Health sciences review (Oxford, England)最新文献_第3页

“Mitazalimab plus mFOLFIRINOX in metastatic pancreatic cancer: Emerging signals of chemo-immunotherapy synergy” Mitazalimab联合mFOLFIRINOX治疗转移性胰腺癌：化学-免疫治疗协同作用的新信号

Health sciences review (Oxford, England) Pub Date : 2025-12-01 Epub Date: 2025-11-10 DOI: 10.1016/j.hsr.2025.100247

Zain Mazhar , Husnain Bashir

引用次数: 0

Clay minerals used in formulations for cutaneous wound healing: An educational review 用于皮肤伤口愈合配方的粘土矿物：教育回顾

Health sciences review (Oxford, England) Pub Date : 2025-12-01 Epub Date: 2025-08-18 DOI: 10.1016/j.hsr.2025.100242

Paligwendé Anne Marie Kaboré , Raogo Ouédraogo , Bavouma Charles Sombié , Zakaline Yabré , Rasmané Semdé

{"title":"Clay minerals used in formulations for cutaneous wound healing: An educational review","authors":"Paligwendé Anne Marie Kaboré , Raogo Ouédraogo , Bavouma Charles Sombié , Zakaline Yabré , Rasmané Semdé","doi":"10.1016/j.hsr.2025.100242","DOIUrl":"10.1016/j.hsr.2025.100242","url":null,"abstract":"<div><div>In recent years, the use of clay minerals in wound treatment has been the subject of extensive researches. The present paper aimed to review studies on clay minerals-based formulations for the treatment of cutaneous wounds, highlighting the healing properties attributable to the addition of these minerals in formulations. A review of literature was conducted using the ScienceDirect, Scopus, and PubMed databases to identify research articles evaluating the wound-healing properties of clay mineral-based formulations. Studies reporting positive outcomes were included. Sixty-three (63) research articles were analyzed. The most commonly used minerals were halloysite nanotubes and montmorillonite. The less commonly used ones included bentonite, laponite, sepiolite, kaolinite, hectorite and palygorskite. In most cases, these minerals were combined with active ingredients such as antibacterials and dispersed in polymeric matrices. The identified pharmaceutical included films, hydrogels, electrospun nanofibers, sponge forms, membranes, powders, patches and creams. The results showed that clay minerals not only improved the mechanical and physical properties of the formulations, but also contributed to wound healing. Their presence accelerated hemostasis, reduced inflammation, stimulated cell proliferation and enhanced tissue remodeling. Furthermore, they potentiated and/or prolonged antibacterial activity, which is crucial for wound healing. Generally, these benefits are closed linked to the inherent physical and chemical properties of the clay minerals. Among clays minerals, halloysite and montmorillonite are of considerable interest in wound management for their proven healing properties. Their abundance in nature, biocompatibility and low cost make them a viable choice for effective wound management.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"17 ","pages":"Article 100242"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Midlife substances use risk factors and cognitive disorder in late life: A systematic review using meta-analysis 中年物质使用危险因素与晚年认知障碍：采用荟萃分析的系统综述

Health sciences review (Oxford, England) Pub Date : 2025-12-01 Epub Date: 2025-09-03 DOI: 10.1016/j.hsr.2025.100243

