Global pediatrics最新文献

{"title":"Infant EEG power predicts early childhood language and motor skills in a rural South African cohort","authors":"Shaina P. Brady ,&nbsp;Peter C. Rockers ,&nbsp;Denise Evans ,&nbsp;Lezanie Coetzee ,&nbsp;Diana C. Lopera-Perez ,&nbsp;Günther Fink ,&nbsp;Davidson H. Hamer ,&nbsp;Aisha K. Yousafzai ,&nbsp;Amanda R. Tarullo","doi":"10.1016/j.gpeds.2025.100298","DOIUrl":"10.1016/j.gpeds.2025.100298","url":null,"abstract":"<div><div>Early neural development underlies fundamental behavioral outcomes. In low- and middle-income countries (LMICs), healthy development is often perturbed by compounded adversities, yet little is known about the neural mechanisms driving these trajectories. The current study explores the relationship between infant EEG power and early childhood developmental outcomes at two timepoints in the Greater Tzaneen subdistrict, Mopani district, Limpopo Province, South Africa. In a sample of 242 children, we assessed how EEG relative power at seven months related to development at 17 and 36 months. Increased left hemisphere theta band activity (4–6 Hz) predicted lower caregiver-reported language and motor skills, and increased left hemisphere beta activity (13–30 Hz) predicted reported motor skills at 17 months. Increased infant gamma power (30–48 Hz) in the left hemisphere was associated with higher observed language and gross motor skills at 36 months. Results suggest that early neural oscillations have small but consistent associations with later language and motor skills in a LMIC context.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100298"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Montenegro Charter for the protection and recovery of children in disasters","authors":"Neboija Kavaric ,&nbsp;Joseph Haddad ,&nbsp;Massimo Pettoello-Mantovani","doi":"10.1016/j.gpeds.2025.100286","DOIUrl":"10.1016/j.gpeds.2025.100286","url":null,"abstract":"<div><div>The Charter was jointly developed by EPA-UNEPSA and the International Pediatric Association (IPA) through the contributions of ideas and recommendations from presidents and delegates of European National Pediatric Societies who participated in the 2nd EPA-UNEPSA Hot Topics International Meeting held in Budva, Montenegro, on June 12, 2025 in collaboration with the Association for Preventive Pediatrics of Montenegro,: Giuseppe Buonocore, former President, Italian Academy of Pediatrics; Robert Cohen, President, Conseil National Professionnel de Pédiatrie, Association Française de Pédiatrie Ambulatoire; Pietro Ferrara vice-President, Italian Society of Pediatrics; Hilary Hoey, former President, Faculty of Paediatrics, Royal College Physicians Ireland; Esin Koc, President, Turkish Neonatal Society &amp; the Union of European Neonatal and Perinatal Societies (UENPS); Georgios Konstantinidis, President, Serbian Pediatric Association; Georgina Kuli Lito, President, Albanian Society of Pediatrics; Hajrija Maksić, President, BIH Pediatric Association; Aida Mujkić, President, Pediatric Society of Croatia; Leyla Namazova, President UPR; Tudor Pop, President, Romanian Society of Preventive Pediatrics; Beiqi Ramus, President, Kosovo Pediatric Association; Aspazija Sofijanova, President, N.Macedonia Pediatric Association; Eli Somekh, former President, Israeli Pediatric Association; Tarana Taghi-zada, President, Azerbaijan Pediatric Association &amp; Vice president, Eurasian Federation Children's Doctors; Stephen Turner, President, Royal College of Paediatrics and Child Health, UK; Mehmet Vural, former President, Turkish Pediatric Association. The International Pediatric Association (IPA) and EPA-UNEPSA gratefully acknowledge their invaluable contributions.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100286"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The unseen burden: Challenges by children and adolescents in witness protection programs in western countries","authors":"Pietro Ferrara ,&nbsp;Margherita Zona ,&nbsp;Ignazio Cammisa ,&nbsp;Ida Giardino ,&nbsp;Maria Pastore ,&nbsp;Mehmet Vural ,&nbsp;Massimo Pettoello-Mantovani ,&nbsp;Francesca Scaltrito ,&nbsp;Clara Pettoello-Mantovani","doi":"10.1016/j.gpeds.2025.100288","DOIUrl":"10.1016/j.gpeds.2025.100288","url":null,"abstract":"<div><div>Witness Protection Programs are indispensable tools in the fight against organized crime, designed to safeguard individuals whose testimonies are crucial for justice. While these programs have demonstrated remarkable success in ensuring the physical safety of adult witnesses, the profound and often unaddressed challenges faced by accompanying children and adolescents represent a critical oversight. This article examines the multifaceted psychosocial, familial, educational, and societal hurdles encountered by children and adolescents relocated within western witness protection programs, focusing in particular on Europe and the US. Drawing upon existing literature, this report elucidates the cumulative trauma, identity disruption, social isolation, and educational instability inherent in their experiences. The analysis reveals a historical underestimation of children's unique vulnerabilities and rights within these programs. Recommendations emphasize the urgent need for a paradigm shift towards child-centric and family-focused western witness protection programs, advocating for holistic assessment, integrated mental health services, prioritized educational continuity, proactive social integration strategies, community engagement, enhanced professional training, and robust long-term research to ensure the comprehensive well-being of this exceptionally vulnerable population.