Gastro hep advances最新文献

{"title":"Initial Validation of the Eosinophilic Gastritis and Gastroenteritis Quality of Life Scale","authors":"Tiffany H. Taft ,&nbsp;Ikuo Hirano ,&nbsp;Nirmala Gonsalves","doi":"10.1016/j.gastha.2025.100627","DOIUrl":"10.1016/j.gastha.2025.100627","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Eosinophilic gastrointestinal disorders (EGIDs) are chronic immune-mediated conditions characterized by gastrointestinal symptoms and gut eosinophilia. Health-related quality of life (HRQoL) is an important metric to understand patient outcomes; the only disease-specific measure of HRQoL exists for eosinophilic esophagitis (EoE) patients. Patients with non-EoE EGIDs experience unique symptoms and treatment options and disease burden of these rare disorders is under-recognized and considered significant. We aim to validate a new measure of HRQoL specific for adults with non-EoE EGIDs.</div></div><div><h3>Methods</h3><div>The Eosinophilic Gastritis and Gastroenteritis Quality of Life Scale (EGGE-QOL) is 20-items scale developed from patient qualitative interviews assessing HRQoL over the past month. Adult patients were recruited from an academic setting and patient advocacy groups to complete an online questionnaire. Psychometric assessment of the EGGE-QOL included reliability measures (internal consistency, split-half reliability), criterion validity (exploratory factor analysis), and concurrent validity (correlations with EGID symptoms, anxiety, depression, fatigue, and sleep disturbance).</div></div><div><h3>Results</h3><div>Forty-one participants completed the study. The EGGE-QOL had excellent reliability (&gt;0.90). Exploratory factor analysis identified a single structure with 3 possible items for removal. Concurrent validity was supported by moderate to large correlations with psychological symptoms, fatigue and sleep, and symptom severity, frequency, and duration. The most important symptom that impacts non-EoE EGID HRQoL may be frequent diarrhea.</div></div><div><h3>Conclusion</h3><div>The EGGE-QOL is a reliable and valid measure of HRQoL for adults with non-EoE EGIDs, representing an important step in understanding the experiences of these patients and assessing how these conditions may impact daily function. Additional studies are necessary to confirm these findings in larger, diverse cohorts.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 5","pages":"Article 100627"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ripple Effect: Safety, Cost, and Environmental Concerns of Using Sterile Water in Endoscopy","authors":"Deepak Agrawal ,&nbsp;Seth Crockett ,&nbsp;Sonali Palchaudhuri ,&nbsp;Lyndon Hernandez ,&nbsp;Kevin Skole ,&nbsp;Rahul Shimpi ,&nbsp;Jim Collins ,&nbsp;Daniel Von Renteln ,&nbsp;Heiko Pohl","doi":"10.1016/j.gastha.2025.100625","DOIUrl":"10.1016/j.gastha.2025.100625","url":null,"abstract":"<div><div>The gastroenterology societies are committed to reducing the carbon footprint of endoscopies and hence, re-examining waste-generating practices. One such practice is the recommendation to use sterile water during endoscopy for endoscopy lens cleaning and colon irrigation. We critically reviewed all published medical literature and guidelines on the safety of the type of water used in endoscopy. We calculated the cradle-to-grave carbon footprint of a 1-L sterile water bottle and compared it to published studies on bottled drinking water. Guidelines recommending sterile water during endoscopy are based on limited evidence and mostly expert opinions. Referenced studies utilize care protocols that are not practiced. There is also considerable cross-referencing of review articles and guidelines. Two clinical studies directly comparing tap and sterile water in gastrointestinal endoscopy found tap water to be a safe and practical cost-saving alternative to sterile water. The calculated carbon footprint of bottled sterile water is 575 g CO₂ equivalent. No direct evidence supports the recommendation and widespread use of sterile water during gastrointestinal endoscopy procedures. It contributes to health-care waste and climate change and is costly. We recommend tap water be used to fill sterile water bottles until evidence shows the need for alternative practice. It would be prudent to re-evaluate guidelines and write new ones that consider harm to the environment and society in the provision of care to patients, especially when the intervention may be more harmful than the risk it aims to address.