Global pediatrics最新文献

{"title":"Foreword: “Highlights and interactivity in pediatrics 2024”. Nurturing continuous advancements in pediatric care","authors":"Giuseppe Buonocore , Roberto Bernardini","doi":"10.1016/j.gpeds.2024.100138","DOIUrl":"10.1016/j.gpeds.2024.100138","url":null,"abstract":"","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"7 ","pages":"Article 100138"},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266700972400006X/pdfft?md5=84050a1b78c380b83f01f984c8685f25&pid=1-s2.0-S266700972400006X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139540042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The timing of 40% oral dextrose gel administration after birth does not influence the incidence of hypoglycemia in at-risk infants","authors":"De Bernardo Giuseppe ,&nbsp;Giordano Maurizio ,&nbsp;Langella Carmen ,&nbsp;Piccirillo Daiana ,&nbsp;Giada Zollo ,&nbsp;Sordino Desiree ,&nbsp;Morlino Francesca ,&nbsp;Beretta Virginia ,&nbsp;Perrone Serafina","doi":"10.1016/j.gpeds.2024.100137","DOIUrl":"10.1016/j.gpeds.2024.100137","url":null,"abstract":"<div><h3>Background</h3><p>Hypoglycemia is the most common metabolic disorder seen in newborns and can cause long-term neurological damage, developmental disorders and poor later school performance. In recent years, the use of oral dextrose gel is widely used as a first-line treatment for prevention of asymptomatic neonatal hypoglycemia. Primary aim of our study was to evaluate the effects of oral administration of 40 % dextrose gel at 30 or 60 min of life on the incidence of hypoglycemia in at-risk infants born by vaginal or cesarean delivery in the first 48 h of life. Secondary aim was to evaluate if the oral administration of 40 % dextrose gel can decrease the use of formula milk.</p></div><div><h3>Methods</h3><p>A retrospective observational study was conducted at the Buon Consiglio Fatebenefratelli Hospital. Newborns birth by vaginal or Caesarean section and that assumed 40 % dextrose gel at 30 or 60 min after birth were respectively divided in 4 groups (Group A, Group B, Group C and Group D). Glycemic monitoring was then carried out with serial measurements at 2, 4, 6, 12 and 48 h of life.</p></div><div><h3>Results</h3><p>No statistically significant differences were found in the reduction of the incidence of hypoglycemia with respect to the timing of administration of the dextrose gel (χ²(3)=0,450; <em>p</em> = 0,930). The use of formula milk was higher in newborns born by Caesarean section that assumed dextrose gel at 30 min of life than other groups (χ²(3)=11,616; <em>p</em> = 0,009; OR (95 %CI)= 3,033 (1,286–7,153).</p></div><div><h3>Conclusions</h3><p>The use of 40 % oral dextrose gel is a useful strategy for the prevention of hypoglycemia especially in infants at risk, independently to mode of delivery. Timing of administration of dextrose gel did not have effect on the incidence of hypoglycemia among groups. Newborns born by Caesarean section and that assumed 40 % oral dextrose gel at 30 min of life assume more formula milk compared to other groups.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"7 ","pages":"Article 100137"},"PeriodicalIF":0.0,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000058/pdfft?md5=8a53e49160ff53d06aa195fac044741a&pid=1-s2.0-S2667009724000058-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139538262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysphagia: A practical approach","authors":"Giuseppina Russo,&nbsp;Caterina Strisciuglio","doi":"10.1016/j.gpeds.2024.100136","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100136","url":null,"abstract":"<div><p>Dysphagia is any disorder of the swallowing process. It can be classified according to the disordered phase of swallowing: oral dysphagia, pharyngeal dysphagia, esophageal dysphagia. Approximately 1% of children in the general population will experience swallowing difficulties, although the incidence is much higher in some clinical populations. Although oropharyngeal dysphagia may be the first symptom of a neuromuscular disorder, gastroesophageal reflux disease (GERD), functional esophageal disorders, and eosinophilic esophagitis are the most common causes of esophageal dysphagia. Treatment and management of dysphagia must be tailored to the clinical characteristics of the individual patient.