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100288"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal oxidative stress and bone development in the first year of life: A preliminary study using REMS","authors":"Serafina Perrone ,&nbsp;Silvia Carloni ,&nbsp;Virginia Beretta ,&nbsp;Serena Benedetti ,&nbsp;Elena Scarpa ,&nbsp;Laura Cannavò ,&nbsp;Chiara Petrolini ,&nbsp;Federica Grassi ,&nbsp;Vincenzo Raitano ,&nbsp;Maria Cristina Albertini ,&nbsp;Domenico Corica ,&nbsp;Tommaso Aversa ,&nbsp;Elvira Di Pasquo ,&nbsp;Maria Elisabeth Street ,&nbsp;Malgorzata Wasniewska ,&nbsp;Andrea Dall’Asta ,&nbsp;Tullio Ghi","doi":"10.1016/j.gpeds.2025.100294","DOIUrl":"10.1016/j.gpeds.2025.100294","url":null,"abstract":"<div><h3>Background</h3><div>Oxidative stress has been implicated in impairing tissue development, but its impact on early postnatal skeletal growth in humans remains poorly understood. This study investigates the relationship between perinatal redox status and bone development during infancy, using Radiofrequency Echographic Multi Spectrometry (REMS), a non-invasive, radiation-free technology for bone quality assessment.</div></div><div><h3>Methods</h3><div>A longitudinal observational study on a cohort of healthy, full-term neonates (<em>n</em> = 65, 29 females and 36 males) was conducted. Total antioxidant capacity (TAC) and markers of protein and DNA oxidation (advanced oxidation protein products (AOPP); 8-hydroxy-2′-deoxyguanosine (8OH-dG)) were measured in arterial cord blood at birth. Auxological parameters were collected at birth and during follow-up visits at 1, 3, 6, and 12 months. Bone quality was assessed using REMS at 3, 6, and 12 months, and results were expressed as age-adjusted Z-scores.</div></div><div><h3>Results</h3><div>Cord blood TAC levels showed a significant positive correlation with birth weight (<em>r</em> = 0.51, <em>p</em> &lt; 0001), length (<em>r</em> = 0.40, <em>p</em> = 0.0013), and birth head circumference (<em>r</em> = 0,42, <em>p</em> = 0,0017). Statistical positive correlations were also found between cord blood TAC and length and weight a 1 month of age (<em>r</em> = 0.51, <em>p</em> &lt; 0.001; <em>r</em> = 0.36, <em>p</em> = 0.0067). In contrast, higher levels of oxidative damage were inversely associated with REMS-derived Z-scores at both 6 and 12 months of life (8OH-dG vs REMS-derived Z-scores at 6 months (<em>r</em>=-0.23, <em>p</em> = 0.02), and AOPP vs REMS-derived Z-scores at 12 months (<em>r</em>=-0.33 <em>p</em> = 0.022; <em>r</em>=-0.64, <em>p</em> &lt; 0.001, respectively). REMS Z-scores also showed strong internal consistency across timepoints (3 vs 6 months, <em>r</em> = 0.53, <em>p</em> &lt; 0.001,; 6 vs 12 months, <em>r</em> = 0.29, <em>p</em> = 0.046). A significant correlation was observed between REMS Z-score and head circumference at 3 months (<em>r</em> = 0.48, <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Our findings suggest that perinatal oxidative balance plays a critical role in early longitudinal growth. REMS appears to be a reliable tool for tracking bone quality in infancy, with potential for future applications in pediatric bone health monitoring. Although limited to healthy infants born from physiological pregnancies, this study provides foundational data in a largely unexplored area and supports the hypothesis that fetal redox status may influence lifelong skeletal outcomes.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100294"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How maternal diet, probiotics, prebiotics, and postbiotics during pregnancy influence neurodevelopment in newborns","authors":"Valentina Biagioli ,&nbsp;Mariarosaria Matera ,&nbsp;Pasquale Striano","doi":"10.1016/j.gpeds.2025.100301","DOIUrl":"10.1016/j.gpeds.2025.100301","url":null,"abstract":"<div><div>The maternal microbiota plays a pivotal role in shaping fetal and neonatal neurodevelopment through the gut–brain axis. Modern lifestyles, cesarean delivery, formula feeding, and Westernized diets contribute to maternal and neonatal dysbiosis, increasing the risk of neurodevelopmental, metabolic, and immune disorders in offspring. This review explores