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Prevalence and neonatal morbidities associated with preterm birth: A three-year retrospective study at Ekiti State University Teaching Hospital, Nigeria 与早产相关的患病率和新生儿发病率:尼日利亚埃基蒂州立大学教学医院的一项为期三年的回顾性研究
Global pediatrics Pub Date : 2026-03-01 Epub Date: 2026-01-12 DOI: 10.1016/j.gpeds.2026.100319
Deborah Tolulope Esan , Deborah Sewanu Alivide , Basil PerfectGodsgift Nmamdi , Adetumise Oluseyi Olajide , Ayodeji Olubunmi Ogunmuyiwa , Blessed Obem Oyama , Timothy Kayode Samson , Carlos Guillermo Ramos
{"title":"Prevalence and neonatal morbidities associated with preterm birth: A three-year retrospective study at Ekiti State University Teaching Hospital, Nigeria","authors":"Deborah Tolulope Esan ,&nbsp;Deborah Sewanu Alivide ,&nbsp;Basil PerfectGodsgift Nmamdi ,&nbsp;Adetumise Oluseyi Olajide ,&nbsp;Ayodeji Olubunmi Ogunmuyiwa ,&nbsp;Blessed Obem Oyama ,&nbsp;Timothy Kayode Samson ,&nbsp;Carlos Guillermo Ramos","doi":"10.1016/j.gpeds.2026.100319","DOIUrl":"10.1016/j.gpeds.2026.100319","url":null,"abstract":"<div><h3>Background</h3><div>Preterm delivery represents a critical public health challenge as the primary cause of infant mortality and significant morbidity among survivors. This retrospective study examined preterm birth prevalence and associated complications at Ekiti State University Teaching Hospital, Nigeria.</div></div><div><h3>Methods</h3><div>Medical records of pregnant women receiving antenatal care and delivering between 2019–2021 were analyzed. Data included maternal characteristics, obstetric history, and neonatal outcomes, with descriptive statistics used for analysis. To assess the significance of the associations, between categorical variables, inferential statistical analyses were conducted using Chi-square test. The statistical significance was set at <em>p</em> &lt; .05.</div></div><div><h3>Results</h3><div>The distribution of neonatal morbidities across selected maternal demographic variables showed significant variation by year of delivery (<em>p</em> &lt; .05), with higher prevalence among married women, Christians, and parents with tertiary education (<em>p</em> &lt; .05). Preterm birth prevalence declined significantly over the years: 20.9 % in 2019, 10.2 % in 2020, and 8.2 % in 2021 (χ² = 30.42, <em>p</em> &lt; .001), indicating a downward trend and a corresponding increase in term deliveries. Maternal factors significantly associated with preterm birth included parity (<em>p</em> &lt; .001), gestational age at booking (<em>p</em> = .042), previous cesarean section (<em>p</em> = .029), history of pregnancy-induced hypertension (<em>p</em> &lt; .001), antepartum hemorrhage (<em>p</em> &lt; .001), pre-eclampsia (<em>p</em> &lt; .001), and eclampsia (<em>p</em> &lt; .001). Most cases occurred among multiparous women (parity 1–4), those booking at ≤20 weeks gestation, and those with histories of pregnancy-induced hypertension or pre-eclampsia. Neonatal variables showed significant variations by year in birth weight (χ² = 180.32, <em>p</em> &lt; .001) and mode of delivery (χ² = 282.28, <em>p</em> &lt; .001), but not in sex (<em>p</em> = .999) or gestation type (<em>p</em> = .693). All reported morbidities (jaundice, fever, anemia, convulsion, and birth defects) were significantly associated with preterm birth (<em>p</em> &lt; .05), with higher prevalence in these conditions.</div></div><div><h3>Conclusion</h3><div>Preterm birth prevalence declined significantly from 2019 to 2021, alongside variations in neonatal morbidities influenced by maternal demographics and obstetric factors. Targeted interventions addressing modifiable risk factors, such as early booking and management of hypertensive disorders, could further reduce preterm births and associated morbidities in similar settings.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100319"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictors of rehabilitation needs, utilization patterns, and out-of-pocket costs among children with disabilities: evidence from a national survey 残疾儿童康复需求、使用模式和自付费用的预测因素:来自全国调查的证据
Global pediatrics Pub Date : 2026-03-01 Epub Date: 2026-01-14 DOI: 10.1016/j.gpeds.2026.100321
Jae Eun Yang , Ah Rim Kim
