Gastro hep advances最新文献

{"title":"Metabolomic Signatures Highlight Fiber-Degrading Bacteroides Species in Mediterranean Diet Response Among Ulcerative Colitis","authors":"Natasha Haskey ,&nbsp;Jiayu Ye ,&nbsp;Jessica Josephson ,&nbsp;Maitreyi Raman ,&nbsp;Sanjoy Ghosh ,&nbsp;Deanna L. Gibson","doi":"10.1016/j.gastha.2024.100606","DOIUrl":"10.1016/j.gastha.2024.100606","url":null,"abstract":"<div><h3>Background and Aims</h3><div>The Mediterranean diet pattern (MDP) is associated with health-associated gut microbes and metabolites. However, the impact of the MDP on the fecal metabolome in ulcerative colitis (UC) remains unclear. We characterized the fecal metabolome of patients with UC with high adherence to the MDP compared to the Canadian habitual diet (CHD). Furthermore, we explored potential differences in the fecal metabolome between dietary responders and nonresponders to the MDP.</div></div><div><h3>Methods</h3><div>Utilizing untargeted metabolomics on a subset of fecal samples obtained from a randomized controlled trial, adult patients with quiescent UC underwent a 12-week intervention following either the MDP (n = 8) or CHD (n = 8). Liquid chromatography-tandem mass spectrometry was employed to profile endogenous fecal metabolites, while 16S amplicon sequencing was utilized to profile the fecal microbiota.</div></div><div><h3>Results</h3><div>A total of 701 human metabolites were detected, with 35 exhibiting significant differential expression between the MDP and CHD groups. Noteworthy, folate biosynthesis, sphingolipid biosynthesis, and steroid biosynthesis were identified as major pathways affected. Moreover, microbial analysis showed that individuals with increased levels of the class Bacteroidia (<em>Bacteroides vulgatus</em> [<em>B. vulgatus</em>], <em>B</em>. <em>uniformis</em>, <em>and B</em>. <em>acidifaciens</em>) in their stool at baseline were more likely to respond to the MDP.</div></div><div><h3>Conclusion</h3><div>High adherence to an MDP is associated with beneficial metabolite changes associated with reducing inflammation in UC. In addition, fiber-degrading microbes abundant before dietary intervention played a role in the responsiveness to the MDP. This work lays the groundwork for developing a metabolic signature associated with the MDP to develop personalized nutrition strategies for UC prevention and treatment. <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> Number: <span><span>NCT03053713</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 4","pages":"Article 100606"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenosine Receptor 3 in Liver Cancer: Expression Variability, Epigenetic Modulation, and Enhanced Histone Deacetylase Inhibitor Effects","authors":"Louise Kaldjob-Heinrich ,&nbsp;Sandro Nuciforo ,&nbsp;Steffen Lemke ,&nbsp;Aaron Stahl ,&nbsp;Stefan Czemmel ,&nbsp;Sepideh Babaei ,&nbsp;Lauriane Blukacz ,&nbsp;Marie-Anne Meier ,&nbsp;Yizheng Zhang ,&nbsp;Christian M. Schürch ,&nbsp;Irene Gonzalez-Menendez ,&nbsp;Pascal Woelffing ,&nbsp;Nisar P. Malek ,&nbsp;Veit Scheble ,&nbsp;Sven Nahnsen ,&nbsp;Manfred Claassen ,&nbsp;Markus Templin ,&nbsp;Hans Bösmüller ,&nbsp;Markus H. Heim ,&nbsp;Daniel Dauch ,&nbsp;Michael Bitzer","doi":"10.1016/j.gastha.2024.11.006","DOIUrl":"10.1016/j.gastha.2024.11.006","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Primary liver cancer, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), has low response rates to existing treatments, highlighting the urgent need for novel treatment options. Adenosine A3 receptor (ADORA3) signaling has emerged as a potential target. Namodenoson, an ADORA3 agonist, has shown promise in early clinical trials for HCC. However, further data are required to clarify ADORA3 expression patterns in liver cancer, mechanisms of action, and the potential for combination therapies to inform patient selection for future clinical trials.</div></div><div><h3>Methods</h3><div>Patient-derived tissue microarrays and RNA-sequencing were employed to investigate ADORA3 expression. Cellular responses to ADORA3 stimulation and combination treatments were studied in HCC and CCA cell lines and patient-derived organoids (PDOs). Genome-wide RNA-Seq analysis, mRNA analysis, and DigiWest protein profiling were performed.