Health sciences review (Oxford, England)最新文献

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Midlife substances use risk factors and cognitive disorder in late life: A systematic review using meta-analysis 中年物质使用危险因素与晚年认知障碍:采用荟萃分析的系统综述
Health sciences review (Oxford, England) Pub Date : 2025-09-03 DOI: 10.1016/j.hsr.2025.100243
Subhadeep Saha , Priya Das , Tanu Das , Partha Das , Ranjan Roy , Tamal Basu Roy
{"title":"Midlife substances use risk factors and cognitive disorder in late life: A systematic review using meta-analysis","authors":"Subhadeep Saha ,&nbsp;Priya Das ,&nbsp;Tanu Das ,&nbsp;Partha Das ,&nbsp;Ranjan Roy ,&nbsp;Tamal Basu Roy","doi":"10.1016/j.hsr.2025.100243","DOIUrl":"10.1016/j.hsr.2025.100243","url":null,"abstract":"<div><div>Globally, geriatric cognitive disorder is one of the eminent and challenging events. There is a significant relationship between long-term substance use and CD. Thus, the main objective of the current study was to synthesize the probable evidence of retrospective studies on the impact of substance use in midlife on cognitive disorders in later life. A systematic review through meta-analysis was conducted to reveal the harmful effects of substance use on any type of CD. All the empirical studies that scrutinized the association between smoking or alcohol consumption in midlife and cognitive disorder in later life were included, adjusted for other covariates based on the required inclusion and exclusion criteria of this study. Database searches were conducted using Google Scholar, Web of Science, SocINDEX, PsycINFO, ProQuest, PubMed, Scopus, and APA PsycINFO. A total of 9 studies were considered to perform the meta-analysis. Almost all the studies (8) examined that midlife substance user were likely to have CD in their later life. Applying the random effect model, the average effect size was estimated as 1.31 [95 % CI: 0.37, 2.25], which indicates that participants who consume alcohol or smoke in midlife had 1.31 times more risk of having CD in their later life than substance abstainers in midlife. In the sub-group analysis between alcohol and smoking, we found that alcohol consumption [RR 1.76, 95 % CI: 0.54, 2.98] is more likely to induce cognitive disorder in late life than smoking [RR 0.75, 95 % CI: 0.02, 1.47]. The result of this systematic analysis suggests that the long-term effects of drinking or smoking are not immune to the brain. So, substance use reduction could be an appropriate population-wide intervention tactic.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"17 ","pages":"Article 100243"},"PeriodicalIF":0.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trauma registries compared: A systemic review of the barriers, enablers, and the path to standardisation 创伤登记比较:对障碍、促成因素和标准化路径的系统回顾
Health sciences review (Oxford, England) Pub Date : 2025-08-19 DOI: 10.1016/j.hsr.2025.100240
Adrian Crawford , Neil Ashwood , Akhshay George , Gur Aziz Singh Sidhu
{"title":"Trauma registries compared: A systemic review of the barriers, enablers, and the path to standardisation","authors":"Adrian Crawford ,&nbsp;Neil Ashwood ,&nbsp;Akhshay George ,&nbsp;Gur Aziz Singh Sidhu","doi":"10.1016/j.hsr.2025.100240","DOIUrl":"10.1016/j.hsr.2025.100240","url":null,"abstract":"<div><div>National trauma registries were introduced 20 years ago to improve care of the multiply injured patients through benchmarking and accreditation of dedicated trauma centres. However, variability in registry design, lack of long-term functional outcome data has limited its use. A standardised dataset has been agreed upon, but not implemented which has made it difficult to obtain meaningful results, particularly in frail elderly populations.</div><div>This narrative synthesis aims to identify enablers of standardised data collection and reporting, that improves care within all levels of hospitalised trauma patients. Eligible studies were identified through systematic searches of Medline, EMBASE, and PsycINFO databases using a comprehensive algorithm designed to maximise sensitivity. Registry websites, annual reports, and data dictionaries were also reviewed. Two researchers independently screened studies extracted data on barriers and enablers, and assessed study quality using the Methodological Index for Non-Randomised Studies (MINORS). A thematic analysis was conducted to synthesise findings.</div><div>Barriers to effective registry included inconsistent funding, limited infrastructure and exclusion of high-risk groups, such as elderly. Enablers included government mandates, standardised methods and broad inclusion criteria. While many registries demonstrated improved mortality tracking and injury prevention strategies, very few captured long-term disability outcomes or needs of elderly patients.</div><div>Trauma care requires standardised registries with comparable datasets to enable benchmarking and improve outcomes focussed on recovery from the long-term impacts of trauma, particularly among frail elderly populations. Collaboration between trauma registries of all levels is essential to develop robust systems that drive meaningful changes in practice worldwide.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"17 ","pages":"Article 100240"},"PeriodicalIF":0.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clay minerals used in formulations for cutaneous wound healing: An educational review 用于皮肤伤口愈合配方的粘土矿物:教育回顾
