"name":"Interdisciplinary cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141163076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proof-of-principle of a lung sealant based on functionalized polyoxazolines: experiments in an ovine acute aerostasis model. 基于官能化聚恶唑啉的肺密封剂的原理验证:绵羊急性气喘模型试验。
Interdisciplinary cardiovascular and thoracic surgery Pub Date : 2024-06-05 DOI: 10.1093/icvts/ivae113
Bob P Hermans, Richard P G Ten Broek, Wilson W L Li, Edwin A Roozen, Shoko Vos, Erik H F M Van Der Heijden, Harry Van Goor, Ad F T M Verhagen
{"title":"Proof-of-principle of a lung sealant based on functionalized polyoxazolines: experiments in an ovine acute aerostasis model.","authors":"Bob P Hermans, Richard P G Ten Broek, Wilson W L Li, Edwin A Roozen, Shoko Vos, Erik H F M Van Der Heijden, Harry Van Goor, Ad F T M Verhagen","doi":"10.1093/icvts/ivae113","DOIUrl":"10.1093/icvts/ivae113","url":null,"abstract":"<p><strong>Objectives: </strong>More effective lung sealants are needed to prevent prolonged pulmonary air leakage (AL). Polyoxazoline-impregnated gelatin patch (N-hydroxysuccinimide ester functionalized poly(2-oxazoline)s; NHS-POx) was promising for lung sealing ex vivo. The aim of this study is to confirm sealing effectiveness in an in vivo model of lung injury.</p><p><strong>Methods: </strong>An acute aerostasis model was used in healthy adult female sheep, involving bilateral thoracotomy, amputation lesions (bronchioles Ø > 1.5 mm), sealant application, digital chest tube for monitoring AL, spontaneous ventilation, obduction and bursting pressure measurement. Two experiments were performed: (i) 3 sheep with 2 lesions per lung (N = 4 NHS-POx double-layer, N = 4 NHS-POx single-layer, N = 4 untreated) and (ii) 3 with 1 lesion per lung (N = 3 NHS-POx single-layer, N = 3 untreated). In pooled linear regression, AL was analysed per lung (N = 7 NHS-POx, N = 5 untreated) and bursting pressure per lesion (N = 11 NHS-POx, N = 7 untreated).</p><p><strong>Results: </strong>Baseline AL was similar between groups (mean 1.38-1.47 l/min, P = 0.90). NHS-POx achieved sealing in 1 attempt in 8/11 (72.7%) and in 10/11 (90.9%) in >1 attempt. Application failures were only observed on triangular lesions requiring 3 folds around the lung. No influences of methodological variation between experiments was detected in linear regression (P > 0.9). AL over initial 3 h of drainage was significantly reduced for NHS-POx [median: 7 ml/min, length of interquartile range: 333 ml/min] versus untreated lesions (367 ml/min, length of interquartile range: 680 ml/min, P = 0.036). Bursting pressure was higher for NHS-POx (mean: 33, SD: 16 cmH2O) versus untreated lesions (mean: 19, SD: 15 cmH2O, P = 0.081).</p><p><strong>Conclusions: </strong>NHS-POx was effective for reducing early AL, and a trend was seen for improvement of bursting strength of the covered defect. Results were affected by application characteristics and lesion geometry.</p>","PeriodicalId":73406,"journal":{"name":"Interdisciplinary cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing patient outcomes: the impact of multimodal preemptive analgesia in video-assisted thoracoscopic lobectomy. 优化患者疗效:视频辅助胸腔镜肺叶切除术中多模式预先镇痛的影响。
Interdisciplinary cardiovascular and thoracic surgery Pub Date : 2024-05-16 DOI: 10.1093/icvts/ivae096
Bing Li, Yu Chen, Rong Ma
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