Health sciences review (Oxford, England)最新文献

{"title":"Engineering liquid metal-based implantable electrodes toward brain-machine interfaces","authors":"Xia Qian ,&nbsp;Caizhi Liao","doi":"10.1016/j.hsr.2023.100118","DOIUrl":"https://doi.org/10.1016/j.hsr.2023.100118","url":null,"abstract":"<div><p>Driven by the development of innovative electrode materials, the brain-machine interface (BMI) has witnessed significant advancements in recent years. However, traditional implantable electrodes, such as metal-based and polymer-based electrodes, often face limitations in terms of flexibility, chronic stability, and long-term biocompatibility. Liquid metal-based electrodes have emerged as a promising alternative to traditional electrode materials, offering unique properties and numerous advantages for BMI applications. In this Review, we provided an in-depth overview of liquid metal-based electrodes. Liquid metal-based electrodes demonstrate several desirable features, including high electrical conductivity, flexibility, biocompatibility, and the ability to conform to the irregular and delicate structures of the brain. We also systematically and thematically discussed their material properties, biocompatibility considerations, performance characteristics, and assorted applications in neural recording, stimulation, brain-machine interfaces, closed-loop feedback systems, and neuroprosthetics. Meanwhile, long-term stability, biocompatibility, electrode-tissue interface, miniaturization, signal processing, and ethical considerations are areas that require further research and innovation. Addressing these challenges will contribute to the successful integration and widespread use of liquid metal-based electrodes in BMI systems.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"9 ","pages":"Article 100118"},"PeriodicalIF":0.0,"publicationDate":"2023-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49811435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy and safety outcomes of bempedoic acid: An updated systematic review and meta-analysis after CLEAR Outcomes trial","authors":"Amit Bhandari ,&nbsp;Prakash Raj Oli ,&nbsp;Dhan Bahadur Shrestha ,&nbsp;Sagun Dawadi ,&nbsp;Bishnu Deep Pathak ,&nbsp;Manoj Bhandari ,&nbsp;Yub Raj Sedhai ,&nbsp;Bibhusan Basnet ,&nbsp;Laxmi Regmi ,&nbsp;Aniruddha Singh ,&nbsp;Nimesh K. Patel","doi":"10.1016/j.hsr.2023.100116","DOIUrl":"https://doi.org/10.1016/j.hsr.2023.100116","url":null,"abstract":"<div><h3>Purpose</h3><p>Statins are the cornerstone therapy for primary or secondary prevention of atherosclerotic cardiovascular disease (ASCVD). However, a significant portion of patients are intolerant to statin or show inadequate lipid-lowering. Bempedoic acid (BA) has been shown to decrease low-density lipoprotein cholesterol (LDL-C) in clinical trials. However, the evidence on the effect of BA on clinical cardiovascular outcomes was limited until the CLEAR Outcomes trial. Thus, to fully appraise the available data, we performed this meta-analysis.</p></div><div><h3>Methods</h3><p>PubMed, Pubmed Central, Embase, and Scopus databases were searched for relevant articles published before May 1, 2023. Pertinent data from the included studies were extracted and analyzed using RevMan v5.4.</p></div><div><h3>Results</h3><p>Out of 2209 studies evaluated, five randomized control trials with 17,384 patients with established ASCVD or at high risk of ASCVD were included for analysis. The BA therapy reduced major adverse cardiovascular events (OR 0.85, CI 0.77-0.93; &lt;0.0001), non-fatal myocardial infarction (OR 0.75, 95 % CI 0.64-0.88; <em>p &lt;</em>0.0001), hospitalization for unstable angina (OR 0.69, CI 0.53-0.89; <em>p</em> = 0.005) and coronary revascularization (OR 0.80, CI 0.61-0.91; &lt;0.0001) significantly without decreasing the risk of all-cause death (OR 1.19, CI 0.73-1.94; <em>p</em> = 0.49), cardiovascular death (OR 1.04, CI 0.87-1.25; <em>p</em> = 0.68) and non-fatal stroke (OR 0.84, CI 0.66-1.06; <em>p</em> = 0.15).</p></div><div><h3>Conclusion</h3><p>Based on our analysis the bempedoic acid addition to therapy reduced cardiovascular events in selective patients who are either intolerant to statins or do not achieve recommended LDL-C levels despite being on a maximum dose of statins and/or ezetimibe.