Health sciences review (Oxford, England)最新文献

{"title":"The impact of reduced perineal lacerations during delivery: A systematic review","authors":"Li-Li Chen ,&nbsp;Meei-Ling Gau ,&nbsp;Mei-Zen Huang ,&nbsp;Chin-Hsing Tsai ,&nbsp;Fang-Ting Chang","doi":"10.1016/j.hsr.2024.100204","DOIUrl":"10.1016/j.hsr.2024.100204","url":null,"abstract":"<div><div>Various interventions to reduce perineal lacerations during childbirth have been reported, but no systematic assessment of each intervention's impact has been conducted. This study conducted an umbrella review to describe and categorize various interventions for preventing perineal lacerations and evaluate their outcomes.</div><div>The review included studies on perineal laceration interventions during childbirth from existing quantitative systematic reviews, with or without meta-analysis. A comprehensive search conducted up to September 2023 spanned eight bibliometric databases and gray literature sources. Two reviewers independently assessed five systematic reviews using the Joanna Briggs Institute checklist and extracted data with a standardized tool. Findings were summarized in a tabular format with supporting text.</div><div>Of the 57 articles initially shortlisted, six were selected for in-depth analysis. These reviews included 77 randomized controlled trials involving 27,782 patients. Perineal massages and antenatal pelvic floor exercises were identified as the most effective interventions, both of which shortened the second stage of labor and reduced laceration rates. The efficacy of other interventions remains uncertain due to limited research. Future studies should explore the impact of varying intensities and frequencies of perineal massages throughout pregnancy. Integrating these practices into antenatal education and routine midwifery care could further improve clinical outcomes and prevent perineal lacerations during labor.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"13 ","pages":"Article 100204"},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revitalizing respiration: A comprehensive review of oxygen therapy in interstitial lung diseases","authors":"Alaa Ramadan ,&nbsp;Alaa R. Ashour ,&nbsp;Alaa M. Sadek ,&nbsp;Esraa Zakaria ,&nbsp;Eman Zakaria ,&nbsp;Aya Abdelhafez Hasan ,&nbsp;Doaa A. Salah ,&nbsp;Omnia Abdelfattah ,&nbsp;Aml Kamal ,&nbsp;Esraa Salah ,&nbsp;Abdelrahman M. Elettreby ,&nbsp;Mohamed Abouzid ,&nbsp;Amogh verma ,&nbsp;Nathan Ezie Kengo ,&nbsp;Eptehal Dongol","doi":"10.1016/j.hsr.2024.100202","DOIUrl":"10.1016/j.hsr.2024.100202","url":null,"abstract":"<div><div>Interstitial Lung Diseases (ILDs) encompass a diverse group of disorders characterised by inflammation and fibrosis, leading to significant impairment in lung function and quality of life. With the increasing prevalence of ILDs, managing these conditions has become a pressing medical and economic challenge. Oxygen therapy is crucial in ILD management, offering benefits beyond hypoxemia correction, including symptom relief and potential influence on disease progression. However, patient compliance, long-term use, side effects, and the psychosocial impact of therapy present ongoing challenges. This narrative review examines the critical role of oxygen therapy in ILDs, highlighting its current applications, associated challenges, and emerging innovations such as targeted therapies, personalized oxygen delivery, and advancements in technology that promise to enhance patient care in this complex field.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"13 ","pages":"Article 100202"},"PeriodicalIF":0.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142427387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the intricacies of immune system dysfunction and its impact on diabetes mellitus: Revisiting the communication strategies to manage diabetes mellitus","authors":"Vaibhav ,&nbsp;Saikh Shireen Nishad ,&nbsp;Dipali Dongare ,&nbsp;Adhrit Chandra Pati Tripathi ,&nbsp;Tripti Tripathi ,&nbsp;Pratima Tripathi","doi":"10.1016/j.hsr.2024.100201","DOIUrl":"10.1016/j.hsr.2024.100201","url":null,"abstract":"<div><div>Type 2 diabetes mellitus (T2DM) is a prevalent chronic condition, accounting for over 90% of diabetes cases globally, characterized by insulin resistance and chronic hyperglycemia. Beyond metabolic dysfunction, T2DM is associated with significant immune system alterations, including impaired macrophage, neutrophil, and natural killer cell functions. These immune dysfunctions contribute to increased susceptibility to infections, inflammation, and complications in diabetic individuals. Chronic