早期骨健康的射频超声多光谱:rem -bone研究方案(试验缩写:rem -bone)

Serafina Perrone , Malgorzata Wasniewska , Maria-Elisabeth Street , Virginia Beretta , Elena Scarpa , Chiara Petrolini , Andrea Dall’Asta , Domenico Corica , Tommaso Aversa , Giorgia Pepe , Letteria Morabito , Federica Grassi , Anna-Mariia Shulhai , Valentina Bianco , Anna Maria Papini , Maria Cristina Albertini , Silvia Carloni , Giuseppe Maglietta , Matteo Puntoni , Caterina Caminiti , Tullio Ghi
{"title":"早期骨健康的射频超声多光谱:rem -bone研究方案(试验缩写:rem -bone)","authors":"Serafina Perrone ,&nbsp;Malgorzata Wasniewska ,&nbsp;Maria-Elisabeth Street ,&nbsp;Virginia Beretta ,&nbsp;Elena Scarpa ,&nbsp;Chiara Petrolini ,&nbsp;Andrea Dall’Asta ,&nbsp;Domenico Corica ,&nbsp;Tommaso Aversa ,&nbsp;Giorgia Pepe ,&nbsp;Letteria Morabito ,&nbsp;Federica Grassi ,&nbsp;Anna-Mariia Shulhai ,&nbsp;Valentina Bianco ,&nbsp;Anna Maria Papini ,&nbsp;Maria Cristina Albertini ,&nbsp;Silvia Carloni ,&nbsp;Giuseppe Maglietta ,&nbsp;Matteo Puntoni ,&nbsp;Caterina Caminiti ,&nbsp;Tullio Ghi","doi":"10.1016/j.gpeds.2025.100261","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Bone health begins with maternal health and nutrition, which influences skeletal mass and bone mineral density (BMD) already in utero. Maximization of bone mass during skeletal growth has become the goal of primary prevention of osteopenia and osteoporosis. The amount of bone gained during growth and its subsequent rate of loss are closely linked to the final skeletal mass in adulthood. Radiofrequency Echographic Multi Spectrometry (REMS) technology has proven to be useful in the assessment of BMD in pregnant women. However, the feasibility of REMS for the assessment of bone status in newborns remains unknown. This multicenter longitudinal study aims at using REMS to evaluate skeletal status in fetuses, newborns and children until 12 months of age.</div></div><div><h3>Methods</h3><div>Two hundred mother-newborn dyads, with infants born at term of gestation, will be consecutively recruited during the prenatal period and followed up until 12 months of life. BMD will be assessed with REMS technology in mothers, fetuses, newborns and infants at 1, 3 6 and 12 months of life. In all enrolled patients, blood will be collected at specific time points and oxidative stress biomarkers, specific microRNAs, and several bone metabolites will be measured in blood, whereas endocrine disruptors will be measured in urine.</div></div><div><h3>Discussion</h3><div>This study is designed to provide robust data on the best method to identify and evaluate bone status starting from intrauterine life. The associations among BMD, maternal nutrition, early exposure to endocrine disruptors, and other investigated molecules will also be investigated in relationship with subsequent body composition and bone health.</div></div><div><h3>Trial registration</h3><div>The protocol was retrospectively registered on ClinicalTrials.gov on December 3<sup>rd</sup>, 2024, with the ID number NCT06750523.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"13 ","pages":"Article 100261"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Radiofrequency echographic multi-spectrometry for early bone health: The REMS-bone study protocol (Trial acronym: REMS-bone)\",\"authors\":\"Serafina Perrone ,&nbsp;Malgorzata Wasniewska ,&nbsp;Maria-Elisabeth Street ,&nbsp;Virginia Beretta ,&nbsp;Elena Scarpa ,&nbsp;Chiara Petrolini ,&nbsp;Andrea Dall’Asta ,&nbsp;Domenico Corica ,&nbsp;Tommaso Aversa ,&nbsp;Giorgia Pepe ,&nbsp;Letteria Morabito ,&nbsp;Federica Grassi ,&nbsp;Anna-Mariia Shulhai ,&nbsp;Valentina Bianco ,&nbsp;Anna Maria Papini ,&nbsp;Maria Cristina Albertini ,&nbsp;Silvia Carloni ,&nbsp;Giuseppe Maglietta ,&nbsp;Matteo Puntoni ,&nbsp;Caterina Caminiti ,&nbsp;Tullio Ghi\",\"doi\":\"10.1016/j.gpeds.2025.100261\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Bone health begins with maternal health and nutrition, which influences skeletal mass and bone mineral density (BMD) already in utero. Maximization of bone mass during skeletal growth has become the goal of primary prevention of osteopenia and osteoporosis. The amount of bone gained during growth and its subsequent rate of loss are closely linked to the final skeletal mass in adulthood. Radiofrequency Echographic Multi Spectrometry (REMS) technology has proven to be useful in the assessment of BMD in pregnant women. However, the feasibility of REMS for the assessment of bone status in newborns remains unknown. This multicenter longitudinal study aims at using REMS to evaluate skeletal status in fetuses, newborns and children until 12 months of age.</div></div><div><h3>Methods</h3><div>Two hundred mother-newborn dyads, with infants born at term of gestation, will be consecutively recruited during the prenatal period and followed up until 12 months of life. BMD will be assessed with REMS technology in mothers, fetuses, newborns and infants at 1, 3 6 and 12 months of life. In all enrolled patients, blood will be collected at specific time points and oxidative stress biomarkers, specific microRNAs, and several bone metabolites will be measured in blood, whereas endocrine disruptors will be measured in urine.</div></div><div><h3>Discussion</h3><div>This study is designed to provide robust data on the best method to identify and evaluate bone status starting from intrauterine life. The associations among BMD, maternal nutrition, early exposure to endocrine disruptors, and other investigated molecules will also be investigated in relationship with subsequent body composition and bone health.</div></div><div><h3>Trial registration</h3><div>The protocol was retrospectively registered on ClinicalTrials.gov on December 3<sup>rd</sup>, 2024, with the ID number NCT06750523.</div></div>\",\"PeriodicalId\":73173,\"journal\":{\"name\":\"Global pediatrics\",\"volume\":\"13 \",\"pages\":\"Article 100261\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-05-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Global pediatrics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667009725000193\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Global pediatrics","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667009725000193","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

