Health sciences review (Oxford, England)最新文献

{"title":"Effectiveness of Colistin in carbapenem resistant Acinetobacter baumannii – A systematic review","authors":"Feroz Ahmed ,&nbsp;Md Toslim Mahmud ,&nbsp;Shabnam Naher ,&nbsp;Md Jowel Rana ,&nbsp;Rifat Ara ,&nbsp;KM Saif-Ur-Rahman","doi":"10.1016/j.hsr.2023.100113","DOIUrl":"https://doi.org/10.1016/j.hsr.2023.100113","url":null,"abstract":"<div><p>Treatment of carbapenem-resistant <em>Acinetobacter baumannii</em> (CR<em>Ab</em>) infections has become a significant challenge for physicians due to its resistance to common antibiotics. Colistin, previously banned, has been reintroduced despite debates about its effectiveness and safety. We aimed to synthesize evidence on the effectiveness of Colistin in the CR<em>Ab</em> infection management, based on current literature. We conducted a comprehensive search to identify relevant studies on the effectiveness of Colistin in treating CR<em>Ab</em> infection in major databases such as Medline through PubMed, Embase, Web of Science, The Cochrane Library, and Scopus. We did not limit the search by age of participants, sex, region, or year of publication, but we only included randomized controlled trials (RCTs), quasi-experimental studies, cohort studies, case-control studies, and cross-sectional studies published in English, which had at least one comparison control group. Two independent authors screened articles, extracted data, and assessed the risk of bias in selected articles using the RoBANS tool. Our search retrieved 7907 articles, of which five were included after the sequential screening. All five studies were retrospective case-control studies from five different countries, with a total of 776 participants. Two studies showed a lower mortality rate in the intervention (Colistin) group as the primary outcome, whereas two studies showed the opposite mortality trend. One study reported a higher rate of infection remission in the intervention group, but the result was not statistically significant. Our systematic review could not find any robust evidence to support the effectiveness of Colistin over commonly used antibiotics. Due to the large discrepancy among the primary outcomes of the included studies, we recommend further randomized controlled trials with a larger number of participants to determine the suitability of Colistin for treating CR<em>Ab</em> infections.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"8 ","pages":"Article 100113"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49799072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A recapitulation of the polycystic ovarian disorder in adult women and the risk of disease associated with the polycystic ovarian disorder","authors":"Kanak Chahar ,&nbsp;Yash Sharma ,&nbsp;Mritunjay Kumar ,&nbsp;Lakshmi Kumari ,&nbsp;Lopamudra Mishra ,&nbsp;Preeti Patel ,&nbsp;Balak Das Kurmi","doi":"10.1016/j.hsr.2023.100110","DOIUrl":"10.1016/j.hsr.2023.100110","url":null,"abstract":"<div><p>Polycystic ovarian disease is a highly prevalent hormonal, metabolic, and reproductive condition (PCOD). The overall health load of PCOD is delicate in individual females with the situation who are in the generative phase due to their increased risk and frequency of prediabetes, diabetes, and additional comorbidities such as obstructive endometrial cancer and mental health disorders, and sleep apnea. However, less information is available that how PCOD affects older women's long-term health. In this review, we wanted to provide a rationalized overview of the longstanding health effects of PCOD and their clinical implications in premenopause and post-menopause. The phenotype of PCOD improves with age, and very little information that is currently available indicates that the cardiometabolic profile of PCOD-positive women does not worsen after menopause. Therefore, based on their possibility during reproductive years, the risk of cardiovascular disorder in older women with PCOD seems to be lower than previously expected and no different from that of older women without PCOD. Due to confusing variables and a paucity of long-term cohort studies, it is challenging to assess the real danger in aged women with PCOD for other comorbidities such as obesity, mood disorders, and endometrial cancer.