Health sciences review (Oxford, England)最新文献_第8页

HDAC inhibitors: A novel approach to hyperglycaemia management and treatment HDAC抑制剂:高血糖管理和治疗的新途径

Health sciences review (Oxford, England) Pub Date : 2023-11-14 DOI: 10.1016/j.hsr.2023.100137

M. Suchitra , Kusuma Praveen Kumar , Manjunath.S. Katagi , Garla Venkateswarlu , P．Sree Mahalakshmi

{"title":"HDAC inhibitors: A novel approach to hyperglycaemia management and treatment","authors":"M. Suchitra , Kusuma Praveen Kumar , Manjunath.S. Katagi , Garla Venkateswarlu , P．Sree Mahalakshmi","doi":"10.1016/j.hsr.2023.100137","DOIUrl":"10.1016/j.hsr.2023.100137","url":null,"abstract":"<div><p>The field of genomics plays a prominent role in treatment of numerous chronic diseases. Diabetes is a persistent metabolic disorder. Current studies and reports have emphasised the importance of several epigenetic markers in the therapy of type 2 diabetes. Histone Deacetylases(HDAC) enzyme regulate the structure of chromatin and the transcription of genes in the nucleus that produce proteins that regulate metabolic processes in the body. It influences gene expression primarily by removing an acetyl group from its precursor protein, and it regulates acetylation metabolic enzymes in mitochondria and cytoplasm. The balance between histone acetylation and deacetylation is an epigenetic layer that modulates gene expression. Gene transcription is associated with histone acetylation induced by histone acetyl transferases, whereas histone hypoacetylation influenced by histone deacetylase activity is related with gene silencing. This review focuses on the role of histone deacetylase inhibitors as a newly discovered treatment for diabetes and its impediment, defining their use in preventing insulin resistance, cell death, and cytokine-mediated attack on pancreatic cells.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"9 ","pages":"Article 100137"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632023000636/pdfft?md5=9004f2b9cd7c3683b00e29f18bfc76bb&pid=1-s2.0-S2772632023000636-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135763715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tibia periprosthetic fracture management – A 30-year systematic review 胫骨假体周围骨折治疗- 30年系统回顾

Health sciences review (Oxford, England) Pub Date : 2023-11-02 DOI: 10.1016/j.hsr.2023.100133

Assala Abu-Mukh , Giacomo Placella , Francesco Anzano , Salvatore Mosca , Vincenzo Salini , Mattia Alessio-Mazzola

{"title":"Tibia periprosthetic fracture management – A 30-year systematic review","authors":"Assala Abu-Mukh , Giacomo Placella , Francesco Anzano , Salvatore Mosca , Vincenzo Salini , Mattia Alessio-Mazzola","doi":"10.1016/j.hsr.2023.100133","DOIUrl":"https://doi.org/10.1016/j.hsr.2023.100133","url":null,"abstract":"<div><p>Periprosthetic fractures are demanding and though uncommon, tibial periprosthetic fractures are furtherly destined to impact clinical and surgical orthopaedics due to the increasing number of arthroplasties performed yearly.</p><p>Systematic research focusing on periprosthetic tibia fractures reported beginning 1990 until 2022 was conducted on the following databases: the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE/PubMed, Embase, Scopus, the Science Citation Index Expanded from Web of Science, ScienceDirect, CINAHL, and LILACS.</p><p>A total of 473 records resulted from the research. Following the exclusion process the studies included were twenty-three (23) with a total of 287 patients and 357 treatments. Periprosthetic tibial fractures prevail in women (72.1 %), in the obese and in rheumatoid arthritis affected patients.</p><p>Treatments consist of conservative treatments (22.7 %), osteosynthesis (16.5 %), revision total knee arthroplasty (23.0 %), intramedullary nailing (2.5 %) and other treatments (30.8 %). Stable fractures are treated in various methods, unstable fractures are mainly treated through revision total knee arthroplasty and intraoperative fractures are treated both conservatively and operatively.</p><p>Periprosthetic tibial fractures are destined to heavily burden orthopaedics traumatology. Periprosthetic tibia fractures are complex and commonly afflict obese and elderly women with history of rheumatoid arthritis. These fractures may be managed following the ASAP algorithm. Stable fractures are treated using different methods and unstable fractures are mainly approached through revision total knee arthroplasty prior to other treatments. Intraoperative fractures are treated both conservatively and surgically.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"9 ","pages":"Article 100133"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632023000594/pdfft?md5=84880bb546e544ee8c4b6745aa0eafbc&pid=1-s2.0-S2772632023000594-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91964373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of styloid process length with cervical carotid artery dissection: Meta-analysis 茎突长度与颈动脉夹层的关系:meta分析

