Health sciences review (Oxford, England)最新文献_第2页

Unravelling the genomic maze: Bioinformatics unleashes insights into Sotos syndrome (Cerebral Gigantism) 揭开基因组迷宫：生物信息学揭示索托斯综合征（脑巨人症）的奥秘

Health sciences review (Oxford, England) Pub Date : 2024-07-17 DOI: 10.1016/j.hsr.2024.100194

Ravinder Sharma , Simarjeet Kaur , Vikas Gupta , Harpreet Grover , Kiran Yadav , Viney Chawla , Pooja A Chawla

{"title":"Unravelling the genomic maze: Bioinformatics unleashes insights into Sotos syndrome (Cerebral Gigantism)","authors":"Ravinder Sharma , Simarjeet Kaur , Vikas Gupta , Harpreet Grover , Kiran Yadav , Viney Chawla , Pooja A Chawla","doi":"10.1016/j.hsr.2024.100194","DOIUrl":"10.1016/j.hsr.2024.100194","url":null,"abstract":"<div><p>The overgrowth condition known as Sotos syndrome is distinguished by its characteristic facial gestalt, macrocephaly, excessive development during childhood, varying degrees of learning problems, and a variety of other abnormalities. Due to abnormally high height, occipitofrontal circumference (OFC), advanced bone age, neonatal problems such as hypotonia and feeding issues, and facial gestalt, the diagnosis is typically recognized after birth. The current work aims to identify potential therapeutic treatments through bioinformatics analysis, focusing on key genes and pathways implicated in the disease. Text mining techniques were employed to identify 41 genes associated with Sotos syndrome, 37 of which were enriched with Gene Ontology (GO) terms and 24 with Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Using protein-protein interaction (PPI) network analysis, two gene modules were extracted using the Molecular Complex Detection (MCODE) algorithm, highlighting 15 hub genes as central candidates. Furthermore, leveraging drug-gene interaction databases and network pharmacology tools, 23 FDA-approved drugs were identified that target 11 of these core hub genes, suggesting potential therapeutic avenues for Sotos syndrome. Only bioinformatics tools were used in this study further in-vitro and in-vivo studies are required because phenotypic differences will vary from person to person depending on the expressivity of the gene. In future this approach may help to collaborate with clinical researchers to integrate bioinformatics findings with real-world clinical data. This will enhance understanding of clinical relevance of the identified genes and pathways and validate bioinformatics predictions with patient-derived samples and clinical histories.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"12 ","pages":"Article 100194"},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000473/pdfft?md5=466e0f40a2696c6b51eb1d2b00049450&pid=1-s2.0-S2772632024000473-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141847122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Is it time to define vaccines to be used for lumpy skin disease? 是时候确定用于治疗块状皮肤病的疫苗了吗？

Health sciences review (Oxford, England) Pub Date : 2024-07-08 DOI: 10.1016/j.hsr.2024.100192

Krishna Prasad Acharya , Bhoj Raj Singh

引用次数: 0

Incidence and risk factors associated with human mastitis 人类乳腺炎的发病率和相关风险因素

Health sciences review (Oxford, England) Pub Date : 2024-07-05 DOI: 10.1016/j.hsr.2024.100191

Pratiksha Gondkar, Hemant Kumar, Khushal Patel

{"title":"Incidence and risk factors associated with human mastitis","authors":"Pratiksha Gondkar, Hemant Kumar, Khushal Patel","doi":"10.1016/j.hsr.2024.100191","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100191","url":null,"abstract":"<div><p>Human mastitis is an infection that affects the mammary glands of females and mainly occurs during the puerperium, a common condition brought on by improper breastfeeding technique. Mastitis is differentiated into lactational and non-lactational types according to its symptoms. Based on the available data, the pooled incidence of mastitis across countries like the USA, UK, Australia, Denmark, Turkey, Finland and New Zealand is estimated to be 13.45%. Poor hygiene, sore and cracked nipples, nipple piercing, smoking and fitted innerwear are reported risk factors. <em>Staphylococcus aureus</em> and <em>Staphylococcus epidermidis</em> are predominant pathogens, with a prevalence range between 50 to 87%, respectively. Mastitis management is essential to reduce infection rates and discover alternate treatments. Studies indicate that antibiotic treatment may be substituted for herbal and probiotic therapies. In addition, if mastitis is not adequately diagnosed in females, there is a high risk of breast cancer. Mastitis is a significant health issue, but it is often overlooked in the field of human medicine. In this review, we have focused on the risk factors, the alternative therapeutic approaches, and the relationship of breast cancer associated with mastitis.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"12 ","pages":"Article 100191"},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000448/pdfft?md5=269a87681bfce596d02d2db52dc997b3&pid=1-s2.0-S2772632024000448-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141582960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sertraline: A potential drug of choice for post-myocardial infarction depression in South Asia 舍曲林：南亚地区心肌梗死后抑郁症的潜在首选药物