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"7 ","pages":"Article 100136"},"PeriodicalIF":0.0,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000046/pdfft?md5=689d502f2c2c8b83eb46b3d6f48e7098&pid=1-s2.0-S2667009724000046-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139487917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of the child with obesity: Role and development of new medications","authors":"Gabriel Á. Martos-Moreno ,&nbsp;Jesús Argente","doi":"10.1016/j.gpeds.2023.100126","DOIUrl":"https://doi.org/10.1016/j.gpeds.2023.100126","url":null,"abstract":"<div><p>Childhood obesity continues to be a major health problem worldwide with the consequent associated comorbidities becoming apparent at very early ages and increasing throughout life. Although the prevention of obesity is essential, it is no less true that its treatment should be considered when prevention has failed and in specific cases of obesity. The treatment of obesity in children and adolescents continues to be based on a program for the reorganization of eating habits, physical activity, and eating behavior. Nevertheless, as a result of the enormous amount of investigation carried out in the past decade in search of efficient treatments for obesity, new drugs are gradually becoming available, including liraglutide, semaglutide, setmelanotide and phentermine/topiramate, among others. Although the treatments mentioned are now available, they are not applicable and/or accessible for every patient and we are all learning about the approach to using these new treatments and it is still early to interpret their effectiveness in the medium and long term. Furthermore, whether the use of these medications, once started, should be for life, remains to be clarified. Regarding bariatric surgery in children and adolescents, the available data are limited with scarce data regarding the long-term results. Thus, there have been important advances in the treatment of childhood obesity, but there are still much to be done.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"7 ","pages":"Article 100126"},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009723000921/pdfft?md5=1a2507990c83fecc63bb3cad32c5705d&pid=1-s2.0-S2667009723000921-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139436466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New therapeutic modalities for rare diseases","authors":"Fatih S. Ezgu","doi":"10.1016/j.gpeds.2024.100134","DOIUrl":"10.1016/j.gpeds.2024.100134","url":null,"abstract":"<div><p>Genetic Diseases affect about 2 % to 3 % of all live births. It has been reported that genetic disorders can account for up to 22 % of infant deaths. Despite this significant effort to create new therapies, treatment is available only for about 5 % of these diseases due to undiscovered etiology or rapid progression to the point of no return. Efforts for new and effective etiology-targeted treatment methods for rare genetic disorders have significantly increased in recent years. Gene-targeted novel treatments such as gene replacement therapy and gene editing, mainly gene-targeted, have significant potential to be the primary treatment modalities in the future.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"7 ","pages":"Article 100134"},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000022/pdfft?md5=bbb6cfaa5bbf163302f6aa773a372848&pid=1-s2.0-S2667009724000022-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139394234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyendemics: From theory to practice","authors":"Giovanni Vitali Rosati","doi":"10.1016/j.gpeds.2023.100132","DOIUrl":"10.1016/j.gpeds.2023.100132","url":null,"abstract":"<div><p>After COVID-19, there was a resurgence of viral and bacterial diseases globally. Data from January 2023 indicates a shift in infectious disease patterns, with influenza, RSV, SARS-CoV-2, and other viruses prevalent, leading to a termed “polyendemia.” Increased cases of invasive group A beta-hemolytic streptococcal disease (SBEA) and scarlet fever, particularly in children, have been reported in various countries. Several factors contribute to the rise in respiratory infections, including the concept of “immunity debt,” interactions between respiratory viruses, and potential immune dysregulation induced by SARS-CoV-2. Recent reports also highlight increased pneumonia cases in Chinese children, attributed to various respiratory viruses. The implications for clinical practice emphasize prevention, advocating safety measures, and promoting vaccination, especially for influenza and COVID-19. A new monoclonal antibody, nirsevimab, offers passive immunization against RSV. Rapid diagnostic tests for the early identification of viruses or bacteria are recommended. The pediatrician underscores the importance of precise diagnosis for epidemiological understanding and future vaccination encouragement.