Health sciences review (Oxford, England) Pub Date : 2023-10-24 DOI: 10.1016/j.hsr.2023.100134

Loay H Abdelnour , Mohammed Kurdy , Abubakr Idris

{"title":"Association of styloid process length with cervical carotid artery dissection: Meta-analysis","authors":"Loay H Abdelnour , Mohammed Kurdy , Abubakr Idris","doi":"10.1016/j.hsr.2023.100134","DOIUrl":"https://doi.org/10.1016/j.hsr.2023.100134","url":null,"abstract":"<div><p>This meta-analysis was conducted to investigate the association of elongated styloid process (Eagle syndrome) and cervical artery dissection (CeAD), particularly carotid. Medline, PubMed Central, CINAHL and ProQuest were searched for case-control studies investigating the association of styloid process length (SPL) and CeAD, particularly carotid. SPL was treated as a continuous variable and mean difference was calculated from means and standard deviations with 95 % confidence interval (CI). SPL >30 mm was compared between cases and controls as a dichotomous variable and odds ratio (OR) was calculated with 95 % CI. Heterogeneity was quantified with χ2-based Cochran's Q-test and I<sup>2</sup>-statistic. Four studies were included comparing 185 dissection cases with 278 controls. Heterogeneity was 50 %, but was reduced to 0 % with sensitivity analysis. Styloid process was significantly longer in dissection group with a mean difference of 2.50 [-0.35, 5.35], <em>P</em> = 0.09. Elimination of one study with high risk of bias resulted in a mean difference of 3.61 [1.47, 5.75], <em>P</em> = 0.0009, and a heterogeneity of 0 %. Two studies showed SPL >30 mm to be more significant in dissection group (OR = 1.53 [0.84,2.80], <em>P</em> = 0.17). With sensitivity analysis the pooled OR was 2.09 [1.04, 4.19], <em>P</em> = 0.04. Three studies showed that mean SPL was significantly longer ipsilateral compared to contralateral side of dissection (mean difference 2.63 [0.46, 4.79], <em>P</em> = 0.02. This meta-analysis suggests that CeAD is significantly associated with styloid process mean length and SPL >30 mm. Case-control studies with bigger numbers are required to substantiate this association.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"9 ","pages":"Article 100134"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632023000600/pdfft?md5=a5552dd47a0e300b4fce7d21bdd8cddd&pid=1-s2.0-S2772632023000600-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92044311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Managing heart failure in diabetics with dual acting sotagliflozin—A review 双作用sotagliflozin-A治疗糖尿病患者心力衰竭

Health sciences review (Oxford, England) Pub Date : 2023-10-20 DOI: 10.1016/j.hsr.2023.100130

Kushal Seni, Pooja A Chawla

{"title":"Managing heart failure in diabetics with dual acting sotagliflozin—A review","authors":"Kushal Seni, Pooja A Chawla","doi":"10.1016/j.hsr.2023.100130","DOIUrl":"https://doi.org/10.1016/j.hsr.2023.100130","url":null,"abstract":"<div><p>Heart failure (HF) is a chronic disorder that decreases heart function and causes a person to be less tolerant to exercise, have a lower quality of life, and prone to death. Novel therapeutic strategies are still needed despite improvements in HF management. Sotagliflozin is a promising medication for the treatment of HF, which is a dual sodium-glucose cotransporter 1 as well as 2 (SGLT1 and SGLT2) inhibitor. The purpose of this in-depth study is to assess sotagliflozin's effectiveness and safety in the treatment of HF. The effects of sotagliflozin on different facets of HF pathophysiology, such as blood flow, myocardial remodeling, and neurohormonal stimulation, are discussed in preclinical and clinical investigations. Sotagliflozin has been shown to be effective in lowering the risk of HF hospitalization and heart attack in patients with HF with either type 2 diabetic mellitus (T2DM) and chronic kidney disease (CKD), according to numerous randomized trials, including the most recent SOLOIST-WHF or SCORED trials. Sotagliflozin's simultaneous inhibition of SGLT1 along with SGLT2 creates a special pharmacological profile that addresses both the metabolic as well as non-metabolic problems seen in HF. This review provides a comprehensive summary of various aspects related to sotagliflozin and heart failure, including the pathophysiology in heart failure, US-FDA approved treatment for HF, mechanism of action, pharmacokinetic, pharmacodynamics data of sotagliflozin, reported adverse drug reactions (ADRs), and ongoing clinical trials.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"9 ","pages":"Article 100130"},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632023000569/pdfft?md5=1f9b8fb097db04d3716e12975b4dcd35&pid=1-s2.0-S2772632023000569-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92135880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review of randomized controlled trials assessing the effect of Vortioxetine on metabolic syndrome risk indicators in patients with depression 评估沃替西汀对抑郁症患者代谢综合征风险指标影响的随机对照试验的系统综述

