Swallowed Nasal Fluticasone Spray for Eosinophilic Esophagitis: An Affordable and Off-Label Path to Histologic Remission

Jameel Alp , Alyssa M. Bren , Tyson Sievers , Joshua A. Sloan
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引用次数: 0

Abstract

Swallowed topical corticosteroids are among the first-line therapies for eosinophilic esophagitis, with budesonide oral suspension recently approved by the Food and Drug Administration. However, off-label options such as fluticasone from metered-dose inhalers remain widely used due to cost and access barriers. We report a case of histologic remission achieved using over-the-counter fluticasone nasal spray administered orally with honey—an approach not previously described in the literature. This patient-led, low-cost method followed incomplete response to both proton pump inhibitors and fluticasone metered-dose inhaler. The case may illustrate a potential alternative steroid delivery method in eosinophilic esophagitis for resource-conscious, individualized care.
吞入氟替卡松鼻喷雾剂治疗嗜酸性食管炎:一种经济实惠的非适应症治疗组织学缓解途径
口服糖皮质类固醇是嗜酸性粒细胞性食管炎的一线治疗方法之一,布地奈德口服混悬液最近获得美国食品和药物管理局批准。然而,由于成本和获取障碍,诸如计量吸入器中的氟替卡松等非适应症选择仍被广泛使用。我们报告了一例使用非处方氟替卡松鼻喷雾剂口服蜂蜜获得组织学缓解的病例,这种方法以前没有在文献中描述过。这种以患者为主导的低成本方法对质子泵抑制剂和氟替卡松计量吸入器均有不完全反应。该病例可能说明了一种潜在的替代类固醇给药方法,用于嗜酸性粒细胞性食管炎的资源意识,个性化护理。
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来源期刊
Gastro hep advances
Gastro hep advances Gastroenterology
CiteScore
0.80
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0.00%
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审稿时长
64 days
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