Health sciences review (Oxford, England)最新文献

{"title":"ESKAPE pathogens and associated quorum sensing systems: New targets for novel antimicrobials development","authors":"Christiana E. Aruwa,&nbsp;Theolyn Chellan,&nbsp;Nosipho W. S'thebe,&nbsp;Yamkela Dweba,&nbsp;Saheed Sabiu","doi":"10.1016/j.hsr.2024.100155","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100155","url":null,"abstract":"<div><p>Globally, antimicrobial (AMR) or multi-drug resistance (MDR) constitutes a current health challenge that is predicted to cause increased infections rates with adverse socioeconomic impacts through increase in healthcare costs. In addition, the group of <em>Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa</em> and <em>Enterobacter</em> spp. (ESKAPE) pathogens cause debilitating infections (community and nosocomial) and are classed as priority 1 AMR pathogens. This systematic report therefore aimed at providing detailed coverage of new targets for novel antimicrobials development against MDR ESKAPE pathogens to mitigate future AMR spread and improve current public health indices. The prevalent ESKAPE bacterial group show high resistance to quinolones, lactams, cephalosporins, carbapenems and other antibiotic groups, and ability to form biofilms linked to various quorum sensing systems (QSSs) that boost their virulence. These QS pathways have become viable targets in drug design efforts for new antimicrobials development. Also, since antibiotics discovery and development has waned in the past decade, the emergence of advanced computational modelling technologies in drug design, repurposing and development efforts may yet bridge the gap. As such, in this work we provided a comprehensive and systematic overview using relevant, included data and findings on ESKAPE pathogens, their QSSs to target for novel antimicrobial agents’ development, the contributions of computational tools at the heart of novel antimicrobial advancements and their roles in bioprospecting and developing novel ‘druggable’ candidates and therapies with anti-biofilm, and anti-quorum sensing activities to mitigate AMR, biofilm and QS-related pathogenicity factors.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"11 ","pages":"Article 100155"},"PeriodicalIF":0.0,"publicationDate":"2024-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000084/pdfft?md5=8d2b08b397c1f7fd490e9c87327382dd&pid=1-s2.0-S2772632024000084-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140141464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status of tertiary healthcare services and its accessibility in rural and remote Australia: A systematic review","authors":"Mazen Baazeem ,&nbsp;Estie Kruger ,&nbsp;Marc Tennant","doi":"10.1016/j.hsr.2024.100158","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100158","url":null,"abstract":"<div><p>The study evaluated the current state and accessibility of tertiary healthcare services in rural Australia. A systematic literature review from 2010 to 2022 was undertaken, utilising databases such as PubMed, MEDLINE, Cochrane Library, ProQuest, and Google Scholar. The PRISMA method was employed to retrieve an initial total of 4768 papers. Upon removal of 2806 duplicates and 1587 irrelevant records, 1962 articles were screened. From these, 375 were assessed for eligibility, leading to the inclusion of eleven studies in the systematic review. Criteria for exclusion included a focus on primary and secondary healthcare, absence of peer review, and unclear methodology.</p><p>A collective survey of 230,339 individuals, focusing on access to tertiary healthcare in rural and remote areas of Australia, was reported in the chosen studies. Several barriers to healthcare access for rural populations were identified, including lack of informed leadership, inadequate clinical governance, limited awareness of modern care models, suboptimal workforce planning and resource utilisation, incorrect risk perception, and insufficient community engagement.</p><p>In conclusion, there is an urgent need to address healthcare disparities and improve service accessibility in Australia's rural and remote areas.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"11 ","pages":"Article 100158"},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000114/pdfft?md5=a8e3569a392efe80df6faae087c7415c&pid=1-s2.0-S2772632024000114-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140103388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Looking at the bright future of health sciences review","authors":"Pooja A. Chawla ,&nbsp;Burcin Ekser","doi":"10.1016/j.hsr.2024.100165","DOIUrl":"10.1016/j.hsr.2024.100165","url":null,"abstract":"","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"10 ","pages":"Article 100165"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000187/pdfft?md5=d664bd1d8c03cee6cb8fdb058167f330&pid=1-s2.0-S2772632024000187-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140270044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social needs of individuals with multimorbidity: A meta-synthesis","authors":"Ahtisham Younas ,&nbsp;Muhammad Ayaz ,&nbsp;Marco Di Nitto ,&nbsp;Esther Nyangate Monari ,&nbsp;Alberto Dal Molin ,&nbsp;Angela Durante","doi":"10.1016/j.hsr.2024.100154","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100154","url":null,"abstract":"<div><p>Social needs refer to the needs associated with the downstream influence of sociocultural and economic determinants affecting the availability of basic amenities, services, and health and social care programs and policies. Social needs are instrumental in shaping the lives and health behaviours of individuals with multimorbidity. Previous reviews explored the care needs, treatment, and support in individuals with multimorbidity. However, the social needs of this population are poorly understood. This review aimed to develop a comprehensive understanding social needs of individuals living with multimorbidity. A meta-synthesis was conducted. Literature was searched within eight databases including gray literature databases. In total, 31 studies published from January 2010 to May 2023 were included in the synthesis. Thematic synthesis approach was used to develop analytical themes and the themes were then mapped to Bradshaw's (1972) taxonomy of social needs. The felt needs included: <em>Requiring strong social network to combat disease-associated challenges and combat social isolation &amp; Need for readily available health and social care assistance. The expressed and comparative needs included: Need for improved health insurance to compensate for disease related expenses</em> and <em>need for social action to address unfair societal behaviors.