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"8 ","pages":"Article 100132"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009723000982/pdfft?md5=2c5ea1ecc90ad5e18e4a9b8e3fb2e112&pid=1-s2.0-S2667009723000982-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139127522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal jaundice: Recommendations for follow-up and treatment","authors":"Emel Okulu","doi":"10.1016/j.gpeds.2023.100131","DOIUrl":"10.1016/j.gpeds.2023.100131","url":null,"abstract":"<div><p>Neonatal jaundice due to hyperbilirubinemia is a common and mostly a harmless problem. However, there is a risk of acute bilirubin encephalopathy and kernicterus, which are rare but can cause permanent neurological damage. In 2022, the American Academy of Pediatrics (AAP) updated its clinical practice guideline for neonatal hyperbilirubinemia in newborns who are at least 35 weeks gestational age. The 2022 AAP guideline incorporates updated phototherapy and exchange transfusion nomograms that feature higher bilirubin thresholds than previous guidelines, and includes risk assessments for escalation-of-care, which is a new definition, universal bilirubin screening procedures, and neurotoxicity risk factors that no longer consider race as a risk factor. It is necessary to exercise caution and consult with local experts when adapting the updated guideline in low- and middle-income countries due to potential lack of resources for screening, follow-up, and treatment.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"7 ","pages":"Article 100131"},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009723000970/pdfft?md5=c0382cbc58d9f22d8d5c9303ebbf6807&pid=1-s2.0-S2667009723000970-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139190653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schinzel-Giedion syndrome: a rare cause of psychomotor delay and refractory seizures","authors":"Gordana Kovačević ,&nbsp;Ružica Kravljanac ,&nbsp;Biljana Vučetić Tadić ,&nbsp;Slavica Ostojić ,&nbsp;Seung Woo Ryu","doi":"10.1016/j.gpeds.2023.100124","DOIUrl":"https://doi.org/10.1016/j.gpeds.2023.100124","url":null,"abstract":"<div><p>Schinzel-Giedion syndrome (SGS) is a rare genetic syndrome characterized by severe developmental delay, facial dysmorphism, seizures, and multiple congenital malformations. Affected children have increased risk of developing neuroepithelial brain tumors.</p><p>We are reporting a case of a 20 months-old boy with profound psychomotor delay, distinctive facial features, congenital cardiac defect and renal malformation, associated with drug-resistant seizures and progressive brain atrophy. Detailed metabolic and genetic investigation was performed. Finally, whole exome sequencing identified a pathogenic variant in SETBP1 gene, which further confirmed the diagnosis of Schinzel-Giedion syndrome.</p><p>In conclusion, determining the etiology of disorders characterized by craniofacial dysmorphia, epilepsy, and severe psychomotor retardation is complex and often requires an exhaustive clinical, neuroradiological, metabolic and genetic examination. In the cases with developmental epileptic encephalopathy associated with craniofacial dysmorphic features, renal, cardiac and other congenital malformations, the diagnosis of Schinzel-Giedion syndrome has to be excluded. Given the association of SGS with an increased risk of tumors, accurate diagnosis enables regular monitoring, facilitating early detection and treatment of potential complications or associated disorders.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"7 ","pages":"Article 100124"},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009723000908/pdfft?md5=e37b494d60784106d9e01322076a5111&pid=1-s2.0-S2667009723000908-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139109262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mother's milk: What more can we do?","authors":"Giuseppe Buonocore","doi":"10.1016/j.gpeds.2023.100123","DOIUrl":"https://doi.org/10.1016/j.gpeds.2023.100123","url":null,"abstract":"","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"7 ","pages":"Article 100123"},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009723000891/pdfft?md5=595b08709efc545ea2fececdbc4e0790&pid=1-s2.0-S2667009723000891-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139109248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A brief focus on 2022 Italian guidelines on the management of bronchiolitis in infants","authors":"Sara Manti ,&nbsp;Eugenio Baraldi","doi":"10.1016/j.gpeds.2023.100129","DOIUrl":"10.1016/j.gpeds.2023.100129","url":null,"abstract":"<div><p>The intersociety consensus document “UPDATE - 2022 Italian guidelines on the management of bronchiolitis in infants” aimed to update the previously published clinical practice guidelines on the prevention and treatment of bronchiolitis in newborns and infants. Moreover, due to the tremendous disagreement among the clinical practice guidelines and approaches to viral bronchiolitis, the new intersociety consensus document also aimed to unify diagnostic and therapeutic criteria, reinforce the current recommendations, and integrate the most recent advances for optimal care of viral bronchiolitis. The document addresses care in both hospitals and primary care.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"8 ","pages":"Article 100129"},"PeriodicalIF":0.0,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009723000957/pdfft?md5=37fd286accf3bd22b88d6c668c33af75&pid=1-s2.0-S2667009723000957-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139193539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}