骨骼健康始于孕产妇的健康和营养,它影响着已经在子宫内的骨量和骨矿物质密度(BMD)。在骨骼生长过程中使骨量最大化已成为预防骨质减少和骨质疏松的主要目标。生长期间获得的骨骼量及其随后的损失率与成年后的最终骨骼质量密切相关。射频超声多光谱(REMS)技术已被证明是有用的评估BMD在孕妇。然而,REMS评估新生儿骨骼状况的可行性尚不清楚。本多中心纵向研究旨在利用REMS评估胎儿、新生儿和12个月前儿童的骨骼状况。方法在产前连续招募200例足月出生的母新生儿,随访至出生后12个月。BMD将在母亲、胎儿、新生儿和婴儿1、6和12个月时用REMS技术进行评估。在所有入选的患者中,将在特定的时间点采集血液,并测量血液中的氧化应激生物标志物、特定的microrna和几种骨代谢物,而在尿液中测量内分泌干扰物。本研究旨在为从宫内生活开始识别和评估骨骼状态的最佳方法提供可靠的数据。骨密度、母体营养、早期暴露于内分泌干扰物和其他被研究分子之间的关联,也将被研究与随后的身体组成和骨骼健康的关系。试验注册该方案于2024年12月3日在ClinicalTrials.gov上回顾性注册,ID号NCT06750523。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Radiofrequency echographic multi-spectrometry for early bone health: The REMS-bone study protocol (Trial acronym: REMS-bone)

Radiofrequency echographic multi-spectrometry for early bone health: The REMS-bone study protocol (Trial acronym: REMS-bone)

Background

Bone health begins with maternal health and nutrition, which influences skeletal mass and bone mineral density (BMD) already in utero. Maximization of bone mass during skeletal growth has become the goal of primary prevention of osteopenia and osteoporosis. The amount of bone gained during growth and its subsequent rate of loss are closely linked to the final skeletal mass in adulthood. Radiofrequency Echographic Multi Spectrometry (REMS) technology has proven to be useful in the assessment of BMD in pregnant women. However, the feasibility of REMS for the assessment of bone status in newborns remains unknown. This multicenter longitudinal study aims at using REMS to evaluate skeletal status in fetuses, newborns and children until 12 months of age.

Methods

Two hundred mother-newborn dyads, with infants born at term of gestation, will be consecutively recruited during the prenatal period and followed up until 12 months of life. BMD will be assessed with REMS technology in mothers, fetuses, newborns and infants at 1, 3 6 and 12 months of life. In all enrolled patients, blood will be collected at specific time points and oxidative stress biomarkers, specific microRNAs, and several bone metabolites will be measured in blood, whereas endocrine disruptors will be measured in urine.

Discussion

This study is designed to provide robust data on the best method to identify and evaluate bone status starting from intrauterine life. The associations among BMD, maternal nutrition, early exposure to endocrine disruptors, and other investigated molecules will also be investigated in relationship with subsequent body composition and bone health.

Trial registration

The protocol was retrospectively registered on ClinicalTrials.gov on December 3rd, 2024, with the ID number NCT06750523.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Global pediatrics
Global pediatrics Perinatology, Pediatrics and Child Health
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信