Health sciences review (Oxford, England)最新文献

{"title":"“Is tirofiban the silver bullet for early neurological deterioration in stroke?”","authors":"Asad Gul Rao","doi":"10.1016/j.hsr.2024.100180","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100180","url":null,"abstract":"","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"11 ","pages":"Article 100180"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000333/pdfft?md5=7afbb11f74c69f794d943baedb73d17b&pid=1-s2.0-S2772632024000333-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141243887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substantial growth of Health Sciences Review","authors":"Burcin Ekser","doi":"10.1016/j.hsr.2024.100182","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100182","url":null,"abstract":"","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"11 ","pages":"Article 100182"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000357/pdfft?md5=7f5bd5837c1699cbb5ab067191537500&pid=1-s2.0-S2772632024000357-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141325601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Best Evidence for exercise management to prevent lymphedema in patients with breast cancer","authors":"Chen Shufang,&nbsp;Wu Sijing,&nbsp;Kuang Yingdie,&nbsp;Xie Zhuoxian","doi":"10.1016/j.hsr.2024.100178","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100178","url":null,"abstract":"<div><p>In order to provide nursing staff with optimal exercise interventions for preventing lymphedema in patients with breast cancer, the AGREE II score, the systematic review tool, the literature evaluation criteria and the evidence grading system of the Joanna Briggs Institute (JBI) Center for Evidence-Based Health Care were used to evaluate the included Based on the guidelines, systematic reviews, and expert consensus, 6 people independently evaluated the quality of the literature, and combined with the judgment of personnel with relevant evidence-based nursing knowledge, the qualified literature was evaluated and the evidence grade was assessed. The included research documents are 2 relevant evidence summaries; 1 guideline; 1 expert consensus; 16 systematic reviews, ranging from exercise contraindications, pre-exercise assessment and testing, exercise intensity, exercise safety, exercise programs, precautions, Eight aspects of health education were summarized and analyzed. This article summarizes the exercise intervention measures and management experience for preventing lymphedema in breast cancer patients, providing a basis for nursing staff to guide breast cancer patients to implement exercise intervention measures, thereby effectively preventing the occurrence of lymphedema.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"12 ","pages":"Article 100178"},"PeriodicalIF":0.0,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277263202400031X/pdfft?md5=73068720fa366bb2b353fbae898e86c9&pid=1-s2.0-S277263202400031X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141542738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of standard Del Nido cardioplegia for the intracardiac repair of tetralogy of Fallot: A systematic review and meta-analysis of randomized controlled trials","authors":"Shajie Ur Rehman Usmani ,&nbsp;Syed Umar Hasan ,&nbsp;Syeda Hoorulain Ahmed ,&nbsp;Neha Pervez ,&nbsp;Amna Zia ,&nbsp;Qiudong Chen ,&nbsp;George Gill ,&nbsp;Georgina Rowe ,&nbsp;Saba Alvi ,&nbsp;Muhammad Mujeeb Zubair","doi":"10.1016/j.hsr.2024.100179","DOIUrl":"10.1016/j.hsr.2024.100179","url":null,"abstract":"<div><p>This meta-analysis compares the efficacy of the standard Del Nido cardioplegia with other agents during intra-cardiac tetralogy of Fallot repair. Meta-analysis was performed on studies comparing standard Del Nido cardioplegia with other types of cardioplegia. Outcomes were pooled using inverse variance and random effects analysis models to calculate the standardized mean difference (SMD) and odds ratio (OR). The SMD for ICU length of stay, duration of mechanical ventilation, and time taken for the heart to return to normal rhythm were -0.06 (<em>P</em> = 0.67), -0.21 (<em>P</em> = 0.06), and 0.23 (<em>P</em> = 0.48), respectively. The OR for the incidence of postoperative arrhythmias was 0.65 (<em>P</em> = 0.32). The standardized mean differences for twenty-four-hour post-operative IL-6, TNF-α, and cTnI levels were 0.29 (<em>P</em> = 0.16), -0.27 (<em>P</em> = 0.01), and -0.60 (<em>P</em> = 0.01), respectively. Del Nido cardioplegia is protective on the myocardium, with lower levels of inflammatory cytokines 24 h post-operation and a significantly reduced incidence of post-operative arrhythmias.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"11 ","pages":"Article 100179"},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000321/pdfft?md5=cc70f29df5b9ee667428da07cfd28159&pid=1-s2.0-S2772632024000321-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141039486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring SK/S1P/S1PR pathway as a target for antiviral drug development","authors":"Sharada Prasanna Swain ,&nbsp;Chandra Sekhara Mahanta ,&nbsp;Madan Maurya ,&nbsp;Debabrata Mandal ,&nbsp;Vipan Parihar ,&nbsp;V. Ravichandiran","doi":"10.1016/j.hsr.2024.100177","DOIUrl":"10.1016/j.hsr.2024.100177","url":null,"abstract":"<div><p>Lysophospholipids are a class of simple phospholipids that shows their biological effects through various G protein-coupled receptors (GPCRs). Sphingosine 1-phosphate (S1P) is one of the most studied lysophospholipid having wide role in various pathophysiological and cellular events, via signalling through five distinct GPCR subtypes, S1P receptors 1–5 (S1PR1-S1PR5).The importance of S1P pathway in drug targets have gained attention significantly after the approval of three S1PR modulators, fngolimod, siponimod and ozanimod, as medicines for patients