Health sciences review (Oxford, England) Pub Date : 2025-08-18 DOI: 10.1016/j.hsr.2025.100242
Paligwendé Anne Marie Kaboré , Raogo Ouédraogo , Bavouma Charles Sombié , Zakaline Yabré , Rasmané Semdé
{"title":"Clay minerals used in formulations for cutaneous wound healing: An educational review","authors":"Paligwendé Anne Marie Kaboré ,&nbsp;Raogo Ouédraogo ,&nbsp;Bavouma Charles Sombié ,&nbsp;Zakaline Yabré ,&nbsp;Rasmané Semdé","doi":"10.1016/j.hsr.2025.100242","DOIUrl":"10.1016/j.hsr.2025.100242","url":null,"abstract":"<div><div>In recent years, the use of clay minerals in wound treatment has been the subject of extensive researches. The present paper aimed to review studies on clay minerals-based formulations for the treatment of cutaneous wounds, highlighting the healing properties attributable to the addition of these minerals in formulations. A review of literature was conducted using the ScienceDirect, Scopus, and PubMed databases to identify research articles evaluating the wound-healing properties of clay mineral-based formulations. Studies reporting positive outcomes were included. Sixty-three (63) research articles were analyzed. The most commonly used minerals were halloysite nanotubes and montmorillonite. The less commonly used ones included bentonite, laponite, sepiolite, kaolinite, hectorite and palygorskite. In most cases, these minerals were combined with active ingredients such as antibacterials and dispersed in polymeric matrices. The identified pharmaceutical included films, hydrogels, electrospun nanofibers, sponge forms, membranes, powders, patches and creams. The results showed that clay minerals not only improved the mechanical and physical properties of the formulations, but also contributed to wound healing. Their presence accelerated hemostasis, reduced inflammation, stimulated cell proliferation and enhanced tissue remodeling. Furthermore, they potentiated and/or prolonged antibacterial activity, which is crucial for wound healing. Generally, these benefits are closed linked to the inherent physical and chemical properties of the clay minerals. Among clays minerals, halloysite and montmorillonite are of considerable interest in wound management for their proven healing properties. Their abundance in nature, biocompatibility and low cost make them a viable choice for effective wound management.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"17 ","pages":"Article 100242"},"PeriodicalIF":0.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utility of the New York heart association functional classification compared to other measures: A systematic review 与其他指标相比,纽约心脏协会功能分类的效用:一项系统综述
Health sciences review (Oxford, England) Pub Date : 2025-08-17 DOI: 10.1016/j.hsr.2025.100241
Kelly D. Stamp , Marilyn A. Prasun , Thomas P. McCoy , Lisa Rathman
{"title":"Utility of the New York heart association functional classification compared to other measures: A systematic review","authors":"Kelly D. Stamp ,&nbsp;Marilyn A. Prasun ,&nbsp;Thomas P. McCoy ,&nbsp;Lisa Rathman","doi":"10.1016/j.hsr.2025.100241","DOIUrl":"10.1016/j.hsr.2025.100241","url":null,"abstract":"<div><div>This systematic review comprised of an assessment of the relevant literature for measures that were most similar to the New York Heart Association Functional Classification. Additionally, we assessed whether those measures compared in accuracy with the New York Heart Association Functional Classification when assigning the functional class of patients with heart failure. The review included seven articles that met the inclusion and exclusion criteria. Our findings were that New York Heart Association Functional Classification was predictive of functional limitations in patients with heart failure with reduced ejection fraction when compared to other measures. However, there was limited evidence to support the predictive ability of New York Heart Association Functional Classification in patients with heart failure with preserved ejection fraction. A more objective way to improve accuracy of New York Heart Association Functional Classification could be to assign metabolic equivalent levels to each functional class.</div><div>For future directions, a clear objective definition of functional class that is in alignment with the associated symptoms is needed to ensure consistent assignment. In addition, further testing of the New York Heart Association Functional Classification in patients with heart failure with preserved ejection fraction with reproducibility is warranted.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"17 ","pages":"Article 100241"},"PeriodicalIF":0.0,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychosis secondary to thyrotoxicosis: An educational review 甲状腺毒症继发精神疾病:教育回顾
