Global pediatrics最新文献

{"title":"Rationale for use for monoclonal antibody and anti-cytokine therapy for multisystem inflammatory syndrome in children: A systematic review","authors":"Jason Louis Reyes ,&nbsp;Sandra Salter ,&nbsp;Frank Sanfilippo ,&nbsp;Pamela Bradshaw ,&nbsp;Bradley MacDonald","doi":"10.1016/j.gpeds.2024.100222","DOIUrl":"10.1016/j.gpeds.2024.100222","url":null,"abstract":"<div><h3>Objective</h3><p>To review systematically the rationale for choice and use of monoclonal antibody and anti-cytokine therapy in multisystem inflammatory syndrome in children.</p></div><div><h3>Study design</h3><p>A systematic review was conducted using electronic databases (MEDLINE, Embase, Global Health, SCOPUS, and Web of Science) and preprint servers (MedRxiv and BioRxiv) between 01/01/2020 and 01/03/22. Studies were included if they had pediatric patients aged &lt;21 years with multisystem inflammatory syndrome that had experienced the use of monoclonal antibodies and anti-cytokine therapy. Randomized controlled trials, cohort studies, case reports, case series and case-control studies were included.</p></div><div><h3>Results</h3><p>Twenty observational studies with 726 patients were included. Anakinra, tocilizumab and infliximab were used in 9.9%, 6.9%, and 12.4% of the cases, respectively. The most common rationale for the initiation of emerging therapy for multisystem inflammatory syndrome in children was for patients who presented with severe disease or refractory to first line therapy. Infliximab tended to be used because of its precedence in managing intravenous immunoglobulin-resistant Kawasaki Disease.</p></div><div><h3>Conclusions</h3><p>Use and choice of monoclonal antibody and anti-cytokine therapy seems to rely more on subjective clinician preferences than rigorous evidence-based studies. More studies exploring the exact pathogenesis of multisystem inflammatory syndrome in children are warranted to identify the key players of the cytokine storm that act as biological targets and their outcomes.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100222"},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000903/pdfft?md5=1d966f2cb78be62108518988834865fd&pid=1-s2.0-S2667009724000903-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141848369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evolving role of social media in paediatric dentistry: A narrative review","authors":"Supriya Bhatara,&nbsp;Mousumi Goswami,&nbsp;Aditya Saxena,&nbsp;Prachi Pathak,&nbsp;Shivya Tuli,&nbsp;Bhawna Saxena","doi":"10.1016/j.gpeds.2024.100221","DOIUrl":"10.1016/j.gpeds.2024.100221","url":null,"abstract":"<div><h3>Background</h3><p>With the advent of newer technologies and advances in internet and communication technologies, we must use the social media tools that have proved to be an integral asset in raising awareness, behaviour guidance and instilling positive dental attitudes and practices in children.</p></div><div><h3>Aim</h3><p>This review aims to discuss how the role of social media has evolved as an adjunctive tool in the field of paediatric dentistry.</p></div><div><h3>Method</h3><p>The review was outlined as per the Scale for the Assessment of Narrative Review Articles (SANRA). A systematic search of various databases was done using relevant MeSH terms and other keywords. Categorisation of the relevant studies was done under the following themes for a comprehensive understanding of the role of social media in paediatric dentistry; a) General Statistics, b) Health promotion, c) Improvement in treatment outcomes, d) Practice building, and e) Ethical and Regulatory Practices.</p></div><div><h3>Results and conclusion</h3><p>Evolving role of social media in paediatric dentistry has significantly transformed communication, patient management and education within the field. However, with the increasing influence of social media, there is a critical need for regulation.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100221"},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000897/pdfft?md5=64c4dd4f52d02a34e6c0e4b0eb58569c&pid=1-s2.0-S2667009724000897-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging machine learning to study how temperament scores predict pre-term birth status","authors":"Erich Seamon ,&nbsp;Jennifer.A. Mattera ,&nbsp;Sarah.A. Keim ,&nbsp;Esther.M. Leerkes ,&nbsp;Jennifer.L. Rennels ,&nbsp;Andrea.J. Kayl ,&nbsp;Kirsty.M. Kulhanek ,&nbsp;Darcia Narvaez ,&nbsp;Sarah.M. Sanborn ,&nbsp;Jennifer.B. Grandits ,&nbsp;Christine Dunkel Schetter ,&nbsp;Mary Coussons-Read ,&nbsp;Amanda.R. Tarullo ,&nbsp;Sarah.J. Schoppe-Sullivan ,&nbsp;Moriah.E. Thomason ,&nbsp;Julie.M. Braungart-Rieker ,&nbsp;Julie.C. Lumeng ,&nbsp;Shannon.N. Lenze ,&nbsp;Lisa M. Christian ,&nbsp;Darby.E. Saxbe ,&nbsp;Maria.A. Gartstein","doi":"10.1016/j.gpeds.2024.100220","DOIUrl":"10.1016/j.gpeds.2024.100220","url":null,"abstract":"<div><h3>Background</h3><p>Preterm birth (birth at &lt;37 completed weeks gestation) is a significant public heatlh concern worldwide. Important health, and developmental consequences of preterm birth include altered temperament development, with greater dysregulation and distress proneness.