Global pediatrics最新文献

{"title":"Prevalence and determinants of scabies among school-age children in selected public primary schools of Debre Tabor town, Northwest Ethiopia: A cross-sectional study, 2023","authors":"Meron Wolanewos Asfaw ,&nbsp;Bacha Mirkena Dhabi ,&nbsp;Tsion Wolanewos Asfaw ,&nbsp;Betelhem Alemu Mulugeta ,&nbsp;Ephrem Mamo Gebrehiwot","doi":"10.1016/j.gpeds.2025.100315","DOIUrl":"10.1016/j.gpeds.2025.100315","url":null,"abstract":"<div><h3>Background</h3><div>Scabies is a parasitic skin infestation affecting all ages worldwide and is classified as a neglected tropical disease. Poverty and poor hygiene drive its spread. Despite national control strategies, scabies remains prevalent in Ethiopia, yet data on its burden and risk factors among school children in Debre Tabor town are limited.</div></div><div><h3>Objective</h3><div>To assess the prevalence and determinants of scabies among school-age children in selected public primary schools in Debre Tabor town, Northwest Ethiopia.</div></div><div><h3>Methods</h3><div>Institution‑based cross‑sectional study was conducted May 5–30, 2023, among 302 school‑age children randomly selected from five primary schools. Data were collected via structured questionnaire and physical examination, with quality assured through pretesting and supervision. Entries were made in Epi‑data 4.6 and analyzed in SPSS 24. Variables with <em>p-value &lt; 0.25</em> in bivariate analysis entered multivariate logistic regression. Adjusted odds ratios (AOR) with 95% confidence intervals (CI) were reported, with significance at <em>p-value &lt; 0.05</em>.</div></div><div><h3>Results</h3><div>The prevalence of scabies was 12.3 % (95 % CI: 9.3 %, 17.2 %). Significant factors included family size &gt;5 (AOR = 4.2, 95 % CI: 1.20–16.35), unimproved water source (AOR = 5.3, 95 % CI: 1.38–20.22), handwashing with water only (AOR = 4.8, 95 % CI: 1.22–18.66), sharing clothes (AOR = 3.7, 95 % CI: 1.05–13.31), bed sharing (AOR = 6.5, 95 % CI: 1.40–30.50) and traveling ≥30 min to fetch water (AOR = 4.9, 95 % CI: 1.15–21.09)</div></div><div><h3>Conclusion</h3><div>Scabies prevalence among school-age children in Debre Tabor was high, driven by household crowding, poor hygiene, and limited water. Targeted interventions in hygiene education, safe water, and behavioral change are essential.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100315"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity of pediatric index of mortality 2 scoring in a pediatric ICU setting in Ethiopia: A prospective observational study","authors":"Mikiyas G. Teferi ,&nbsp;Bethel A. Awoke ,&nbsp;Iyassu S. Melkie ,&nbsp;Oghenekenu Oshare ,&nbsp;Soliana Solomon Birhanu ,&nbsp;Gelila Gemeda Gage ,&nbsp;Biruk T. Mengistie ,&nbsp;Chernet T. Mengistie ,&nbsp;Alehilign M. Abebe","doi":"10.1016/j.gpeds.2026.100322","DOIUrl":"10.1016/j.gpeds.2026.100322","url":null,"abstract":"<div><h3>Background</h3><div>Mortality prediction scoring systems are essential tools for quality assessment and clinical decision-making in pediatric intensive care units (PICUs). The Pediatric Index of Mortality 2 (PIM2) is widely used in high-income countries, but its validity in resource-limited settings remains uncertain.</div></div><div><h3>Objective</h3><div>To evaluate the validity of PIM2 in predicting mortality among children admitted to a PICU in Ethiopia.</div></div><div><h3>Methods</h3><div>A prospective observational study was conducted at Hawassa University Comprehensive Specialized Hospital PICU, Ethiopia, from February 1 to July 31, 2025. All children aged 1 month to 14 years admitted during the study period were enrolled. PIM2 scores were calculated within one hour of PICU admission using physiological and clinical variables. The primary outcome was mortality at PICU discharge. Discrimination was assessed using the area under the receiver operating characteristic curve (AUROC), and calibration was evaluated using the Hosmer-Lemeshow goodness-of-fit test.</div></div><div><h3>Results</h3><div>Of 76 enrolled patients, 31 (40.8 %) died and 45 (59.2 %) survived. Median age was 24 months (IQR 12–48 months), and 47 (61.8 %) were male. The median PIM2 score was 8.5 % (IQR 3.2–25.6 %). PIM2 demonstrated poor discrimination with an AUROC of 0.651 (95 % CI 0.525–0.777, <em>p</em> = 0.029). Calibration was also poor (Hosmer-Lemeshow χ²=15.8, <em>p</em> = 0.045). The standardized mortality ratio was 1.32, indicating observed mortality exceeded predicted mortality by 32 %.