Global pediatrics最新文献

{"title":"Bilateral corneal perforation due to vitamin A deficiency in a child with seizures","authors":"Maiah Zarrabi ,&nbsp;Giovanni A. Campagna ,&nbsp;Xander Parisky ,&nbsp;Irwin Weiss ,&nbsp;Simon Sheung Man Fung","doi":"10.1016/j.gpeds.2024.100170","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100170","url":null,"abstract":"<div><p>Dietary vitamin A deficiency is exceptionally rare in resource-rich countries. A well-known consequence of vitamin A deficiency is xeropthalmia, a spectrum which includes pathologic dryness of the conjunctiva and cornea, which can lead to corneal infection, thinning, or perforation, portending a very poor visual prognosis. This case describes a 10-year-old boy with Lennox-Gastaut syndrome and autism who developed malnutrition and deficiencies of multiple micronutrients, including copper, zinc, and an undetectable vitamin A blood level, secondary to dietary restriction for seizure control. After experiencing 3 months of nonspecific symptoms of ocular surface disease including eye dryness, eye redness, and tearing, he developed rapidly progressive keratomalacia and polymicrobial corneal ulcers. Despite treatment with topical antibiotics, he ultimately suffered bilateral corneal perforation requiring full-thickness corneal transplants. This report aims to raise the awareness of potentially debilitating nutrient deficiencies related to restricted diets, which are becoming increasingly common in numerous chronic pediatric conditions including epilepsy. This report also brings attention to the severe, long-term complications that can arise from nutrient deficiencies. Pediatric providers should consider a diagnosis of vitamin A deficiency in any child with a history of a restricted diet and ophthalmological symptoms.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"8 ","pages":"Article 100170"},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000381/pdfft?md5=df45dd30c99175251d6120b8f1502592&pid=1-s2.0-S2667009724000381-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140349791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early development of infants born prematurely who were conceived through assisted reproductive technologies","authors":"Vesna Pavlović ,&nbsp;Aleksandra Stojadinović ,&nbsp;Georgios Konstantinidis ,&nbsp;Katarina Katić","doi":"10.1016/j.gpeds.2024.100166","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100166","url":null,"abstract":"<div><h3>Objective</h3><p>This study aims to determine physical and psychomotor development characteristics during the first 24 months of life in prematurely born children conceived with assistive reproductive technologies and to determine specific risk factors for deviation from typical development.</p></div><div><h3>Patients and methods</h3><p>The study included 308 prematurely born children (154 conceived with assistive reproductive technologies – ART group and 154 conceived naturally – NC group) hospitalized at the Institute for the Health Care of Children and Adolescents of Vojvodina in Serbia. The physical and psychomotor development was monitored during the first two years of life.</p></div><div><h3>Results</h3><p>Birth weight was statistically significantly higher in the NC group than in the ART group, and IUGR was more often present in the ART group than in the NC group of newborns. The mean values of body weight, length, and head circumference of children from both groups did not differ statistically significantly at 18 months. At 12 and 18 months, children from the ART group significantly more often had below-average scores on the test for assessment of psychomotor development (corrected GDQ &lt;90) than children from the NC group, but not at 24 months. Logistic regression analysis has shown that at 12 and 18 months, multiple pregnancy is an independent risk factor for lower GDQ.</p></div><div><h3>Conclusion</h3><p>At the age of 12 months, prematurely born children conceived with ART do not differ in physical development from prematurely born children after natural conception. At 12 and 18 months, prematurely born children conceived with ART achieve lower global developmental scores than children conceived naturally, but not at 24 months of age. Multiple pregnancies are an independent risk factor for lower achievement on the test for assessment of psychomotor development in prematurely born children.