hyperglycemia triggers an inflammatory response that weakens the body's immune defenses, further complicating disease management. This review delves into the intricate interplay between T2DM and the immune system, emphasizing how immune cell dysfunction exacerbates insulin resistance and impacts infection control. It also explores the role of pro-inflammatory markers and cellular responses in T2DM pathophysiology. Additionally, the article examines innovative strategies for managing T2DM, such as personalized medicine, telemedicine, and artificial intelligence. Personalized medicine tailors treatment to individual genetic, environmental, and lifestyle factors, while telemedicine facilitates remote monitoring and care. Artificial intelligence aids in early detection, personalized treatment plans, and enhanced patient management. By addressing both immune system alterations and advanced management strategies, this article provides a comprehensive understanding of T2DM and advocates for a more integrated approach to improve outcomes and patient care.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"13 ","pages":"Article 100201"},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142327792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing menopause management: Nonhormonal therapy for vasomotor symptoms","authors":"Shanzey Rai ,&nbsp;Natalia Aslam Khan","doi":"10.1016/j.hsr.2024.100200","DOIUrl":"10.1016/j.hsr.2024.100200","url":null,"abstract":"","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"13 ","pages":"Article 100200"},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000539/pdfft?md5=8857f209d392c804918acb0ef662b049&pid=1-s2.0-S2772632024000539-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142313064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing the power of natural products against bacterial urinary tract infections: A perspective review for cultivating solutions","authors":"Rahima Tanbin Tama ,&nbsp;Md. Sakhawat Hossain ,&nbsp;Md. Ashikur Rahaman ,&nbsp;Md. Ashraful Alam ,&nbsp;Md-Mafizur Rahman ,&nbsp;Anzana Parvin ,&nbsp;Rifaia Sultana Chowdhury ,&nbsp;Md. Shahidul Islam","doi":"10.1016/j.hsr.2024.100199","DOIUrl":"10.1016/j.hsr.2024.100199","url":null,"abstract":"<div><p>Urinary tract infection (UTI) is a prevalent and recurrent bacterial infection affecting millions of people across the world, often necessitating antibiotic treatment. However, the rise of multidrug-resistant (MDR) strains, commonly known as \"superbugs,\" has complicated the treatment process. This perspective review summarized the mechanisms of herbal or natural therapeutics intervention in UTI from the perspective of UTI bacterial pathogenesis. Initially, the review explores the mechanism of UTI development, identifying the types of UTI-causing bacteria, the complexity of UTI infection, and the human host's immune system against UTI. Then, this review synthesizes the active compounds of natural therapeutics for UTI, exploring their active compounds, efficacy, and mechanisms of action. After that, we summarized the emerging research on herbal compound interventions in UTI and analyzed the literature in this regard, including clinical applications, suggestions for potential natural bioactive compound consumption with the aim of UTI complications, as well as the association between novel mechanisms of UTI remission with the potential for active natural compounds intervention. Finally, we noted key future recommendations for using natural therapeutics. In conclusion, this review sheds light on the potential role of herbal or natural compounds in UTI treatment, from proposed mechanisms to prospects, offering a promising alternative or complement to conventional therapies in relieving UTIs.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"13 ","pages":"Article 100199"},"PeriodicalIF":0.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000527/pdfft?md5=97985aa6af8e26f4cd9178c95c273045&pid=1-s2.0-S2772632024000527-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the therapeutic potential of butein: A comprehensive review","authors":"Pougang Golmei,&nbsp;Sweta Kasna,&nbsp;Sachin Kumar","doi":"10.1016/j.hsr.2024.100197","DOIUrl":"10.1016/j.hsr.2024.100197","url":null,"abstract":"<div><p>This exhaustive review examines the therapeutic possibilities of butein, an organic compound sourced from plants, which has a long history in traditional medicine. Initiating with an investigation of plant-based remedies in native societies, the review emphasizes the importance of researching the physiological effects of plant-derived