Health sciences review (Oxford, England) Pub Date : 2025-07-08 DOI: 10.1016/j.hsr.2025.100237
Hana Taha , Salma Abdel Wahed , Vanja Berggren
{"title":"Psychosis secondary to thyrotoxicosis: An educational review","authors":"Hana Taha ,&nbsp;Salma Abdel Wahed ,&nbsp;Vanja Berggren","doi":"10.1016/j.hsr.2025.100237","DOIUrl":"10.1016/j.hsr.2025.100237","url":null,"abstract":"<div><div>Excess thyroid hormones have a major effect on brain metabolism and neurotransmitter systems. This study aimed to examine the complex relationship between thyrotoxicosis and psychosis including symptoms and treatment options. This literature review summarized 37 case reports of psychosis secondary to thyrotoxicosis that were published in PubMed, Medline, Web of Science and Google Scholar searches between Jan 2011 and Dec 2024. The results indicated that the case reports of females were significantly more than those of males. The most common psychiatric symptom was agitation (27.02 %) while mania and psychomotor agitation were the least common one (2.7 %). For thyrotoxicosis symptoms, tachycardia (32.43 %) was the most frequently mentioned symptom, and the least common ones were goiter and high blood pressure (13.51 %). The findings of this review emphasize the value of collaborative treatment combining psychiatrist and endocrinologist to address the complex clinical presentations and treatment modalities.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"16 ","pages":"Article 100237"},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding Brugada syndrome: A comprehensive analysis of pathophysiology, genetic foundations and advanced clinical management 解码Brugada综合征:病理生理学、遗传学基础和先进临床管理的综合分析
Health sciences review (Oxford, England) Pub Date : 2025-07-07 DOI: 10.1016/j.hsr.2025.100238
Aman Kumar , Junaid Tantray , Sourabh Kosey , Chingtham Henthoibi Devi , Bhupendra Prajapati
{"title":"Decoding Brugada syndrome: A comprehensive analysis of pathophysiology, genetic foundations and advanced clinical management","authors":"Aman Kumar ,&nbsp;Junaid Tantray ,&nbsp;Sourabh Kosey ,&nbsp;Chingtham Henthoibi Devi ,&nbsp;Bhupendra Prajapati","doi":"10.1016/j.hsr.2025.100238","DOIUrl":"10.1016/j.hsr.2025.100238","url":null,"abstract":"<div><h3>Background</h3><div>Sudden cardiac death is linked to the hereditary condition known as Brugada syndrome (BrS), an autosomal dominant heart illness. Another name for it is sudden nocturnal death syndrome, a novel arrhythmogenic condition that has drawn attention because of its intricate pathophysiology and potential medical applications. BrS is generally considered a fairly uncommon condition, with an estimated 0.05 % global frequency and 0.4 % pattern. The reported prevalence of BrS ranges from 1 in 2000 to 1 in 5000.</div></div><div><h3>Objective</h3><div>This study seeks to provide a complete understanding of the pathophysiology, genetic basis, diagnostic criteria, and treatment methods related to Brugada syndrome.</div></div><div><h3>Methods</h3><div>A narrative synthesis of current research was undertaken, concentrating on epidemiology, electrophysiological processes, genetic alterations (specifically SCN5A), and clinical management techniques, including risk stratification tools and treatment modalities.</div></div><div><h3>Results</h3><div>BrS has a worldwide prevalence estimated between 1 in 2000 and 1 in 5000 persons. Genetic mutations, especially affecting heart sodium channels, provide an arrhythmogenic substrate resulting in distinctive ECG abnormalities. Diagnosis is driven by revised clinical criteria and electrophysiological results. Management involves the use of implanted cardioverter-defibrillators (ICDs) and medication. Recent findings have clarified genotype-phenotype connections and enhanced patient risk classification</div></div><div><h3>Conclusion</h3><div>Brugada syndrome is a complicated cardiac illness needing standardized diagnostic techniques and specialized therapeutic options. Future research should concentrate on enhancing genetic screening, risk prediction models, and the development of tailored medicines to lower sudden cardiac death risk.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"16 ","pages":"Article 100238"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of bimatoprost sustained-release implant in treating severe intraocular pressure in open glaucoma: A meta-analysis 比马前列素缓释植入治疗开放性青光眼严重眼压的疗效:一项荟萃分析