</div></div><div><h3>Conclusions</h3><div>PIM2 showed poor performance in predicting mortality in an Ethiopian PICU setting. This finding highlights the need for local recalibration or development of context-specific mortality prediction tools for resource-limited settings with different case-mix, disease patterns, and treatment protocols.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100322"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147395155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert consensus on implementation and use of caffeine in Ethiopia","authors":"Gesit Metaferia ,&nbsp;Mahlet Abayneh ,&nbsp;Asrat Demtse ,&nbsp;Hailu Berta ,&nbsp;Bogale Worku ,&nbsp;Daniele Trevisanuto ,&nbsp;Corrado Moretti ,&nbsp;Camilla Gizzi","doi":"10.1016/j.gpeds.2025.100314","DOIUrl":"10.1016/j.gpeds.2025.100314","url":null,"abstract":"<div><div>Methylxanthines such as caffeine and aminophylline are routinely administered to prevent apnea of prematurity. Caffeine is one of the most extensively studied drugs in neonatology and, for this reason, it has been included in the World Health Organization’s list of essential medicines since 2009. Unfortunately, caffeine is still not available in many low-resource settings. In Ethiopia, its introduction has begun, but national recommendations are still lacking.</div><div>In this manuscript, we present the process and results of an international expert consensus on the use of caffeine for the prevention and treatment of apnea of prematurity, aimed at supporting its implementation as an essential drug in Ethiopian hospitals. The article's influence may extend beyond Ethiopia, serving as a model for other low- and middle-income countries seeking to integrate caffeine into their neonatal care protocols.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100314"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of pediatric invasive pneumococcal disease in an inner-city tertiary care center: A 13-year study and post-pandemic insights","authors":"Sarah Habbal ,&nbsp;Nahed Abdel-Haq ,&nbsp;Basim Asmar ,&nbsp;Ronald Thomas ,&nbsp;Jocelyn Yu Ang","doi":"10.1016/j.gpeds.2025.100316","DOIUrl":"10.1016/j.gpeds.2025.100316","url":null,"abstract":"<div><h3>Background</h3><div>Invasive pneumococcal disease (IPD) remains a significant cause of morbidity and mortality in children. While global IPD incidence declined during the COVID-19 pandemic due to mitigation measures, a resurgence followed the relaxation of these interventions.</div></div><div><h3>Objectives</h3><div>The primary objective is to describe the epidemiology of IPD at our institution after the introduction of PCV-13 and to compare trends before and after the COVID-19 pandemic.</div></div><div><h3>Methods</h3><div>A retrospective chart review of IPD patients ≤21 years of age admitted between January 2010 - February 2024 at the Children’s Hospital of Michigan, Detroit. Patients were further categorized into 2 groups: pre-pandemic (2016-2020) and pandemic/post-pandemic (2020-2024).</div></div><div><h3>Results</h3><div>143 cases were included. IPD incidence decreased during the pandemic (2020-2021) to 0.6-0.8 per 1000 hospital admissions but rebounded in 2022-2023 to 1.7-1.4 per 1,000 hospital admissions. Of 143 patients 99/143(69 %) had no known risk factor and 12/143 (8.3 %) had sickle cell disease. 73 % (90/143) were fully immunized. Pneumococcal antibodies were tested in 37 patients and 20/37(54 %) had low titers; 16/20 (80 %) were fully immunized. No statistically significant differences were observed between the two periods regarding age, gender, clinical presentation or clinical outcome (<em>p</em> = &gt;0.05). However, the proportion of unimmunized children was significantly higher in the post-pandemic period (<em>n</em> = 8/43, 20.5 %) compared to pre-pandemic period (<em>n</em> = 2/49, 4.8 %; <em>p</em> = 0.03).</div></div><div><h3>Conclusions</h3><div>IPD incidence increased during the two years post COVID-19 pandemic, potentially due to decreased vaccination. Recognizing these epidemiological shifts and addressing vaccination gaps with use of updated vaccine are critical in preventing future IPD outbreaks.