{"title":"Predictors of rehabilitation needs, utilization patterns, and out-of-pocket costs among children with disabilities: evidence from a national survey","authors":"Jae Eun Yang ,&nbsp;Ah Rim Kim","doi":"10.1016/j.gpeds.2026.100321","DOIUrl":"10.1016/j.gpeds.2026.100321","url":null,"abstract":"<div><div>This study examined predictors of rehabilitation therapy needs, utilization time, and out-of-pocket (OOP) costs among children with disabilities in South Korea. We conducted a cross-sectional secondary analysis using data from the 2020 National Survey of the Disabled, including 338 children under 18 years of age. Rehabilitation needs, weekly therapy duration, and OOP costs were analyzed using descriptive statistics, chi-square tests, and logistic regression, with duration- and cost-related analyses restricted to the subsample of 250 children currently receiving therapy. Rehabilitation needs were significantly associated with brain lesions, speech disabilities, and receipt of housing benefits. Younger age, greater disability severity, higher household income, and stronger family support were related to longer weekly therapy duration. Average monthly OOP expenditures were 186 640 KRW, with higher costs linked to increased utilization, higher income, better home accessibility, and greater perceived discrimination, while lower satisfaction with welfare projects was associated with higher costs. Logistic regression identified brain lesions (OR 7.63), speech disabilities (OR 2.44), and housing benefit receipt (OR 3.28) as strong predictors of rehabilitation needs. Despite limitations in survey weighting and measurement, these findings highlight substantial socioeconomic and disability-related disparities in rehabilitation access and financial burden. Policy efforts are needed to reduce inequities, strengthen family-centered multidisciplinary rehabilitation services, and expand equitable access for children with disabilities and their families.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100321"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Family music therapy combined with oral motor intervention in preterm infants: A randomized controlled trial on feeding competence and parental mental health 家庭音乐疗法联合口腔运动干预对早产儿喂养能力和父母心理健康的随机对照试验
Global pediatrics Pub Date : 2025-12-01 Epub Date: 2025-08-05 DOI: 10.1016/j.gpeds.2025.100271
Qiong Le , Hong Lan , Meng-yun Hu , Li-fen Wu , Lin Wang , Shuang Wang , Jing Tao , Hong-ping Wang
{"title":"Family music therapy combined with oral motor intervention in preterm infants: A randomized controlled trial on feeding competence and parental mental health","authors":"Qiong Le ,&nbsp;Hong Lan ,&nbsp;Meng-yun Hu ,&nbsp;Li-fen Wu ,&nbsp;Lin Wang ,&nbsp;Shuang Wang ,&nbsp;Jing Tao ,&nbsp;Hong-ping Wang","doi":"10.1016/j.gpeds.2025.100271","DOIUrl":"10.1016/j.gpeds.2025.100271","url":null,"abstract":"<div><h3>Objective</h3><div>The study aimed to evaluate the combined effects of family music therapy and oral motor intervention on oral feeding outcomes, oral motor function, and parental anxiety and depression in preterm infants, with the goal of providing new effective strategies for preterm infants’ feeding.</div></div><div><h3>Design</h3><div>This was a randomized controlled trial.</div></div><div><h3>Setting and Participants</h3><div>A total of 130 preterm infants from the neonatal ward were enrolled and randomly assigned to a control group and a study group in a 1:1 ratio using a computer-generated random sequence.</div></div><div><h3>Methods</h3><div>The control group received standard neonatal care and oral motor intervention, while the study group additionally received family music therapy. The primary outcome measures included oral feeding outcomes, oral motor function scores, and parental anxiety and depression scores.</div></div><div><h3>Results</h3><div>On the 7th day, statistically significant differences in normal morphology scores were observed between the two groups (<em>P</em> &lt; 0.05). On the 14th day, significant differences were noted in the Oral Mobility Scale scores (<em>P</em> &lt; 0.05). The study group had shorter total oral feeding transition time, nasogastric tube indwelling time, and hospital stay. There were no significant differences in complications between the two groups (<em>P</em> &gt; 0.05). Post-intervention, parental anxiety and depression scores were significantly lower in the study group (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>The findings of this study suggest that combining family music therapy with oral motor intervention improved oral motor function, accelerated the feeding process in preterm infants, and reduced parental anxiety and depression.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100271"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infuence of prebiotics on childhood autism: Evidences and implications 益生元对儿童自闭症的影响:证据和启示