with multiple sclerosis (MS). S1P, a signal transmitter, is converted to S1P by phosphorylation of Sphingosine kinase (SK1 or SK2) enzymes. S1P acts as an extracellular and intracellular ligand for receptors, S1PR1–5. The SK1/S1P axis and the connected S1PR1–5 plays important roles in many cellular events involving cell signalling, the cell survival/apoptosis, the production of pro-inflammatory cytokine responses, maintaining vascular integrity etc. Further sphingolipids, glycosphingolipids and ceramides acts as receptor/co-receptor for viral entry &amp; downstream signalling, formation of lipid raft-mediated microdomain, viral induced apoptosis. S1P receptor modulator fingolimod shows antiviral activity against human immunodeficiency virus. Currently, the clinical trials of ozanimod (a sphingosine receptor modulator), and opaganib (a SK2inhibitor) are being conducted for treatment of COVID-19. In this review we explored the different roles of sphingolipids, S1P, S1PR, SK in viral infections including a special focus on SARS-CoV2. It is worth to target SK/S1P pathway to develop antiviral drugs, by repurposing existing inhibitors/modulators, and designing new specific inhibitors of SK1, SK2, and SP receptors.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"11 ","pages":"Article 100177"},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000308/pdfft?md5=988d81f24632091ba4eedbf40739ac1c&pid=1-s2.0-S2772632024000308-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141035675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transplant health inequities research from an operations perspective","authors":"Mustafa Akan","doi":"10.1016/j.hsr.2024.100176","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100176","url":null,"abstract":"<div><p>Organ transplantation has been proven to be an effective treatment for end-stage kidney, heart, liver and lung diseases. Recognizing the effects of health inequalities related to transplantation is important for underserved populations. This scoping review aims to map the scope of the operational management literature on health inequalities corresponding to deceased donor organ transplantation and to highlight knowledge gaps for direct future research. The document also describes some open questions that we hope will continue to attract the attention of researchers interested in the operational aspects of organ transplantation.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"11 ","pages":"Article 100176"},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000291/pdfft?md5=89f9b463e40b1e6175825ca698b4eebe&pid=1-s2.0-S2772632024000291-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140644520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on cerebral malaria—Pathogenesis and role of EphA2 receptor in maintaining blood brain barrier integrity","authors":"Mohd Sayeed Shaikh ,&nbsp;Mirza Salman Baig ,&nbsp;Syed Sarfaraz Ali ,&nbsp;Anas Ahmad ,&nbsp;Md Mujtba Shaikh ,&nbsp;Paresh R Mahaparale ,&nbsp;Md Faiyazuddin","doi":"10.1016/j.hsr.2024.100175","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100175","url":null,"abstract":"<div><p>Plasmodium species causes cerebral malaria (CM), a dangerous parasitic illness. The World Health Organization estimates that there were roughly 228 million cases of malaria in 2018, which resulted in 405,000 tragic deaths. There was an approximate 20 % mortality rate among children diagnosed with CM who were admitted to the hospital. 67 % of the victims were children less than five years old. Patients who survive CM may experience lifetime post-CM complications and a higher risk of childhood neurodisability. The present review discuss about cellular mechanisms and immunological responses causing cerebral malaria. The breakdown of tight junctions and adherence junctions between endothelial cells (ECs) is the cause of an increase in the permeability of the blood brain barrier (BBB). It is obvious that this barrier can be breached by two different mechanisms: a) the apoptosis of ECs, and b) a loosening of the tight junctions between cells. T cells have been shown to have an important role in the development of cerebral malaria in an experimental mouse model (ECM). EphA2 receptors has been identified as contributing to many neurological illnesses and plays an important role in CM, associated with an impairment of the BBB. EphA2 is a key target protein that promotes EC apoptosis by targeting ephrin A ligand-expressing CD8+ T cell adhesion. Prominent role of the EphA2 receptors in CM has never been highlighted so far. Despite an intensive research, there is still a lack of successful malaria vaccines. The most advanced vaccines created so far, RTS,S/AS01 and R21/Matrix-M, focus on combating the early stages of the P. falciparum parasite. This review also discuss about the progress made for developing an effective vaccine for cerebral malaria.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"11 ","pages":"Article 100175"},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277263202400028X/pdfft?md5=e829e31fb49c0e933eac97008172fe6b&pid=1-s2.0-S277263202400028X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140551074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the microbial symphony: Next-Gen sequencing and bioinformatics insights into the human gut microbiome","authors":"Keerti Maheshwari ,&nbsp;Pankaj Musyuni ,&nbsp;Amitava Moulick ,&nbsp;Harshita Mishra ,&nbsp;Adam Ekielski ,&nbsp;Pawan Kumar Mishra ,&nbsp;Geeta Aggarwal","doi":"10.1016/j.hsr.2024.100173","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100173","url":null,"abstract":"<div><p>Hundreds of bacteria, viruses, eukaryotes, and archaea comprise the human intestinal microbiota, which constitutes a complex ecology. Recent years have established the significance of the gastrointestinal microbiome in the study of biological