</em> Individuals with multimorbidity sought improved social connectedness and access to readily available health and social care resources. Social stigma associated with disease, race, disability, and physical appearance affects the meeting of individuals' general and health care related social needs.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"10 ","pages":"Article 100154"},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000072/pdfft?md5=379cbc9cc1519a01941bcbf24e44c6e2&pid=1-s2.0-S2772632024000072-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139719039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External fixation versus intramedullary nailing for the treatment of open tibial shaft fractures: A meta-analysis of randomized controlled trials","authors":"Zhao Chen,&nbsp;Rong Luo,&nbsp;Fei Xing,&nbsp;Zhou Xiang","doi":"10.1016/j.hsr.2024.100152","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100152","url":null,"abstract":"<div><p>The aim of this study is to compare external fixation versus intramedullary (IM) nailing to determine which strategy was more suitable for patients with open tibial shaft fractures. Eleven RCTs that compared the therapeutic outcomes between external fixation and IM nailing in patients suffering from open tibial shaft fractures were screened out from the PubMed, Embase, and Cochrane Library in this analysis. For open tibia fractures of Gustilo-Anderson I-IIIA, significantly lower incidence of malunion and superficial infection was revealed for the IM nailing group when compared with the external fixation group. Further subgroup analyses within I-IIIA fractures showed comparable results between fractures managed with IM nails and ring external fixators. In conclusion, IM nailing is recommended over external fixation for open tibia fractures of I-IIIA. In addition, the use of ring external fixators may be more suitable than the ordinary external fixators for the treatment of I-IIIA fractures.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"10 ","pages":"Article 100152"},"PeriodicalIF":0.0,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000059/pdfft?md5=2b93b124d6a54218043ac4bce26082e3&pid=1-s2.0-S2772632024000059-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139714762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does surgery with metallic implants achieve better outcomes than non-operative treatment or more novel techniques following patella fracture in the frail host?–A systematic review","authors":"Timothy M. Morris ,&nbsp;Jan R. Dixon ,&nbsp;Thomas E. Baldock ,&nbsp;Willy Wang ,&nbsp;William G.P. Eardley","doi":"10.1016/j.hsr.2024.100153","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100153","url":null,"abstract":"<div><p>Patella fractures are uncommon injuries but in frail patients they may confer significant morbidity. Tension band metallic wiring (TBW) is frequently employed to manage these injuries yet complication rates are high. Up to one-third of patients require reoperation. In the frail host especially, patella fractures can result in significant functional impairment impacting on independence. Using the PRISMA guidelines, this systematic review interrogates the literature on patella fractures in the frail host. The evidence was found to be minimal and of low quality, comprising only eight cohort studies or case series. Sample sizes were small; in half of the included studies, 16 participants or less were included. 2493 patients were included from all extracted studies. The average age of patients was 71 years old with 60.5 % being female. AO/OTA 34-C2/3 fractures were the most common fracture patterns, comprising 41 % of patients. Current literature suggests that computed tomography (CT) scanning pre-operatively is appropriate. Marked heterogeneity was found in operative strategy; both metallic and non-metallic implants were investigated but metallic TBW and cerclage were the most prevalent techniques. Only one study investigated non-operative treatment. More than one in four patients (26.59 %) required reoperation and over one in five patients (22.53 %) suffered hardware complications. Average range of movement achieved was 121.28° +/- 13° but the investigation of other outcome measures was inconsistent. Further investigation into both patella fractures and, more specifically patella fractures in the poor host, is warranted. Nevertheless, due to its limited incidence, a multicentre approach is required and should be considered a priority for the orthopaedic community.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"10 ","pages":"Article 100153"},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000060/pdfft?md5=cca6ad48baeb5d37320a2ba06da46a90&pid=1-s2.0-S2772632024000060-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139709559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The treasure trove of the genus Carex: A phytochemical and pharmacological review","authors":"Rahul Gajbhiye ,&nbsp;Shreya Sen Sarma ,&nbsp;Deepak Kumar ,&nbsp;Sanjiv Singh","doi":"10.1016/j.hsr.2024.100151","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100151","url":null,"abstract":"<div><p><em>Carex</em> genus contains over 2000 species distributed all around the globe and used for their medicinal and food values. Owing to their traditional and medicinal properties the genus has gained due attention, especially in the last couple of decades which led to the identification of terpenoids, lignans, quinazolinones, phenolic acids, and phenylpropanoids as the major phytochemicals. Besides these several studies reported the therapeutic applications of the extracts and phytochemicals in different experimental conditions. The present review aims to present a comprehensive overview of the present standing of <em>Carex</em> genus that may promote further scientific exploration and their utilization.