chemicals. The multifaceted biological activities of butein, encompassing its anti-inflammatory, antioxidant, anti-cancer, and neuroprotective properties are systematically analyzed. Detailed discussions elucidate the underlying mechanisms driving these activities and the wide-ranging applications of butein in managing various illnesses such as cancer, neurodegenerative disorders, and cardiovascular ailments. The article also explores the challenges associated with developing butein as a therapeutic agent, including issues with bioavailability and toxicity. The authors deliberate on diverse approaches to surmount these obstacles, incorporating the application of innovative drug delivery systems and the synthesis of artificial analogs. On the whole, this review offers a thorough outline of the therapeutic potential of butein and underscores the significance of investigating plant-based compounds for the formulation of novel medications. It is deduced that butein holds substantial promise as a therapeutic remedy, necessitating further exploration to fully comprehend its mechanisms of operation and potential applications in clinical environments.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"13 ","pages":"Article 100197"},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000503/pdfft?md5=9b3960f2d13a8b570acd42c1a6bfc0d4&pid=1-s2.0-S2772632024000503-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142164935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in ulcerative colitis management: A critical assessment of etrasimod therapy","authors":"Kushal Seni ,&nbsp;Aniket Saini ,&nbsp;Rabin Debnath ,&nbsp;Arshdeep Singh ,&nbsp;Anjali Sharma ,&nbsp;Deepak Singh Bisht ,&nbsp;Viney Chawla ,&nbsp;Pooja A Chawla","doi":"10.1016/j.hsr.2024.100196","DOIUrl":"10.1016/j.hsr.2024.100196","url":null,"abstract":"<div><p>Ulcerative Colitis (UC) is a persistent inflammatory condition of the colon that occurs due to the disruption in the epithelial barrier and immunological responses. In UC the episodes of inflammation are relapsing and remitting in the colonic mucosa. Etrasimod, an S1P receptor modulator, is a potential therapy for UC. The goal of this review is to compile the data related to effectiveness and safety studies of etrasimod in the treatment of UC. Pre-clinical and clinical studies examine how etrasimod affects many aspects of UC pathophysiology, including S1P receptor regulation, immune cell migration, and improved gut barrier function. Etrasimod mainly inhibits the lymphocytes entry into the peripheral blood and prevents the migration of lymphocytes into the inflammation cycle. This article gives a comprehensive account of several factors linked to etrasimod and ulcerative colitis, including the pathology of ulcerative colitis, US-FDA approved treatment for UC, mechanism of action of etrasimod, pharmacokinetic, pharmacodynamic data of etrasimod, reported risk and related aspects and completed and ongoing clinical trials.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"12 ","pages":"Article 100196"},"PeriodicalIF":0.0,"publicationDate":"2024-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000497/pdfft?md5=4a3196e7ca54c973b37354acd69e2153&pid=1-s2.0-S2772632024000497-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142002102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of take-home methadone treatment among patients with opioid use disorders during COVID-19: A systematic review","authors":"Shabnam Naher ,&nbsp;Sabbir Pervez ,&nbsp;Feroz Ahmed ,&nbsp;Odunayo Elijah ,&nbsp;Md. Toslim Mahmud ,&nbsp;KM Saif-Ur-Rahman","doi":"10.1016/j.hsr.2024.100195","DOIUrl":"10.1016/j.hsr.2024.100195","url":null,"abstract":"<div><h3>Background</h3><p>The COVID-19 pandemic has exacerbated the global overdose crisis, increased opioid-related deaths and highlighted the need for innovative treatment strategies. This study critically evaluates the efficacy of take-home methadone for patients with opioid use disorders (OUDs) during public health emergencies.</p></div><div><h3>Methods</h3><p>Adhering to PRISMA reporting guidelines, this systematic review scrutinized RCTs and quasi-experimental studies on opioid agonist treatments (OATs), notably methadone, from Medline, Web of Science (core collection), Embase, Cochrane Library, and Scopus, spanning January 2020 to May 2024. It targeted global patients of any age, contrasting take-home methadone with in-clinic dosing, omitting non-English studies or those solely analyzing program delivery modifications without take-home dose discussions. Key outcomes included emergency room (ER) visits, treatment retention, overdose rates, alongside secondary outcomes like patient health, quality of life (QoL), and satisfaction. Registered with PROSPERO (CRD42023474723), the review prioritized treatment impacts and language inclusivity.