Global pediatrics Pub Date : 2025-12-01 Epub Date: 2025-09-13 DOI: 10.1016/j.gpeds.2025.100295
Mariagiovanna Di Chiano , Emanuela Calò
{"title":"Infuence of prebiotics on childhood autism: Evidences and implications","authors":"Mariagiovanna Di Chiano ,&nbsp;Emanuela Calò","doi":"10.1016/j.gpeds.2025.100295","DOIUrl":"10.1016/j.gpeds.2025.100295","url":null,"abstract":"<div><div>Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communication and social interaction across multiple contexts, as well as restricted, repetitive, and stereotyped patterns of behaviour, interests, or activities. In this context, individuals often exhibit behavioural alterations and frequent gastrointestinal disturbances, which are often associated with gut dysbiosis.</div><div>In recent years, interest in prebiotics as modulators of the gut microbiota has grown significantly, as these compounds promote the growth of beneficial bacteria and the production of metabolites with potential neuroprotective effects.</div><div>This review summarizes the main preclinical and clinical evidence on the use of prebiotics in the context of ASD, describing the biological mechanisms underlying their potential therapeutic effects.</div><div>Several studies suggest that supplementation with prebiotics, such as galacto-oligosaccharides and fructo-oligosaccharides, may improve both gastrointestinal symptoms and certain behavioral aspects in individuals with ASD. These effects are thought to be mediated through modulation of the microbiota, reduction of inflammation, and regulation of the gut–brain–microbiota axis.</div><div>However, the literature highlights significant methodological heterogeneity and inconsistent findings, underscoring the need for more rigorous and standardized studies.</div><div>In conclusion, prebiotics represent a promising complementary therapeutic strategy in ASD, but further research is needed to precisely determine their efficacy, safety, and optimal use.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100295"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
International legal implications for children in conflict zones 对冲突地区儿童的国际法律影响
Global pediatrics Pub Date : 2025-12-01 Epub Date: 2025-08-15 DOI: 10.1016/j.gpeds.2025.100285
Clara Pettoello-Mantovani , Margherita Zona , Francesca Scaltrito , Ignazio Cammisa , Ida Giardino , Pietro Ferrara
{"title":"International legal implications for children in conflict zones","authors":"Clara Pettoello-Mantovani ,&nbsp;Margherita Zona ,&nbsp;Francesca Scaltrito ,&nbsp;Ignazio Cammisa ,&nbsp;Ida Giardino ,&nbsp;Pietro Ferrara","doi":"10.1016/j.gpeds.2025.100285","DOIUrl":"10.1016/j.gpeds.2025.100285","url":null,"abstract":"<div><div>This article examines the unique vulnerability of children in armed conflict, emphasizing the interplay between their developmental stage, inherent dependency, and evolving legal status. It explores the international legal framework for child protection, which integrates International Humanitarian Law, International Human Rights Law, and International Criminal Law to mitigate the impacts of conflict and ensure accountability for violations. Despite the existence of robust legal instruments, a persistent gap remains between legal norms and their effective implementation, resulting in ongoing harm to children. The article highlights how international law not only prohibits acts such as killing, maiming, and attacks on schools and hospitals but also mandates obligations for recovery, reintegration, and access to health and education—implicitly addressing the psycho-physical harm children endure. Arguing that legal understanding must extend beyond legal professionals to include healthcare providers, the article calls for interdisciplinary collaboration to protect children more effectively. It concludes by advocating for the integration of Mental Health and Psychosocial Support (MHPSS) as an explicit and adequately resourced component of the right to health in humanitarian responses, to address the full spectrum of children's needs in conflict settings.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100285"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coping strategies, anxiety and self-efficacy among participants in neonatal resuscitation courses for instructors 新生儿复苏指导课程参与者的应对策略、焦虑和自我效能感