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"10 ","pages":"Article 100151"},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000047/pdfft?md5=9e2da5461c9ebfbb427c8075d99438b3&pid=1-s2.0-S2772632024000047-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139714761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards integration of artificial intelligence into medical devices as a real-time recommender system for personalised healthcare: State-of-the-art and future prospects","authors":"Talha Iqbal ,&nbsp;Mehedi Masud ,&nbsp;Bilal Amin ,&nbsp;Conor Feely ,&nbsp;Mary Faherty ,&nbsp;Tim Jones ,&nbsp;Michelle Tierney ,&nbsp;Atif Shahzad ,&nbsp;Patricia Vazquez","doi":"10.1016/j.hsr.2024.100150","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100150","url":null,"abstract":"<div><p>In the era of big data, artificial intelligence (AI) algorithms have the potential to revolutionize healthcare by improving patient outcomes and reducing healthcare costs. AI algorithms have frequently been used in health care for predictive modelling, image analysis and drug discovery. Moreover, as a recommender system, these algorithms have shown promising impacts on personalized healthcare provision. A recommender system learns the behaviour of the user and predicts their current preferences (recommends) based on their previous preferences. Implementing AI as a recommender system improves this prediction accuracy and solves cold start and data sparsity problems. However, most of the methods and algorithms are tested in a simulated setting which cannot recapitulate the influencing factors of the real world. This review article systematically reviews prevailing methodologies in recommender systems and discusses the AI algorithms as recommender systems specifically in the field of healthcare. It also provides discussion around the most cutting-edge academic and practical contributions present in the literature, identifies performance evaluation matrices, challenges in the implementation of AI as a recommender system, and acceptance of AI-based recommender systems by clinicians. The findings of this article direct researchers and professionals to comprehend currently developed recommender systems and the future of medical devices integrated with real-time recommender systems for personalized healthcare.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"10 ","pages":"Article 100150"},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000035/pdfft?md5=186657276eb1c8c06c8cb477e66360a1&pid=1-s2.0-S2772632024000035-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139674814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescents’ mental health in low- and middle-income countries","authors":"Anila Naz Ali Sher","doi":"10.1016/j.hsr.2024.100149","DOIUrl":"10.1016/j.hsr.2024.100149","url":null,"abstract":"","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"10 ","pages":"Article 100149"},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000023/pdfft?md5=22e8f74f536162eb9ec0e65626ab7b83&pid=1-s2.0-S2772632024000023-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139640839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk and protective factors that predict posttraumatic stress disorder after traumatic injury: A systematic review","authors":"Kristen Jones ,&nbsp;Mark Boschen ,&nbsp;Grant Devilly ,&nbsp;Jessica Vogler ,&nbsp;Harley Flowers ,&nbsp;Charlotte Winkleman ,&nbsp;Martin Wullschleger","doi":"10.1016/j.hsr.2023.100147","DOIUrl":"https://doi.org/10.1016/j.hsr.2023.100147","url":null,"abstract":"<div><p>Posttraumatic stress disorder (PTSD) is one of the most common psychiatric disorders following traumatic injury, affecting up to 51 % of adults admitted to trauma centres. Identification of people at risk of PTSD is an important component of holistic, evidence-based care in trauma centres. This is also increasingly becoming a recommendation across Level 1 Trauma Centres worldwide. The purpose of this paper was to systematically review published literature regarding factors that increase or decrease one's risk of PTSD within a year of admission to a trauma hospital. Systematic review methodology was implemented with utilisation of extensive search criteria. This broadened search strategy was used to address some identified limitations in titles and abstracts of relevant papers. Forward and backward citation of included papers was implemented to ascertain secondary sources. Titles, abstracts, and full texts were independently reviewed by two authors. Sixty-one papers met inclusion criteria and 58 predictors were analysed with at least one analysis. There was strong scientific evidence for assault, acute stress disorder, and baseline pain as predictors of PTSD. There was strong scientific evidence that age, education, ethnicity, premorbid health concerns, marital status, injury severity, mechanism of injury, and length of stay were <em>not</em> predictors. Several methodological concerns were identified across the included papers, such as heterogeneity in operational definitions of predictors and lack of application to theoretical frameworks of PTSD. Gaps remain in the literature regarding the impact of risk factors included in well-known frameworks such as the cognitive model of PTSD, requiring future research to inform appropriate early intervention in this at-risk population.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"10 ","pages":"Article 100147"},"PeriodicalIF":0.0,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632023000739/pdfft?md5=3523b2298d4fe9c019b857732ccad358&pid=1-s2.0-S2772632023000739-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139653660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}