</p></div><div><h3>Findings</h3><p>The final search yielded 1,222 records, with two studies included (four records). Despite included only two studies (four records) due to a focused selection criterion, findings indicate overall participant satisfaction with take-home methadone, suggesting its potential as a viable treatment modality during public health emergencies. However, the limited study number and focus on indirect outcome measures underscore the need for further comprehensive research.</p></div><div><h3>Interpretation</h3><p>This review champions flexible dosing, technology integration, and stigma reduction in OUD treatment, urging longitudinal research on take-home methadone's continued impacts. Despite constraints, it enriches OUD management for enhanced public health outcomes, highlighting future research avenues.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"12 ","pages":"Article 100195"},"PeriodicalIF":0.0,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000485/pdfft?md5=8bd31289558931817ddcf45aa0a4d193&pid=1-s2.0-S2772632024000485-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141962831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling the genomic maze: Bioinformatics unleashes insights into Sotos syndrome (Cerebral Gigantism)","authors":"Ravinder Sharma ,&nbsp;Simarjeet Kaur ,&nbsp;Vikas Gupta ,&nbsp;Harpreet Grover ,&nbsp;Kiran Yadav ,&nbsp;Viney Chawla ,&nbsp;Pooja A Chawla","doi":"10.1016/j.hsr.2024.100194","DOIUrl":"10.1016/j.hsr.2024.100194","url":null,"abstract":"<div><p>The overgrowth condition known as Sotos syndrome is distinguished by its characteristic facial gestalt, macrocephaly, excessive development during childhood, varying degrees of learning problems, and a variety of other abnormalities. Due to abnormally high height, occipitofrontal circumference (OFC), advanced bone age, neonatal problems such as hypotonia and feeding issues, and facial gestalt, the diagnosis is typically recognized after birth. The current work aims to identify potential therapeutic treatments through bioinformatics analysis, focusing on key genes and pathways implicated in the disease. Text mining techniques were employed to identify 41 genes associated with Sotos syndrome, 37 of which were enriched with Gene Ontology (GO) terms and 24 with Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Using protein-protein interaction (PPI) network analysis, two gene modules were extracted using the Molecular Complex Detection (MCODE) algorithm, highlighting 15 hub genes as central candidates. Furthermore, leveraging drug-gene interaction databases and network pharmacology tools, 23 FDA-approved drugs were identified that target 11 of these core hub genes, suggesting potential therapeutic avenues for Sotos syndrome. Only bioinformatics tools were used in this study further in-vitro and in-vivo studies are required because phenotypic differences will vary from person to person depending on the expressivity of the gene. In future this approach may help to collaborate with clinical researchers to integrate bioinformatics findings with real-world clinical data. This will enhance understanding of clinical relevance of the identified genes and pathways and validate bioinformatics predictions with patient-derived samples and clinical histories.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"12 ","pages":"Article 100194"},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000473/pdfft?md5=466e0f40a2696c6b51eb1d2b00049450&pid=1-s2.0-S2772632024000473-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141847122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is it time to define vaccines to be used for lumpy skin disease?","authors":"Krishna Prasad Acharya ,&nbsp;Bhoj Raj Singh","doi":"10.1016/j.hsr.2024.100192","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100192","url":null,"abstract":"<div><p>Only homologous LSD vaccine should be used in absence of efficacy of experimental studies indicating the effectiveness of heterologous LSD vaccine.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"12 ","pages":"Article 100192"},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277263202400045X/pdfft?md5=460d1a4a0442835439ffa37ced3d0888&pid=1-s2.0-S277263202400045X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141607498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}