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"8 ","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2024-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000344/pdfft?md5=4203f97c7d8c5bfffd245f04c8b80506&pid=1-s2.0-S2667009724000344-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140296251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute disseminated encephalomyelitis (ADEM) and systemic lupus erythematosus (SLE) in children: What relationship?","authors":"S. Safadi,&nbsp;S. Tizki,&nbsp;I. Ouafik,&nbsp;H. Ouhsousou,&nbsp;A. Daoudi,&nbsp;K. Nainia","doi":"10.1016/j.gpeds.2024.100169","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100169","url":null,"abstract":"<div><p>Acute disseminated encephalomyelitis (ADEM) is a severe acute inflammatory process of the Central Nervous System (CNS) consisting of multiple foci of perivascular demyelination. It is a relatively frequent complication of infections and immunization among children. Systemic lupus Erythematosus (SLE), is a chronic autoimmune disease, of unknown etiology, that touches multiple organs simultaneously or additionally, with serious morbidity and mortality. More frequent in females, it can be associated with other auto-immune diseases. ADEM is rarely reported as the initial presentation of SLE, even rarer in the pediatric population. We present one case of a 13 years old girl with a history of ADEM, who was diagnosed with SLE eight months later.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"8 ","pages":"Article 100169"},"PeriodicalIF":0.0,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266700972400037X/pdfft?md5=f7b848e82b8a548d5ed177bf2caf15d3&pid=1-s2.0-S266700972400037X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140349790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in neonatal outcomes between normal and preeclampsia complicated pregnancies","authors":"Tamara Šljivančanin Jakovljević ,&nbsp;Olivera Kontić-Vučinić ,&nbsp;Željko Miković ,&nbsp;Tanja Lazic Mitrovic","doi":"10.1016/j.gpeds.2024.100163","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100163","url":null,"abstract":"<div><p>This study aims to explore potential variations in neonatal outcomes between pregnancies without complications and those complicated by preeclampsia within a tertiary gynecology and obstetrics center in Serbia. By focusing on neonatal outcomes, the research seeks to provide a nuanced understanding of how preeclampsia may impact the health and well-being of newborns in this specific medical setting. The investigation will shed light on any distinctive patterns or disparities in outcomes, contributing valuable insights to the broader understanding of maternal and neonatal health within the context of preeclampsia in the Serbian healthcare system.</p></div><div><h3>Material and Method</h3><p>This case-control study included 50 preeclampsia patients and 50 healthy normotensive pregnant women followed up in the Clinic for Gynecology and Obstetrics, Clinical Center of Serbia. Neonatal outcomes in both groups were monitored until discharge from the hospital. Appropriate statistical tests were applied for experimental and clinical data analysis.</p></div><div><h3>Results</h3><p>Cesarean Section was significantly more frequent in preeclampsia than in the normal pregnancy group. The mean gestational age of birth and Apgar scores were significantly lower in newborns of preeclamptic mothers than in healthy control (<em>p</em> &lt; 0.001). Hospitalization was longer after preeclampsia-complicated pregnancies than uncomplicated controls. Admission to the neonatal intensive care unit, along with perinatal complications such as perinatal asphyxia, respiratory distress syndrome, neonatal convulsions, intracranial hemorrhage, jaundice, anemia, and infection, were significantly more common in the preeclampsia group than in the controls (<em>p</em> &lt; 0.001). In the whole study group, only one newborn from a pregnancy complicated with early and severe preeclampsia had a lethal outcome.</p></div><div><h3>Discussion and Conclusions</h3><p>The incidence of Cesarean sections exhibited a noteworthy increase in pregnancies complicated by preeclampsia, contrasting with a reduction in both gestational age and Apgar Scores when compared to the group with normal pregnancies. This investigation underscores a significant elevation in overall morbidity rates among newborns born to mothers grappling with preeclampsia in comparison to those born from uncomplicated pregnancies. The findings emphasize the multifaceted impact of preeclampsia on perinatal outcomes, underscoring the importance of comprehensive care strategies to address the unique challenges posed by this complication during pregnancy.