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 5","pages":"Article 100625"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematemesis as a Result of Hepatic Arterioportal Fistula Formation","authors":"Hannah Zuercher ,&nbsp;Juan Gonzalez ,&nbsp;Andreas Zori","doi":"10.1016/j.gastha.2024.10.019","DOIUrl":"10.1016/j.gastha.2024.10.019","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 3","pages":"Article 100579"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental Discovery of Duodenal Kaposi Sarcoma","authors":"Rangesh Modi ,&nbsp;David Hakimian ,&nbsp;Edwin McDonald","doi":"10.1016/j.gastha.2024.100598","DOIUrl":"10.1016/j.gastha.2024.100598","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 4","pages":"Article 100598"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143237941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Fibrosis-4 is Associated With Increased Risk of Cirrhosis Decompensation and Liver-Related Mortality in at-Risk Patients With Metabolic Dysfunction–Associated Steatotic Liver Disease","authors":"Elizabeth E. Powell ,&nbsp;Gunter Hartel ,&nbsp;Katharine M. Irvine ,&nbsp;James O’Beirne ,&nbsp;Vikas Bhasker ,&nbsp;Patricia C. Valery","doi":"10.1016/j.gastha.2024.100607","DOIUrl":"10.1016/j.gastha.2024.100607","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 4","pages":"Article 100607"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Oral Anticoagulant and Antiplatelet Agents on Performance of Multitarget Colorectal Cancer Screening Test∗","authors":"Reilly A. Coombs ,&nbsp;James L. Adkins ,&nbsp;Andrew M. Turunen ,&nbsp;Nadim I. Salfiti ,&nbsp;Sahil Khanna ,&nbsp;Sushil Kumar Garg","doi":"10.1016/j.gastha.2024.100610","DOIUrl":"10.1016/j.gastha.2024.100610","url":null,"abstract":"<div><h3>Background and Aims</h3><div>The multitarget stool DNA (mt-sDNA) test is a noninvasive screening tool for colorectal cancer. We aimed to clarify the effects of antiplatelet and anticoagulant medications on the diagnostic performance of this test.</div></div><div><h3>Methods</h3><div>We retrospectively identified patients undergoing mt-sDNA testing from Mayo Clinic sites across the US during a 5-year period. Participants with positive stool testing results and subsequent high-quality colonoscopy were included. Participants were grouped by medication use: antiplatelets, anticoagulants, both, or none of these medications. The primary outcomes were the effects on positive predictive value (PPV) of the test for identifying advanced adenoma by antithrombotic use.</div></div><div><h3>Results</h3><div>Of the 11,761 persons with a positive mt-sDNA test result, 8926 persons (age range, 45–91 years) underwent colonoscopy at our institution, of which 7750 were deemed high quality. Among these, 2435 patients were diagnosed with advanced adenomas, for a PPV of 31.4% for detecting advanced adenomas with the mt-sDNA test. The PPVs for advanced adenoma were 32.1% in nonantithrombotic users, 29.2% in antiplatelet users, 30.9% in anticoagulant users, and 31.7% in users of both medications. Additionally, among all patients with positive mt-sDNA testing and subsequent follow-up colonoscopy (n = 8926), colorectal cancer developed in 116 patients, for a notable 1.3% risk of cancer after positive test results and colonoscopy.</div></div><div><h3>Conclusion</h3><div>In a large retrospective cohort in the US, the PPV of mt-sDNA testing for advanced adenomas was 31.4%. Use of antiplatelet or anticoagulant agents did not affect the PPV for detection of advanced adenomas.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 4","pages":"Article 100610"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duodenal Organoids From Metabolic Dysfunction-Associated Steatohepatitis Patients Exhibit Absorptive and Barrier Alterations","authors":"Alia Hadefi ,&nbsp;Morgane Leprovots ,&nbsp;Gilles Dinsart ,&nbsp;Maryam Marefati ,&nbsp;Marjorie Vermeersch ,&nbsp;Daniel Monteyne ,&nbsp;David Pérez-Morga ,&nbsp;Anne Lefort ,&nbsp;Frédérick Libert ,&nbsp;Laurine Verset ,&nbsp;Claire Liefferinckx ,&nbsp;Christophe Moreno ,&nbsp;Jacques Devière ,&nbsp;Eric Trépo ,&nbsp;Marie-Isabelle Garcia","doi":"10.1016/j.gastha.2024.100599","DOIUrl":"10.1016/j.gastha.2024.100599","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma. Though MASH is closely tied to metabolic risk factors, the underlying pathogenic mechanisms remain scarcely understood. Recent research has emphasized the importance of the gut-liver axis in its pathogenesis, an aspect less explored in human studies. Here, we investigated whether the duodenal epithelium of MASH patients could exhibit intrinsic dysfunctions.</div></div><div><h3>Methods</h3><div>Duodenal epithelial organoids were generated from 16 MASH patients and 14 healthy controls. Biopsies and patient-derived organoid transcriptomes were then analyzed to evaluate if specific intestinal pathways were differentially modulated in MASH subjects. Functional assays were performed to assess the duodenal epithelial absorptive potential and barrier functionality.