Gastro hep advances最新文献

{"title":"Disproportionate rates of liver injury in people with cystic fibrosis on elexacaftor/tezacaftor/ivacaftor in Queensland, Australia","authors":"Ellie Johnson , Timothy Riddles , Daniel Smith , Daniel Henderson , Philip Masel , David W. Reid , Vanessa Moore , Ieuan E.S. Evans","doi":"10.1016/j.gastha.2025.100641","DOIUrl":"10.1016/j.gastha.2025.100641","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 6","pages":"Article 100641"},"PeriodicalIF":0.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood Socioeconomic Deprivation and 30-Day Outcomes After Admission for Common Gastrointestinal Conditions: A Large Nationwide Study","authors":"Beau Blass BS ,&nbsp;Jay B. Lusk MD, MBA ,&nbsp;Hannah Mahoney MS ,&nbsp;Molly N. Hoffman MPH ,&nbsp;Amy G. Clark PhD ,&nbsp;Jonathan Bae MD ,&nbsp;Matthew J. Townsend MD, MSc, MPP ,&nbsp;Amit Patel MD ,&nbsp;Andrew J. Muir MD, MHS ,&nbsp;Bradley G. Hammill DrPH","doi":"10.1016/j.gastha.2025.100614","DOIUrl":"10.1016/j.gastha.2025.100614","url":null,"abstract":"<div><h3>Background and Aims</h3><div>To study the associations of neighborhood socioeconomic disadvantage with 30-day mortality and readmission for common gastrointestinal conditions, adjusting for individual demographics, comorbidities, access to healthcare resources, and treatment facility characteristics.</div></div><div><h3>Methods</h3><div>We analyzed a nationwide sample of United States Medicare beneficiaries hospitalized from 2017-2019 for common gastrointestinal diseases, grouped by Diagnosis Related Groups (DRGs). We then estimated the association of neighborhood socioeconomic disadvantage, measured by the Area Deprivation Index (ADI), with 30-day mortality and readmission utilizing logistic regression models with restricted cubic splines. We performed multi-step adjustments for individual socioeconomic status and demographics, medical comorbidities, access to inpatient and outpatient healthcare resources, and hospital-level characteristics.</div></div><div><h3>Results</h3><div>In total, 1,293,483 patients in the mortality cohort and 1,289,106 patients in the readmission cohort were included in analysis. The fully-adjusted model demonstrated an association between neighborhood deprivation and 30-day mortality for patients with common gastrointestinal diseases, with the strongest associations for non-malignant pancreatic disorders (OR 1.59, 95% CI 1.25-2.01), esophageal disorders (OR 1.50, 95% 1.02-2.21), gastrointestinal hemorrhage (OR 1.40, 95% CI 1.29-1.52), and biliary tract disorders (OR 1.40, 95% CI 1.16-1.69) in the most deprived groups. Neighborhood deprivation was not associated with 30-day readmission after full adjustment.</div></div><div><h3>Conclusion</h3><div>We describe an independent association between neighborhood deprivation and 30-day mortality for patients with common gastrointestinal diseases, which remains even after controlling for individual poverty, demographics and comorbidities, access to healthcare resources, and characteristics of treating facilities.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 5","pages":"Article 100614"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143792377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Phenotypes May be Able to Identify Populations with Non-Alcoholic Fatty Liver-Spectrum Disease","authors":"Bridget M. Geyer MD, MSc ,&nbsp;Feier Chang ,&nbsp;Peng Wu ,&nbsp;Benjamin A. Goldstein PhD ,&nbsp;Kara Wegermann MD ,&nbsp;Sunny L. Chung MD ,&nbsp;Matthew Phelan MS ,&nbsp;Joseph Wawrzynski MD ,&nbsp;Jacqueline B. Henson MD ,&nbsp;Howard Lee MD ,&nbsp;Phil Ambery MBChB, FRCP, FFPM ,&nbsp;Cynthia A. Moylan MD, MHS ,&nbsp;Neha Pagidipati MD, MPH","doi":"10.1016/j.gastha.2024.100611","DOIUrl":"10.1016/j.gastha.2024.100611","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Despite causing significant morbidity and mortality, non-alcoholic fatty liver disease (NAFLD) is underdiagnosed. Clinical indices developed to identify hepatic steatosis are often used by providers but their potential for use at the population level remains unexplored. We assessed clinical phenotypes for their ability to identify potential patients with NAFLD and non-alcoholic steatohepatitis (NASH) in the electronic health record (EHR).