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"9 ","pages":"Article 100116"},"PeriodicalIF":0.0,"publicationDate":"2023-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49891729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An update on breast cancer chemotherapy-associated toxicity and their management approaches","authors":"Urvashi Langeh ,&nbsp;Vishal Kumar ,&nbsp;Palak Ahuja ,&nbsp;Charan Singh ,&nbsp;Arti Singh","doi":"10.1016/j.hsr.2023.100119","DOIUrl":"https://doi.org/10.1016/j.hsr.2023.100119","url":null,"abstract":"<div><p>As the incidence rate of breast cancer is increasing at an alarming rate these days, this is leading to an increase in the use of chemotherapy drugs. Here we used a systematic review to identify studies that reported adverse events related to chemotherapy and its management. We searched PubMed Central, Cochrane Library, Research Gate, Sci-Hub, and Web of Knowledge for relevant references. We included data from 1978 to 2021 in our analysis. Additionally, in this review, we have attempted to elucidate how cancer chemotherapy has affected the mind and body of the cancer survivor. We also provided insight into the adjuvant therapies that enable survivors to lead quality lives. Due to incomplete knowledge and sometimes fear of adverse effects, patients are reluctant to undergo cancer treatment. Combining cancer drugs with those that overcome associated side effects is a promising area for better patient outcomes.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"9 ","pages":"Article 100119"},"PeriodicalIF":0.0,"publicationDate":"2023-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49811433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling general practitioners' barriers to deal with long COVID: Experiences from Malta","authors":"Sarah Cuschieri ,&nbsp;Sarah Moreels","doi":"10.1016/j.hsr.2023.100121","DOIUrl":"https://doi.org/10.1016/j.hsr.2023.100121","url":null,"abstract":"","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"9 ","pages":"Article 100121"},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49811437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Workplace hazing in nursing: An integrative literature review","authors":"Anette Kaagaard Kristensen ,&nbsp;Martin Lund Kristensen ,&nbsp;Eva Gemzøe Mikkelsen","doi":"10.1016/j.hsr.2023.100120","DOIUrl":"https://doi.org/10.1016/j.hsr.2023.100120","url":null,"abstract":"<div><p>This study aims to provide an integrative literature review of what characterizes the antecedents, experiences, and outcomes of nursing students’ and nurses’ workplace hazing experiences. The review combines theoretical and empirical studies of workplace hazing, nursing students, and newly graduated nurses’ transition experiences. An electronic database search was performed in CINAHL, Google Scholar, MEDLINE, ProQuest, PsycINFO, PUBMED, Scopus, and Web of Science. Fifty-five papers collecting data from 8,131 respondents (1,733 nursing students and 80 newly graduated nurses) published from 1968 to 2023 and reporting on research occurring in a non-virtual workplace setting, were synthesized and analyzed using thematic coding. The study found that nursing students and new nurses are typically exposed to segregation and person- and work-based workplace hazing by their experienced colleagues during the transition, adversely affecting their physical, emotional, and psychological well-being and relational quality expectations. Applying the workplace hazing perspective to the nursing literature on newcomers’ transition experiences contributes to a nuanced understanding of the phenomenon and its underlying motivation and illuminates its ambiguous moral character. Furthermore, despite prioritizing the group's welfare above that of the newcomer, hazing's adverse individual outcomes might ultimately damage the workgroup and organization and contribute to a further nursing shortage.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"9 ","pages":"Article 100120"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49811374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classical Hodgkin lymphoma histologic subtypes distribution among geographical regions and correlation with Human Development Index","authors":"Alberto Moscona-Nissan,&nbsp;María Fernanda Mancilla-Osuna,&nbsp;Andrea Bardán-Duarte,&nbsp;Mario Enrique Rendón-Macías","doi":"10.1016/j.hsr.2023.100117","DOIUrl":"https://doi.org/10.1016/j.hsr.2023.100117","url":null,"abstract":"<div><p>Classical Hodgkin lymphoma (cHL) is classified into nodular sclerosis (NS), mixed cellularity (MC), lymphocyte rich (LR), and lymphocyte depleted (LD) histologic subtypes. Epidemiologic studies demonstrate remarkable diversity of subtype distribution among geographical regions and socioeconomic conditions. However, previous research has not examined the statistical correlation between subtypes’ proportion of cases among countries and socioeconomic factors, reported through a standardized parameter as the Human Development Index (HDI). Our aim was to analyze cHL histologic subtypes' frequency patterns among geographic regions and establish a correlation with countries' socioeconomic conditions.