Health sciences review (Oxford, England) Pub Date : 2024-07-05 DOI: 10.1016/j.hsr.2024.100193

Muhammad Shaheer Bin Faheem , Hafiz Muhammad Kamran Ahmed Mughal , Kanza Zahid , Omer Farooq , Muhammad Ibraiz Bilal , Danish Ali Ashraf

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Challenges and opportunities in precision therapy for diabetic patients 糖尿病患者精准治疗的挑战与机遇

Health sciences review (Oxford, England) Pub Date : 2024-07-02 DOI: 10.1016/j.hsr.2024.100190

Ruchika Sharma , Pankaj Musyuni , Jaseela Majeed , Geeta Aggarwal

{"title":"Challenges and opportunities in precision therapy for diabetic patients","authors":"Ruchika Sharma , Pankaj Musyuni , Jaseela Majeed , Geeta Aggarwal","doi":"10.1016/j.hsr.2024.100190","DOIUrl":"10.1016/j.hsr.2024.100190","url":null,"abstract":"<div><p>Diabetes, a chronic condition characterized by an inability to maintain normal glucose levels significantly accounts for enhancing the cost of healthcare expenditure. Managing diabetes using a standard medication protocol more often leads to progressive failure in effectively treating the associated complications. The recent trends involve understanding of diabetes's genetic architecture and its consequences have provided the background for application of precision medicine for customizing protocols for preventing and managing the diabetes therapy. Further, utilizing the electronic health data and genetic information for assisting care and planning therapeutic protocol for monogenic form of diabetes is well-executed example of genomic medicine. The present write-up emphasized recent advances about the causes and effects of diabetes genetics. This also drive to the need for the further investigation for ensuring the appropriate knowledge to enable patients and healthcare providers to make informed decisions for obtaining the best possible outcome.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"12 ","pages":"Article 100190"},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000436/pdfft?md5=91c275318bee0cf82e54dd8d44d869cd&pid=1-s2.0-S2772632024000436-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141638288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted therapy for Chronic Obstructive Pulmonary Disease: Dupilumab's role in patients with elevated eosinophils 慢性阻塞性肺病的靶向治疗：杜匹单抗在嗜酸性粒细胞升高患者中的作用

Health sciences review (Oxford, England) Pub Date : 2024-07-02 DOI: 10.1016/j.hsr.2024.100189

Muzamil Akhtar , Mehmood Akhtar

引用次数: 0

The impact of rate of nicotine metabolism, as measured by the nicotine metabolite ratio (NMR), on smoking behaviours during pregnancy: A scoping review 以尼古丁代谢物比值（NMR）衡量的尼古丁代谢率对孕期吸烟行为的影响：范围界定综述

Health sciences review (Oxford, England) Pub Date : 2024-06-30 DOI: 10.1016/j.hsr.2024.100186