Health sciences review (Oxford, England) Pub Date : 2023-10-14 DOI: 10.1016/j.hsr.2023.100129

Karthik Sankar , Sushma Viswanathan , Uma maheswari mugundan , Roshini Kizhakkedeth Nazar , Saranya Ramasamy , Rajanandh Muhasaparur Ganesan

{"title":"A systematic review of randomized controlled trials assessing the effect of Vortioxetine on metabolic syndrome risk indicators in patients with depression","authors":"Karthik Sankar , Sushma Viswanathan , Uma maheswari mugundan , Roshini Kizhakkedeth Nazar , Saranya Ramasamy , Rajanandh Muhasaparur Ganesan","doi":"10.1016/j.hsr.2023.100129","DOIUrl":"https://doi.org/10.1016/j.hsr.2023.100129","url":null,"abstract":"<div><h3>Background</h3><p>The majority of antidepressants have been reported to cause metabolic syndrome (MetS). Paucity of information available for the effect of Vortioxetine on MetS. The study aims to assess the systematic review of Vortioxetine on depressive patients' blood pressure (BP), central obesity, fasting plasma glucose (FPG), triglycerides (TGs), and high-density lipoprotein (HDL) levels, which are risk factors for the MetS.</p></div><div><h3>Methods</h3><p>PRISMA guidelines were followed in conducting this systematic review. The protocol has been registered with PROSPERO (CRD42021272614). Randomized controlled trials (RCTs) that evaluated the effect of Vortioxetine on MetS risk indicators were searched in electronic databases. RCTs that included adult patients 18–75 years of age, Major depression patients (MDD) and prescribed with Vortioxetine drug. Preclinical research, editorials, letters, reviews, case reports, studies in pediatric populations, unpublished gray literature were excluded Abstract and title screening was performed, followed by full-text screening using the Covidence software. Data were extracted, and analysis was done using Cochrane Review Manager (RevMan v5.1).</p></div><div><h3>Results</h3><p>Following the screening process, 8 RCTs (6 blinded and 2 open-label) were selected for systematic review. The MetS risk factors for Vortioxetine treatment in depressed patients were ambiguous from the available research. However, 4 of 8 RCTs have shown that Vortioxetine is an effective and safe treatment for depression. All the trials were methodological of high quality. <em>Conclusions:</em> A single study evaluating all the five MetS risk variables in depressed patients on Vortioxetine therapy is needed before recommending Vortioxetine as a first-line or switch therapy for depression.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"9 ","pages":"Article 100129"},"PeriodicalIF":0.0,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49811377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virus-like particles (VLPs)-based vaccines against COVID-19: Where do we stand amid the ongoing evolution of SARS-CoV-2? 基于病毒样颗粒（VLPs）的新冠肺炎疫苗：在SARS-CoV-2的持续进化中，我们的立场是什么？

Health sciences review (Oxford, England) Pub Date : 2023-10-10 DOI: 10.1016/j.hsr.2023.100127