</p><p>We conducted a systematic review in national registries, population-based reports and multicenter studies addressing histologic subtype frequency in different countries from 1980 to 2021. We evaluated 26,174 cHL patients from 27 countries among five geographic regions. For each cHL subtype, we calculated the Pearson correlation coefficient, determination coefficient and created scatter plots.</p><p>North and Central America and Europe were the regions with the highest overall proportion of NS cases, while East and South Asia and Africa had the highest proportion of MC and LD cases. A significant positive correlation was confirmed between NS proportion of cases among countries and a higher HDI (R²=0.33, <em>r</em> = 0.57, <em>p</em>&lt;0.001). Conversely, a negative correlation was found between MC and LD subtype proportion of cases and a higher HDI (R²=0.35, <em>r</em>=-0.59, <em>p</em>&lt;0.001 for MC and R²=0.08, <em>r</em>=-0.29, <em>p</em>&gt;0.05 for LD). LR subtype distribution showed no correlation with HDI (R² &lt;0.00001, <em>r</em> = 0.002, and <em>p</em>&gt;0.05).</p><p>Early Epstein-Barr virus infection, host-related factors (as an altered immune response, nutritional status), human immunodeficiency virus infection, among other factors could explain these differences. Understanding cHL distribution patterns and their underlying causes, could allow to create public health interventions to improve social determinants of health in developing countries.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"9 ","pages":"Article 100117"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49811436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the role of medicinal plants and Gut microbiota in colon cancer: Towards microbiota- based strategies for prevention and treatment","authors":"Arumugam Vignesh ,&nbsp;Thomas Cheeran Amal ,&nbsp;Subramaniam Selvakumar ,&nbsp;Krishnan Vasanth","doi":"10.1016/j.hsr.2023.100115","DOIUrl":"10.1016/j.hsr.2023.100115","url":null,"abstract":"<div><p>Colon cancer remains one of the leading causes of morbidity and mortality worldwide. Given its widespread prevalence, the identification of new anticancer drugs is crucial. Medicinal plants have provided many natural products that have proven to be successful anticancer drugs in clinical use and have shown significant efficacy. Over the last decade, researchers have gathered significant information regarding the contribution of gut microbiota to the development and progression of colon cancer. Manipulating the gut microbiota to reverse microbial dysbiosis is an innovative strategy for addressing human diseases and intestinal disorders. Recent scientific findings have shown that this approach has a significant positive impact on the prevention and treatment of colon cancer. This review aims to provide a comprehensive understanding of the fundamental concepts related to intestinal microbiota and dysbiosis, as well as the interactions between microbiota and phytochemicals that can affect the bioavailability and bioactivity of these compounds. The primary components of the gut, including carbohydrates, enzymes, lipids, vitamins, and secondary metabolites such as alkaloids, flavonoids, polyphenols, and terpenoids, can activate gut dysbiosis. While these strategies show promising outcomes by rectifying microbiota proportion, modifying innate immune systems, emphasizing gut barrier operation, inhibiting pathogen colonization, and exhibiting selective cytotoxicity against colon cancer cells, further research is necessary to fully understand their mechanisms of action. This review also highlights the relationship between medicinal plants, gut microbiota, and colon cancer, which may lead to the development and clinical translation of potential microbiota-based strategies for cancer prevention.