Min-Tz Weng , Angela Ratsch , Jared A Miles , Qiuda Zheng , Kathryn J Steadman

{"title":"The impact of rate of nicotine metabolism, as measured by the nicotine metabolite ratio (NMR), on smoking behaviours during pregnancy: A scoping review","authors":"Min-Tz Weng , Angela Ratsch , Jared A Miles , Qiuda Zheng , Kathryn J Steadman","doi":"10.1016/j.hsr.2024.100186","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100186","url":null,"abstract":"<div><p>Smoking during pregnancy is detrimental to the foetus and the mother, but quitting smoking can be challenging for pregnant women. The nicotine metabolite ratio (NMR), the ratio between 3-hydroxycotinine and cotinine, indicates the rate of nicotine metabolism and is associated with smoking behaviours and cessation success in the general population. Our goal was to establish what is currently known about the rate of nicotine metabolism during pregnancy. A search was conducted from inception to January 2024 using PubMed, EMBASE, CINAHL, PsycINFO, Web of Science, and Medline. Inclusion criteria encompassed pregnant women actively using any tobacco or nicotine-containing products for whom cotinine and 3-hydroxycotinine levels were assessed in maternal saliva, blood, or urine samples. Exclusion criteria comprised non-English articles, passive exposure to smoking, and absence of cotinine and 3-hydroxycotinine measurements. In half of the studies, more than 75% of participants were White. Four studies demonstrated that NMR (i.e. rate of nicotine metabolism) increased during pregnancy. Two studies found opioid use can increase NMR, and higher NMR correlated with greater nicotine dependence during pregnancy. One study found that higher NMR was associated with heavy cigarette use during pregnancy. Similarly, one study revealed pregnant women with higher NMR are less likely to quit smoking. However, one study linked lower NMR to lower birth weight, particularly among African-American populations compared to White populations. NMR tends to increase during pregnancy, complicating smoking cessation. Although race is an important determinant of NMR, the limited range of ethnic backgrounds highlights a need for further research in diverse populations.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"12 ","pages":"Article 100186"},"PeriodicalIF":0.0,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000394/pdfft?md5=b735b2d48bc89c954adf1cc8f39be48d&pid=1-s2.0-S2772632024000394-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141540873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transforming pediatric speech and language disorder diagnosis and therapy: The evolving role of artificial intelligence 改变儿科言语和语言障碍的诊断与治疗：人工智能不断发展的作用

Health sciences review (Oxford, England) Pub Date : 2024-06-24 DOI: 10.1016/j.hsr.2024.100188

Ankur Bhardwaj , Mridul Sharma , Sahil Kumar , Sumit Sharma , Prabodh Chander Sharma

{"title":"Transforming pediatric speech and language disorder diagnosis and therapy: The evolving role of artificial intelligence","authors":"Ankur Bhardwaj , Mridul Sharma , Sahil Kumar , Sumit Sharma , Prabodh Chander Sharma","doi":"10.1016/j.hsr.2024.100188","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100188","url":null,"abstract":"<div><p>Integrating artificial intelligence (AI) with healthcare offers a viable way to treat difficult issues like children's speech-sound disorder (SSD).AAC, or augmentative alternative communication, has shown great promise in helping people with SSD, and AI-driven methods hold even more promise for improving diagnosis and therapy. This review paper explores the synergy of AI, ML, and AAC in pediatric speech and language impairments. It also highlights current developments and potential future directions. Healthcare providers can improve communication outcomes for kids with speech impairments, increase early detection, and provide personalised therapy by utilizing AI and ML techniques. In addition to encouraging parental involvement, the combination of AI and AAC technologies spurs advancements in speech therapy applications. AI has the potential to transform healthcare and improve the quality of life for people with speech and language problems as it develops and works in tandem with medical knowledge.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"12 ","pages":"Article 100188"},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000412/pdfft?md5=c864e0a389ace1998e31ba275221792d&pid=1-s2.0-S2772632024000412-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141582961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transforming multidrug-resistant tuberculosis care: The potentials of telemedicine in resource-limited settings 转变耐多药结核病护理：远程医疗在资源有限环境中的潜力

Health sciences review (Oxford, England) Pub Date : 2024-06-24 DOI: 10.1016/j.hsr.2024.100185

David B. Olawade , Judith Eberhardt , Aanuoluwapo Clement David-Olawade , Malik A. Balogun , Obasanjo A. Bolarinwa , Deborah T. Esan