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"8 ","pages":"Article 100110"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43617366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the effects of lysergic acid diethylamide and the importance of its prevention","authors":"Burak Okumuş ,&nbsp;Ahmet Metin ,&nbsp;İ. Afşin Kariper","doi":"10.1016/j.hsr.2023.100107","DOIUrl":"10.1016/j.hsr.2023.100107","url":null,"abstract":"<div><p>This review is on lysergic acid diethylamide (LSD), which has a halogenic effect and is addictive. Up to now, LSD has been used for pleasure-inducing or spiritual purposes. Since it is soluble in water, it can be administered in different forms. The final decision about whether it is addictive or not is undecided. The use of LSD is extensive and is also used for treating psychiatric disorders such as depression, post-traumatic stress disorder, and addiction. In this review, firstly, general information on LSD was explained. Then, its physicochemical properties (solubility, melting point, stability), pharmacokinetics, receptor interactions, mechanism of action, studies with healthy subjects (subjective effects, autonomic and endocrine effects, psychiatric effects), and preventive studies against addiction effects were discussed. Finally, there are recommendations for the use of LSD.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"8 ","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49652430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of monoclonal antibodies targeting IL-5 in severe eosinophilic asthma: A systematic review and meta-analysis of randomized controlled trials","authors":"Noor Alam ,&nbsp;S. Latha ,&nbsp;Anoop Kumar","doi":"10.1016/j.hsr.2023.100103","DOIUrl":"10.1016/j.hsr.2023.100103","url":null,"abstract":"<div><h3>Background</h3><p>Recently, mepolizumab and benralizumab have been approved for the treatment of severe eosinophilic asthma.</p></div><div><h3>Objective</h3><p>Thus, the main objective of the current study was to find out the exact efficacy and safety profile of mepolizumab and benralizumab in severe eosinophilic asthma.</p></div><div><h3>Methods</h3><p>The relevant randomized controlled trials were searched in PubMed and clinical trials websites from inception to January 2022. All the analysis were done using RevMan5.</p></div><div><h3>Results</h3><p>There is a significant reduction of asthma exacerbation in the mepolizumab and benralizumab group. However, there is no significant differences were observed in the FEV1 change. Overall adverse drug reactions (ADRs) such as headache and injection site reactions are found non-significant in the mepolizumab and benralizumab group, however, bronchitis, nasopharyngitis, upper respiratory tract infection (URTI), sinusitis, and serious adverse event (SAEs) were found to be significantly less. The subgroup analysis has also shown a similar kind of efficacy in the mepolizumab and benralizumab group however, safety analysis results have shown better safer profile of benralizumab as compared to mepolizumab. The sensitivity analysis results have shown non-alteration in the conclusion of the study regarding efficacy parameters however, overall adverse events, sinusitis, and nasopharyngitis results are altered after the exclusion of outliers.</p></div><div><h3>Conclusion</h3><p>Mepolizumab and benralizumab appear to be safe and effective in treatment of severe eosinophilic asthma. However, more data is required to draw a valid conclusion, particularly with mepolizumab.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"8 ","pages":"Article 100103"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45194392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the value of letters in biomedicine","authors":"Timothy Daly ,&nbsp;Jaime A. Teixeira da Silva","doi":"10.1016/j.hsr.2023.100102","DOIUrl":"10.1016/j.hsr.2023.100102","url":null,"abstract":"<div><p>The letter is a unique and versatile literary format in the published biomedical literature. Here we argue for more inclusive editorial practices to encourage authors to publish more of them. At the same time, we offer an appreciation of the complementarity of letters to commentaries, and how the strengths of one paper type could make up for the weaknesses of the other.