Global pediatrics最新文献

{"title":"Fraser syndrome with extremely rare features of unilateral anophthalmia and penile torsion in an Afghan neonate: A case report","authors":"Turyalai Hakimi ,&nbsp;Mansoor Aslamzai","doi":"10.1016/j.gpeds.2025.100258","DOIUrl":"10.1016/j.gpeds.2025.100258","url":null,"abstract":"<div><h3>Background</h3><div>Fraser syndrome is a very rare genetic disorder with multiple organ-system abnormalities. The diagnosis is usually made on the basis of clinical examination, and management requires a multidisciplinary approach.</div></div><div><h3>Case Presentation</h3><div>We present a case of Fraser syndrome with very rare manifestations of unilateral anophthalmia and moderate penile torsion in an Afghan neonate who was born to a 16-year-old mother. Physical findings and a CT scan of the brain and eyes were used to diagnose the aforementioned syndrome. The surgical repairs of cryptophthalmos and penile torsion were planned to be performed after infancy, and the baby was discharged in good health.</div></div><div><h3>Conclusion</h3><div>Anophthalmia and penile torsion are very rare components of Fraser syndrome. Very young maternal age may play a predisposing role in the pathogenesis of Fraser syndrome. The multiple organ defects in Fraser syndrome make this entity more challenging to deal with, particularly in low-resourced settings.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"12 ","pages":"Article 100258"},"PeriodicalIF":0.0,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of timing for initiating formula feeding on the short-term prognosis of very low birth weight infants","authors":"Katsumi Mizuno","doi":"10.1016/j.gpeds.2025.100259","DOIUrl":"10.1016/j.gpeds.2025.100259","url":null,"abstract":"<div><h3>Background</h3><div>For very low birth weight (VLBW) infants, breast milk, particularly mothers' own milk (MOM), is the optimal nutrition. Donor human milk (DHM) is recommended when MOM is insufficient. However, the optimal timing for transitioning from DHM to formula remains unclear. This study examines the impact of formula initiation timing on complications in VLBW infants.</div></div><div><h3>Methods</h3><div>We analyzed data from 744 VLBW infants (&lt;1500 g) who initiated enteral feeding with DHM within 24 hours of birth using a human milk bank database (2018–2024). Postmenstrual age (PMA) at formula initiation was assessed for associations with bronchopulmonary dysplasia (BPD), home oxygen therapy (HOT), retinopathy of prematurity (ROP), and necrotizing enterocolitis (NEC).</div></div><div><h3>Results</h3><div>The median PMA at formula initiation was 34.6 weeks. Delayed formula initiation reduced the risk of BPD, HOT, and NEC. Compared to formula initiation before 32 weeks, odds ratios for BPD ranged from 0.186 (34–36 weeks) to 0.239 (no formula). Formula initiation at 32–34 weeks significantly lowered ROP requiring treatment (OR 0.305). Logistic regression analysis indicated a trend toward reduced NEC risk when formula initiation occurred after 34 weeks (<em>p</em> = 0.0504).</div></div><div><h3>Conclusion</h3><div>Delaying formula initiation until after 34 weeks PMA reduces complications in VLBW infants. Early enteral nutrition with MOM or DHM within 24 hours of birth is crucial, and later formula introduction may provide better outcomes. Further studies are needed to refine feeding guidelines</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"12 ","pages":"Article 100259"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of survival of human immune deficiency virus infected children after commencing anti-retroviral therapy in Kembata-Tembaro zone: A facility-based retrospective cohort study","authors":"Tarekegn Tessema ,&nbsp;Mitiku Desalegn ,&nbsp;Lonsako Abute ,&nbsp;Tadele Yohannes","doi":"10.1016/j.gpeds.2025.100257","DOIUrl":"10.1016/j.gpeds.2025.100257","url":null,"abstract":"<div><h3>Background</h3><div>HIV infection is one of the most significant challenges to global health faced by care providers. On the other hand, malnutrition is prevalent in developing countries; it remains a serious problem among HIV-positive children even with the provision of Anti-Retroviral Therapy (ART).</div></div><div><h3>Objective</h3><div>To explore determinants of survival of human immune deficiency virus-infected children after commencing Anti-Retroviral Therapy in Kembata-Tembaro Zone, Southern Ethiopia, 2022.</div></div><div><h3>Methods</h3><div>A facility-based retrospective cohort study was employed among 305 HIV-infected children on ART from May 5-June 4/2022 at public hospitals in Kembata-tembaro zone. The data were collected by using a checklist. Data were entered and cleaned using <em>Epi</em> info 3.5.3 and analysed using SPSS version 25.0 software. The cumulative survival time after initiation of ART was calculated using the Kaplan-Meier survival curve. A Multivariable Cox proportional model was fitted to identify factors affecting survival after initiation of ART and variables having P value≤ 0.05 were considered statistically significant predictors of mortality.