</div></div><div><h3>Methods</h3><div>We conducted a single-center retrospective cohort study of adult patients from January 1, 2016-Decmber 31, 2022. We developed four phenotypes: clinical NAFLD (C-NAFLD), clinical NASH (C-NASH), NAFLD with diagnosis (D-NAFLD) and NASH with diagnosis (D-NASH) and compared characteristics across them to identify differences between patients with and without ICD diagnoses.</div></div><div><h3>Results</h3><div>Each of the (C) phenotypes identified a cohort of patients who had clinical evidence suggestive of disease without a documented diagnosis. Black patients were overrepresented in the (C) relative to (D) groups (C-NAFLD 24.3% vs. D-NAFLD 21.2%; C-NASH 28.5% vs. D-NASH 14.0%). Patients with D-NASH were more likely to be prescribed medications that may be effective in treating NAFLD-NASH spectrum disease, i.e., glucagon-like peptide 1 (GLP-1) receptor agonists (C-NASH 5.0% vs. D-NASH 16.7%, p &lt; 0.001). Fewer patients with D-NASH had cardiovascular (C-NASH 58.0% vs D-NASH 46.3%, p &lt; 0.001) and heart failure (C-NASH 33.9% vs. D-NASH 24.8%, p &lt; 0.001) hospitalizations than those with C-NASH.</div></div><div><h3>Conclusions</h3><div>Non-invasive clinical indices may improve identification of patients with or at risk for NAFLD-NASH at the population level. Systematic differences between populations with and without ICD diagnoses of NAFLD-spectrum disease suggest disparities in the application of screening and diagnostic procedures.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 5","pages":"Article 100611"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143792376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Intermuscular Dissection for a Nonsurgical Patient With T2 Lower Rectal Cancer","authors":"Takemasa Hayashi ,&nbsp;Katsuro Ichimasa ,&nbsp;Shin-ei Kudo","doi":"10.1016/j.gastha.2025.100638","DOIUrl":"10.1016/j.gastha.2025.100638","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 6","pages":"Article 100638"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143917539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Never Brush off Abdominal Pain: A Case of a Grill Brush Bristle Causing Colonic Perforation","authors":"Bibek Saha ,&nbsp;Vijayvardhan Kamalumpundi ,&nbsp;Jenny J. Cao ,&nbsp;Crystal H. Kang ,&nbsp;Allison Reinhardt ,&nbsp;Joelle N. Friesen ,&nbsp;Bright Thilagar","doi":"10.1016/j.gastha.2025.100645","DOIUrl":"10.1016/j.gastha.2025.100645","url":null,"abstract":"<div><div>Acute abdominal pain constitutes 7% to 20% of all emergency department visits. While abdominal pain encompasses a broad differential, etiologies of enteritis can be divided into 4 major categories, with infection being the most common. We present the first case of enteritis caused by sigmoid colon and possibly jejunal perforation secondary to grill brush bristle ingestion. Despite comprehensive workup for enteritis, the cause remained elusive in our case, necessitating computed tomography enterography, which revealed the foreign body. Clinicians should maintain a high index of suspicion for foreign body ingestion, including grill brush bristle, in cases of unexplained enteritis, as this represents an uncommon but life-threatening etiology.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 6","pages":"Article 100645"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Care of Patients With Inflammatory Bowel Disease With Inadequate Response or Intolerance to Upadacitinib","authors":"Lynn Kobeissi,&nbsp;Kristi Briggs,&nbsp;Caya McFalls,&nbsp;Mark Lazarev,&nbsp;Joanna Melia","doi":"10.1016/j.gastha.2025.100648","DOIUrl":"10.1016/j.gastha.2025.100648","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 6","pages":"Article 100648"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailored Strategies are Needed to Address Racial and Ethnic Disparities in Pancreatic Cancer Risk Prediction","authors":"Wansu Chen ,&nbsp;Botao