Health sciences review (Oxford, England)最新文献_第5页

Early versus late surgical stabilisation of unstable thoracolumbar spine fractures in adult polytrauma patients: A systematic review and meta-analysis 成人多发伤患者不稳定胸腰椎骨折的早期与晚期手术稳定：一项系统回顾和荟萃分析

Health sciences review (Oxford, England) Pub Date : 2025-03-01 Epub Date: 2025-01-29 DOI: 10.1016/j.hsr.2025.100217

Sebastian Ndlovu , Stanley Masunda , Emmanuel Oladeji , Ahmed Lashin , Ahmed Kaddah , Khalid A. Shah

{"title":"Early versus late surgical stabilisation of unstable thoracolumbar spine fractures in adult polytrauma patients: A systematic review and meta-analysis","authors":"Sebastian Ndlovu , Stanley Masunda , Emmanuel Oladeji , Ahmed Lashin , Ahmed Kaddah , Khalid A. Shah","doi":"10.1016/j.hsr.2025.100217","DOIUrl":"10.1016/j.hsr.2025.100217","url":null,"abstract":"<div><div>Controversy remains with regards to the timing of surgical stabilisation of unstable thoracolumbar fractures in adult polytrauma patients. We aimed to compare early versus late fixation of thoracolumbar spine fractures focusing on length of hospital stay (HLOS), length of stay in ICU (ICULOS), respiratory complications, mortality, and long-term functional outcome measures.</div><div>Electronic database search was conducted on PubMed, Cochrane, CENTRAL, and Embase spanning 1999 to 2023 using a developed search strategy. The time cut off used to distinguish between early and late stabilisation was 72 h from injury. Statistical analysis of primary outcome data was performed with Comprehensive Meta-analysis software using the standardised difference in means as the effect size index.</div><div>2082 articles were retrieved, eighty screened by full text and a final eleven studies comprising 3874 patients deemed eligible for inclusion in this review. The overall level of evidence of included studies was low with only one prospective cohort study. A subgroup meta-analysis using a random effects model showed that early fixation of unstable thoracolumbar spinal fractures leads to a statistically significant decrease in HLOS compared to late fixation with a mean effect size of -0.502. Early fixation was also associated with reduced ICULOS and respiratory complications.</div><div>Early surgical stabilisation of unstable thoracolumbar spine fractures within 72h of injury is safe and associated with favorable short-term outcomes in adult polytrauma patients with unstable thoracolumbar spine fractures. Further high-level prospective studies are recommended to investigate whether the short-term gains shown can translate to superior long-term functional outcomes.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"14 ","pages":"Article 100217"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143340813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introducing the “Gamechanger“ - Myoreflextherapy 介绍“游戏改变者”——Myoreflextherapy

Health sciences review (Oxford, England) Pub Date : 2025-03-01 Epub Date: 2025-01-27 DOI: 10.1016/j.hsr.2025.100215

JC Baudrexl , K Mosetter , R Mosetter , D Gagiannis

{"title":"Introducing the “Gamechanger“ - Myoreflextherapy","authors":"JC Baudrexl , K Mosetter , R Mosetter , D Gagiannis","doi":"10.1016/j.hsr.2025.100215","DOIUrl":"10.1016/j.hsr.2025.100215","url":null,"abstract":"<div><div>Chronic pain conditions, mental illnesses and, more recently, post-COVID syndrome are still difficult to treat satisfactorily in many cases, despite rapid medical progress. New, highly individualised treatment approaches are required to alleviate and ideally even cure complaints that are relevant to everyday life. Myoreflex therapy is a new type of therapeutic procedure that has been developed since the early 1980s on the basis of various findings and sciences, but has so far only been sparsely described in the international literature. The aim of this paper is to provide an overview of the findings to date and to categorise the therapy within the current therapeutic landscape. For this purpose, a comprehensive literature search was conducted in MEDLINE/Pubmed, Google Scholar and the Cochrane database. In addition, the most important data from the basic works on the initial description of myoreflex therapy were extracted and summarised in condensed form. In this way, the significance of myoreflex therapy as a new, integrative and holistically orientated form of therapy can be demonstrated. It represents a neurophysiologically based further development of osteopathy, acupressure and concentrative movement therapy and utilises neuronal control circuits to additionally tense defined muscle groups in order to stimulate self-regulation and reduce pain. By combining various established therapeutic principles in this new method, chronic pain conditions, psychologically induced musculoskeletal changes and non-specific post-acute COVID symptoms can be treated much more effectively.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"14 ","pages":"Article 100215"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Barriers to timely diagnosis and management of breast cancer in Africa: Implications for improved outcomes 非洲及时诊断和管理乳腺癌的障碍：对改善结果的影响