</div></div><div><h3>Results</h3><div>Overall, 43(14.1 %) died with an overall survival rate of 3.3 per 1000 child-months of observation. Undernourished children had a lower survival time than well-nourished children with mean survival time of 92.7 and 62.3 months respectively. Children with advanced WHO clinical stage III or IV (AHR: 6.1; 95 %CI: 1.4, 26.7), severe wasting at the baseline (AHR: 8.7; 95 %CI: 3.2, 23.6), high viral load level (AHR: 3.5; 95 %CI: 0.15, 0.61) and fair/poor adherence to ART (AHR: 3.7; 95 %CI: 2.3, 13.5) were significantly associated with survival of HIV-positive children in this study.</div></div><div><h3>Conclusion</h3><div>a significant difference in survival time was observed between undernourished and well-nourished children with a high rate of mortality. Severe wasting, WHO clinical stage III or IV, high viral load level and fair/poor adherence were identified as the determinants of survival.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"12 ","pages":"Article 100257"},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the viet-modified screening tools for the assessment of malnutrition in pediatrics (V-mSTAMP)","authors":"Thi Thu Lieu Nguyen ,&nbsp;Thu Huyen Doan ,&nbsp;Ngoc Anh Doan ,&nbsp;Thi Phuong Duong ,&nbsp;Thi Thanh Xuan Le ,&nbsp;Thi Huong Le ,&nbsp;Thi My Thuc Luu","doi":"10.1016/j.gpeds.2025.100256","DOIUrl":"10.1016/j.gpeds.2025.100256","url":null,"abstract":"<div><h3>Background</h3><div>The Screening Tool for the Assessment of Malnutrition in Pediatrics (STAMP) is designed for hospitalized children aged 2 weeks to 16 years. The modified version, Viet-Modified STAMP (V-mSTAMP), has been adapted for Vietnamese pediatric patients to address local nutritional risks and dietary patterns.</div></div><div><h3>Aims</h3><div>To validate the modified Screening Tool for the Assessment of Malnutrition in Pediatrics for use in Vietnamese pediatric patients.</div></div><div><h3>Methods</h3><div>The study validated the STAMP through a cross-sectional study at the National Children's Hospital, Vietnam. It involved 200 hospitalized children, using STAMP and V-mSTAMP for screening; the Subjective Global Nutrition Assessment (SGNA) and a nutritional standardized method which is a collaborative effort between the Academy of Nutrition and Dietetics (AND) and the American Society for Parenteral and Enteral Nutrition (ASPEN) for nutritional assessment; and comparing V-mSTAMP effectiveness with other reference standards.</div></div><div><h3>Results</h3><div>The average age of the patients was 10.8 ± 7.2 years. The V-mSTAMP screened 50.5 % of patients at no risk, 15 % at medium risk, and 34.5 % at high risk of malnutrition, with sensitivity ranging from 88.3 % to 94.2 % and specificity ranging from 61.3 % to 84.9 % compared to various standards. The area under the ROC curve ranged from 0.7 to 0.9. The agreement between V-mSTAMP and STAMP was 86.5 % (kappa = 0.7), and the internal reliability of V-mSTAMP showed 98 % agreement (kappa = 0.89).</div></div><div><h3>Conclusion</h3><div>Our study indicated the V-mSTAMP demonstrated high sensitivity and specificity when compared to the reference standards, with good reliability. Thus, the V-mSTAMP is an effective method for screening malnutrition in Vietnamese pediatric patients.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"12 ","pages":"Article 100256"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gross and fine motor milestones in the first two years of life - representative data for Germany","authors":"Heinz Krombholz","doi":"10.1016/j.gpeds.2025.100254","DOIUrl":"10.1016/j.gpeds.2025.100254","url":null,"abstract":"<div><h3>Aims / Background</h3><div>This paper analyzes the development of 18 gross and fine motor development steps (milestones) in the first two years of life and presents norms for children with normal birth weight and underweight children.</div></div><div><h3>Design / Method</h3><div>The data come from a research project with more than 3400 parents, mainly in Germany, who participated. Using a “citizen-science approach,” parents reported their children's developmental progress online based on a calendar that charts 14 gross and four fine motor skills from birth to the point when children manage to walk.</div></div><div><h3>Results / Conclusion</h3><div>Only small and insignificant differences in reaching milestones were found between girls and boys. In addition, no impact of kind of delivery, nutrition, size at birth, siblings, age of mothers, social status of parents, and month of birth on motor development was found. However, preterm or underweight newborns showed a significant delayed motor development compared to newborns with normal birth weight. Therefore, separate norm values are presented for the total sample and for normal birth weight and underweight children.