Subhadeep Saha , Priya Das , Tanu Das , Partha Das , Ranjan Roy , Tamal Basu Roy

{"title":"Midlife substances use risk factors and cognitive disorder in late life: A systematic review using meta-analysis","authors":"Subhadeep Saha , Priya Das , Tanu Das , Partha Das , Ranjan Roy , Tamal Basu Roy","doi":"10.1016/j.hsr.2025.100243","DOIUrl":"10.1016/j.hsr.2025.100243","url":null,"abstract":"<div><div>Globally, geriatric cognitive disorder is one of the eminent and challenging events. There is a significant relationship between long-term substance use and CD. Thus, the main objective of the current study was to synthesize the probable evidence of retrospective studies on the impact of substance use in midlife on cognitive disorders in later life. A systematic review through meta-analysis was conducted to reveal the harmful effects of substance use on any type of CD. All the empirical studies that scrutinized the association between smoking or alcohol consumption in midlife and cognitive disorder in later life were included, adjusted for other covariates based on the required inclusion and exclusion criteria of this study. Database searches were conducted using Google Scholar, Web of Science, SocINDEX, PsycINFO, ProQuest, PubMed, Scopus, and APA PsycINFO. A total of 9 studies were considered to perform the meta-analysis. Almost all the studies (8) examined that midlife substance user were likely to have CD in their later life. Applying the random effect model, the average effect size was estimated as 1.31 [95 % CI: 0.37, 2.25], which indicates that participants who consume alcohol or smoke in midlife had 1.31 times more risk of having CD in their later life than substance abstainers in midlife. In the sub-group analysis between alcohol and smoking, we found that alcohol consumption [RR 1.76, 95 % CI: 0.54, 2.98] is more likely to induce cognitive disorder in late life than smoking [RR 0.75, 95 % CI: 0.02, 1.47]. The result of this systematic analysis suggests that the long-term effects of drinking or smoking are not immune to the brain. So, substance use reduction could be an appropriate population-wide intervention tactic.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"17 ","pages":"Article 100243"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The dual role of skin microbiome modulation in precision care for atopic dermatitis: A review 皮肤微生物组调节在特应性皮炎精准护理中的双重作用：综述

Health sciences review (Oxford, England) Pub Date : 2025-12-01 Epub Date: 2025-10-27 DOI: 10.1016/j.hsr.2025.100245

Chen Xue

{"title":"The dual role of skin microbiome modulation in precision care for atopic dermatitis: A review","authors":"Chen Xue","doi":"10.1016/j.hsr.2025.100245","DOIUrl":"10.1016/j.hsr.2025.100245","url":null,"abstract":"<div><div>Atopic dermatitis (AD), a complex dermatological disorder characterized by chronic inflammation and skin barrier dysfunction, serves as a prototypical chronic inflammatory skin disease whose pathogenesis is intricately linked to dysbiosis of the skin microbiota. Modulating the skin microbiota to restore microbial homeostasis has emerged as a crucial dimension in AD management and a focal point of contemporary research. This comprehensive review examines the pivotal role of cutaneous microbiota in both the initiation and progression of AD, with particular emphasis on the profound implications of microbial dysbiosis for skin barrier integrity and inflammatory cascades. Building upon recent scientific evidence, we systematically elaborate innovative applications of microbiota modulation in AD care, elucidating the mechanistic foundations of emerging intervention strategies and their demonstrated clinical efficacy, thereby offering novel perspectives for precision medicine in AD management. Furthermore, we critically evaluate current limitations in AD-related skin microbiome research and propose future research trajectories, establishing both theoretical frameworks and practical guidelines for advancing clinical translation of cutaneous microbiome investigations.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"17 ","pages":"Article 100245"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychosis secondary to thyrotoxicosis: An educational review 甲状腺毒症继发精神疾病：教育回顾

Health sciences review (Oxford, England) Pub Date : 2025-09-01 Epub Date: 2025-07-08 DOI: 10.1016/j.hsr.2025.100237

Hana Taha , Salma Abdel Wahed , Vanja Berggren

引用次数: 0

Driving and sustaining trauma-informed organizational change: The role of healthcare leadership 推动和维持创伤知情的组织变革：医疗保健领导的作用

Health sciences review (Oxford, England) Pub Date : 2025-09-01 Epub Date: 2025-06-24 DOI: 10.1016/j.hsr.2025.100236

Amidu Alhassan , Sana Rasheed , Ahmed Asad Raza , Bushra Murtaza , Azka Mujeeb , Ayesha Iqbal Mansoor