how maternal diet, microbiota composition, probiotics, prebiotics, and postbiotics during pregnancy and lactation influence the microbial and neurodevelopmental trajectory of newborns. Evidence suggests that prenatal microbial transfer begins in utero, while birth mode and breastfeeding strongly shape early microbial colonization. Dysbiosis, maternal immune activation, and pro-inflammatory conditions such as obesity or gestational diabetes disrupt microglial maturation and increase the risk of neurodevelopmental disorders, including autism spectrum disorder, ADHD, and mood disorders. Conversely, maternal adherence to a Mediterranean diet, combined with selected probiotic, prebiotic, and postbiotic supplementation, supports microbial diversity, enhances barrier function, and promotes neuroprotective metabolite production.</div><div>In conclusion, early maternal interventions targeting microbiota composition—through diet and microbial therapies—represent a promising strategy to optimize neonatal neurodevelopment and long-term health. Future personalized approaches, guided by maternal microbiota profiling, could strengthen preventive pediatric care.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100301"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Neonatal umbilical hernia: A simple noninvasive technique” [Global Pediatrics 13C (2025) 100280]","authors":"Jayalaxmi Shripati Aihole","doi":"10.1016/j.gpeds.2025.100289","DOIUrl":"10.1016/j.gpeds.2025.100289","url":null,"abstract":"","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100289"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the place for digital health and AI in pediatric primary care? A call to action from the European Confederation of Primary Care Paediatricians (ECPCP)","authors":"Laura Reali,&nbsp;Annamaria Sapuppo,&nbsp;Doron Dushnitzky","doi":"10.1016/j.gpeds.2025.100290","DOIUrl":"10.1016/j.gpeds.2025.100290","url":null,"abstract":"<div><div>Digitalization and technological breakthroughs have transformed pediatric medical services via integrated digital health systems, encompassing telemedicine, teleconsultation, and artificial intelligence applications. This article examines the potential and current status of digital health (DH) and artificial intelligence (AI) in pediatric primary care (PPC), as well as their impact on clinical practice, patient outcomes, and healthcare delivery. In pediatric populations, digital health technologies—including wearable devices, electronic health records (EHRs), and mobile health applications—have significantly improved care coordination, health education, and remote monitoring. Telemedicine facilitates mental health assessments and the management of chronic illnesses, increasing accessibility and convenience. AI applications demonstrate potential in individualized treatment planning, email management, therapeutic decision assistance, and diagnostic imaging. The COVID-19 pandemic accelerated the implementation of these technologies, which are particularly beneficial in emergencies and remote care scenarios. Nonetheless, impediments to adoption exist, including the necessity for human oversight, interoperability challenges, socioeconomic limitations, and data privacy concerns. Artificial intelligence and digital health technologies possess substantial potential to enhance patient-centered care by augmenting efficiency, quality, and accessibility. Successful implementation necessitates meticulous consideration of safety, efficacy, ethical oversight, and appropriate resource allocation. Future research should focus on addressing the individual needs of patients and healthcare professionals, with regulatory compliance, personalized care, and precise diagnosis.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100290"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the motor proficiency and physical capacity of asthmatic children and adolescents: A cross-sectional study","authors":"Josiane G Luiz ,&nbsp;Évelim Leal de Freitas Dantas Gomes ,&nbsp;Manoella Cavalcante de Andrade ,&nbsp;Dirceu Costa","doi":"10.1016/j.gpeds.2025.100284","DOIUrl":"10.1016/j.gpeds.2025.100284","url":null,"abstract":"<div><h3>Background</h3><div>Exercise restrictions due to asthma are associated with a sedentary lifestyle and reduced physical activity. Based on the limited data available in the literature, improvements in motor proficiency among individuals with respiratory diseases may be related to increased physical activity and better performance in activities of daily living. Therefore, the aim of this study was to evaluate motor proficiency and its association with aerobic capacity in children and adolescents with asthma.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted. Motor proficiency was evaluated using the Movement Assessment Battery for Children – 2nd edition (MABC-2). Aerobic capacity was assessed using the Modified Shuttle Walk Test (MSWT). Asthma control was determined using the Asthma Control Questionnaire (ACQ6).