Health sciences review (Oxford, England)最新文献

{"title":"Provision of telehealth services to pediatric clients during the COVID-19 pandemic: A scoping review related to health outcomes","authors":"Gergana Damianova Kodjebacheva ,&nbsp;Taylor Culinski ,&nbsp;Bushra Kawser ,&nbsp;Saman Amin","doi":"10.1016/j.hsr.2024.100156","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100156","url":null,"abstract":"<div><h3>Objective</h3><p>The objective was to conduct a scoping review of interventions on health outcomes among pediatric populations with a variety of health conditions with comparison groups where at least one group was receiving telehealth services during a period within the COVID-19 pandemic.</p></div><div><h3>Methods</h3><p>Utilizing the PubMed, Embase, PsycInfo, and CINAHL databases, peer-reviewed studies in English on health outcomes following interventions where at least one group was receiving telehealth services were identified. Interventions could have either quasi-experimental designs with at least two groups or randomized designs. No limitations were placed on the health outcomes included in this review. Studies were restricted to those conducted during a period within the COVID-19 pandemic (i.e., published until December 5, 2022). The reporting in this registered scoping review was guided by the standards of the Preferred Reporting Items for Systematic Review and Meta-Analysis Statement Extension for Scoping Reviews (PRISMA-ScR). For the purpose of data charting, information on participant descriptive characteristics and intervention strategies, outcomes, and findings was extracted.</p></div><div><h3>Results</h3><p>Ten articles met the criteria from our search on December 5, 2022. Various conditions were represented, such as autism spectrum disorder, Duchenne muscular dystrophy, Tourette syndrome, and other physical, mental, and developmental disorders. A total of 4 studies were randomized-controlled trials (RCTs), and the remaining 6 had quasi-experimental designs. Comparison groups received in-person visits, mixed-mode services, different telehealth services, or wait-list interventions. In 6 out of the 8 studies with defined outcomes that were quantified, children receiving telehealth services had statistically significant better health outcomes compared to those in control groups. In 2 of these 8 studies, children receiving telehealth services had either better though not statistically significant health outcomes or had similar health outcomes compared to those in control groups. Examples of health outcome improvements with telehealth use were lower hyperactivity levels, increased muscular strength, and a decrease in tic severity.</p></div><div><h3>Conclusion</h3><p>Health outcome improvements with telehealth use tended to be similar to or superior than those in the control group. Additional investigations, especially RCTs, are advised.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"11 ","pages":"Article 100156"},"PeriodicalIF":0.0,"publicationDate":"2024-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000096/pdfft?md5=fc7f501120d4a5a7f35e91cff473b99c&pid=1-s2.0-S2772632024000096-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140320937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning for siRNA efficiency prediction: A systematic review","authors":"Dominic D. Martinelli","doi":"10.1016/j.hsr.2024.100157","DOIUrl":"10.1016/j.hsr.2024.100157","url":null,"abstract":"<div><p>Therapeutic applications of small interfering RNAs (siRNAs) have recently facilitated advancements in the biopharmaceutical industry, expanding opportunities for pharmacological intervention to targets previously deemed “undruggable.” Hence, determining rational design principles to inform the selection of effective siRNA sequences and appropriate chemical modifications has been a significant undertaking in the field. To accelerate the process of empirical siRNA design, machine learning (ML) techniques have been applied to the problem of siRNA efficacy prediction. This systematic review provides a comprehensive, yet succinct overview of advancements in this ML task by examining the evolution of model architectures trained to predict siRNA efficacy, features selected to represent individual samples and inform predictions, and the challenges associated with the use of ML in the context of therapeutic siRNA discovery. Consensus and conflict throughout the literature are discussed, promoting a nuanced understanding of this problem. Finally, the vast potential for future directions is addressed, supporting further research in computational biomedicine.