</div></div><div><h3>Results</h3><div>Tissue microarray analysis revealed higher ADORA3 expression in nonmalignant samples and a subset of tumors with weak or absent ADORA3 expression. This was supported by RNA sequencing data from The Cancer Genome Atlas and needle biopsy samples. Cell lines and PDOs exhibited antiproliferative effects with the ADORA3 agonist Namodenoson, confirmed by receptor dependency tests with specific antagonists and siRNA experiments. Genome-wide RNA-Seq analysis suggested chromatin remodeling events after ADORA3 stimulation. mRNA expression and DigiWest profiling identified downregulation of histone deacetylases and histone H3 modifications. Combination treatments with different ADORA3 agonists and histone deacetylase inhibitors significantly enhanced antiproliferative effects in almost all selected combinations, supported by investigations in PDOs.</div></div><div><h3>Conclusion</h3><div>ADORA3 expression varies considerably in HCC or CCA, ranging from high to absent receptor detection. This observation might help to identify patients for clinical studies. Additionally, Namodenoson’s epigenetic modulating activity suggests epigenetic drugs as promising candidates for combination treatment.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 3","pages":"Article 100590"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143167833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perindopril-Induced Collagenous Colitis: Case Report and Literature Review","authors":"Eddy Fares,&nbsp;Weam El Hajj,&nbsp;Stéphane Nahon,&nbsp;Gilles Macaigne","doi":"10.1016/j.gastha.2024.09.009","DOIUrl":"10.1016/j.gastha.2024.09.009","url":null,"abstract":"<div><div>We report the first case of collagenous colitis attributed to perindopril use, in a 90-year-old woman. The patient developed diarrhea with hypokalemia, 3 weeks after perindopril was introduced in her medications for uncontrolled hypertension. Significant thickening of the basal epithelial membrane (up to 80 μm) was found on random colon biopsies. Diarrhea resolved within 3 days after perindopril withdrawal. Four months later, left colon biopsies revealed a normalization of the basal membrane thickness. The intrinsic imputability of perindopril as the causative agent of microscopic colitis is considered to be reasonable by the French accountability technique. There was no rechallenge test conducted.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 2","pages":"Article 100554"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Intermuscular Dissection for a Nonsurgical Patient With T2 Lower Rectal Cancer","authors":"Takemasa Hayashi ,&nbsp;Katsuro Ichimasa ,&nbsp;Shin-ei Kudo","doi":"10.1016/j.gastha.2025.100638","DOIUrl":"10.1016/j.gastha.2025.100638","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 6","pages":"Article 100638"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143917539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Never Brush off Abdominal Pain: A Case of a Grill Brush Bristle Causing Colonic Perforation","authors":"Bibek Saha ,&nbsp;Vijayvardhan Kamalumpundi ,&nbsp;Jenny J. Cao ,&nbsp;Crystal H. Kang ,&nbsp;Allison Reinhardt ,&nbsp;Joelle N. Friesen ,&nbsp;Bright Thilagar","doi":"10.1016/j.gastha.2025.100645","DOIUrl":"10.1016/j.gastha.2025.100645","url":null,"abstract":"<div><div>Acute abdominal pain constitutes 7% to 20% of all emergency department visits. While abdominal pain encompasses a broad differential, etiologies of enteritis can be divided into 4 major categories, with infection being the most common. We present the first case of enteritis caused by sigmoid colon and possibly jejunal perforation secondary to grill brush bristle ingestion. Despite comprehensive workup for enteritis, the cause remained elusive in our case, necessitating computed tomography enterography, which revealed the foreign body. Clinicians should maintain a high index of suspicion for foreign body ingestion, including grill brush bristle, in cases of unexplained enteritis, as this represents an uncommon but life-threatening etiology.