</div></div><div><h3>Results</h3><div>Organoid formation efficiency was similar between control-derived duodenal epithelial organoids and MASH-derived duodenal epithelial organoids (MDEOs) (71% and 69%, respectively). Despite global heterogeneity in growth patterns, MDEOs frequently exhibited cystic spheroid morphology. MDEOs displayed altered digestive potential associated with reduced mature absorptive cell fate, but they retained their lipid metabolic capacity, possibly mediated by lipid oxidation in stem/progenitor cells. Additionally, MDEOs misexpressed components of tight and adherens junctions and desmosomes compared to controls. However, MDEOs maintained pore and leak pathway integrity, indicating that the duodenal epithelial barrier remained functionally preserved under tested conditions.</div></div><div><h3>Conclusion</h3><div>This study provides evidence that the duodenal epithelium of MASH patients exhibits significant alterations in its nutrition-related and barrier functions. This study sheds light on the intricate dynamics of duodenal epithelial alterations in MASH, highlighting potential therapeutic avenues for restoring intestinal functions.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 4","pages":"Article 100599"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recipients of Early Liver Transplants for Alcohol-Related Liver Disease May Reside in Areas With Lower Social Vulnerability","authors":"James Flanary ,&nbsp;Elizabeth A. King ,&nbsp;FNU Baimaji ,&nbsp;Alexandra T. Strauss ,&nbsp;Nicole Welch ,&nbsp;Annette Bellar ,&nbsp;Courtney B. Sherman ,&nbsp;Bilal Hameed ,&nbsp;Mandana Khalili ,&nbsp;Srinivasan Dasarathy ,&nbsp;Andrew M. Cameron ,&nbsp;Po-Hung Chen","doi":"10.1016/j.gastha.2024.08.020","DOIUrl":"10.1016/j.gastha.2024.08.020","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 1","pages":"Article 100542"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11719348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological Findings of Hypervitaminosis A Liver Disease","authors":"Richard H. Goodheart ,&nbsp;Dilini Gunawardena ,&nbsp;Adam Doyle","doi":"10.1016/j.gastha.2024.08.010","DOIUrl":"10.1016/j.gastha.2024.08.010","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 1","pages":"Article 100531"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11713470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usability of a Mobile Point-of-Care App for the Index of Severity for Eosinophilic Esophagitis","authors":"Evan S. Dellon ,&nbsp;Glenn T. Furuta ,&nbsp;Nick Tomeo ,&nbsp;Anya Karavanov ,&nbsp;Zoe Smernoff ,&nbsp;Joy Harrington ,&nbsp;Seema S. Aceves","doi":"10.1016/j.gastha.2024.100604","DOIUrl":"10.1016/j.gastha.2024.100604","url":null,"abstract":"<div><h3>Background and Aims</h3><div>A new application (app) allows the Index of Severity for EoE (I-SEE) to be used at the point of care. We aimed to perform usability testing of the I-SEE mobile app and identify areas for improvement.</div></div><div><h3>Methods</h3><div>We recruited 60 practitioners (20 adult and 20 pediatric gastroenterologists; 20 allergists) to use I-SEE on ≥5 EoE patients seen in clinic and undergo interviews by trained qualitative researchers. The interview guide focused on overall user experience, user satisfaction, and desired improvements. It also explored potential perceived barriers to using the app and I-SEE.</div></div><div><h3>Results</h3><div>Though I-SEE was new to most providers, they found it took only a few minutes to calculate the score. All interviewees either “agreed” (5%) or “strongly agreed” (95%) with the statement, “The app was easy to navigate,” and almost all (95%) either “agreed” (42%) or “strongly agreed” (53%) with “The app’s features and functionalities were intuitive and easy to understand”. The large majority (85%) reported satisfaction with the app. Responses were similar for allergists, and adult and pediatric gastroenterologists. Areas of suggested improvement included updating design features, incorporation into electronic medical records, addressing if scoring for children and adults should be different, and clarifying clinical implications of I-SEE for management.</div></div><div><h3>Conclusion</h3><div>The I-SEE app was user friendly and able to be completed rapidly in clinical practice. Interviewee feedback led to app updates to improve visualization and use. In the future, scoring for children should be confirmed and I-SEE should be validated by linking severity to treatment and monitoring recommendations.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 4","pages":"Article 100604"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}