</p></div><div><h3>Aims</h3><p>The present study leveraged advanced quantitative techniques, namely machine learning approaches, to discern the contribution of narrowly defined and broadband temperament dimensions to birth status classification (full-term vs. preterm). Along with contributing to the literature addressing temperament of infants born preterm, the present study serves as a methodological demonstration of these innovative statistical techniques.</p></div><div><h3>Study design</h3><p>This study represents a metanalysis conducted with multiple samples (<em>N</em> = 19) including preterm (<em>n</em> = 201) children and (<em>n</em> = 402) born at term, with data combined across investigations to perform classification analyses.</p></div><div><h3>Subjects</h3><p>Participants included infants born preterm and term-born comparison children, either matched on chronological age or age adjusted for prematurity.</p></div><div><h3>Outcome measures</h3><p>Infant Behavior Questionnaire-Revised Very Short Form (IBQ-R VSF) was completed by mothers, with factor and item-level data considered herein.</p></div><div><h3>Results and conclusions</h3><p>Accuracy estimates were generally similar regardless of the comparison groups. Results indicated a slightly higher accuracy and efficiency for IBQR-VSF item-based models vs. factor-level models. Divergent patterns of feature importance (i.e., the extent to which a factor/item contributed to classification) were observed for the two comparison groups (chronological age vs. adjusted age) using factor-level scores; however, itemized models indicated that the two most critical items were associated with effortful control and negative emotionality regardless of comparison group.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100220"},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000885/pdfft?md5=1a2af592f73c14d491cf4291a9e9e8ef&pid=1-s2.0-S2667009724000885-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The past and the future of paediatric primary care","authors":"Laura Reali ,&nbsp;Arianna Turriziani Colonna ,&nbsp;Shimon Barak","doi":"10.1016/j.gpeds.2024.100218","DOIUrl":"10.1016/j.gpeds.2024.100218","url":null,"abstract":"<div><p>The significant advancement that medicine has achieved in the past century is the transition from a focus on \"treating the sick\" to a focus on \"caring for health.\" The focus of pediatric primary care (PPC) is to care for the health and well-being of infants, children, and adolescents in their environment. It places emphasis on their autonomy and personal well-being while also involving parents, guardians, and caregivers. They provide this care within their family, community, and culture. Primary care pediatricians (PCPs) play a vital role in tackling global child health issues such as complex and chronic non-communicable diseases or refugee children. The primary focus of the ECPCP core curriculum for PCPs and the WHO's Pocketbook is to highlight the importance of enhancing primary healthcare, namely through the integration of comprehensive management for all pediatric disorders and conditions. PCPs should receive training on accessibility, closeness, continuity, and trust, as well as collaboration with related specialists. The ECPCP curriculum emphasizes fundamental subjects and abilities that are crucial for future PCPs.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100218"},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000861/pdfft?md5=286f567a86c3238adfd7cbd71f2497df&pid=1-s2.0-S2667009724000861-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141844489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A tool to assess early motor skill development: A study of Danish health visitors’ practice","authors":"Marlene Rosager Lund Pedersen ,&nbsp;Silja Høyer Preisler ,&nbsp;Julie Nicoline Østergaard Bang ,&nbsp;Danae Dinkel ,&nbsp;Lise Hestbæk","doi":"10.1016/j.gpeds.2024.100219","DOIUrl":"10.1016/j.gpeds.2024.100219","url":null,"abstract":"<div><p>In Denmark, health visitors play a crucial role in identifying early motor skill difficulties. In 74 % of the Danish municipalities, they use a motor skill assessment tool for infants aged 9–11 months, consisting of evaluating nine motor milestones. The assessment results in one of three remarks: 'age-appropriate motor development', ‘heightened