Gastro hep advances最新文献

{"title":"Perindopril-Induced Collagenous Colitis: Case Report and Literature Review","authors":"Eddy Fares,&nbsp;Weam El Hajj,&nbsp;Stéphane Nahon,&nbsp;Gilles Macaigne","doi":"10.1016/j.gastha.2024.09.009","DOIUrl":"10.1016/j.gastha.2024.09.009","url":null,"abstract":"<div><div>We report the first case of collagenous colitis attributed to perindopril use, in a 90-year-old woman. The patient developed diarrhea with hypokalemia, 3 weeks after perindopril was introduced in her medications for uncontrolled hypertension. Significant thickening of the basal epithelial membrane (up to 80 μm) was found on random colon biopsies. Diarrhea resolved within 3 days after perindopril withdrawal. Four months later, left colon biopsies revealed a normalization of the basal membrane thickness. The intrinsic imputability of perindopril as the causative agent of microscopic colitis is considered to be reasonable by the French accountability technique. There was no rechallenge test conducted.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 2","pages":"Article 100554"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic Signatures Highlight Fiber-Degrading Bacteroides Species in Mediterranean Diet Response Among Ulcerative Colitis","authors":"Natasha Haskey ,&nbsp;Jiayu Ye ,&nbsp;Jessica Josephson ,&nbsp;Maitreyi Raman ,&nbsp;Sanjoy Ghosh ,&nbsp;Deanna L. Gibson","doi":"10.1016/j.gastha.2024.100606","DOIUrl":"10.1016/j.gastha.2024.100606","url":null,"abstract":"<div><h3>Background and Aims</h3><div>The Mediterranean diet pattern (MDP) is associated with health-associated gut microbes and metabolites. However, the impact of the MDP on the fecal metabolome in ulcerative colitis (UC) remains unclear. We characterized the fecal metabolome of patients with UC with high adherence to the MDP compared to the Canadian habitual diet (CHD). Furthermore, we explored potential differences in the fecal metabolome between dietary responders and nonresponders to the MDP.</div></div><div><h3>Methods</h3><div>Utilizing untargeted metabolomics on a subset of fecal samples obtained from a randomized controlled trial, adult patients with quiescent UC underwent a 12-week intervention following either the MDP (n = 8) or CHD (n = 8). Liquid chromatography-tandem mass spectrometry was employed to profile endogenous fecal metabolites, while 16S amplicon sequencing was utilized to profile the fecal microbiota.</div></div><div><h3>Results</h3><div>A total of 701 human metabolites were detected, with 35 exhibiting significant differential expression between the MDP and CHD groups. Noteworthy, folate biosynthesis, sphingolipid biosynthesis, and steroid biosynthesis were identified as major pathways affected. Moreover, microbial analysis showed that individuals with increased levels of the class Bacteroidia (<em>Bacteroides vulgatus</em> [<em>B. vulgatus</em>], <em>B</em>. <em>uniformis</em>, <em>and B</em>. <em>acidifaciens</em>) in their stool at baseline were more likely to respond to the MDP.</div></div><div><h3>Conclusion</h3><div>High adherence to an MDP is associated with beneficial metabolite changes associated with reducing inflammation in UC. In addition, fiber-degrading microbes abundant before dietary intervention played a role in the responsiveness to the MDP. This work lays the groundwork for developing a metabolic signature associated with the MDP to develop personalized nutrition strategies for UC prevention and treatment. <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> Number: <span><span>NCT03053713</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 4","pages":"Article 100606"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Are TikTok Users Saying About Colorectal Cancer? An Examination of Content, Quality, and Emerging Themes","authors":"Bharathi Selvan,&nbsp;Melissa M. Tran,&nbsp;Christine O’Connell,&nbsp;Julius M. Wilder","doi":"10.1016/j.gastha.2024.08.013","DOIUrl":"10.1016/j.gastha.2024.08.013","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 1","pages":"Article 100534"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11714384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EUS