Health sciences review (Oxford, England) Pub Date : 2025-07-05 DOI: 10.1016/j.hsr.2025.100235
Saad Mutlaq Alosaimi , Ahmad Al Habash , Shahad Salah Alsubhi (Literature Search)
{"title":"Efficacy of bimatoprost sustained-release implant in treating severe intraocular pressure in open glaucoma: A meta-analysis","authors":"Saad Mutlaq Alosaimi ,&nbsp;Ahmad Al Habash ,&nbsp;Shahad Salah Alsubhi (Literature Search)","doi":"10.1016/j.hsr.2025.100235","DOIUrl":"10.1016/j.hsr.2025.100235","url":null,"abstract":"<div><div>This meta-analysis investigates the efficacy and safety of the bimatoprost sustained-release (SR) implant for reducing intraocular pressure (IOP) in patients with open-angle glaucoma (OAG), particularly those with severe or uncontrolled IOP. A comprehensive search of multiple databases identified twelve randomized controlled trials including a total of 2808 patients. Pooled analysis demonstrated that the bimatoprost SR implant significantly reduced IOP compared to placebo, with a mean difference of –1.53 mmHg. The implant also increased the proportion of patients achieving desired IOP reduction and was associated with a modest improvement in rescue rates. Adverse events were generally low, with no treatment-emergent adverse events reported in the intervention group. These findings suggest that the bimatoprost SR implant is a safe and effective alternative for patients with OAG who may struggle with adherence to daily eye drops. Further studies are recommended to evaluate its long-term impact on disease progression and visual outcomes.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"16 ","pages":"Article 100235"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Driving and sustaining trauma-informed organizational change: The role of healthcare leadership 推动和维持创伤知情的组织变革:医疗保健领导的作用
Health sciences review (Oxford, England) Pub Date : 2025-06-24 DOI: 10.1016/j.hsr.2025.100236
Amidu Alhassan , Sana Rasheed , Ahmed Asad Raza , Bushra Murtaza , Azka Mujeeb , Ayesha Iqbal Mansoor
{"title":"Driving and sustaining trauma-informed organizational change: The role of healthcare leadership","authors":"Amidu Alhassan ,&nbsp;Sana Rasheed ,&nbsp;Ahmed Asad Raza ,&nbsp;Bushra Murtaza ,&nbsp;Azka Mujeeb ,&nbsp;Ayesha Iqbal Mansoor","doi":"10.1016/j.hsr.2025.100236","DOIUrl":"10.1016/j.hsr.2025.100236","url":null,"abstract":"<div><div>Trauma is a major public health concern, both omnipresent and burdensome. Trauma-informed care [TIC] is regarded as a multilevel approach that alters the way organizations perceive and address trauma. TIC has shown a beneficial impact on patient health, employee well-being, and institutional performance. Efforts to implement TIC necessitate leadership backing and the establishment of policies to guarantee consistent application. This review examines the implementation and sustainability of TIC in healthcare, focusing on its principles, role of leadership, challenges, and strategies. It aims to provide insights to enhance patient outcomes, support staff well-being, and foster a trauma-informed healthcare culture. TIC is a well-established framework for supporting trauma survivors and improving outcomes in emergency departments. Studies have shown that implementing TIC education programs can reduce the number of patients subjected to physical restraints and the overall time spent in restraints. Strategic leaders must develop standardized policies to guide the change process. Staff trained under certified programs provide better results in trauma-informed healthcare by influencing their knowledge, behavior, and beliefs. Organizational challenges include the need for repeated training and ongoing support. Community clinics face time constraints in consultations, financial constraints, and high patient turnover. Sustaining trauma-informed change requires systemic strategies that prioritize safety, empowerment, and collaboration. Supportive leadership empowers employees through shared decision-making and continuous training. Embedding TIC into organizational policies ensures sustainability by promoting safety, equity, and inclusivity. Future research should evaluate and refine TIC practices to build a stronger evidence base.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"16 ","pages":"Article 100236"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A surgeon’s primer on Unique Device Identifier (UDI) capture: Where do we stand on implant surveillance and how can we improve? 外科医生对唯一设备标识符(UDI)捕获的入门:我们在植入物监测方面处于什么位置?我们如何改进?