attention required', or 'intervention needed'. This article aims to: 1) determine the relative importance of each milestone in the overall assessment score, 2) investigate the consistencies in test usage across municipalities, and 3) explore factors influencing health visitors' assessments. This mixed methods study utilizes questionnaires and interviews with health visitors from two municipalities. Findings indicate a general consistency in the importance of each motor milestone in both municipalities, with the exception of the milestone 'chews food with a coarser consistency and takes an interest in eating by him/herself.' The health visitors also consider the achievement of the nine-motor milestones more important as the child gets older. Health visitors in both municipalities follow a uniform approach, emphasizing continuous child development over specific motor milestone achievement. They also consider factors like interaction, sensory perception, overall and social development, and the joy of movement, which are not part of the formal assessment. This illustrates that the health visitors have a dynamic system approach to testing motor development, broadening the motor assessment beyond the tool's milestones.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100219"},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000873/pdfft?md5=9cf8cade5f7d13c9d4aa07e73e858ca1&pid=1-s2.0-S2667009724000873-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141848250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteogenesis imperfecta type II with patent ductus arteriosus, severe persistent pulmonary hypertension, sepsis and severe thrombocytopenia in a neonate: A case report","authors":"Mansoor Aslamzai ,&nbsp;Mohammad Sharif Sediqi ,&nbsp;Mohmand Mangal ,&nbsp;Ataullah Shinwarie","doi":"10.1016/j.gpeds.2024.100203","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100203","url":null,"abstract":"<div><h3>Background</h3><p>Osteogenesis imperfecta type II is a rare congenital anomaly that usually causes death in utero or shortly after birth.</p></div><div><h3>Case Presentation</h3><p>This study reports a rare case of osteogenesis imperfecta type II in an Afghan girl who was one day old. The defect was accompanied by a patent ductus arteriosus, severe persistent pulmonary hypertension of the newborn, sepsis, severe thrombocytopenia, and low birth weight during the first four days of life. These disorders were diagnosed by medical history, physical examination, blood investigation, computed tomography, x-ray, and doppler ultrasonography. On the fifth day of life, the newborn suffered an abrupt cardio-pulmonary arrest that resulted in her death, presumably due to brainstem compression or severe persistent pulmonary hypertension of the newborn.</p></div><div><h3>Conclusion</h3><p>Osteogenesis imperfecta type II can result in life-threatening complications during the first week of life.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100203"},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266700972400071X/pdfft?md5=8440e903f407a366a14cb6ed93fb7f65&pid=1-s2.0-S266700972400071X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiota and gut immunity in infants and young children","authors":"Giuseppe Buonocore","doi":"10.1016/j.gpeds.2024.100202","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100202","url":null,"abstract":"<div><p>The human gut microbiome plays a critical role in maintaining human health, particularly in the intricate relationship between stable microbial communities in the gastrointestinal tract and the early development of host immunity. After birth, the maturation of immune cells and the gut microbiome occur simultaneously, adapting to the complexities of the gut environment. The close link between the gut microbiome and the immune system has far-reaching implications, influencing the onset of several diseases in infants and young children, such as food allergies, necrotizing colitis, obesity, and inflammatory bowel disease. Consequently, the composition of the infant gut microbiome serves as a predictive factor for disease risk and progression. The establishment of a symbiosis between the immune system and the gut microbiome has significant implications for susceptibility or resistance to disease later in life. Maternal factors, including mode of delivery and feeding practices, exert a significant influence on the infant gut microbiota.