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"8 ","pages":"Article 100102"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45827380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of cardiovascular risks in rheumatoid arthritis patients: Management, treatment and future perspectives","authors":"Nishant Johri ,&nbsp;Shivani Varshney ,&nbsp;Smriti Gandha ,&nbsp;Aditya Maurya ,&nbsp;Piyush Mittal ,&nbsp;Sarita Jangra ,&nbsp;Rajkumar Garg ,&nbsp;Amit Saraf","doi":"10.1016/j.hsr.2023.100108","DOIUrl":"10.1016/j.hsr.2023.100108","url":null,"abstract":"<div><p>Rheumatoid arthritis (RA) patients exhibit a notable 50%-70% elevation in heart disease risk compared to the general population, attributable to their heightened susceptibility to cardiovascular disease (CVD). The contribution of the rheumatology branch in preventing cardiovascular (CV) risk remains challenging to comprehend fully. Traditional CV risk factors alone fail to elucidate the augmented mortality and morbidity linked to RA; rather, the cumulative inflammatory burden and cardiotoxicity associated with antirheumatic therapy emerge as pivotal determinants. A noteworthy correlation exists between the use of anti-inflammatory medications, commonly prescribed for arthritis, and an increased risk of premature mortality. Despite acknowledging and comprehending the burden of CVD in RA, caring for affected individuals continues to present challenges. Effective management of CV risk in RA necessitates meticulous consideration of established risk factors and behavioral adaptations. Collaborative engagement among rheumatologists, cardiologists, internists, and primary care providers becomes imperative for optimally attending to RA patients at cardiovascular risk. This review critically evaluates pivotal studies in this domain, shedding light on potential future directions for enhancing CV risk management in RA patients.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"8 ","pages":"Article 100108"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47604149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and meta-analysis of robotic radical hysterectomy vs. open radical hysterectomy for early stage cervical cancer","authors":"Greg Marchand ,&nbsp;Ahmed Taher Masoud ,&nbsp;Ahmed Abdelsattar ,&nbsp;Amanda Arroyo ,&nbsp;Carmen Moir ,&nbsp;Daniela Gonzalez Herrera ,&nbsp;Madison Blanco ,&nbsp;Kate Ruffley ,&nbsp;Brooke Hamilton ,&nbsp;Mary Petersen ,&nbsp;Sarena Fernandez ,&nbsp;Hollie Ulibarri","doi":"10.1016/j.hsr.2023.100109","DOIUrl":"10.1016/j.hsr.2023.100109","url":null,"abstract":"<div><h3>Objective</h3><p>Recent data has brought into question the safety of minimally invasive techniques for radical hysterectomy in the treatment of early stage cervical cancer. After the publication of several new studies, we aimed to compare robotic radical hysterectomy (RRH) with open radical hysterectomy (ORH) in the management of women with early stage cervical cancer, while excluding minimally invasive cases performed without robotic assistance.</p></div><div><h3>Data Sources</h3><p>We searched six databases from inception until 11/30/2021. The original search found 233 unique papers, and ultimately 35 studies, comprising 11,888 total radical hysterectomies, met criteria for our final analysis. We included all studies including the intervention of RRH for early stage cervical cancer, with the comparator of ORH. We included randomized clinical trials (RCTs), case-control, retrospective cohort, and prospective cohort. We included studies that had robotic and laparoscopic arms, but excluded any studies that did not specifically provide specific data as to each group. We analyzed continuous data using mean difference and a 95% confidence interval, while dichotomous data were analyzed using odds ratio and a 95% confidence interval.</p></div><div><h3>Results</h3><p>We found that there was no significant difference between RRH and ORH regarding five-year Overall Survival (OR=1.28[0.66,2.46], (<em>P</em> = 0.46)), disease free survival (OR=0.94[0.77,1.14], (<em>P</em> = 0.51)), or recurrence (OR=0.92[0.75,1.13], (<em>P</em> = 0.44)) intraoperative complications (OR=0.75[0.55,1.02], (<em>P</em> = 0.07)), or mortality (OR=0.81[0.53,1.22], (<em>P</em> = 0.31)).</p><p>We found that RRH was better than ORH in terms of estimated blood loss (MD=-397.95[-471.65,-324.24], (<em>P</em> &lt; 0.001)), blood transfusion rate (OR=0.13[0.10,0.17], (<em>P</em> = 0.001), post-operative complications (OR=0.65[0.46,0.91], (<em>P</em> = 0.01)), and length of hospital stay (MD=-3.99[-4.67,-3.31], (<em>P</em> &lt; 0.001)). While ORH was better than RRH regarding operation time (MD=15.34[2.21,28.47], (<em>P</em> = 0.02)) and number of resected lymph nodes (MD=-2.64[-4.12,-1.15], (<em>P</em> = 0.005)).