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"8 ","pages":"Article 100163"},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000319/pdfft?md5=7719945af000164399bc42d62ddd3141&pid=1-s2.0-S2667009724000319-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140191815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early childhood development and its association with women's empowerment in the context of urban poverty in Ethiopia","authors":"Tefera Darge Delbiso","doi":"10.1016/j.gpeds.2024.100168","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100168","url":null,"abstract":"<div><h3>Background</h3><p>Empowered women, with increased access to and control over resources, stronger social networks, greater decision-making power, and a more positive gender attitude, significantly contribute to better family well-being. While there is ample evidence regarding the association between child nutrition and women's empowerment, studies examining the association between early childhood development (ECD) and women's empowerment are scarce.</p></div><div><h3>Aims</h3><p>The aim of this study was to estimate the prevalence of ECD delays among 12–36 months old and investigate its association with women's empowerment among the urban poor in Ethiopia.</p></div><div><h3>Methods</h3><p>The study included a sample of 432 women who were unemployed or had irregular employment during the data collection period, along with their children in urban Ethiopia. The ECD was assessed using the Age and Stage Questionnaire (ASQ-3), a tool designed to accurately identify developmental delays in infants and young children and categorized as on track, needs monitoring, and possible delays. Women's empowerment was measured using a multidimensional index that captured access to and control over resources, decision-making power, and social capital, and then categorized into lowest, medium, and highest empowerment levels. The association between ECD domains and women's empowerment was analyzed using ordinal logistic regression, after adjusting for confounders.</p></div><div><h3>Results</h3><p>The study found a high prevalence of delays in ECD domains, with fine motor domain accounting for the largest delay (40.6 %). Children of less empowered mothers are more likely to have the highest development delays in communication (OR=2.22; 95 % CI: 1.36; 3.62), gross motor (OR=1.69; 95 % CI: 1.04; 2.76), problem solving (OR=1.85; 95 % CI: 1.15; 2.98), and personal-social (OR=2.59; 95 % CI: 1.62; 4.15) skills compared to children of more empowered mothers.</p></div><div><h3>Conclusions</h3><p>The study highlights the significance of women's empowerment in promoting ECD, especially in developing countries where ECD programs are fragmented and lacks coordination. Therefore, targeted interventions that improve women's empowerment could lead to improved ECD outcomes.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"8 ","pages":"Article 100168"},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000368/pdfft?md5=8c9d1b1ae2c1ed90894500f275beff1c&pid=1-s2.0-S2667009724000368-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140180308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of external genitalia during mini-puberty: Is it related to somatic growth or pubertal hormones?","authors":"Hazal Arıkan Gacemer ,&nbsp;Büşra Gürpınar Tosun ,&nbsp;Didem Helvacıoğlu ,&nbsp;Zehra Yavaş Abalı ,&nbsp;Belma Haliloğlu ,&nbsp;Serap Demircioğlu Turan ,&nbsp;Abdullah Bereket ,&nbsp;Tülay Güran ,&nbsp;Massimo Pettoello-Mantovani","doi":"10.1016/j.gpeds.2024.100155","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100155","url":null,"abstract":"<div><p>Although hypothalamic-pituitary-gonadal axis activation and hormone levels in mini-puberty are similar to the pubertal period¹, its role in human development and reproduction has not been fully elucidated². We aimed to evaluate the effects of somatic growth and reproductive hormones on the development of external genitalia during mini-puberty</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"8 ","pages":"Article 100155"},"PeriodicalIF":0.0,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266700972400023X/pdfft?md5=58c6c966fe5260c23a2acb5ee4c0e5d7&pid=1-s2.0-S266700972400023X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139993240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between chronic diuretics and postnatal growth in preterm infants with bronchopulmonary dysplasia","authors":"Anna Wanzenberg ,&nbsp;Brittany M. Thompson ,&nbsp;Kimberly Van ,&nbsp;Sreekanth Viswanathan","doi":"10.1016/j.gpeds.2024.100165","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100165","url":null,"abstract":"<div><h3>Background</h3><p>Chronic diuretics such as thiazides and spironolactone are frequently used off-label in preterm infants with evolving or established bronchopulmonary dysplasia (BPD). Infants who are high risk for BPD are already predisposed to poor postnatal growth and the effect of chronic diuretics on postnatal growth is not well studied.