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"11 ","pages":"Article 100157"},"PeriodicalIF":0.0,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000102/pdfft?md5=e15194de59769fe7dc7978c299f39da7&pid=1-s2.0-S2772632024000102-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140272437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cipaglucosidase alfa-atga: Unveiling new horizons in Pompe disease therapy","authors":"Arshdeep Singh ,&nbsp;Rabin Debnath ,&nbsp;Aniket Saini ,&nbsp;Kushal Seni ,&nbsp;Anjali Sharma ,&nbsp;Deepak Singh Bisht ,&nbsp;Viney Chawla ,&nbsp;Pooja A Chawla","doi":"10.1016/j.hsr.2024.100160","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100160","url":null,"abstract":"<div><p>Pompe disease is a lysosomal storage disease characterized by impaired glycogen breakdown due to an acid α-glucosidase (GAA) enzyme deficiency. Without therapy, children with the severe infantile form do not survive past their first year of life. POMBILITI which is intended to treat late-onset Pompe disease. The enzyme cipaglucosidase alfa-atga, which is produced from Chinese Hamster Ovary (CHO) cells, is a component of this novel drug. This enzyme is produced using a highly developed process known as perfusion methodology. Recombinant human α-glucosidase (rhGAA) is expressed and produced in CHO cells using the perfusion process. This drug helps to treat Pompe disease by the breakdown of glycogen within lysosomes. Late-onset Pompe disease is characterized by a deficiency in Alpha glucosidase, leading to the accumulation of glycogen within lysosomes and subsequent cellular dysfunction. POMBILITI's targeted approach involves the administration of the rhGAA enzyme, providing a therapeutic replacement for the deficient natural enzyme. This drug aims to restore the normal physiological function of lysosomes, thereby mitigating the impact of Pompe disease on affected individuals. The current study is focused on the drug cipaglucosidase alfa-atga which the FDA has approved for the treatment of Pompe disease on 28 September 2023.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"11 ","pages":"Article 100160"},"PeriodicalIF":0.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000138/pdfft?md5=3bdff161a233a6477caa05ad78ea5831&pid=1-s2.0-S2772632024000138-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140141465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence following perineal proctosigmoidectomy with levatorplasty: Review and meta-analyses","authors":"Sahil Sharma ,&nbsp;Tyler McKechnie ,&nbsp;Jigish Khamar ,&nbsp;Simarpreet Ichhpuniani ,&nbsp;Cagla Eskicioglu","doi":"10.1016/j.hsr.2024.100159","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100159","url":null,"abstract":"<div><h3>Background</h3><p>Full-thickness rectal prolapse remains a challenging pathology to correct surgically with significant recurrence rates. Among perineal approaches, the proctosigmoidectomy with levatorplasty, commonly referred to as the Altemeier procedure is frequently performed. The addition of levatorplasty has been postulated to improve recurrence rates, however, its efficacy varies across studies. The aim of this study was to systematically review recurrence rates following proctosigmoidectomy with levatorplasty, and to meta-analyze pooled data comparing recurrence rates between proctosigmoidectomy with and without a levatorplasty.</p></div><div><h3>Methods</h3><p>A search of EMBASE, OVID Medline, and CENTRAL was performed from database inception to October 2021 aimed at identifying studies investigating recurrences of rectal prolapse following proctosigmoidectomy with levatorplasty. Primary endpoint was recurrence of rectal prolapse. Articles that did not report this endpoint or did not evaluate proctosigmoidectomy with levatorplasty were excluded. A pairwise meta-analysis was performed using Mantel-Haenszel random effects.</p></div><div><h3>Results</h3><p>From 200 citations, 14 primary studies met inclusion criteria. A total of 620 patients (88.9% female, mean age: 71 years) underwent proctosigmoidectomy with levatorplasty, and 117 without levatorplasty. Of the patients undergoing levatorplasty, 86 (13.8%) experienced a recurrence. Mean follow up was 46 months. Meta-analysis comparing recurrence rates between proctosigmoidectomy with and without levatorplasty demonstrated no significant difference (RR 0.80, 0.92, 95% CI 0.32–2.59, <em>P</em> = 0.87, I² = 77%). Narrative review of postoperative quality of life metrics demonstrated decreased incontinence with levatorplasty as measured by Wexner and ICIQ-SIF scores.</p></div><div><h3>Discussion</h3><p>The addition of a levatorplasty does not significantly reduce the risk of recurrent rectal prolapse after proctosigmoidectomy, however it may improve postoperative continence.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"11 ","pages":"Article 100159"},"PeriodicalIF":0.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000126/pdfft?md5=0bff61fa4e5809c0a358e299824171a3&pid=1-s2.0-S2772632024000126-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140134604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-ECG predictors of atrial fibrillation in ischaemic stroke: A systematic review","authors":"Luke Bonavia ,&nbsp;Alexander Berry-Noronha ,&nbsp;Edmund Song ,&nbsp;Daniel Grose ,&nbsp;Damian Johnson ,&nbsp;Erin Maylin ,&nbsp;Ramesh Sahathevan","doi":"10.1016/j.hsr.2024.100161","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100161","url":null,"abstract":"<div><p>The use of novel biomarkers to predict future atrial fibrillation (AF) risk may aid decision making with anti-coagulant therapy for stroke prevention. The purpose of our study was to determine whether quantitative echocardiography, blood tests, imaging, anthropometry are predictive of atrial fibrillation. Electrocardiography was not the scope of this review.