{"title":"Driving and sustaining trauma-informed organizational change: The role of healthcare leadership","authors":"Amidu Alhassan , Sana Rasheed , Ahmed Asad Raza , Bushra Murtaza , Azka Mujeeb , Ayesha Iqbal Mansoor","doi":"10.1016/j.hsr.2025.100236","DOIUrl":"10.1016/j.hsr.2025.100236","url":null,"abstract":"<div><div>Trauma is a major public health concern, both omnipresent and burdensome. Trauma-informed care [TIC] is regarded as a multilevel approach that alters the way organizations perceive and address trauma. TIC has shown a beneficial impact on patient health, employee well-being, and institutional performance. Efforts to implement TIC necessitate leadership backing and the establishment of policies to guarantee consistent application. This review examines the implementation and sustainability of TIC in healthcare, focusing on its principles, role of leadership, challenges, and strategies. It aims to provide insights to enhance patient outcomes, support staff well-being, and foster a trauma-informed healthcare culture. TIC is a well-established framework for supporting trauma survivors and improving outcomes in emergency departments. Studies have shown that implementing TIC education programs can reduce the number of patients subjected to physical restraints and the overall time spent in restraints. Strategic leaders must develop standardized policies to guide the change process. Staff trained under certified programs provide better results in trauma-informed healthcare by influencing their knowledge, behavior, and beliefs. Organizational challenges include the need for repeated training and ongoing support. Community clinics face time constraints in consultations, financial constraints, and high patient turnover. Sustaining trauma-informed change requires systemic strategies that prioritize safety, empowerment, and collaboration. Supportive leadership empowers employees through shared decision-making and continuous training. Embedding TIC into organizational policies ensures sustainability by promoting safety, equity, and inclusivity. Future research should evaluate and refine TIC practices to build a stronger evidence base.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"16 ","pages":"Article 100236"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of bimatoprost sustained-release implant in treating severe intraocular pressure in open glaucoma: A meta-analysis 比马前列素缓释植入治疗开放性青光眼严重眼压的疗效：一项荟萃分析

Health sciences review (Oxford, England) Pub Date : 2025-09-01 Epub Date: 2025-07-05 DOI: 10.1016/j.hsr.2025.100235

Saad Mutlaq Alosaimi , Ahmad Al Habash , Shahad Salah Alsubhi (Literature Search)

{"title":"Efficacy of bimatoprost sustained-release implant in treating severe intraocular pressure in open glaucoma: A meta-analysis","authors":"Saad Mutlaq Alosaimi , Ahmad Al Habash , Shahad Salah Alsubhi (Literature Search)","doi":"10.1016/j.hsr.2025.100235","DOIUrl":"10.1016/j.hsr.2025.100235","url":null,"abstract":"<div><div>This meta-analysis investigates the efficacy and safety of the bimatoprost sustained-release (SR) implant for reducing intraocular pressure (IOP) in patients with open-angle glaucoma (OAG), particularly those with severe or uncontrolled IOP. A comprehensive search of multiple databases identified twelve randomized controlled trials including a total of 2808 patients. Pooled analysis demonstrated that the bimatoprost SR implant significantly reduced IOP compared to placebo, with a mean difference of –1.53 mmHg. The implant also increased the proportion of patients achieving desired IOP reduction and was associated with a modest improvement in rescue rates. Adverse events were generally low, with no treatment-emergent adverse events reported in the intervention group. These findings suggest that the bimatoprost SR implant is a safe and effective alternative for patients with OAG who may struggle with adherence to daily eye drops. Further studies are recommended to evaluate its long-term impact on disease progression and visual outcomes.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"16 ","pages":"Article 100235"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How is professionalism measured in health care professions? 如何衡量卫生保健专业的专业性？

Health sciences review (Oxford, England) Pub Date : 2025-09-01 Epub Date: 2025-05-19 DOI: 10.1016/j.hsr.2025.100224

Anas Alnasser , Brett Williams , Cameron M Gosling

{"title":"How is professionalism measured in health care professions?","authors":"Anas Alnasser , Brett Williams , Cameron M Gosling","doi":"10.1016/j.hsr.2025.100224","DOIUrl":"10.1016/j.hsr.2025.100224","url":null,"abstract":"<div><div>This scoping study aims to explore the available literature, key concepts, and strategic approaches for measuring professionalism in the health sector. The central research question is: How is professionalism evaluated across various healthcare fields?</div><div>Professionalism is essential for quality care and trust within healthcare institutions. Understanding how it is measured can enhance healthcare delivery.</div><div>This review was conducted following the JBI approach and adhering to PRISMA-ScR guidelines.</div><div>Electronic databases were systematically searched for articles published between 2005 and 2024. A total of 1,558 articles were identified, and after screening titles and abstracts, 44 papers were included for analysis.</div><div>The review revealed a diverse range of valid and reliable methods used to measure and describe professionalism in healthcare. Included studies utilized both qualitative and quantitative approaches and spanned various contexts, highlighting the adaptability and robustness of measurement techniques.</div><div>The findings underscore the critical role of professionalism in delivering quality care and fostering trust in healthcare settings. Employing multiple measurement approaches is essential for effectively assessing healthcare personnel's behaviour, ultimately enhancing trust and service quality.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"16 ","pages":"Article 100224"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding Brugada syndrome: A comprehensive analysis of pathophysiology, genetic foundations and advanced clinical management 解码Brugada综合征：病理生理学、遗传学基础和先进临床管理的综合分析