Guided Enterocolostomy for the Palliation of Malignant Small Bowel Obstruction From a Cecal Adenocarcinoma","authors":"Brandon Rodgers,&nbsp;Abraham Mathew,&nbsp;Hadie Razjouyan","doi":"10.1016/j.gastha.2024.10.016","DOIUrl":"10.1016/j.gastha.2024.10.016","url":null,"abstract":"<div><div>Malignant bowel obstruction is a challenging complication in advanced gastrointestinal malignancies with varying treatment strategies including medical, surgical and endoscopic therapies, each with their own limitations. Endoscopic ultrasound–guided enterocolostomy has been previously reported as an option for patients who are not surgical candidates or ideal candidates for enteral stenting. In this case, endoscopic ultrasound–guided enterocolostomy is used for the palliation in a patient with a completely obstructing large cecal adenocarcinoma who declined surgical intervention.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 3","pages":"Article 100576"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover: Properties of Human Colonic Myenteric Neurons Differ Depending on Age, Disorder, and Colonic Region","authors":"","doi":"10.1016/j.gastha.2025.100616","DOIUrl":"10.1016/j.gastha.2025.100616","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 1","pages":"Article 100616"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143164272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anorectal Friction Force Is Reduced in Fecal Incontinence","authors":"Hans Gregersen ,&nbsp;Bhavesh Patel ,&nbsp;Xiaomei Guo ,&nbsp;Giuliana Barron Del Solar ,&nbsp;Samuel Eisenstein ,&nbsp;Ghassan Kassab","doi":"10.1016/j.gastha.2024.10.020","DOIUrl":"10.1016/j.gastha.2024.10.020","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 3","pages":"Article 100580"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143167819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Integrin αvβ6 Antibody Titer as a Predictive Biomarker of Future Treatment Escalation in Patients With Ulcerative Colitis","authors":"Shuji Yamamoto,&nbsp;Takeshi Kuwada,&nbsp;Masahiro Shiokawa,&nbsp;Hiroki Kitamoto,&nbsp;Makoto Okabe,&nbsp;Hiroshi Seno","doi":"10.1016/j.gastha.2024.10.022","DOIUrl":"10.1016/j.gastha.2024.10.022","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 3","pages":"Article 100582"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143167820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Portal Vein Recanalization Transjugular Intrahepatic Portosystemic Shunt for Noncirrhotic Chronic Portal Vein Thrombosis Leading to Successful Pregnancy: Case Report","authors":"Andy Yu ,&nbsp;Gabriel M. Knight ,&nbsp;Justin Boike ,&nbsp;Bartley Thornburg ,&nbsp;Riad Salem","doi":"10.1016/j.gastha.2024.09.001","DOIUrl":"10.1016/j.gastha.2024.09.001","url":null,"abstract":"<div><div>Portal vein recanalization transjugular intrahepatic portosystemic shunt (PVR-TIPS) is a safe and effective procedure for decompression of portal hypertension (PH). In this short case series, 2 women with chronic noncirrhotic portal vein thrombosis were treated with PVR-TIPS. Both patients hoped to conceive. Without treatment for their PH, their pregnancies posed a significant risk of life-threatening variceal bleeding. Both patients tolerated the procedure well and delivered without complications of PH. In future cases of noncirrhotic portal vein thrombosis in patients hoping to conceive, PVR-TIPS should be considered for definitive treatment of PH.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 1","pages":"Article 100546"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11713488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Text Message System for the Prediction of Colonoscopy Bowel Preparation Adequacy Before Colonoscopy: An Artificial Intelligence Image Classification Algorithm Based on Images of Stool Output","authors":"Chethan Ramprasad ,&nbsp;Divya Saini ,&nbsp;Henry Del Carmen ,&nbsp;Lev Krasnovsky ,&nbsp;Rajat Chandra ,&nbsp;Ryan Mcgregor ,&nbsp;Russell T. Shinohara ,&nbsp;Eric Eaton ,&nbsp;Meghna Gummadi ,&nbsp;Shivan Mehta ,&nbsp;James D. Lewis","doi":"10.1016/j.gastha.2024.09.011","DOIUrl":"10.1016/j.gastha.2024.09.011","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Inadequate bowel preparation which occurs in 25% of colonoscopies is a major barrier to the effectiveness of screening for colorectal cancer. We aim to develop an artificial intelligence (machine learning) algorithm to assess photos of stool output after bowel preparation to predict inadequate bowel preparation before colonoscopy.