Health sciences review (Oxford, England) Pub Date : 2025-03-01 Epub Date: 2025-02-03 DOI: 10.1016/j.hsr.2025.100221

Roland Muyisa , Emile Watumwa , Judith Malembe , Jacques Wahangire , Ghyslaine Kalivanda , Apollinaire Saa Sita , Soly Kamwira

{"title":"Barriers to timely diagnosis and management of breast cancer in Africa: Implications for improved outcomes","authors":"Roland Muyisa , Emile Watumwa , Judith Malembe , Jacques Wahangire , Ghyslaine Kalivanda , Apollinaire Saa Sita , Soly Kamwira","doi":"10.1016/j.hsr.2025.100221","DOIUrl":"10.1016/j.hsr.2025.100221","url":null,"abstract":"<div><div>Breast cancer (BC) is a significant health challenge in Africa, characterized by high incidence, morbidity, and mortality rates. This systematic review aims to identify factors delaying BC diagnosis and treatment, evaluate management outcomes, and highlight the contributing pathways.</div><div>The study thoroughly searched electronic databases for articles on breast cancer in Africa, focusing on publications in English or French from the past decade. Independent reviewers screened the articles, extracting relevant data according to PRISMA guidelines.</div><div>Barriers to early detection and management in Africa include poor symptom recognition, limited awareness, financial constraints, fear of diagnosis, and reliance on traditional medicine. Poor outcomes are often linked to advanced disease stages and larger tumor sizes, along with factors like the luminal B subtype and HIV status. Strategies to improve outcomes should focus on raising awareness, enhancing knowledge of hormonal tumor status, and implementing expedited referral pathways for women with concerning symptoms.</div><div>Urgent measures for early detection and management are essential to address the breast cancer burden in Africa and improve patient outcomes.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"14 ","pages":"Article 100221"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combatting multi-drug resistance in urinary tract infections among diabetic populations: A perspective review 糖尿病人群尿路感染多药耐药研究综述

Health sciences review (Oxford, England) Pub Date : 2025-03-01 Epub Date: 2025-01-10 DOI: 10.1016/j.hsr.2025.100209

Rahima Tanbin Tama , Md. Sakhawat Hossain , Md. Shahidul Islam , Rifaia Sultana Chowdhury , Md. Ashikur Rahaman , Md. Ashraful Alam

{"title":"Combatting multi-drug resistance in urinary tract infections among diabetic populations: A perspective review","authors":"Rahima Tanbin Tama , Md. Sakhawat Hossain , Md. Shahidul Islam , Rifaia Sultana Chowdhury , Md. Ashikur Rahaman , Md. Ashraful Alam","doi":"10.1016/j.hsr.2025.100209","DOIUrl":"10.1016/j.hsr.2025.100209","url":null,"abstract":"<div><div>Diabetes mellitus (DM) is a chronic condition that lowers life expectancy and quality of life when left untreated or improperly managed. Infections, both common and pathogenic, such as emphysematous pyelonephritis, malignant otitis externa, mucormycosis, and Fournier's gangrene, are more common in diabetic patients. Because patients with diabetes have a lower prognosis and more frequent Urinary tract infections (UTIs) than those without diabetes. Based on the literature, we carried out a review study that examined the characteristics of the prevalence of UTIs among diabetic patients in various countries over time, as well as the associated risk factors, processes, and therapeutic issues. The results show that compared to people without diabetes, diabetic patients with UTIs have higher rates of hospitalization, recurrence, and mortality, as well as a more frequent evolution to bacteremia. Pregnancy, advanced age, multidrug-resistant bacteria, and the length of a patient's diabetes seem to be the potential risk factors that have been found. With rare exceptions, the antibiotic susceptibility profile and bacterial strains responsible for UTIs in patients with DM are similar to those in non-diabetics; nonetheless, careful selection of antimicrobial agents, and treatment duration should match that needed for complicated UTIs.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"14 ","pages":"Article 100209"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photodynamic Therapy (PDT) in drug delivery: Nano-innovations enhancing treatment outcomes 光动力疗法（PDT）在药物传递：纳米创新提高治疗效果

Health sciences review (Oxford, England) Pub Date : 2025-03-01 Epub Date: 2025-01-27 DOI: 10.1016/j.hsr.2025.100218