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 6","pages":"Article 100645"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Care of Patients With Inflammatory Bowel Disease With Inadequate Response or Intolerance to Upadacitinib","authors":"Lynn Kobeissi,&nbsp;Kristi Briggs,&nbsp;Caya McFalls,&nbsp;Mark Lazarev,&nbsp;Joanna Melia","doi":"10.1016/j.gastha.2025.100648","DOIUrl":"10.1016/j.gastha.2025.100648","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 6","pages":"Article 100648"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailored Strategies are Needed to Address Racial and Ethnic Disparities in Pancreatic Cancer Risk Prediction","authors":"Wansu Chen ,&nbsp;Botao Zhou ,&nbsp;Tiffany Q. Luong ,&nbsp;Fagen Xie ,&nbsp;Bechien U. Wu","doi":"10.1016/j.gastha.2025.100657","DOIUrl":"10.1016/j.gastha.2025.100657","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 6","pages":"Article 100657"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xanthomatosis Coli Associated With Nontuberculous Mycobacterial Disease","authors":"Naoya Masuda ,&nbsp;Kenji Yamazaki ,&nbsp;Ryoji Kushima","doi":"10.1016/j.gastha.2025.100692","DOIUrl":"10.1016/j.gastha.2025.100692","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 8","pages":"Article 100692"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Childhood Experiences Are Associated With an Increased Risk of Dyspepsia in Patients Undergoing Upper Endoscopy","authors":"Rachel Zuzul ,&nbsp;Allison O. Taylor ,&nbsp;Caroline Labriola ,&nbsp;Frances Wang ,&nbsp;Grace Sekaya ,&nbsp;Tomi Akinyemiju ,&nbsp;Meira Epplein ,&nbsp;Katherine S. Garman","doi":"10.1016/j.gastha.2025.100680","DOIUrl":"10.1016/j.gastha.2025.100680","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Stress is a risk factor for dyspepsia; however, neither the type nor timing of stress exposures across the lifespan in this syndrome are well understood. We aimed to understand the association between both adverse childhood experiences (ACEs) and experience of current life stress with dyspepsia by collecting and analyzing survey data from a racially diverse cohort of adult research patients presenting for upper endoscopy (esophagogastroduodenoscopy).</div></div><div><h3>Methods</h3><div>The Gastric Immune Response and Cancer Interception study is a cohort study that enrolled adults scheduled for esophagogastroduodenoscopy at an academic center and administered a detailed survey, including questions on ACEs, current adult stress, and dyspepsia symptoms. Endoscopy and pathology results were abstracted from the medical record. Multivariable logistic regression was performed to determine the association between stress exposures and dyspepsia outcomes.</div></div><div><h3>Results</h3><div>Among 187 participants who completed dyspepsia questions, exposure to 2 or more ACEs compared to none was associated with over a two-and-a-half-fold increase in the odds of self-reported dyspepsia (age-adjusted odds ratio = 2.56; 95% confidence interval: 1.24–5.25), with the strongest association with ACE measures of childhood abuse. ACEs were also associated with epigastric pain syndrome (<em>P</em> &lt; .001) and mixed syndrome (<em>P</em> = .0001), but not with postprandial distress syndrome (<em>P</em> = .095). No association was found between current adult stress and dyspepsia.</div></div><div><h3>Conclusion</h3><div>In patients undergoing endoscopy, exposure to multiple ACEs were associated with dyspepsia. These findings suggest that assessing ACEs in patients with dyspepsia could help provide additional insights into factors associated with dyspepsia symptoms beyond <em>Helicobacter pylori</em> infection and acid-related injury.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 7","pages":"Article 100680"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supine-Position Endoscopic Retrograde Cholangiopancreatography for a Patient With Severe Motor and Intellectual Disabilities","authors":"Kimitoshi Kubo ,&nbsp;Issei Ashida ,&nbsp;Noriko Kimura","doi":"10.1016/j.gastha.2024.06.014","DOIUrl":"10.1016/j.gastha.2024.06.014","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 1","pages":"Article 100507"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141710315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}