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100316"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of surgery in NEC: Do respiratory requirements influence time to operating room?","authors":"Amna Minhas ,&nbsp;Georgi Mladenov ,&nbsp;Joyce McRae ,&nbsp;Arsalan Javid ,&nbsp;Rosemary Vannix ,&nbsp;Andrew Hopper ,&nbsp;Nicole Kraus ,&nbsp;Andrei Radulescu","doi":"10.1016/j.gpeds.2025.100304","DOIUrl":"10.1016/j.gpeds.2025.100304","url":null,"abstract":"<div><h3>Purpose</h3><div>Necrotizing enterocolitis (NEC) is a severe gastrointestinal emergency in preterm infants, often associated with respiratory compromise. We evaluated the association between respiratory support requirements at NEC diagnosis and time to surgery in very low birth weight (VLBW) infants with surgical NEC.</div></div><div><h3>Methods</h3><div>A retrospective review of VLBW, preterm neonates (&lt; 1500 grams and &lt;34 weeks gestational age) with surgical NEC from January 2010 till December 2019 was conducted at an academic tertiary care center. Respiratory parameters were recorded after NEC onset. Time to the operating room (OR) was defined as median duration (hours) from diagnosis to surgery. High respiratory support group was defined as patients on invasive respiratory support.</div></div><div><h3>Results</h3><div>Sixteen neonates were included. Mean gestational age and age at diagnosis were 26.9 ± 2.9 weeks and 18.9 ± 12.3 days, respectively. Average birth weight was 951 ± 338 grams. Infants in the high respiratory support group (<em>n</em> = 10) had a shorter median time to OR (28 vs 229 h, <em>p</em> = 0.2), with respiratory acidosis significantly more prevalent in this group (90 % vs. 33 %, <em>p</em> = 0.03). These infants had longer hospital stays (159 vs. 73 days, <em>p</em> = 0.2) and a higher likelihood of multiple surgeries (80 % vs. 50 %, <em>p</em> = 0.3). Mortality was higher in neonates with low respiratory requirements, though this difference did not reach statistical significance (50 % vs. 20 %, <em>p</em> = 0.3).</div></div><div><h3>Conclusion</h3><div>Higher respiratory support requirements at NEC diagnosis were linked to earlier surgical intervention, greater disease severity, and prolonged hospitalization. While limited by small sample size, our findings suggest that worsening respiratory status may serve as an early, objective marker of clinical deterioration, warranting closer monitoring and potentially expediting surgical decision-making in very low birth weight infants.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100304"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145625227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical spectrum and outcomes of tracheobronchial foreign body aspiration in children: A retrospective cohort study","authors":"Nadim Nafie Haddad","doi":"10.1016/j.gpeds.2025.100310","DOIUrl":"10.1016/j.gpeds.2025.100310","url":null,"abstract":"<div><h3>Background</h3><div>Foreign body aspiration (FBA) is one of the principal causes of respiratory emergencies in children that can be prevented. This research paper was an attempt to describe the clinical manifestation, radiographic appearance, and prognosis of tracheobronchial FBA in children and to determine which factors predict abnormal postoperative recovery.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted at Azadi Teaching Hospital, the main tertiary referral center in Kirkuk, Iraq, from January 2015 to December 2024. Medical records of 245 children (&lt;15 years) with bronchoscopically confirmed tracheobronchial foreign bodies were reviewed. Demographic, clinical, radiological, and operative data were collected. Logistic regression was used to identify independent predictors of abnormal postoperative outcomes.</div></div><div><h3>Results</h3><div>The mean was 3.93 ± 3.10 years; half of them were female. The percentage of organic foreign bodies was 73.9 percent with the right main bronchus being the most common location (41.6%). There were abnormal radiology in 49.4 percent. The postoperative outcomes were full recovery (42.9%), mild cough (45.7%), respiratory distress that needed RCU observation (11.0%), and one death (0.4). Independent predictors of abnormal postoperative outcomes were abnormal radiographs (AOR = 15.22; 95% CI: 7.16–32.37; p = 0.001) and younger age. There was good model performance (AUC = 0.81).