</p></div><div><h3>Objective</h3><p>Exploratory study to determine the association between chronic diuretic exposure and short-term postnatal growth in preterm infants born at less than ≤ 29 weeks gestational age (GA).</p></div><div><h3>Methods</h3><p>Single-center retrospective cohort study in a level IV neonatal intensive care unit over a 2-year period (2021–22). Eligible infants exposed to chronic diuretics &gt; 5 days for BPD (diuretic group) were compared to infants who were not (non-diuretic group).</p></div><div><h3>Results</h3><p>In total, 53 infants (19 diuretic, and 35 non-diuretic group) were identified. The GA (25.3 vs 27.0 weeks) and birth weight (780 vs. 995 gs) were significantly lower in diuretic vs. non-diuretic group (<em>p</em> = 0.01). Diuretic group had higher intubation rate at birth, more days on non-invasive ventilation, higher incidence of moderate/severe BPD, and longer hospital stay (all <em>p</em> &lt; 0.05). The GA adjusted z-scores for weight, length, and head circumference at birth, at 36-week corrected GA, and at discharge were similar in both groups. Also, the z-score change from birth at 36-week corrected GA, and at discharge were similar in both groups. There was no significant short-term change in weight z-score in the 2 weeks following chronic diuretic exposure.</p></div><div><h3>Conclusions</h3><p>Chronic diuretic exposure has no significant association with short-term postnatal growth in preterm infants.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"8 ","pages":"Article 100165"},"PeriodicalIF":0.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000332/pdfft?md5=b3d1f3dbf99ed083cd31abfa8f079a73&pid=1-s2.0-S2667009724000332-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139985289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the factors associated with anemia in neonates admitted to the Neonatal Unit of Maiwand Teaching Hospital: A cross-sectional study","authors":"Mansoor Aslamzai ,&nbsp;Yazdan Danish ,&nbsp;Turyalai Hakimi ,&nbsp;Bashir Jawadi","doi":"10.1016/j.gpeds.2024.100164","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100164","url":null,"abstract":"<div><h3>Background</h3><p>While anemia has been associated with severe outcomes in neonates, there is a lack of scientific data regarding the associated factors of this problem in newborn babies of Afghanistan; hence, this study was undertaken to fill that gap. The objective of this study was to evaluate the factors associated with anemia in neonates who were admitted to the Neonatal Unit.</p></div><div><h3>Methods</h3><p>This analytic cross-sectional study with retrospective document review was conducted at the Neonatal Unit of the Maiwand Teaching Hospital in Kabul City, Afghanistan, in 2023. SPSS 26 and certain statistical methods were used to carry out the statistical analysis.</p></div><div><h3>Results</h3><p>Of the 220 newborns enrolled in this study, anemia occurred in 26.8% of them. Based on gestational age, the occurrence rates of neonatal anemia within groups of term and preterm neonates were 23% and 41.3%, respectively. The occurrence of neonatal anemia was found to be 60% in extremely low birth weight, 41.2% in very low birth weight, 27.2% in low-birth-weight neonates, and 23.9% in normal birth weight neonates. The neonates in the anemic group versus the non-anemic group had a mean birth weight of (2516.18 ± 898.79 vs 2749.62 ± 766.02 g, <em>P</em> = 0.03, 95%CI= -691_-9.9), a mean gestational age of (35.47 ± 3.7 vs 37.4 ± 2.5 w, <em>P</em> = 0.04, 95% CI= -1.6_ -0.9), a mean age of (11.41 ± 6.39 vs 9.9 ± 6.88 days, <em>P</em> = 0.35, 95%CI= -1.6_4.6), a mean CRP level of (13.6 ± 7.6 vs 9.8 ± 5.6 mg, <em>P</em> = 0.01, 95%CI= 0.8_7.8) and a mean hemoglobin level of (11.1 ± 1.7 vs 17.3 ± 2.5 g, <em>P</em> = 0.04, 95%CI=-7.4_-5.1). There was a significant association between neonatal anemia and preterm birth (OR=2.4, <em>P</em> = 0.04, 95%CI=0.08_0.5), male sex (OR=2.4, <em>P</em> = 0.04, 95%CI= 0.1_0.3), neonatal sepsis (OR=2.5, <em>P</em> = 0.01, 95%CI= 0.1_ 0.6), cesarean delivery (OR=3.4, <em>P</em> = 0.00, 95%CI=1.7_6.5), maternal age greater than 35 years (OR=2.9, <em>P</em> = 0.03, 95%CI=0.04_0.6), no iron intake by the mother during pregnancy (OR=1.9, <em>P</em> = 0.002, 95%CI=1.1_3.4), antepartum hemorrhage (OR=4.7, <em>P</em> = 0.00, 95%CI=1.3_10.3), and poor household income (OR=2.6, <em>P</em> = 0.03, 95%CI=0.03_0.2).