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"12 ","pages":"Article 100254"},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anorectal manometry under adequate sedation or anesthesia as a highly reliable diagnostic tool for Hirschsprung's disease in neonates and young infants: A multicenter retrospective study","authors":"Yohei Sanmoto ,&nbsp;Atsuki Naoe ,&nbsp;Yudai Goto ,&nbsp;Mikihiro Inoue ,&nbsp;Kouji Masumoto","doi":"10.1016/j.gpeds.2025.100255","DOIUrl":"10.1016/j.gpeds.2025.100255","url":null,"abstract":"<div><h3>Background</h3><div>Hirschsprung's disease is a congenital disorder characterized by the absence of enteric ganglion cells. The diagnostic gold standard for Hirschsprung's disease is a rectal mucosal biopsy; however, its accuracy in neonates and young infants remains limited. Although less invasive, the diagnostic performance of anorectal manometry (ARM) in these populations remains controversial. We evaluated the diagnostic performance of ARM in patients with Hirschsprung's disease by age group.</div></div><div><h3>Methods</h3><div>This multicenter retrospective study compared the diagnostic outcomes of ARM and biopsy across three age categories: neonates (&lt;28 days), infants ≤6 months, and children aged &gt;6 months. Additionally, logistic regression analysis was performed to assess changes in the probability of accurate diagnosis and exclusion of Hirschsprung's disease by ARM with increasing age.</div></div><div><h3>Results</h3><div>Overall, 113 patients were included in this study. The median patient age (range) at the time of ARM was 103 (3–3913) days. Most patients (83.2 %) underwent ARM under intravenous sedation or inhalation anesthesia. ARM revealed higher sensitivity than did biopsy in neonates (100 % vs. 45.5 %, <em>P</em> = 0.012) and infants aged ≤6 months (97.1 % vs. 79.6 %, <em>P</em> = 0.022). With increasing age, the probability of accurate diagnosis for Hirschsprung's disease by ARM significantly decreased (<em>P</em> = 0.031), although the probability of accurate exclusion showed no significant change (<em>P</em> = 0.35).</div></div><div><h3>Conclusion</h3><div>ARM, when performed under appropriate sedation or anesthesia, yields superior sensitivity for diagnosing Hirschsprung's disease in young children than does biopsy. However, diagnostic accuracy decreases with age, requiring careful interpretation in patients aged &gt;6 months.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"12 ","pages":"Article 100255"},"PeriodicalIF":0.0,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143808394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A charter of children's rights in the context of primary care","authors":"Milena Lo Giudice ,&nbsp;Mattia Doria ,&nbsp;Laura Reali","doi":"10.1016/j.gpeds.2025.100251","DOIUrl":"10.1016/j.gpeds.2025.100251","url":null,"abstract":"","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"12 ","pages":"Article 100251"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143825524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical imaging features of sturge-weber syndrome in a 10-month-old infant: A case report","authors":"Biruk T. Mengistie ,&nbsp;Chernet T. Mengistie ,&nbsp;Michael A. Negussie ,&nbsp;Solyana Bereded ,&nbsp;Eden H. Hagos ,&nbsp;Abebe M. Woldeyohannes","doi":"10.1016/j.gpeds.2025.100253","DOIUrl":"10.1016/j.gpeds.2025.100253","url":null,"abstract":"<div><div>Sturge-Weber Syndrome (SWS) is a rare, non-inherited neurocutaneous disorder characterized by facial capillary malformations, leptomeningeal angiomatosis, and ocular abnormalities such as glaucoma. While its hallmark imaging findings are well-documented, atypical presentations, especially in early infancy, remain underreported. This case report describes a 10-month-old male infant with a rare and severe presentation of SWS. The patient exhibited hallmark features, including a port-wine stain, glaucoma, and leptomeningeal enhancement, alongside atypical imaging findings such as diffuse bilateral cerebral atrophy, asymmetric pial angiomatosis, bilateral choroid plexus enlargement, and tortuous perimedullary veins. Neurological symptoms included recurrent tonic-clonic seizures starting within the first year of life, alongside persistent ophthalmologic complications. Advanced imaging played a pivotal role in identifying these unusual features, underscoring the variability in SWS presentations and the need for comprehensive neuroimaging in young patients. This report highlights the importance of early diagnosis, multidisciplinary management, and vigilant follow-up to address the diverse challenges posed by SWS, while expanding the documented spectrum of its manifestations.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"12 ","pages":"Article 100253"},"PeriodicalIF":0.0,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antenatal substance exposure and infants’ telomere length: A scoping review","authors":"Holly Wei ,&nbsp;Lori A. Devlin ,&nbsp;Yan Cao ,&nbsp;Aaron Wei ,&nbsp;Christiana M. Keinath ,&nbsp;Rose Mary Xavier","doi":"10.1016/j.gpeds.2025.100252","DOIUrl":"10.1016/j.gpeds.2025.100252","url":null,"abstract":"<div><h3>Background</h3><div>Antenatal substance exposure due to maternal substance use during pregnancy has increased significantly, leading to suboptimal health outcomes for infants. Telomere length (TL) is a biological aging marker that may be affected by antenatal substance exposures. A comprehensive review of relevant studies is crucial for providing insights into the etiology of infant developmental outcomes.