</p></div><div><h3>Conclusions</h3><p>The previously seen increase in cancer recurrence and decrease in survival no longer seem to be present when we consider the newest high-quality data and exclude non-robotic minimally invasive techniques. RRH was associated with less estimated blood loss, a lower transfusion rate, a shorter hospital stay, and fewer postoperative complications. ORH seems to be associated with a higher number of resected lymph nodes, and a shorter operative time.</p><p><strong>Trial registration details: Prospero Prospective Registration Number</strong>: CRD42022306991 <strong>Registration link</strong>: <span>https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=306991</span><svg><path></path></svg></p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"8 ","pages":"Article 100109"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44636624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory properties of tenofovir in human liver cells","authors":"Songezo Vazi,&nbsp;Sanet van Zyl,&nbsp;Roné Vorster -de Wet,&nbsp;Charlette Tiloke","doi":"10.1016/j.hsr.2023.100114","DOIUrl":"10.1016/j.hsr.2023.100114","url":null,"abstract":"<div><h3>Background</h3><p>Tenofovir is one of the antiretroviral (ARV) drugs used as a first-line regimen known to suppress HIV viral load successfully. However, its clinical application is limited by a lack of understanding of its inflammatory response in human liver cells. Liver toxicity has been linked to long-term use of tenofovir.</p></div><div><h3>Objectives</h3><p>This review was conducted to outline tenofovir's potential pro and anti-inflammatory properties in liver cells at acute and chronic exposure.</p></div><div><h3>Methods</h3><p>The relevant studies were analysed in PubMed, Google Scholar, Medline and Web of Science. This analysis outlined tenofovir's potential pro and anti-inflammatory properties in liver cells at acute and chronic exposure, with special attention to inflammatory markers.</p></div><div><h3>Results</h3><p>Tenofovir's acute and chronic usage is associated with mitochondrial toxicity, resulting in hepatocyte damage through mitochondrial DNA (mtDNA) depletion. Tenofovir has been shown to cause mitochondrial dysfunction and elevate mitochondrial reactive oxygen species (MtROS), resulting in hepatotoxicity. Enhanced generation of MtROS can activate the NF-κB signalling pathway through the IĸB kinase (IKK) complex system. NF-κB is an important pro-inflammatory transcription factor that plays a significant role in oxidative stress-induced inflammation. Following its activation, it can increase the transcription of various genes and subsequently regulate inflammation.</p></div><div><h3>Conclusion</h3><p>This review demonstrated that tenofovir exhibits its cytotoxic effect via induced mitochondrial dysfunction; however, its impact on liver inflammation is yet to be determined. Therefore, a study investigating tenofovir's inflammatory properties in HepG₂ cells at acute and chronic exposure is warranted.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"8 ","pages":"Article 100114"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48759361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does an acute care surgery model decrease the rate of negative appendicectomy in the Australian experience: A systematic review and meta-analysis","authors":"Alex Britcliffe,&nbsp;Ashleigh Spittle,&nbsp;Suraj Rathnayake","doi":"10.1016/j.hsr.2023.100106","DOIUrl":"10.1016/j.hsr.2023.100106","url":null,"abstract":"<div><h3>Background</h3><p>Australia performs more appendicectomies per capita than nearly any other country. The surgical specialty responsible for performing appendicectomies in Australia, General Surgery, has recently undergone a paradigm shift away from traditional models of care and towards Acute Surgical Unit (ASU) models. ASUs are defined by the presence of a dedicated emergency general surgeon and the separation of elective and emergency surgical caseload. The aim of this meta-analysis is to determine the effect of care model type on the rate of negative appendicectomy, as well as other clinical outcomes pertaining to the appendicectomy patient.