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100202"},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000708/pdfft?md5=2680013c3afe54bda6cb331360134410&pid=1-s2.0-S2667009724000708-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance and benefits of investing in child health and research","authors":"Terence Stephenson","doi":"10.1016/j.gpeds.2024.100217","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100217","url":null,"abstract":"<div><p>This article discusses the importance and benefits of investing in child health and paediatric research in terms of: 1) Primary prevention, 2) Secondary prevention, 3) Tertiary prevention, 4) Learning from the Covid-19 pandemic, 5) Long-term follow-up studies, 6) Direct benefits to recruits participating in research, 7) Investing in the early years of development and 8) Investing in health – the economic argument</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100217"},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266700972400085X/pdfft?md5=9c7754c79999574ddf268706c830f96a&pid=1-s2.0-S266700972400085X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowing, recognizing, and preventing shaken baby syndrome: The role of primary care pediatrician","authors":"Anna Libera Latino ,&nbsp;Paola Miglioranzi ,&nbsp;Elena Coppo ,&nbsp;Federica Giannotta","doi":"10.1016/j.gpeds.2024.100206","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100206","url":null,"abstract":"<div><p>The Shaken Baby Syndrome (SBS) is the result of a severe form of physical abuse inflicted on children under the age of 2, mostly by parents or other caregivers, to quiet their inconsolable crying. The violent shaking of the child results in devastating consequences up to death or can lead to serious neurological sequelae and/or compromise of their neurodevelopment. The clinical diagnosis of SBS is not always easy and immediate, especially in cases where the picture presents with subtle signs and symptoms not directly attributable to abuse: it is therefore fundamental that the family pediatrician is aware of this nosological entity, suspects it in the presence of certain risk factors, always considers it in the differential diagnosis like any other pathology, and above all prevents it through sensitization and education of parents and other caregivers to adequately manage their child's crying. This article aims to emphasize the role of primary care pediatricians in knowing, recognizing, and preventing the shaken baby syndrome.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100206"},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000745/pdfft?md5=f5f3cfc269c1a3bae87a60bfea712545&pid=1-s2.0-S2667009724000745-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with feeding behavior in the early neonatal period focusing on early skin-to-skin contact and epidural analgesia: A prospective observational study at a single hospital in Japan","authors":"Aya Tomita,&nbsp;Emi Tahara-Sasagawa,&nbsp;Kaori Yonezawa,&nbsp;Yuriko Usui,&nbsp;Megumi Haruna","doi":"10.1016/j.gpeds.2024.100216","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100216","url":null,"abstract":"<div><h3>Background</h3><p>The feeding behavior of newborns is influenced by the conditions of both the mother and newborn before and after birth.</p></div><div><h3>Aims</h3><p>This study aimed to investigate the factors associated with newborn feeding behavior, focusing on skin-to-skin contact (SSC) as a promoting factor and epidural analgesia as an inhibiting factor, using the Japanese version of the Infant Breastfeeding Assessment Tool (IBFAT).</p></div><div><h3>Study Design</h3><p>Prospective observational study conducted in Japan.</p></div><div><h3>Participants</h3><p>A total of 176 pairs of healthy mothers and their healthy full-term newborns.</p></div><div><h3>Outcome Measures</h3><p>The primary outcome was newborn feeding behaviors measured using the Japanese version of IBFAT within about one day of birth. Stepwise multiple regression analysis was performed to explore the relationship between IBFAT scores and variables that might influence newborn feeding behavior.</p></div><div><h3>Results</h3><p>Multiple regression analysis revealed that lower IBFAT scores were associated with a higher dose of epidural fentanyl (β = −0.40), and higher IBFAT scores were associated with a longer duration of SSC (β = 0.26), even after adjusting for gestational weeks and Apgar scores. The dose and duration of synthetic oxytocin administration were not associated with IBFAT scores in the multivariate analysis.</p></div><div><h3>Conclusions</h3><p>Our study showed a dose-dependent relationship between fentanyl and SSC, suggesting that consistently implementing SSC for the maximum duration possible may enhance newborn feeding behaviors, which are reduced by fentanyl administration.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100216"},"PeriodicalIF":0.0,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000848/pdfft?md5=4c0a74a3954e774b0df7363ff16f8028&pid=1-s2.0-S2667009724000848-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}