</p><p>Incremental increases in atrial volume and atrial diameter were most commonly associated with AF development. Likewise, incremental Brain Natriuretic Peptide (BNP) and N-terminal pro-(BNP) levels also correlate with AF risk. Anthropometric predictors such as BMI, lean mass and fat mass were also predictive of AF. Of studies reporting stroke topology, the presence of cortical infarcts, posterior circulation infarcts, multi-territory infarcts were independently predictive of AF.</p><p>Newer echocardiographic techniques such as atrial and ventricular strain analysis were shown to be predictive of AF in multiple studies. Use of these biomarkers in composite scoring systems may accurately predict AF development and further help stratify patients that may benefit from anticoagulation for stroke prevention.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"11 ","pages":"Article 100161"},"PeriodicalIF":0.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277263202400014X/pdfft?md5=a67a8998e291d8330439da5cfb70b759&pid=1-s2.0-S277263202400014X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140160650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ESKAPE pathogens and associated quorum sensing systems: New targets for novel antimicrobials development","authors":"Christiana E. Aruwa,&nbsp;Theolyn Chellan,&nbsp;Nosipho W. S'thebe,&nbsp;Yamkela Dweba,&nbsp;Saheed Sabiu","doi":"10.1016/j.hsr.2024.100155","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100155","url":null,"abstract":"<div><p>Globally, antimicrobial (AMR) or multi-drug resistance (MDR) constitutes a current health challenge that is predicted to cause increased infections rates with adverse socioeconomic impacts through increase in healthcare costs. In addition, the group of <em>Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa</em> and <em>Enterobacter</em> spp. (ESKAPE) pathogens cause debilitating infections (community and nosocomial) and are classed as priority 1 AMR pathogens. This systematic report therefore aimed at providing detailed coverage of new targets for novel antimicrobials development against MDR ESKAPE pathogens to mitigate future AMR spread and improve current public health indices. The prevalent ESKAPE bacterial group show high resistance to quinolones, lactams, cephalosporins, carbapenems and other antibiotic groups, and ability to form biofilms linked to various quorum sensing systems (QSSs) that boost their virulence. These QS pathways have become viable targets in drug design efforts for new antimicrobials development. Also, since antibiotics discovery and development has waned in the past decade, the emergence of advanced computational modelling technologies in drug design, repurposing and development efforts may yet bridge the gap. As such, in this work we provided a comprehensive and systematic overview using relevant, included data and findings on ESKAPE pathogens, their QSSs to target for novel antimicrobial agents’ development, the contributions of computational tools at the heart of novel antimicrobial advancements and their roles in bioprospecting and developing novel ‘druggable’ candidates and therapies with anti-biofilm, and anti-quorum sensing activities to mitigate AMR, biofilm and QS-related pathogenicity factors.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"11 ","pages":"Article 100155"},"PeriodicalIF":0.0,"publicationDate":"2024-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000084/pdfft?md5=8d2b08b397c1f7fd490e9c87327382dd&pid=1-s2.0-S2772632024000084-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140141464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status of tertiary healthcare services and its accessibility in rural and remote Australia: A systematic review","authors":"Mazen Baazeem ,&nbsp;Estie Kruger ,&nbsp;Marc Tennant","doi":"10.1016/j.hsr.2024.100158","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100158","url":null,"abstract":"<div><p>The study evaluated the current state and accessibility of tertiary healthcare services in rural Australia. A systematic literature review from 2010 to 2022 was undertaken, utilising databases such as PubMed, MEDLINE, Cochrane Library, ProQuest, and Google Scholar. The PRISMA method was employed to retrieve an initial total of 4768 papers. Upon removal of 2806 duplicates and 1587 irrelevant records, 1962 articles were screened. From these, 375 were assessed for eligibility, leading to the inclusion of eleven studies in the systematic review. Criteria for exclusion included a focus on primary and secondary healthcare, absence of peer review, and unclear methodology.</p><p>A collective survey of 230,339 individuals, focusing on access to tertiary healthcare in rural and remote areas of Australia, was reported in the chosen studies. Several barriers to healthcare access for rural populations were identified, including lack of informed leadership, inadequate clinical governance, limited awareness of modern care models, suboptimal workforce planning and resource utilisation, incorrect risk perception, and insufficient community engagement.