</p></div><div><h3>Conclusions</h3><p>Newborns admitted to the Neonatal Unit had a significant prevalence of neonatal anemia. The highest occurrence rates were seen within groups of preterm and extremely low-birth-weight newborn babies. Neonatal anemia was found to be associated with lower mean neonatal birth weight and gestational age, as well as with preterm birth, male sex, a higher CRP level, neonatal sepsis, older maternal age, cesarean delivery, no maternal iron consumption, antepartum hemorrhage, and a poor household income.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"8 ","pages":"Article 100164"},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000320/pdfft?md5=fbdd527585b9b9dc5614565eb15f8f82&pid=1-s2.0-S2667009724000320-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140063139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creating value for humanity: An innovative pharma paradigm for holistic health and education","authors":"Jane Cestovaliev","doi":"10.1016/j.gpeds.2024.100157","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100157","url":null,"abstract":"<div><p>This article explores the transformative potential of an innovative pharmaceutical company dedicated to creating and offering the highest quality natural products for children and families. Anchored in the expertise of world-recognized scientists in medical and herbal sciences, the companies typically integrate advanced technologies, utilize premium ingredients, and rigorously test products through clinical studies. However, the innovative core philosophy should revolve around the inseparable concepts of nature and nurture, with a foundational belief that everything necessary for food or medicine can be found in our natural environment. Furthermore, the article underscores the significance of early childhood development in shaping a quality adult life, aiming to inspire individuals and society to create environments conducive to positive child development. A pharma producer, according to this paradigm, should exist not just to treat ailments but to build the foundations of childhood that bring happiness in adulthood. The guiding principles emphasize the transformative power of love, care, and community knowledge, echoing Nelson Mandela's idea that education is the most powerful weapon to change the world. The article concludes by asserting that such innovative pharmaceutical companies should not only follow but champion these concepts, dedicating a portion of their profits to social projects aimed at education.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"8 ","pages":"Article 100157"},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000253/pdfft?md5=6e3f9d900ef86fb60a003ce378b54853&pid=1-s2.0-S2667009724000253-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139985292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MIS-C and Kawasaki disease: Different illnesses or part of the same spectrum?","authors":"Angelo Ravelli","doi":"10.1016/j.gpeds.2024.100150","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100150","url":null,"abstract":"<div><p>During COVID-19 pandemic pediatricians have been challenged by the occurrence of the multisystem inflammatory syndrome in children (MIS-C). This condition displays some features similar to those of Kawasaki disease (KD), but was is characterized by clinical signs and symptoms that are infrequent in this illness, such as diarrhea, abdominal pain, neurologic dysfunction and cardiac involvement, especially myocarditis. Many children with MIS-C necessitated ICU admission due to development of multiorgan failure and circulatory shock, usually of myocardial origin. Management is based on the administration of intravenous immunoglobulin, glucocorticoids and, in the most severe forms, anakinra. The clinical similarities between MIS-C and KD have raised an intense debate about whether they represent different illnesses with overlapping clinical features or are part of the same disease spectrum. Most authorities favor the assumption that MIS-C is distinct from KD, based on epidemiological, clinical and immunological differences between the two entities. Others argue that the two disorders may represent a continuum, with some differences in phenotype and severity being related to viral load or strain or magnitude or kinetics of immune response. The present article is aimed to analyze critically the rationale and evidence in favor of the second hypothesis.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"8 ","pages":"Article 100150"},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000186/pdfft?md5=9c8373d0b599c5469087af2fb5d9101c&pid=1-s2.0-S2667009724000186-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139936986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}