microorganisms. Diverse techniques for cultural extraction and analysis make it difficult to cultivate intestinal gut bacteria species. To determine the causative microorganism, it is necessary to investigate microbes and bacteria. Novel and efficacious remedies for illnesses are required. Bioinformatics and next-generation sequencing can assist in the analysis of enormous quantities of sequenced data for bacterial investigations, thereby expanding sequencing. However, advancements in sequencing technology have broadened the scope of bioinformatics identification and analysis. With next-generation sequencing techniques such as metagenomic, 16S rRNA, and meta-transcriptomic sequencing, experimental data regarding the immunological response of the intestinal gut microbiome to genetic manipulation seems to be helpful in identifying the diseases. Despite significant progress over the past two decades, there is still a lack of understanding about the ecology of diseases and treatments. The present review highlights how microbial gene sequencing and analysis of sequencing information can help manage human gut issues.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"11 ","pages":"Article 100173"},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000266/pdfft?md5=da82d24864c3695ff2457efc8920d74a&pid=1-s2.0-S2772632024000266-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140543801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of baicalein against neurodegenerative diseases: An updated review","authors":"Nazia Siddiqui ,&nbsp;Mohd Talib ,&nbsp;Prabhash Nath Tripathi ,&nbsp;Anoop Kumar ,&nbsp;Alok Sharma","doi":"10.1016/j.hsr.2024.100172","DOIUrl":"https://doi.org/10.1016/j.hsr.2024.100172","url":null,"abstract":"<div><p>Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and epilepsy sickness, currently impact millions of people globally. Thus yet, the primary etiology of these ailments has not been determined. Regretfully, no medication can prevent the onset of these illnesses. The primary risk factor for these illnesses developing is age. Recently, there has been an increase in interest among researchers to investigate the potential therapeutic benefits of herbal remedies for neurodegenerative diseases. Flavonoids, tannins, terpenoids, alkaloids, and phenols are examples of secondary metabolites that have been used to prevent adverse effects and delay disease progression. Baicalein (5,6,7-trihydroxyflavone), a flavonoid found in the traditional Chinese herb Huangqin (Scutellaria Baicalensis George), helps block the age-associated damage pathways linked to neurological diseases. This review offers a plausible argument in favour of baicalein's beneficial effect in models of AD, PD, HD, and epilepsy. Baicalein reduces amyloid-beta and Tau oligomers, oxidative stress, and acetylcholinesterase activity in AD by binding to the enzyme's active site. Additionally, Baicalein reduces mitochondrial dysfunction against N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuro-inflammation in PD via inhibiting the NLRP3/caspase-1/gasdermin-D pathway. In HD, Baicalein was used to test its possible neuroprotective ability via N-methyl-<span>D</span>-aspartate receptor antagonism against quinolinic acid-induced neurotoxicity. Moreover, Baicalein reduces inflammation in epilepsy by controlling the insulin-like growth factor 1 receptor in microglia to prevent pilocarpine-induced epilepsy. The protective effect of Baicalein provides the potential future therapeutic approach against various neurological disorders.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"11 ","pages":"Article 100172"},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000254/pdfft?md5=d261778a472fcc729aaf20654136ebde&pid=1-s2.0-S2772632024000254-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140618250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What does major trauma patients’ healthcare experiences tell us about their needs post-injury: A systematic review","authors":"Ruth Tanti ,&nbsp;Peter Fisher ,&nbsp;Gillian Hunt ,&nbsp;Emily Pearson ,&nbsp;Róisín Cunningham","doi":"10.1016/j.hsr.2024.100174","DOIUrl":"10.1016/j.hsr.2024.100174","url":null,"abstract":"<div><p>This review explored major trauma patients (MTP) healthcare experiences and their subsequent needs post-injury. Four electronic databases (PsycInfo, Medline, CINAHL and PsychArticles) were searched in May 2023 for studies that were in English, peer-reviewed primary qualitative research and recruited MTP participants. Eleven studies incorporating perspectives of 305 MTP were included and analysed using thematic synthesis. Physical pain, psychological difficulties, vulnerability and powerlessness influence MTP healthcare experiences. MTP described the positive and negative experiences of staff interactions and the integral role of communication on their healthcare experiences. A need for follow-up care, rehabilitation and to acknowledge the barriers to regaining independence and normality, was also reported. Varying needs related to psychological support, information provision, rehabilitation and follow-up care, impacted on MTP healthcare experiences and their expectations from services. Developing a more nuanced understanding of perceived power dynamics between staff and MTP, and gaps in rehabilitation service provision, would enable services to pro-actively tackle these issues. A continued investigation of MTP communication needs is required to enhance the care of MTPs.</p></div>","PeriodicalId":73214,"journal":{"name":"Health sciences review (Oxford, England)","volume":"11 ","pages":"Article 100174"},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772632024000278/pdfft?md5=a8496b1c4293d4334d42e3647595d03a&pid=1-s2.0-S2772632024000278-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140401854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}