Health sciences review (Oxford, England) Pub Date : 2025-09-01 Epub Date: 2025-07-07 DOI: 10.1016/j.hsr.2025.100238

Aman Kumar , Junaid Tantray , Sourabh Kosey , Chingtham Henthoibi Devi , Bhupendra Prajapati

{"title":"Decoding Brugada syndrome: A comprehensive analysis of pathophysiology, genetic foundations and advanced clinical management","authors":"Aman Kumar , Junaid Tantray , Sourabh Kosey , Chingtham Henthoibi Devi , Bhupendra Prajapati","doi":"10.1016/j.hsr.2025.100238","DOIUrl":"10.1016/j.hsr.2025.100238","url":null,"abstract":"<div><h3>Background</h3><div>Sudden cardiac death is linked to the hereditary condition known as Brugada syndrome (BrS), an autosomal dominant heart illness. Another name for it is sudden nocturnal death syndrome, a novel arrhythmogenic condition that has drawn attention because of its intricate pathophysiology and potential medical applications. BrS is generally considered a fairly uncommon condition, with an estimated 0.05 % global frequency and 0.4 % pattern. The reported prevalence of BrS ranges from 1 in 2000 to 1 in 5000.</div></div><div><h3>Objective</h3><div>This study seeks to provide a complete understanding of the pathophysiology, genetic basis, diagnostic criteria, and treatment methods related to Brugada syndrome.</div></div><div><h3>Methods</h3><div>A narrative synthesis of current research was undertaken, concentrating on epidemiology, electrophysiological processes, genetic alterations (specifically SCN5A), and clinical management techniques, including risk stratification tools and treatment modalities.</div></div><div><h3>Results</h3><div>BrS has a worldwide prevalence estimated between 1 in 2000 and 1 in 5000 persons. Genetic mutations, especially affecting heart sodium channels, provide an arrhythmogenic substrate resulting in distinctive ECG abnormalities. Diagnosis is driven by revised clinical criteria and electrophysiological results. Management involves the use of implanted cardioverter-defibrillators (ICDs) and medication. Recent findings have clarified genotype-phenotype connections and enhanced patient risk classification</div></div><div><h3>Conclusion</h3><div>Brugada syndrome is a complicated cardiac illness needing standardized diagnostic techniques and specialized therapeutic options. Future research should concentrate on enhancing genetic screening, risk prediction models, and the development of tailored medicines to lower sudden cardiac death risk.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"16 ","pages":"Article 100238"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A surgeon’s primer on Unique Device Identifier (UDI) capture: Where do we stand on implant surveillance and how can we improve? 外科医生对唯一设备标识符（UDI）捕获的入门：我们在植入物监测方面处于什么位置？我们如何改进？

Health sciences review (Oxford, England) Pub Date : 2025-09-01 Epub Date: 2025-06-10 DOI: 10.1016/j.hsr.2025.100234

Alberto Jarrin Lopez , Amartya Dave , Tejas Sathe , Hanmin Lee

{"title":"A surgeon’s primer on Unique Device Identifier (UDI) capture: Where do we stand on implant surveillance and how can we improve?","authors":"Alberto Jarrin Lopez , Amartya Dave , Tejas Sathe , Hanmin Lee","doi":"10.1016/j.hsr.2025.100234","DOIUrl":"10.1016/j.hsr.2025.100234","url":null,"abstract":"<div><div>The Unique Device Identifier (UDI) system was developed to improve the identification and tracking of medical devices throughout their lifecycle. Despite its potential to enhance patient outcomes, streamline supply chain management, and facilitate swift responses to device recalls, widespread adoption remains limited. In the absence of regulatory policies enforcing standardized UDI practices, this paper underscores the critical role surgeons play in implementing and advocating for UDI’s utility within their institutions. By reviewing published roadmaps and playbooks, we highlight key steps for successful adoption. We examine case studies from early adopter institutions—Mercy Health, Duke University Health System, and Kaiser Permanente—that have successfully integrated UDI systems, demonstrating tangible benefits. Recognizing the barriers to nationwide UDI implementation as well as the unique role of surgeons at the intersection of patient care and device innovation, we conclude by proposing practical, actionable steps for surgeons to drive change within their institution.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"16 ","pages":"Article 100234"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0