</div></div><div><h3>Conclusion</h3><div>The most common example of the foreign body aspiration of the tracheobronchial is in toddlers and is mostly due to organic matter. Age and abnormal chest radiographic results are the major predictors of postoperative complications in younger ages. Early identification, prompt bronchoscopy and vigorous postoperative care are pivotal to the decrease of morbidity and in particular among high-risk children. Radiographic findings during the presentation could assist in sorting out children at risk to be closely observed during the postoperative period. Raising awareness of the risks of small organic objects is crucial with the prevention in the areas of the seed ingestion.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100310"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal ultrasound screening for abdominal manifestations of neurofibromatosis type 1 in the pediatric population: A case series","authors":"Tuzger N ,&nbsp;Milani D ,&nbsp;Grilli F ,&nbsp;Pavesi MA ,&nbsp;Vespro V ,&nbsp;Carnevali A ,&nbsp;Chiaraviglio MF ,&nbsp;Natacci F ,&nbsp;Fabiano V","doi":"10.1016/j.gpeds.2025.100311","DOIUrl":"10.1016/j.gpeds.2025.100311","url":null,"abstract":"","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100311"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145797328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of clinical instructors performance in radiographic assessment of primary molar furcation areas: A pilot study","authors":"Hyun-Joo Lim ,&nbsp;Rojin Adabdokht ,&nbsp;Hollis Lai,&nbsp;Manuel O. Lagravere Vich,&nbsp;Camila Pacheco-Pereira,&nbsp;Naeem Hedayatipoor,&nbsp;Ida Kornerup","doi":"10.1016/j.gpeds.2025.100317","DOIUrl":"10.1016/j.gpeds.2025.100317","url":null,"abstract":"<div><h3>Purpose and Background</h3><div>This study aimed to evaluate the diagnostic performance, agreement, and consistency of pediatric dentistry instructors in radiographic diagnosis of furcation lesions. Radiographic identification of furcation lesions in primary molars is challenging due to the superimposition of anatomic features and the developing permanent tooth buds. Clinical instructors’ inconsistencies in diagnosing this lesion may compromise patient outcomes and student training.</div></div><div><h3>Methods</h3><div>Eight clinical instructors assessed 20 radiographs in two blinded rounds. A validated reference diagnosis dataset was established by two calibrated specialists, using paired pre-treatment and follow-up radiographs. Total and subgroup analysis was performed between instructors with and without specialty training. Diagnostic performance was measured by sensitivity, specificity, and accuracy. Agreement and consistency were evaluated using Fleiss’ and Cohen’s Kappa.</div></div><div><h3>Results</h3><div>Overall sensitivity, specificity, and accuracy were 0.75, 0.77, and 0.76, respectively, with no significant differences between pediatric specialists and general dentists (<em>p</em> = 0.79). Agreement was moderate overall (<em>K</em> = 0.50 - 0.59), ranging from fair to moderate in general dentists and substantial in specialists. Intra-rater consistency was substantial to almost perfect overall and in both groups (<em>K</em> = 0.62- 0.82).</div></div><div><h3>Conclusions</h3><div>Instructors demonstrated satisfactory accuracy and high intra-rater consistency in diagnosing furcation lesions, however inter-rater agreement was suboptimal. Standardized guidelines or could improve calibration and teaching reliability.