Global pediatrics Pub Date : 2025-12-01 Epub Date: 2025-09-03 DOI: 10.1016/j.gpeds.2025.100291
Francesca Saretta , Laura Polloni , Francesco Cavallin , Giuseppe De Bernardo , Paolo Ernesto Villani , Rossana Schiavo , Daniele Trevisanuto
{"title":"Coping strategies, anxiety and self-efficacy among participants in neonatal resuscitation courses for instructors","authors":"Francesca Saretta ,&nbsp;Laura Polloni ,&nbsp;Francesco Cavallin ,&nbsp;Giuseppe De Bernardo ,&nbsp;Paolo Ernesto Villani ,&nbsp;Rossana Schiavo ,&nbsp;Daniele Trevisanuto","doi":"10.1016/j.gpeds.2025.100291","DOIUrl":"10.1016/j.gpeds.2025.100291","url":null,"abstract":"<div><h3>Aim</h3><div>To investigate coping strategies, anxiety and self-efficacy among participants in Neonatal Resuscitation Courses for instructors.</div></div><div><h3>Methods</h3><div>Cross-sectional study. Sixty-four participants in two Neonatal Resuscitation Courses for Instructors were assessed by using validated questionnaires.</div></div><div><h3>Results</h3><div>Overall, self-efficacy and functional coping strategies were moderate/high, while levels of anxiety were quite low. Self- efficacy was positively correlated with positive attitude (<em>r</em> = 0.29; <em>p</em> = 0.02) and problem solving (<em>r</em> = 0.44; <em>p</em> &lt; 0.01) and inversely correlated with avoidance strategies (<em>r</em>=-0.30; <em>p</em> = 0.01) and anxiety (trait <em>r</em>=-0.47; <em>p</em> &lt; 0.01; state <em>r</em>=-0.35; <em>p</em> = 0.01). Emotional maturity was positively correlated with positive attitude (<em>r</em> = 0.42; <em>p</em> &lt; 0.01) and problem solving (<em>r</em> = 0.45; <em>p</em> &lt; 0.01) and inversely correlated with anxiety (trait -0.51; <em>p</em> &lt; 0.01; state <em>r</em>=-0.34; <em>p</em> = 0.01). Finalization of action was positively correlated with problem solving (<em>r</em> = 0.40; <em>p</em> &lt; 0.01) and inversely correlated with avoidance strategies (<em>r</em>=-0.34; <em>p</em> = 0.01) and trait anxiety (<em>r</em>=-0.32; <em>p</em> = 0.01). Relational fluidity was positively correlated with turning to religion (<em>r</em> = 0.28; <em>p</em> = 0.03) and inversely correlated with avoidance strategies (<em>r</em>=-0.31; <em>p</em> = 0.01), and trait anxiety (<em>r</em>=-0.42; <em>p</em> &lt; 0.01). Context analysis was positively correlated with problem solving (<em>r</em> = 0.34; <em>p</em> = 0.01) and inversely correlated with state anxiety (<em>r</em>=-0.36; <em>p</em> &lt; 0.01). Problem solving was significantly higher in doctors compared to nurses (<em>p</em> = 0.01).</div></div><div><h3>Conclusions</h3><div>Neonatal resuscitation instructor candidates displayed high self-efficacy and functional coping strategies, with low anxiety levels. This may help professionals to better deal with stressful and demanding situations and reinforce adaptive work management.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100291"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug‑related problems and associated factors among hospitalized pediatric patients in a general hospital, Tigrai, northern Ethiopia: a cross-sectional study 埃塞俄比亚北部提格拉伊一家综合医院住院儿科患者的药物相关问题及相关因素:一项横断面研究
Global pediatrics Pub Date : 2025-12-01 Epub Date: 2025-09-09 DOI: 10.1016/j.gpeds.2025.100293
Gebretekle Gebremichael Hailesilase, Haylay Araya Gebrezgabiher, Abrahaley Mulu Kidane