</p></div><div><h3>Methods</h3><p>A comprehensive literature search of Medline, Embase and Cochrane library was performed to identify studies investigating the effect of ASU care model on the outcomes of appendicectomy for Australian and New Zealand patients. These studies were required to have a comparison to a pre-existing or geographically related traditional care cohort. The PRISMA guidelines were used to identify, screen and analyse papers. Random-effects methods were used to perform a meta-analysis of negative appendicectomy rate and other relevant outcomes. Results were reported in either odds ratio or weighted mean difference.</p></div><div><h3>Results</h3><p>Thirteen studies meeting the inclusion criteria were identified describing the outcomes of 8787 patients undergoing appendicectomy in Australian and New Zealand hospitals. There was no effect on negative appendicectomy rate between the ASU and traditional cohorts (OR: 1.10, CI: 0.944-1.262, p-value 0.20). Furthermore, no significant effect on time-to-theatre (WMD: 1.107, CI: 0.332 – 2.882, p-value 0.22), length of stay (MD: 0.563, CI: 0 – 1.135, p-value 0.13) or complication rate (OR: 0.872, CI: 0.596 – 1.148, <em>p</em>-value 0.36) was observed between the two cohorts.</p></div><div><h3>Conclusion</h3><p>Rates of negative appendicectomy in Australia are similar in both ASU and traditional model cohorts. Significant improvements in appendicectomy outcomes seen under an ASU model in international data, or in data for other emergency conditions, have not been replicated on this meta-analysis of the Australian literature.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"8 ","pages":"Article 100106"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47024460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conduction system pacing vs. biventricular pacing for cardiac resynchronization therapy in heart failure with reduced ejection fraction: An updated systematic review and meta-analysis","authors":"Dhan Bahadur Shrestha ,&nbsp;Abinash Baniya ,&nbsp;Sandesh Lamichhane ,&nbsp;Manoj Shahi ,&nbsp;Jurgen Shtembari ,&nbsp;Abhishek J. Deshmukh ,&nbsp;Dinesh Voruganti ,&nbsp;Nimesh Kirit Patel ,&nbsp;Kunal Sangal ,&nbsp;Saraschandra Vallabhajosyula ,&nbsp;Neel J. Patel ,&nbsp;Prashant D. Bhave ,&nbsp;S. Patrick Whalen ,&nbsp;Ghanshyam Shantha","doi":"10.1016/j.hsr.2023.100104","DOIUrl":"10.1016/j.hsr.2023.100104","url":null,"abstract":"<div><h3>Background</h3><p>Conduction system pacing (CSP) is considered an effective and physiological form of pacing in patients requiring cardiac resynchronization therapy (CRT).</p></div><div><h3>Objective</h3><p>To compare electrocardiographic (ECG), echocardiographic (ECHO) characteristics and clinical outcomes among patients with heart failure with reduced ejection fraction (HFrEF) undergoing CRT with CSP or biventricular pacing (BVP).</p></div><div><h3>Methods</h3><p>This study protocol was registered in the PROSPERO registry (CRD42022375155) and the review was conducted per the PRISMA protocol. Four major databases were searched from inception till October 20, 2022, for relevant studies comparing CSP to BVP for CRT in patients with HFrEF.</p></div><div><h3>Results</h3><p>From a total of 10,072 references identified, 35 full-text were assessed and 18 studies (6 RCTs, 12 observational studies) were included in the review. Following left bundle branch area pacing (LBBAP), on average, paced QRS duration was 28 ms narrower in comparison to BVP (MD -27.69, CI -36.59 to -18.80), and a similar result was obtained with HBP vs. BVP as well. Left ventricular ejection fraction (LVEF) improvement was greater with CSP in comparison to BVP [LBBAP (MD 6.03, CI 4.16–7.91); HBP (MD 3.79, CI 0.46–7.11); HPSP (MD 6.60, CI 4.42–8.78). There were higher odds of being responders (OR 3.82, CI 1.88–7.75)/super responders (OR 2.08, CI 1.53–2.82) (per ECHO findings) in the CSP group, and overall mortality (OR 0.61, CI 0.40–0.93) and hospitalization for HF (HHF) (OR 0.37, CI 0.25–0.55) was lower in CSP group.</p></div><div><h3>Conclusion</h3><p>Our analysis showed better ECG, ECHO, and clinical outcomes in terms of mortality and HHF with CSP compared to BVP.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"8 ","pages":"Article 100104"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44907032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}