Ahmed N. Al-Jamal , Ali Fawzi Al-Hussainy , Bahira Abdulrazzaq Mohammed , Hadi Hussein Abbas , Issa Mohammed Kadhim , Zahraa Hassan Ward , Debarshi Kar Mahapatra , Tomy Muringayil Joseph , Ehsan kianfar , Sabu Thomas

引用次数: 0

Revolution in cancer treatment methods: Perspective review of factors affecting the final results of nanoparticles used in magnetic fluid hyperthermia 癌症治疗方法的革命：影响磁流体热疗中使用的纳米颗粒最终结果的因素的观点综述

Health sciences review (Oxford, England) Pub Date : 2025-03-01 Epub Date: 2025-01-11 DOI: 10.1016/j.hsr.2025.100212

P. Rastgoo Oskoui, M. Rezvani

引用次数: 0

Beyond boundaries: Charting the frontier of healthcare with big data and ai advancements in pharmacovigilance 超越边界：利用大数据和人工智能在药物警戒方面的进步，绘制医疗保健的前沿

Health sciences review (Oxford, England) Pub Date : 2025-03-01 Epub Date: 2025-01-13 DOI: 10.1016/j.hsr.2025.100214

Arohi Agarwal , Gagan Singh , Samyak Jain , Piyush Mittal

{"title":"Beyond boundaries: Charting the frontier of healthcare with big data and ai advancements in pharmacovigilance","authors":"Arohi Agarwal , Gagan Singh , Samyak Jain , Piyush Mittal","doi":"10.1016/j.hsr.2025.100214","DOIUrl":"10.1016/j.hsr.2025.100214","url":null,"abstract":"<div><div>The healthcare sector is intricate, generating vast amounts of data from various sources at an accelerated pace. The contemporary trend of Big Data Analytics is pivotal, impacting not only the pharmaceutical industry but also transforming healthcare, contributing to personalized treatment, aiding in preventive healthcare, managing electronic health records, facilitating adverse drug reporting, and incorporating consumer reviews. This article provides an overview of the inevitable influence of big data and the utilization of artificial intelligence in revolutionizing both healthcare and the pharmaceutical sector. It delves into the notable benefits and challenges encountered in advancing data analytics of the early 21st century.In many countries, Post-marketing surveillance of drug safety relinquishes on a systematic analysis of spontaneous using Generative artificial intelligence (AI) to overcome gaps in the present PV ecosystem is critical to maintaining an uninterrupted record of security and effectiveness within healthcare analytics, data mining techniques, predictive analytics, and the emergence of scientific fields like bioinformatics and health informatics are empowered by Big Data. Nevertheless, the integration of AI in healthcare, especially in pharmacovigilance, aligns with the evolving landscape of electronic health information technology. In conclusion, review highlights the transformative impact of Big Data and AI in healthcare, emphasizing their applications in pharmacovigilance and pharmacoepidemiology. The continuous evolution of these technologies holds promise for improving patient safety, personalized medicine, and overall healthcare outcomes.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"14 ","pages":"Article 100214"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methods to train and evaluate clinical communication skills of medical professionals and medical interpreters 方法对医学专业人员和医学口译员进行临床沟通技巧的培训和评价

Health sciences review (Oxford, England) Pub Date : 2025-03-01 Epub Date: 2024-12-15 DOI: 10.1016/j.hsr.2024.100208

Naoko Ono , Jinghua Yang , Taeko Hamai

{"title":"Methods to train and evaluate clinical communication skills of medical professionals and medical interpreters","authors":"Naoko Ono , Jinghua Yang , Taeko Hamai","doi":"10.1016/j.hsr.2024.100208","DOIUrl":"10.1016/j.hsr.2024.100208","url":null,"abstract":"<div><div>There is increasing recognition of the importance of communication through medical interpreters in medical care provision for foreigners. However, there is no established method for developing the communication skills of medical interpreters. This literature review summarized methods of communication skills training and evaluation for medical professionals, and investigated the applicability of such methods to medical interpreters. A literature review was performed according to the process described in the PRISMA-S (Preferred Reporting Items for Systematic Review and Meta-Analysis Literature Search Extension), a guideline for systematic reviews in healthcare. Analysis of the extracted articles showed that 13 articles described original communication skills training programs for medical professionals, and 5 articles described pre-existing programs. A common evaluation method was the comparison of questionnaire survey responses before and after training. The results were used to identify key recommendations for future directions in establishing methods for developing the communication skills of medical interpreters. Most studies were on CST programs for oncology, and most used in-person training programs. This review clarified currently used methods of training and evaluating the clinical communication skills of medical professionals, and their potential applicability to medical interpreters. The findings indicate the need to develop communication skills training programs tailored to situations that medical interpreters encounter in their work.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"14 ","pages":"Article 100208"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of Healthcare Challenges in the UK and the US: Medical Errors, Aging, Private Healthcare and Governance 回顾英国和美国的医疗保健挑战：医疗差错、老龄化、私人医疗保健和治理