{"title":"Drug‑related problems and associated factors among hospitalized pediatric patients in a general hospital, Tigrai, northern Ethiopia: a cross-sectional study","authors":"Gebretekle Gebremichael Hailesilase,&nbsp;Haylay Araya Gebrezgabiher,&nbsp;Abrahaley Mulu Kidane","doi":"10.1016/j.gpeds.2025.100293","DOIUrl":"10.1016/j.gpeds.2025.100293","url":null,"abstract":"<div><h3>Background</h3><div>Drug-related problems (DRPs) are associated with increased risks of morbidities and mortalities. However, there are limited studies on DRPs among hospitalized pediatric patients in Ethiopia. This study aimed to evaluate DRPs and associated factors among hospitalized pediatric patients in Adigrat general hospital, Tigrai, northern Ethiopia.</div></div><div><h3>Methods</h3><div>A retrospective cross-sectional study was conducted among hospitalized pediatric patients in Adigrat general hospital. Data was collected from the patients’ medical charts between 01 July 2024 and 31 August 2024. Potential drug-drug interactions were screened using Micromedex 2.0 software. Logistic regression was used to analyze association of variables with DRPs. Data was analyzed using statistical package for social science version 21 and statistical significance was set at P value &lt; 0.05 in the multivariate analysis.</div></div><div><h3>Results</h3><div>A total of 114 (77.6 %) patients had at least one DRP. A total of 325 DRPs were identified in those 114 patients, averaging 2.85 (1<span><math><mo>−</mo></math></span>13) DRPs per patient. Moreover, 15.0 % of the patients experienced <span><math><mo>≥</mo></math></span>5 DRPs. Regarding the proportion of DRPs, unnecessary drug therapy, ADRs and dosage too low accounted for 22.8, 18.5 and 18.1 % of the DRPs, respectively. Substantial proportions (<em>n</em> = 47; 14.5 %) of the ADRs were due to potential drug-drug interactions. Anti-infectives for systemic use (68.8 %) and drugs of the alimentary tract and metabolism (10.2 %) were the most commonly implicated drug classes in DRPs. The number of diseases per patient was significantly associated with the occurrence of DRPs (Adjusted Odds ratio = 5.875, 95 % CI: 1.735–19.895).</div></div><div><h3>Conclusions</h3><div>The DRPs were prevalent among hospitalized pediatric patients. Unnecessary drug therapy, ADRs and dosage too low were the most widespread categories of DRPs. Clinicians should follow pediatrics guidelines and use drug interaction screening databases when prescribing drugs to pediatric patients.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100293"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early bone health: exploring relationship between oxidative stress and skeletal development in newborn infants 早期骨骼健康:探索新生儿氧化应激与骨骼发育的关系
Global pediatrics Pub Date : 2025-12-01 Epub Date: 2025-09-04 DOI: 10.1016/j.gpeds.2025.100292
Serafina Perrone , Laura Cannavò , Virginia Beretta , Elena Scarpa , Serena Benedetti , Chiara Petrolini , Vincenzo Raitano , Domenico Corica , Tommaso Aversa , Maria Cristina Albertini , Andrea Dall’Asta , Maria Elisabeth Street , Tullio Ghi , Silvia Carloni , Malgorzata Wasniewska
{"title":"Early bone health: exploring relationship between oxidative stress and skeletal development in newborn infants","authors":"Serafina Perrone ,&nbsp;Laura Cannavò ,&nbsp;Virginia Beretta ,&nbsp;Elena Scarpa ,&nbsp;Serena Benedetti ,&nbsp;Chiara Petrolini ,&nbsp;Vincenzo Raitano ,&nbsp;Domenico Corica ,&nbsp;Tommaso Aversa ,&nbsp;Maria Cristina Albertini ,&nbsp;Andrea Dall’Asta ,&nbsp;Maria Elisabeth Street ,&nbsp;Tullio Ghi ,&nbsp;Silvia Carloni ,&nbsp;Malgorzata Wasniewska","doi":"10.1016/j.gpeds.2025.100292","DOIUrl":"10.1016/j.gpeds.2025.100292","url":null,"abstract":"<div><div>Bone health during childhood is critical for proper skeletal development and long-term quality of life. The process of bone formation relies on a balance of mineralization and cellular activity, which is regulated by oxidative stress (OS). While physiological levels of reactive oxygen species (ROS) are important for normal bone cell function and homeostasis, excessive OS can contribute to the development of bone diseases, such as osteoarthritis and osteoporosis. Enzymes like xanthine oxidoreductase are involved in amplifying ROS production, which can lead to cartilage degradation and disrupted bone remodeling. Despite increasing recognition of OS as a risk factor in adult skeletal health, its impact on fetal and neonatal bone development remains underexplored. In vitro and animal model studies, including those using free radicals exposure, have been performed to understand how OS impairs osteogenesis.</div><div>This review examines the role of OS in perinatal bone development analyzing key environmental risk factors and the potential long-term consequences of early-life redox imbalance on skeletal health.