Manish Dhawan , AbdulRahman A. Saied , Manish Sharma

{"title":"Virus-like particles (VLPs)-based vaccines against COVID-19: Where do we stand amid the ongoing evolution of SARS-CoV-2?","authors":"Manish Dhawan , AbdulRahman A. Saied , Manish Sharma","doi":"10.1016/j.hsr.2023.100127","DOIUrl":"https://doi.org/10.1016/j.hsr.2023.100127","url":null,"abstract":"<div><p>The causative agent of the COVID-19 pandemic is undergoing several changes, and the evolutionary cascade of SARS-CoV-2 has led to the emergence of a range of variants of SARS-CoV-2. Additionally, the emergence of recombinant variants or super variants such as XBB.1.5, XBB.1.16, XBB.1.9.1, and XBB.1.9.2 has raised several concerns among the scientific community regarding the efficacy of various vaccines. The scientists are still figuring out the consequences of the variants and recombinant variants, such as their implications for the emergence of reinfection. In this context, a range of vaccines have been developed to overcome the consequences of COVID-19, but they all come with their disadvantages. While considering the disadvantages and advantages of various vaccine platforms, scientists are exploring virus-like particles (VLPs) to develop vaccines against COVID-19. Therefore, an updated review of literature has been conducted to elucidate their usage of VLPs-based vaccines to manage COVID-19. Considering the consequences of the ongoing evolution of SARS-CoV-2, the article discusses the potential role of VLPs in the development of efficient and reliable vaccines against COVID-19. Further, we have explained how VLPs generate a potent and long-lasting immune response, along with the recent VLPs in clinical trials. Additionally, we have highlighted the limitations of VLPs along with possible solutions and future directions that will overcome such limitations.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"9 ","pages":"Article 100127"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49811375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Convolutional neural networks for traumatic brain injury classification and outcome prediction 卷积神经网络在颅脑损伤分类和预后预测中的应用

Health sciences review (Oxford, England) Pub Date : 2023-10-05 DOI: 10.1016/j.hsr.2023.100126

Laura Zinnel, Sarah A. Bentil

引用次数: 0

The impact of COVID-19 pandemic in high-burden countries for tuberculosis: A systematic review 新冠肺炎大流行对结核病高负担国家的影响：系统综述

Health sciences review (Oxford, England) Pub Date : 2023-10-05 DOI: 10.1016/j.hsr.2023.100128

Swapna Ponnampalli , Naga Venkata Suryanarayana Birudukota

{"title":"The impact of COVID-19 pandemic in high-burden countries for tuberculosis: A systematic review","authors":"Swapna Ponnampalli , Naga Venkata Suryanarayana Birudukota","doi":"10.1016/j.hsr.2023.100128","DOIUrl":"https://doi.org/10.1016/j.hsr.2023.100128","url":null,"abstract":"<div><h3>Purpose</h3><p>Tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are the two most significant health challenges faced by the public. Numerous confirmed COVID-19 cases worldwide are concentrated in nations already burdened with TB. The COVID-19 pandemic has surpassed all other health issues globally and has significantly impacted the prevalence of TB.</p></div><div><h3>Methods</h3><p>A PubMed literature search (2020–2022) using the keywords, “Tuberculosis”, “Drug-resistant Tuberculosis”, “Impact of the Pandemic”, “SARS-CoV2” “COVID-19″ and “Public health”, was performed. Additional statistical information has been gathered from online databases such as the WHO COVID-19 dashboard, Nikshay Portal, and Worldometer, India.</p></div><div><h3>Results</h3><p>India, Indonesia, and the Philippines were the major contributors to the steep fall in global TB case notifications. Being the highest TB burden country, detailed trends were observed in monthly TB reports in India, compared with the newly confirmed COVID-19 cases. Flow diagrams of TB studies along with COVID-19 reports have been included in the review.</p></div><div><h3>Discussion</h3><p>A remarkable strain in the TB control programs was seen in high-TB troubled countries during the COVID-19 pandemic, in comparison to pre-pandemic and post-pandemic. A possible key to the prevention of the burden of TB lies in dealing with its risk factors; simultaneously raising the funds and sustaining investment in healthcare systems to address the needs of the poor and robust to the threat of epidemics. These countries should have a perpetual TB strategy to reach the target by 2030, together with an effective strategy for COVID-19 management.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"9 ","pages":"Article 100128"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49811385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exciting growth of health sciences review in 2023 2023年健康科学评论增长令人兴奋

Health sciences review (Oxford, England) Pub Date : 2023-09-30 DOI: 10.1016/j.hsr.2023.100125

Sarah Cuschieri , Burcin Ekser

引用次数: 0

Emerging the Role of Mercury in Stroke: A Mini Review 汞在中风中的作用：一项小型综述

Health sciences review (Oxford, England) Pub Date : 2023-09-17 DOI: 10.1016/j.hsr.2023.100122

Kamaljeet, Amit Sharma

引用次数: 0