Health sciences review (Oxford, England) Pub Date : 2025-06-10 DOI: 10.1016/j.hsr.2025.100234
Alberto Jarrin Lopez , Amartya Dave , Tejas Sathe , Hanmin Lee
{"title":"A surgeon’s primer on Unique Device Identifier (UDI) capture: Where do we stand on implant surveillance and how can we improve?","authors":"Alberto Jarrin Lopez ,&nbsp;Amartya Dave ,&nbsp;Tejas Sathe ,&nbsp;Hanmin Lee","doi":"10.1016/j.hsr.2025.100234","DOIUrl":"10.1016/j.hsr.2025.100234","url":null,"abstract":"<div><div>The Unique Device Identifier (UDI) system was developed to improve the identification and tracking of medical devices throughout their lifecycle. Despite its potential to enhance patient outcomes, streamline supply chain management, and facilitate swift responses to device recalls, widespread adoption remains limited. In the absence of regulatory policies enforcing standardized UDI practices, this paper underscores the critical role surgeons play in implementing and advocating for UDI’s utility within their institutions. By reviewing published roadmaps and playbooks, we highlight key steps for successful adoption. We examine case studies from early adopter institutions—Mercy Health, Duke University Health System, and Kaiser Permanente—that have successfully integrated UDI systems, demonstrating tangible benefits. Recognizing the barriers to nationwide UDI implementation as well as the unique role of surgeons at the intersection of patient care and device innovation, we conclude by proposing practical, actionable steps for surgeons to drive change within their institution.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"16 ","pages":"Article 100234"},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the understanding and management of multiple sclerosis phenotypes 多发性硬化症表型的认识和治疗进展
Health sciences review (Oxford, England) Pub Date : 2025-06-10 DOI: 10.1016/j.hsr.2025.100232
Ali Msheik, Zeinab Al Mokdad, Reem Hmede, Rami Atat
{"title":"Advances in the understanding and management of multiple sclerosis phenotypes","authors":"Ali Msheik,&nbsp;Zeinab Al Mokdad,&nbsp;Reem Hmede,&nbsp;Rami Atat","doi":"10.1016/j.hsr.2025.100232","DOIUrl":"10.1016/j.hsr.2025.100232","url":null,"abstract":"<div><div>Multiple sclerosis is a chronic autoimmune disease of the central nervous system characterized by inflammation, demyelination, and neurodegeneration. This review synthesizes current understanding of multiple sclerosis subtypes, diagnostic criteria, and the evolving landscape of therapeutic strategies. It highlights advances in imaging modalities and biomarkers that enhance disease characterization and monitoring. Clinically isolated syndrome and radiologically isolated syndrome are recognized as early indicators of multiple sclerosis, with specific magnetic resonance imaging features and cerebrospinal fluid findings aiding in diagnosis and prognosis. Relapsing-remitting multiple sclerosis remains the most prevalent form, with many patients eventually progressing to secondary progressive multiple sclerosis. Primary progressive multiple sclerosis presents unique diagnostic and therapeutic challenges. Recent years have seen a shift toward early aggressive therapy, with monoclonal antibodies like ocrelizumab and ofatumumab demonstrating significant efficacy in reducing disease activity. New oral agents and autologous hematopoietic stem cell transplantation show promise, particularly in refractory or highly active cases. Siponimod and other selective S1P modulators are emerging as treatments for active SPMS, though therapeutic options for non-active progressive forms remain limited. Biomarkers such as neurofilament light are under investigation for their roles in early detection, subtype differentiation, and monitoring disease progression. This review underscores the growing role of precision medicine in multiple sclerosis, driven by improved diagnostics, individualized treatment approaches, and novel therapeutic targets</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"16 ","pages":"Article 100232"},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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