</div></div><div><h3>Methods</h3><div>Patients were asked to text a photo of their stool in the commode when they believed that they neared completion of their colonoscopy bowel preparation. Boston Bowel Preparation Scores of 7 and below were labeled as inadequate or fair. Boston Bowel Preparation Scores of 8 and 9 were considered good. A binary classification image-based machine learning algorithm was designed.</div></div><div><h3>Results</h3><div>In a test set of 61 images, the binary classification machine learning algorithm was able to distinguish inadequate/fair preparation from good preparation with a positive predictive value of 78.6% and a negative predictive value of 60.8%. In a test set of 56 images, the algorithm was able to distinguish normal colonoscopy duration (&lt;25 minutes) from long colonoscopy duration (&gt;25 minutes) with a positive predictive value of 78.6% and a negative predictive value of 65.5%.</div></div><div><h3>Conclusion</h3><div>Patients are willing to submit photos of their stool output during bowel preparation through text messages before colonoscopy. This machine learning algorithm demonstrates the ability to predict inadequate/fair preparation from good preparation based on image classification of stool output. It was less accurate to predict long duration of colonoscopy.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 2","pages":"Article 100556"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Varying Histology of Hepatic Sarcoidosis and the Relation of Bile Duct Damage and Loss to the Presence of Portal Hypertension and Cirrhosis","authors":"Divya B. Dasani ,&nbsp;Maria Isabel Fiel ,&nbsp;Camila C. Simoes ,&nbsp;Adam S. Morgenthau ,&nbsp;Thomas D. Schiano","doi":"10.1016/j.gastha.2024.10.001","DOIUrl":"10.1016/j.gastha.2024.10.001","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Sarcoidosis is a multisystem disorder characterized by nonnecrotizing granulomas. Studies suggest 20%–70% of patients with sarcoidosis have abnormal liver chemistries or abdominal imaging. Hepatic sarcoidosis may be complicated by portal hypertension (portal HTN) with or without cirrhosis. Few studies have reviewed the liver histopathology of sarcoidosis.</div></div><div><h3>Methods</h3><div>Searching the pathology database using the terms “sarcoidosis” and “liver,” patients were identified and cross-referenced to patients in the Sarcoidosis Clinic. Patients met the diagnostic criteria for sarcoidosis. Those with isolated granulomatous hepatitis were excluded. Demographics, abdominal imaging, biochemistries, and detailed histological features were cataloged.</div></div><div><h3>Results</h3><div>Patients were separated into 2 groups: those with portal HTN with or without cirrhosis (pHTN+) and those without portal HTN (pHTN-). Fifty-three patients had biopsies available for review (pHTN+, n = 33; pHTN-, n = 20). The groups did not differ in the location, type, or number of granulomas. The pHTN + group had more bile duct damage (<em>P</em> = .025) and loss (<em>P</em> = .019). Patients in the pHTN + group also had biliary cirrhosis, nodular regenerative hyperplasia, or outflow obstruction.</div></div><div><h3>Conclusion</h3><div>There are several causes for portal HTN in sarcoidosis. Thus, liver biopsy is essential in its evaluation. Bile duct damage and loss are associated with the presence of portal HTN and cirrhosis. Biliary abnormalities may occur independently of granulomatous inflammation, and can thus identify a subset of patients at risk for progressive liver disease.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 2","pages":"Article 100561"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}