{"title":"Transforming multidrug-resistant tuberculosis care: The potentials of telemedicine in resource-limited settings","authors":"David B. Olawade , Judith Eberhardt , Aanuoluwapo Clement David-Olawade , Malik A. Balogun , Obasanjo A. Bolarinwa , Deborah T. Esan","doi":"10.1016/j.hsr.2024.100185","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100185","url":null,"abstract":"<div><p>Multidrug-resistant tuberculosis (MDR-TB) is a significant public health challenge in low-resource settings owing to limited healthcare access and quality. However, telemedicine can potentially improve healthcare delivery by overcoming geographical barriers. This comprehensive review aimed to provide an overview of the current trends in utilizing telemedicine for MDR-TB control in low-resource settings. A systematic literature search were conducted in PubMed and CINAHL electronic databases and Google Scholar search engine to identify relevant articles on telemedicine and MDR-TB control in low-resource settings. The selected articles were analyzed and synthesized to provide a comprehensive overview of telemedicine's current trends and applications in MDR-TB control. The review results shows that telemedicine allows remote screening and diagnosis, facilitating early detection and timely treatment, provides access to experts through teleconsultation, which ensures optimal treatment outcomes, fosters training and education of healthcare providers, and supports follow-up care through teleconsultation and remote monitoring. Furthermore, telemedicine integration with data collection methods could improve MDR-TB surveillance and intervention. Findings from this review show the potential of telemedicine to improve MDR-TB control and patient health in low-resource settings. This makes it a promising prevention and management option. However, successful implementation requires overcoming limitations such as connectivity, infrastructure, and cultural barriers. Telemedicine can considerably improve MDR-TB control and reduce disease burden in underserved populations by utilizing possibilities and addressing the challenges.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"12 ","pages":"Article 100185"},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000382/pdfft?md5=aefc45a9a91fc0b78cad95ea8b3c6833&pid=1-s2.0-S2772632024000382-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141483581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The prevalence of Vitiligo and its associated risk factors in the middle East and Africa: A systematic review and meta-analysis 中东和非洲的白癜风发病率及其相关风险因素：系统回顾与荟萃分析

Health sciences review (Oxford, England) Pub Date : 2024-06-24 DOI: 10.1016/j.hsr.2024.100187

Michael Khoury, Toufic Dabit, Hanna Siniora, Julie Fashho, Ahmad A. Toubasi

{"title":"The prevalence of Vitiligo and its associated risk factors in the middle East and Africa: A systematic review and meta-analysis","authors":"Michael Khoury, Toufic Dabit, Hanna Siniora, Julie Fashho, Ahmad A. Toubasi","doi":"10.1016/j.hsr.2024.100187","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100187","url":null,"abstract":"<div><p>Vitiligo is a prevalent chronic autoimmune skin disorder. However, the data about its prevalence and risk factors in the Middle East (ME) and Africa is scarce. Thus, we decided to conduct a systematic review and meta-analysis to assess the prevalence and risk factors of vitiligo in the ME and African regions. On the 25th of June 2023 a systematic search of the following database: PubMed, Scopus, Web of Sciences and Cochrane was conducted. All articles were included if they were observational studies that reported the prevalence or risk factors of any type of Vitiligo in one or more ME or African countries with no restriction to the type of vitiligo, age group, or gender. The total number of the included participants was 226,115 from 38 studies. The overall prevalence of vitiligo was 3 % (95 %CI: 2 %-4 %) while the prevalence among males and females were 1 % (95 %CI: 1 %-2 %) and 1 % (95 %CI: 1 %-2 %), respectively. The prevalence among pediatrics was 2 % (95 %CI: 1 %-2 %) while it was 10 % (95 %CI: 7 %-13 %) among adults. The models showed that the prevalence of vitiligo in Africa was 3 % (95 %CI: 1 %-4 %) while the pooled prevalence of vitiligo in Arabian countries was 2 % (95 %CI: 1 %-3 %). Sub-group analysis according to the year of publication showed that the pooled prevalence before 2010 was 3 % (95 %CI: 2 %-4 %). On the other hand, the pooled prevalence after 2010 was 2 % (95 %CI: 1 %-4 %). Clinicians should pay attention to the high prevalence of vitiligo and the characteristics of vitiligo patients. Also, governmental efforts should be taken to increase the awareness about vitiligo in the ME and African countries to increase early diagnosis and management of the disease resulting in better outcomes.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"12 ","pages":"Article 100187"},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000400/pdfft?md5=1121730b9d14abfe8fa530b7aed5a0eb&pid=1-s2.0-S2772632024000400-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141540872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0