</div></div><div><h3>Results</h3><div>Fifty participants not engaged in regular physical activity (25 with asthma and 25 controls) were evaluated. The mean age was 7.7 ± 2.65 years in the asthma group (AG) and 10.9 ± 3.89 years in the control group (CG). Both groups performed below predicted values in the MSWT (58.7 ± 21.3 % AG and 66.8 ± 29.2 % CG). The AG performed significantly worse than the CG on the aiming and catching subscale of the MABC-2 (15.4 ± 5.23 and 20.1 ± 7.06, <em>p</em> = 0.01, respectively). Moreover, a moderate negative correlation was found between manual dexterity and asthma control (<em>r</em> = -0.51, <em>p</em> = 0.02). Each 9.79-point increase in the MABC-2 manual dexterity subscale was associated with a 1.72-point reduction in the ACQ6.</div></div><div><h3>Conclusions</h3><div>Low aerobic capacity appears to negatively impact balance, and poor asthma control appears to negatively affect manual dexterity in the AG. Moreover, the AG had worse performance in aiming and catching compared to the CG.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100284"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of pain and pain management practices in hospitalized children in Ayder, Tigray, Ethiopia","authors":"Hansa Haftu Lemma,&nbsp;Afewerk Salih,&nbsp;Amanuel Hadgu,&nbsp;Dawit Seyum,&nbsp;Goitom Gebrekidan","doi":"10.1016/j.gpeds.2025.100296","DOIUrl":"10.1016/j.gpeds.2025.100296","url":null,"abstract":"<div><h3>Background</h3><div>Pain in children is a commonly unaddressed, neglected, and undertreated issue. This study aims to assess pain, the clinical profile associated with pain, and pain management practices in children.</div></div><div><h3>Methodology</h3><div>A hospital-based cross-sectional study was conducted in the Pediatric ward from March 20 to June 30, 2020. A total of 238 children were selected using a stratified sampling method. Pain was assessed through history (guardian/patient report), the FLACC scale (for infants and young children), and a numerical pain scale for older children. Data were analyzed using SPSS, with statistical significance considered at p-value &lt; 0.05.</div></div><div><h3>Results</h3><div>All 238 patients were enrolled in the study. The mean age of the study subjects was 6.6 ± 5.5 years. The severity of pain was assessed at the time of admission, during the hospital stay, and at discharge. The overall pain prevalence, as reported by caregivers and patients, was 67.6 %. Based on different pain assessment tools for various age groups, the magnitude of pain was 64.3 % at admission, 55.9 % during the hospital stay, and 26.5 % at discharge. Multivariable regression showed that age, area of residency, and diagnosis were significantly associated with pain. Eighty-four children (39.3 %, 84/214) who were in pain did not receive any pain relief. Paracetamol was used as an analgesic in 31.8 % of patients, and &gt;50 % of paracetamol doses were administered as needed.</div></div><div><h3>Conclusion</h3><div>Pain remains a prevalent problem at admission and during the hospital stay. A significant number of patients were not properly assessed or treated for pain.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100296"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Neonatal umbilical hernia: A simple noninvasive technique”","authors":"Jayalaxmi Shripati Aihole","doi":"10.1016/j.gpeds.2025.100297","DOIUrl":"10.1016/j.gpeds.2025.100297","url":null,"abstract":"<div><div>Umbilical hernias are a common congenital anomaly in infants, characterized by the protrusion of abdominal contents through an incompletely closed umbilical fascial ring. While the majority of these hernias resolve spontaneously within the first few years of life, a small but significant proportion can lead to complications such as incarceration, strangulation, or evisceration, necessitating urgent surgical intervention. Current clinical guidelines predominantly advocate for watchful waiting in asymptomatic cases. However, this expectant approach can cause considerable parental anxiety and does not actively support the natural closure process. This clinical report describes the Jayalaxmi Shripati Aihole-JSA's Maneuver, a practical, parent-administered manual compression technique designed to potentially accelerate the spontaneous closure of umbilical hernias and mitigate the risk of complications during the watchful waiting period. Preliminary observations from 55 neonates and infants suggest that this simple, no-cost intervention may hasten the resolution of the hernia, improve infant comfort, and enhance parent-child bonding. Further rigorous research is warranted to validate the efficacy and safety of this technique.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100297"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}