</div><div>The sensitivity of the fetal bone to OS suggests that oxidative damage during this critical period can result in impaired bone growth, low birth weight, and long-term skeletal disorders. Oxidative stress interferes with osteoblast differentiation, enhances adipocyte formation from mesenchymal stem cells, and stimulates osteoclast activity, leading to bone resorption. Clinical studies on the impact of OS on neonatal bone metabolism remain limited. Identifying key risk factors for early-life redox imbalance could be crucial in developing potential antioxidant therapies to support skeletal health during childhood</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100292"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Esophageal Atresia: From worry to wisdom–Parental information needs and considerations on etiology, care, and parental support 食道闭锁:从忧虑到智慧——父母对病因、护理和父母支持的信息需求和考虑
Global pediatrics Pub Date : 2025-12-01 Epub Date: 2025-10-18 DOI: 10.1016/j.gpeds.2025.100299
Katherine Merritt Doucet , Juliana Coronado , Rebecca Leslie , Emily Whitesel , Benjamin Zendejas , Dusica Bajic
{"title":"Esophageal Atresia: From worry to wisdom–Parental information needs and considerations on etiology, care, and parental support","authors":"Katherine Merritt Doucet ,&nbsp;Juliana Coronado ,&nbsp;Rebecca Leslie ,&nbsp;Emily Whitesel ,&nbsp;Benjamin Zendejas ,&nbsp;Dusica Bajic","doi":"10.1016/j.gpeds.2025.100299","DOIUrl":"10.1016/j.gpeds.2025.100299","url":null,"abstract":"<div><div>Esophageal atresia (EA) is one of the most common congenital gastrointestinal anomalies, posing complex challenges across diagnosis, treatment, and long-term care. This narrative review addresses four key domains: etiology and diagnosis; surgical repair techniques; feeding challenges; and parental stress and support. It outlines current evidence and clinical considerations relevant to families, clinical staff, and researchers. By highlighting informational gaps and long-term concerns, the review supports improved communication, care planning, and research direction for optimizing outcomes in children with EA.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100299"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of photography for qualitative data collection with adolescent mothers: a scoping review 使用摄影对青少年母亲的定性数据收集:范围审查
Global pediatrics Pub Date : 2025-12-01 Epub Date: 2025-08-09 DOI: 10.1016/j.gpeds.2025.100283
Daniela de Castro Barbosa Leonello , Giovanna Ushirobira Souza , Rhyquelle Rhibna Neris , Giovanna Cristina Machado Kayzuka , Marina Prado de Souza , Adriana Moraes Leite
{"title":"The use of photography for qualitative data collection with adolescent mothers: a scoping review","authors":"Daniela de Castro Barbosa Leonello ,&nbsp;Giovanna Ushirobira Souza ,&nbsp;Rhyquelle Rhibna Neris ,&nbsp;Giovanna Cristina Machado Kayzuka ,&nbsp;Marina Prado de Souza ,&nbsp;Adriana Moraes Leite","doi":"10.1016/j.gpeds.2025.100283","DOIUrl":"10.1016/j.gpeds.2025.100283","url":null,"abstract":"<div><h3>Introduction</h3><div>Photography has been increasingly explored in data collection processes, as it enriches the process and allows the interviewee to take on the role of protagonist [1]. Among the methods that use images, <em>Photovoice</em> and Photo-Elicitation stand out in qualitative research [2]. The objective of this research was to map the development of Photo-Elicitation and <em>Photovoice</em> methods with adolescent mothers as data collection techniques.</div></div><div><h3>Methods</h3><div>A scoping review was conducted from August to October 2024. The guiding question formulated was: \"How have Photo-Elicitation and <em>Photovoice</em> been developed with adolescent mothers as a data collection method?\". The search strategy included LILACS, PubMed, CINAHL, and <em>Web of Science</em>.</div></div><div><h3>Results</h3><div>A total of 46 articles were found, mostly published in English. Ten were selected after full-text reading.</div></div><div><h3>Conclusion</h3><div>The literature converges in considering Photo-Elicitation and <em>Photovoice</em> as visual and interactive resources that facilitate the communication of adolescent mothers' experiences.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100283"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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