Health sciences review (Oxford, England) Pub Date : 2025-03-01 Epub Date: 2025-01-11 DOI: 10.1016/j.hsr.2025.100211

John S. Bolwell

{"title":"A Review of Healthcare Challenges in the UK and the US: Medical Errors, Aging, Private Healthcare and Governance","authors":"John S. Bolwell","doi":"10.1016/j.hsr.2025.100211","DOIUrl":"10.1016/j.hsr.2025.100211","url":null,"abstract":"<div><div>Deaths and serious injuries caused by medical errors continue to beset the healthcare systems of all developed countries. Most are due to failures in the processes of care exacerbated by poor communication between healthcare providers and with patients, particularly the elderly with varying degrees of cognitive impairment. The global phenomenon of aging populations due to declining birthrates and increased life expectancy may have detrimental consequences for societies and is briefly considered. The most common medical errors are failure to diagnose, misdiagnoses, failure to treat, surgical and anesthetic errors, negligent postoperative care, medication errors, failure to order, or act on, laboratory tests, and birth injuries (mother and baby). Estimated numbers of deaths vary widely, for example 22,000 to 40,000 in the UK and 98,000 to 251,000 in the US which attests to the complexity of accurate quantification. Regardless of the true magnitude there is no doubt that several deaths due to preventable medical errors occur in each hospital every year and there are 1,148 public and private hospitals in the UK and 6,120 in the US. The history and efficacy of preventative measures such as continuing professional development, continuity of care, multi-disciplinary-team management and quality assurance programs are summarized. The UK and the US have worse healthcare outcomes and shorter average life expectancies than comparable developed countries and these issues are discussed. Reforms which might contribute to the delivery of safe, universal and sustainable healthcare in the UK and the US are reviewed.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"14 ","pages":"Article 100211"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Difference in nicotine metabolism as a potential factor causing disparities in tobacco consumption estimates by wastewater-based epidemiology 基于废水流行病学的烟草消费估算差异的潜在因素是尼古丁代谢差异

Health sciences review (Oxford, England) Pub Date : 2025-03-01 Epub Date: 2025-01-10 DOI: 10.1016/j.hsr.2025.100210

Min-Tz Weng , Kathryn J Steadman , Kelly Zhong , Maryam Al-Gharibeh , Qiuda Zheng , Phong K Thai

{"title":"Difference in nicotine metabolism as a potential factor causing disparities in tobacco consumption estimates by wastewater-based epidemiology","authors":"Min-Tz Weng , Kathryn J Steadman , Kelly Zhong , Maryam Al-Gharibeh , Qiuda Zheng , Phong K Thai","doi":"10.1016/j.hsr.2025.100210","DOIUrl":"10.1016/j.hsr.2025.100210","url":null,"abstract":"<div><div>Wastewater-based epidemiology (WBE) can be used for estimating tobacco consumption at a population level. It involves analysing wastewater for the nicotine biomarkers cotinine (COT) and 3-hydroxycotinine (3HC). However, large discrepancies between WBE estimates for tobacco consumption compared to surveys and sales data have been reported. We hypothesise it could be partly related to genetic differences in CYP2A6 enzyme activity affecting COT and 3HC excretion. To review the use of COT and 3HC excretion factors within WBE calculations of tobacco consumption, a literature search for relevant articles was conducted using PubMed, EMBASE, CINAHL, PsycINFO, Web of Science, and Medline. A total of 34 papers were identified across the Americas, Oceania, Asian and European regions. In contrast to the other regions, 100 % of WBE cases involving East and Southeast Asian populations exhibited an underestimation of tobacco use when compared to surveys or sales data. The excretion factors used across all 34 papers had been derived from urine samples from predominantly White populations. People of Asian descent tend to have lower urinary concentrations of COT and 3HC than White populations due to slower CYP2A6 enzyme activity diverting nicotine metabolism towards non-CYP2A6 pathways. We show that using excretion factors that better represent Asian populations in WBE calculations can result in more accurate estimates of tobacco use. Measurement and use of excretion factors tailored to specific ethnic backgrounds can be expected to enhance the precision of WBE analysis.</div></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"14 ","pages":"Article 100210"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143158067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0