</p><p>In conclusion, there is an urgent need to address healthcare disparities and improve service accessibility in Australia's rural and remote areas.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"11 ","pages":"Article 100158"},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000114/pdfft?md5=a8e3569a392efe80df6faae087c7415c&pid=1-s2.0-S2772632024000114-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140103388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Looking at the bright future of health sciences review","authors":"Pooja A. Chawla ,&nbsp;Burcin Ekser","doi":"10.1016/j.hsr.2024.100165","DOIUrl":"10.1016/j.hsr.2024.100165","url":null,"abstract":"","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"10 ","pages":"Article 100165"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000187/pdfft?md5=d664bd1d8c03cee6cb8fdb058167f330&pid=1-s2.0-S2772632024000187-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140270044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social needs of individuals with multimorbidity: A meta-synthesis","authors":"Ahtisham Younas ,&nbsp;Muhammad Ayaz ,&nbsp;Marco Di Nitto ,&nbsp;Esther Nyangate Monari ,&nbsp;Alberto Dal Molin ,&nbsp;Angela Durante","doi":"10.1016/j.hsr.2024.100154","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100154","url":null,"abstract":"<div><p>Social needs refer to the needs associated with the downstream influence of sociocultural and economic determinants affecting the availability of basic amenities, services, and health and social care programs and policies. Social needs are instrumental in shaping the lives and health behaviours of individuals with multimorbidity. Previous reviews explored the care needs, treatment, and support in individuals with multimorbidity. However, the social needs of this population are poorly understood. This review aimed to develop a comprehensive understanding social needs of individuals living with multimorbidity. A meta-synthesis was conducted. Literature was searched within eight databases including gray literature databases. In total, 31 studies published from January 2010 to May 2023 were included in the synthesis. Thematic synthesis approach was used to develop analytical themes and the themes were then mapped to Bradshaw's (1972) taxonomy of social needs. The felt needs included: <em>Requiring strong social network to combat disease-associated challenges and combat social isolation &amp; Need for readily available health and social care assistance. The expressed and comparative needs included: Need for improved health insurance to compensate for disease related expenses</em> and <em>need for social action to address unfair societal behaviors.</em> Individuals with multimorbidity sought improved social connectedness and access to readily available health and social care resources. Social stigma associated with disease, race, disability, and physical appearance affects the meeting of individuals' general and health care related social needs.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"10 ","pages":"Article 100154"},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000072/pdfft?md5=379cbc9cc1519a01941bcbf24e44c6e2&pid=1-s2.0-S2772632024000072-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139719039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External fixation versus intramedullary nailing for the treatment of open tibial shaft fractures: A meta-analysis of randomized controlled trials","authors":"Zhao Chen,&nbsp;Rong Luo,&nbsp;Fei Xing,&nbsp;Zhou Xiang","doi":"10.1016/j.hsr.2024.100152","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100152","url":null,"abstract":"<div><p>The aim of this study is to compare external fixation versus intramedullary (IM) nailing to determine which strategy was more suitable for patients with open tibial shaft fractures. Eleven RCTs that compared the therapeutic outcomes between external fixation and IM nailing in patients suffering from open tibial shaft fractures were screened out from the PubMed, Embase, and Cochrane Library in this analysis. For open tibia fractures of Gustilo-Anderson I-IIIA, significantly lower incidence of malunion and superficial infection was revealed for the IM nailing group when compared with the external fixation group. Further subgroup analyses within I-IIIA fractures showed comparable results between fractures managed with IM nails and ring external fixators. In conclusion, IM nailing is recommended over external fixation for open tibia fractures of I-IIIA. In addition, the use of ring external fixators may be more suitable than the ordinary external fixators for the treatment of I-IIIA fractures.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"10 ","pages":"Article 100152"},"PeriodicalIF":0.0,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000059/pdfft?md5=2b93b124d6a54218043ac4bce26082e3&pid=1-s2.0-S2772632024000059-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139714762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}