Ashish Gera , Laxmi Yadav , Chandragauda R. Patil , Mahesh K. Posa , Bandapally Chandrakanth , Sachin Kumar
{"title":"Oroxylin A: Nature's arsenal against liver fibrosis, cancer, and inflammatory diseases","authors":"Ashish Gera , Laxmi Yadav , Chandragauda R. Patil , Mahesh K. Posa , Bandapally Chandrakanth , Sachin Kumar","doi":"10.1016/j.hsr.2023.100143","DOIUrl":null,"url":null,"abstract":"<div><p>Oroxylin A (ORA), a natural compound found in plants, has emerged as a promising therapeutic agent against liver fibrosis, cancer, and inflammatory diseases. Chronic inflammation fuels cancer development and progression by promoting cellular transformation, survival, invasion, and metastasis, while cancer can create an inflammatory microenvironment, further enhancing its growth and invasiveness. Inflammasome activation also plays a crucial role in liver fibrosis which is characterized by the abnormal accumulation of extracellular matrix components in the liver. This review aims to explore the efficacy of ORA and its mechanisms of action in these disease contexts. ORA targets hepatic stellate cells, key players in the development of liver fibrosis. By modulating signaling pathways such as transforming growth factor-beta (TGF-β), mitogen-activated protein kinase (MAPK) pathways, and nuclear factor-kappa B (NF-κB), ORA effectively inhibits HSC activation and reduces the production of excessive extracellular matrix proteins. ORA exhibits a multitude of beneficial effects in cancer treatment. It demonstrates anti-proliferative, pro-apoptotic, anti-metastatic, and anti-angiogenic properties by interfering with various molecular pathways involved in cancer progression. ORA displays anti-inflammatory properties by suppressing the production of proinflammatory cytokines and influencing signaling pathways. This mechanism allows ORA to mitigate inflammation, a hallmark of many diseases, including inflammatory conditions. The therapeutic potential of ORA opens up new avenues for drug discovery and development. Ongoing research focuses on exploring new plant sources and novel compounds to expand the range of natural therapeutic candidates. Overall, this review highlights the comprehensive potential of ORA as a safe therapeutic agent. In the field of chronic diseases, ORA has demonstrated anti-inflammatory, anti-fibrotic, and anti-cancer potentials, making it an interesting compound for research</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"10 ","pages":"Article 100143"},"PeriodicalIF":0.0000,"publicationDate":"2023-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632023000697/pdfft?md5=422d9834d4daf007d6b850421f21f9cb&pid=1-s2.0-S2772632023000697-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Health sciences review (Oxford, England)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772632023000697","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Oroxylin A (ORA), a natural compound found in plants, has emerged as a promising therapeutic agent against liver fibrosis, cancer, and inflammatory diseases. Chronic inflammation fuels cancer development and progression by promoting cellular transformation, survival, invasion, and metastasis, while cancer can create an inflammatory microenvironment, further enhancing its growth and invasiveness. Inflammasome activation also plays a crucial role in liver fibrosis which is characterized by the abnormal accumulation of extracellular matrix components in the liver. This review aims to explore the efficacy of ORA and its mechanisms of action in these disease contexts. ORA targets hepatic stellate cells, key players in the development of liver fibrosis. By modulating signaling pathways such as transforming growth factor-beta (TGF-β), mitogen-activated protein kinase (MAPK) pathways, and nuclear factor-kappa B (NF-κB), ORA effectively inhibits HSC activation and reduces the production of excessive extracellular matrix proteins. ORA exhibits a multitude of beneficial effects in cancer treatment. It demonstrates anti-proliferative, pro-apoptotic, anti-metastatic, and anti-angiogenic properties by interfering with various molecular pathways involved in cancer progression. ORA displays anti-inflammatory properties by suppressing the production of proinflammatory cytokines and influencing signaling pathways. This mechanism allows ORA to mitigate inflammation, a hallmark of many diseases, including inflammatory conditions. The therapeutic potential of ORA opens up new avenues for drug discovery and development. Ongoing research focuses on exploring new plant sources and novel compounds to expand the range of natural therapeutic candidates. Overall, this review highlights the comprehensive potential of ORA as a safe therapeutic agent. In the field of chronic diseases, ORA has demonstrated anti-inflammatory, anti-fibrotic, and anti-cancer potentials, making it an interesting compound for research
Oroxylin A（ORA）是一种存在于植物中的天然化合物，已成为一种治疗肝纤维化、癌症和炎症性疾病的有效药物。慢性炎症可促进细胞转化、存活、侵袭和转移，从而助长癌症的发展和恶化，而癌症可创造炎症微环境，进一步增强其生长和侵袭能力。炎症小体的激活在肝纤维化中也起着至关重要的作用，肝纤维化的特点是肝脏中细胞外基质成分的异常积累。本综述旨在探讨 ORA 在这些疾病中的疗效及其作用机制。ORA靶向肝星状细胞，它们是肝纤维化发展过程中的关键角色。通过调节信号通路，如转化生长因子-β（TGF-β）、丝裂原活化蛋白激酶（MAPK）通路和核因子-卡巴B（NF-κB），ORA能有效抑制造血干细胞的活化，减少过量细胞外基质蛋白的产生。ORA 在癌症治疗中表现出多种有益作用。它通过干扰涉及癌症进展的各种分子途径，具有抗增殖、促凋亡、抗转移和抗血管生成的特性。ORA 可抑制促炎细胞因子的产生并影响信号通路，从而具有抗炎特性。这种机制使 ORA 能够减轻炎症，而炎症是包括炎症在内的许多疾病的标志。ORA 的治疗潜力为药物发现和开发开辟了新途径。目前的研究重点是探索新的植物来源和新型化合物，以扩大天然候选疗法的范围。总之，本综述强调了 ORA 作为一种安全治疗剂的综合潜力。在慢性疾病领域，ORA 具有抗炎、抗纤维化和抗癌潜力，是一种值得研究的化合物。
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