Zhou ,&nbsp;Tiffany Q. Luong ,&nbsp;Fagen Xie ,&nbsp;Bechien U. Wu","doi":"10.1016/j.gastha.2025.100657","DOIUrl":"10.1016/j.gastha.2025.100657","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 6","pages":"Article 100657"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family History of Eosinophilic Esophagitis or Other Eosinophilic Gastrointestinal Disease Is Not Associated With Response to Topical Steroids in Eosinophilic Esophagitis","authors":"Angela Z. Xue ,&nbsp;Sean S. LaFata ,&nbsp;Timothy S. Gee ,&nbsp;Hannah L. Thel ,&nbsp;Brenderia A. Cameron ,&nbsp;Akshatha Kiran ,&nbsp;Adolfo A. Ocampo ,&nbsp;Justin McCallen ,&nbsp;Christopher J. Lee ,&nbsp;Stephanie A. Borinsky ,&nbsp;Walker D. Redd ,&nbsp;Trevor S. Barlowe ,&nbsp;Rayan N. Kaakati ,&nbsp;Cary C. Cotton ,&nbsp;Swathi Eluri ,&nbsp;Craig C. Reed ,&nbsp;Evan S. Dellon","doi":"10.1016/j.gastha.2024.11.001","DOIUrl":"10.1016/j.gastha.2024.11.001","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 3","pages":"Article 100585"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143139833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Assessment of Liver Transplant Trends and Outcomes Among Adults With Steatotic Liver Disease in the U.S.","authors":"Shyam Patel ,&nbsp;Sohil Patel ,&nbsp;Wei Zhang ,&nbsp;Ashwani K. Singal ,&nbsp;Ramsey Cheung ,&nbsp;Robert J. Wong","doi":"10.1016/j.gastha.2024.100609","DOIUrl":"10.1016/j.gastha.2024.100609","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Steatotic liver disease (SLD) is the leading indication for liver transplantation (LT) among U.S. adults. We aim to provide comprehensive updates of LT trends and outcomes among adults with SLD, highlighting racial, ethnic, and sociodemographic disparities.</div></div><div><h3>Methods</h3><div>Using data from the 2010 to 2023 United Network for Organ Sharing registry, we performed a retrospective cohort study evaluating LT waitlist trends, waitlist outcomes, and post-LT survival among 65,675 adults with SLD. Disparities in LT outcomes were evaluated using adjusted competing risks analyses.</div></div><div><h3>Results</h3><div>From 2014 to 2023, there was an increasing proportion of Hispanics, women, and younger adults with SLD listed for LT. For Hispanics, this was driven by metabolic dysfunction–associated steatohepatitis (MASH); 19.9% of MASH wait-listings in 2023 were Hispanics. For women and younger adults (18–39 years), this was driven by alcohol-associated liver disease (ALD); 30.9% and 16.4% of ALD-related wait-listings in 2023 were women and younger adults, respectively. Women (vs men) had greater waitlist removal risk (subdistribution hazard ratio (sHR) 1.12, 95% confidence interval (CI) 1.07–1.18) and lower likelihood of LT receipt (sHR 0.87, 95% CI, 0.85–0.90). Ethnic minorities had worse outcomes, particularly Hispanics, who had a 37% higher risk of waitlist removal (sHR 1.37, 95% CI, 1.30–1.45) and 16% lower likelihood of LT receipt (sHR 0.86, 95% CI, 0.82–0.87) vs non-Hispanic whites. Disparities in post-LT survival were also observed.</div></div><div><h3>Conclusion</h3><div>In 2023, nearly one-quarter of MASH liver transplant waitlist registrants were Hispanics. Approximately half and 1 in 6 ALD waitlist registrants were women and younger adults, respectively. These concerning trends are amplified by the disparities in LT outcomes observed among women and ethnic minorities.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 4","pages":"Article 100609"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microfluidic Flow Promotes a Steatotic Phenotype in Induced Pluripotent Stem Cell–Derived Hepatocytes that is Influenced by Disease State of the Donor","authors":"Ekta Minocha ,&nbsp;Linan Jiang ,&nbsp;Ashwani Kumar Gupta ,&nbsp;Richard M. Green ,&nbsp;Yitshak Zohar ,&nbsp;Jason A. Wertheim","doi":"10.1016/j.gastha.2024.100601","DOIUrl":"10.1016/j.gastha.2024.100601","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 4","pages":"Article 100601"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143237195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}