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100317"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"European project on the competence in pediatric atopic dermatitis management in primary care: Pilot study in a Balkan region","authors":"Massimo Pettoello-Mantovani ,&nbsp;Tena Niseteo ,&nbsp;Georgios Konstantinidis ,&nbsp;Donjeta Bali ,&nbsp;Angel Carrasco-Sanz ,&nbsp;Maria Pastore ,&nbsp;Mehmet Vural ,&nbsp;Francesca Scaltrito ,&nbsp;Tudor Lucian Pop ,&nbsp;Giuseppe Buonocore","doi":"10.1016/j.gpeds.2026.100323","DOIUrl":"10.1016/j.gpeds.2026.100323","url":null,"abstract":"<div><div>Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease that frequently begins in early childhood and imposes a substantial clinical and psychosocial burden on affected patients and their families. Given its high prevalence and the limited availability of pediatric dermatology services across many European regions, general pediatricians play a pivotal role in diagnosis, severity assessment, and initial management. As part of an EPA-UNEPSA initiative to evaluate and enhance pediatric competence in AD care across Europe, this pilot study assessed knowledge, attitudes, and management practices among general pediatricians in Serbia. In April 2025, an anonymous, web-based, 19-item questionnaire developed by EPA-UNEPSA experts was distributed to primary care pediatricians; 14% of all national pediatricians completed the survey. The questionnaire explored understanding of AD pathophysiology, use of standardized scoring systems, therapeutic decision-making, complementary therapy use, allergy workup, prevention strategies, and referral thresholds. Results indicate strong theoretical knowledge, with near-universal recognition of the multifactorial nature of AD (100%) and awareness of objective severity tools such as SCORAD (96.8%). Most respondents (93.7%) believe primary care physicians should diagnose and treat AD; however, only around half feel capable of managing &gt;45% of cases, revealing a substantial “competency gap.” Pediatricians report structured use of complementary therapies, widespread reliance on nutraceuticals, in particular a combined Omega-3, GLA, and Vitamin D nutraceutical formulation (61,80%), and high acceptance of microbiota-targeted approaches. Ambiguity persists regarding prevention with neonatal emollients and perceived prevalence of food allergies. These findings highlight the need for targeted educational programs to strengthen longitudinal management capacity and support harmonized, evidence-based AD care across Europe. Finally, the importance to expanding this project to other European countries in order to validate the results of this pilot study and to compare the degree of the divergences across diverse healthcare systems.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100323"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147395157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multisystem Inflammatory Syndrome in Children (MIS-C): A clinical and research overview in the framework of a personalized medicine approach","authors":"Francesca Scaltrito ,&nbsp;Maria Teresa Grimaldi ,&nbsp;Grazia Tolfa ,&nbsp;Roberta De Benedetto ,&nbsp;Domenico Adduce ,&nbsp;Maria Pastore ,&nbsp;Sara Cannito ,&nbsp;Ida Giardino ,&nbsp;Massimo Pettoello-Mantovani","doi":"10.1016/j.gpeds.2025.100313","DOIUrl":"10.1016/j.gpeds.2025.100313","url":null,"abstract":"<div><div>Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but severe pediatric condition first identified in Europe and the United States in early 2020, following initial reports from the United Kingdom and Italy. Also known as Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS), MIS-C was rapidly recognized as a delayed, potentially life-threatening complication arising after SARS-CoV-2 infection. Unlike acute COVID-19, which is often mild or asymptomatic in children, MIS-C is characterized by a pronounced hyperinflammatory response, with symptoms typically appearing two to five weeks after the initial infection. The syndrome has raised major concern due to its potential for rapid clinical deterioration and severe multi-organ involvement, particularly affecting the cardiovascular system.</div><div>Over the past five years, a growing body of research has substantially advanced our understanding of MIS-C, encompassing its pathophysiological mechanisms, clinical presentation, diagnostic criteria, treatment strategies, and long-term outcomes. In view of the persistent epidemiology of COVID-19, this article synthesizes current knowledge within the framework of a personalized medicine approach, highlights recent insights from advanced peer-reviewed studies, and underscores the need for tailored therapeutic strategies to optimize patient care.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100313"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}