</div></div><div><h3>Objectives</h3><div>This scoping review, guided by the PRISMA guideline, aims to identify and summarize the existing research on the relationships between infants’ antenatal substance exposure and TL.</div></div><div><h3>Methods</h3><div>A systematic literature search was conducted using PubMed, Cochrane, Embase, Cumulative Index to Nursing and Allied Health Literature, and PsycINFO. Search terms included antenatal, prenatal, infant, and various psychotropic substances. The review included studies examining the associations between antenatal substance exposure and TL. The last literature search was conducted on April 16, 2023.</div></div><div><h3>Results</h3><div>Seven articles met the inclusion criteria, addressing diverse substances such as alcohol, opioids, and tobacco. Among the seven studies, one evaluated the influence of antenatal alcohol exposure, one assessed antenatal opioid exposure, and five investigated antenatal tobacco exposure. The findings across the articles were varied, with five reporting indirect correlations and two reporting direct correlations between antenatal substance exposure and the TL in exposed infants.</div></div><div><h3>Conclusions</h3><div>This scoping review identified a significant gap in the current literature about the associations between antenatal substance exposure and TL in infants. The diverse findings emphasize the need for further research to explore whether TL could serve as a potential biomarker for predicting the effects of substance exposure on offspring. This study lays the foundation for future investigation and contributes to understanding the complex relationship between antenatal substance exposure and telomere biology in infants.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"12 ","pages":"Article 100252"},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge of human papillomavirus vaccine as a determinant of uptake among guardians of adolescent girls: A single hospital in nairobi, kenya","authors":"Irene Nzisa ,&nbsp;Rose Kamenwa ,&nbsp;James Orwa ,&nbsp;Pauline Samia","doi":"10.1016/j.gpeds.2025.100249","DOIUrl":"10.1016/j.gpeds.2025.100249","url":null,"abstract":"<div><div>Cervical cancer is one of the most common preventable cancers, causing significant morbidity and mortality in women, especially in Sub-Saharan Africa. Despite the availability of free HPV vaccination, the proportion of adolescent girls vaccinated against HPV remains low.</div></div><div><h3>Methods</h3><div>Our aim was to identify knowledge and factors influencing HPV vaccine uptake among parents of adolescent girls and to determine the proportion of adolescent girls vaccinated within three months after the provision of additional information on cervical cancer and HPV vaccine. We undertook a mixed methods study design, with an initial cross-sectional part followed by a prospective cohort study among guardians of adolescent girls aged 9–18 years attending Aga Khan University Hospital Nairobi, Kenya. Guardians of adolescent girls who had not received the HPV vaccine were provided with standardized written information regarding cervical cancer, HPV vaccine availability, and utility. Guardians were then contacted three months later to evaluate subsequent HPV vaccine uptake.</div></div><div><h3>Results</h3><div>A total of 432 guardians participated in the study. The majority (94.7 %) knew about cervical cancer, 84.9 % of them had heard about the HPV vaccine, and 48 % were aware of the free vaccination campaign. Only 13.2 % (<em>n</em> = 57) of the participants reported that their daughters had been vaccinated prior to this study. Factors associated with vaccine uptake included the level of knowledge (<em>p</em> ≤ 0.001) and the age of the parents (<em>p</em> = 0.030). Reasons commonly cited for not taking the vaccine included lack of information (73 %), lack of awareness (45 %), safety concerns (13 %) and concerns about affordability (7 %). A total of 306 participants were followed up three months later, and 9.2 % (<em>n</em> = 28) of them reported that their daughters had been vaccinated.</div></div><div><h3>Conclusion</h3><div>The knowledge of the HPV vaccine was good at 67 %. However, uptake of the HPV vaccine was low in this study population despite providing them with additional information about the HPV vaccine. Higher levels of parental knowledge and older age were associated with a greater likelihood of HPV vaccine uptake. Innovative methods to reassure hesitant parents about HPV vaccination for their daughters are urgently needed in the Kenyan general population.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"12 ","pages":"Article 100249"},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}