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"9 ","pages":"Article 100115"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43858330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on biotechnologically derived techniques to combat COVID-19 situation","authors":"Akanksha Jain ,&nbsp;Sonia Bajaj ,&nbsp;Parag Jain ,&nbsp;Ashish Majumdar ,&nbsp;Ayushi Singh ,&nbsp;Pranay Soni","doi":"10.1016/j.hsr.2023.100112","DOIUrl":"10.1016/j.hsr.2023.100112","url":null,"abstract":"<div><p>The severe acute respiratory illness caused by the recent global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), a new strain, is a serious health crisis. Since new virus strains are continuously developing, the 2019 coronavirus disease pandemic, also known as COVID-19, is a major concern around the world. Human mortality and economic loss have been significantly impacted by the varying degrees of severity of COVID-19 symptoms, which can range from no symptoms at all to the lethal acute respiratory distress syndrome (ARDS). Scientists around the world have taken a \"war footing\" in their search for a method to detect, treat, and immunise against the extremely dangerous COVID-19 virus so that society can return to its pre-pandemic state. Since its first publication, the number of laboratory-based and point-of-care (POC) techniques for detecting and monitoring the outbreak status of COVID-19 viral infection has increased. A rapidly growing and increasingly used approach for detecting COVID-19 is the RT-PCR-based viral nucleic acid test (NAT). Due to the urgent situation caused by the spread of COVID-19, the rapid development of effective, safe immunisations is urgently required. Rapid implementation of mass immunisation measures is the greatest challenge against the spread of the COVID-19 pandemic. The extremely contagious COVID-19 virus originated during the SARS-CoV-2 virus pandemic, and the development of diagnostics and possible vaccine candidates has been greatly aided by new biotechnologies and the interdisciplinary approaches they permit. Phase III clinical trials have shown promise for several potential vaccinations against COVID-19, and these vaccines have been granted emergency use authorisation (EUA) for distribution. However, it is critical to find most promising vaccine candidates to protect against the harmful strains that are anticipated to arise in the future and the most effective ways to give them. This review article will aid in the development of diagnostic tests and immunisations for COVID-19, which may contribute to the global eradication of virus</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"8 ","pages":"Article 100112"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44205411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated detection and natural remediation technology as a low-cost alternative for wastewater treatment","authors":"Kritika S. Sharma ,&nbsp;Kajal Panchal ,&nbsp;Monika Chhimwal ,&nbsp;Dinesh Kumar","doi":"10.1016/j.hsr.2023.100111","DOIUrl":"10.1016/j.hsr.2023.100111","url":null,"abstract":"<div><p>Water pollution has become a worldwide concern because the demand for fresh water is increasing exponentially, while its availability is under threat. There is a societal need to treat wastewater to save our freshwater bodies from becoming polluted. Although several techniques are acquirable in the market to purify polluted water, such as reverse osmosis, ion exchange, membrane process, etc., they are expensive. This review delves into recent developments in heavy metal ions detection via nanosensors and natural remediation technologies for wastewater treatment. Current trends of plant utilization in NPs synthesis for heavy metal ions sensing and natural remediation processes are focused on and addressed ahead. A hypothetical model using first nanosensor to detect heavy metal ions and later natural remediation techniques for wastewater treatment has been put forward. The proposed model facilitated by further research inputs may pave the way for potential and efficient wastewater treatment. This review begins with an introduction to heavy metal pollution, nanotechnology, its role in water treatment and green synthesis of nanoparticles. Then, it covers the detection of toxic metal ions using green synthesized nanosensors. Followed by recent advancements in natural remediation technologies such as waste stabilization ponds, floating rafts, phytoremediation, phytofilters and dendroremediation.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"8 ","pages":"Article 100111"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41458102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with treatment success among lung cancer patients: A structured literature review","authors":"Janaki Santhiveeran","doi":"10.1016/j.hsr.2023.100105","DOIUrl":"10.1016/j.hsr.2023.100105","url":null,"abstract":"","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"8 ","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47737644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}