Gastro hep advances最新文献

{"title":"Cover: LincPRKD: A Long Intergenic Noncoding RNA Activated in Gastric Cancer","authors":"","doi":"10.1016/S2772-5723(25)00089-5","DOIUrl":"10.1016/S2772-5723(25)00089-5","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 5","pages":"Article 100702"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional and Structural Investigation of Myenteric Neurons in the Human Colon","authors":"Kristin Elfers ,&nbsp;Alina Sophia Sehnert ,&nbsp;Alexander Wagner ,&nbsp;Ulrich Zwirner ,&nbsp;Helena Linge ,&nbsp;Ulf Kulik ,&nbsp;Daniel Poehnert ,&nbsp;Markus Winny ,&nbsp;Benjamin Gundert ,&nbsp;Heiko Aselmann ,&nbsp;Gemma Mazzuoli-Weber","doi":"10.1016/j.gastha.2024.08.016","DOIUrl":"10.1016/j.gastha.2024.08.016","url":null,"abstract":"<div><h3>Background and Aims</h3><div>The enteric nervous system independently controls gastrointestinal function including motility, which is primarily mediated by the myenteric plexus, therefore also playing a crucial role in functional intestinal disorders. Live recordings from human myenteric neurons proved to be challenging due to technical difficulties. Using the neuroimaging technique, we are able to record human colonic myenteric neuronal activity and investigate their functional properties in a large cohort of patients.</div></div><div><h3>Methods</h3><div>Activity from myenteric neurons in wholemount preparations of different sampling sites of fresh, human colonic tissue was recorded using neuroimaging with the voltage sensitive dye 1-(3-sulfanatopropyl)-4-[beta[2-(di-n-octylamino)-6-naphthyl]vinyl]pyridinium betaine. Neuronal responses were analyzed following stimulation with nicotine and serotonin (5-HT) for differences based on the donor’s age, the disorder indicative for surgery and the colonic region. Immunohistochemistry was performed to calculate the total neuronal numbers.</div></div><div><h3>Results</h3><div>Stimulation with nicotine and 5-HT elicited reproducible action potential discharge in a proportion of human myenteric neurons. The responses to 5-HT were significantly greater in tissues from older patients and from those with inflammatory disorders, while neuronal activity to nicotinergic stimulation was comparable in all patients. Neuronal numbers declined with rising patient’s age and was highest in the sigmoid colon.</div></div><div><h3>Conclusion</h3><div>Neuroimaging with 1-(3-sulfanatopropyl)-4-[beta[2-(di-n-octylamino)-6-naphthyl]vinyl]pyridinium betaine was successfully adapted to record reproducible responses from human colonic myenteric neurons upon pharmacological stimulation. Evidence exists for an impact of age and inflammation on the serotonergic neuronal signaling and for differences in neuronal numbers in the distinct colonic regions as well as a neuronal decrease with age.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 1","pages":"Article 100537"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11714724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Provider Adherence to the 2020 US Multi-Society Task Force Guidelines for Surveillance After Colonoscopy With Polypectomy","authors":"Benjamin E. Cassell ,&nbsp;Katherine Scholand ,&nbsp;Wyatt Tarter ,&nbsp;Camille J. Hochheimer ,&nbsp;Colleen Long ,&nbsp;Gregory L. Austin","doi":"10.1016/j.gastha.2024.08.011","DOIUrl":"10.1016/j.gastha.2024.08.011","url":null,"abstract":"<div><h3>Background and Aims</h3><div>The 2020 United States Multi-Society Task Force on Colorectal Cancer guidelines for surveillance after colonoscopy with polypectomy introduced significant changes in surveillance intervals. We sought to identify rates of adherence to these new guidelines at an academic medical center.</div></div><div><h3>Methods</h3><div>Average-risk screening colonoscopies where 1 to 4 polyps &lt;10 mm were removed between January 1, 2020, and June 30, 2021 were included. To determine predictors of nonadherence, a multivariable logistic regression analysis was conducted and included patient and procedure-related variables. Bayesian changepoint analysis was applied to identify timing of change in adherence. Multinomial logistic regression was used to identify predictors of variability within the guidelines.</div></div><div><h3>Results</h3><div>One thousand twenty-six procedures were analyzed. Adherence to the guidelines was 85%. In procedures with 1 to 2 polyps, increasing size (odds ratio [OR] 0.84 per mm; 95% confidence interval [CI]: 0.75–0.93) and a mixture of tubular adenomas (TA) and hyperplastic polyps (OR 0.35; 95% CI: 0.21–0.59) were associated with nonadherence. Among procedures with 1 to 2 TAs, age (OR 0.86 per 5-year increase; 95% CI: 0.75–0.99), increasing size (OR 0.86 per mm; 95% CI: 0.75–0.99) and polyp number (OR 0.54; 95% CI: 0.33–0.90) were associated with nonadherence. Changepoint analysis identified a potential changepoint on September 2, 2020 (95% credible interval April 2, 2020–February 22, 2020). Larger TAs were less likely to receive a 10-year recommendation (OR 0.61, 95% CI 0.5–0.75).</div></div><div><h3>Conclusion</h3><div>Adherence rates to the 2020 surveillance guidelines were high with a potential changepoint identified on 2/9/20. Deviation from guidelines was associated with patient and procedure related variables.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 1","pages":"Article 100532"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11714692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Program Offering CT Colonography for Colorectal Cancer Screening Avoided Colonoscopy and Sedation Risks in Heart Transplant Candidates and Expedited Screening: A Retrospective Observational Study","authors":"Diane R.M. Somlo ,&nbsp;Reece J. Goiffon ,&nbsp;James M. Richter ,&nbsp;Asishana A. Osho ,&nbsp;Cordula Magee ,&nbsp;Sonali Palchaudhuri","doi":"10.1016/j.gastha.2024.10.014","DOIUrl":"10.1016/j.gastha.2024.10.014","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 3","pages":"Article 100574"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143167835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and Treatment Patterns of Fistulizing Crohn’s Disease in a Large, Real-World Australasian Cohort","authors":"Jack McNamara ,&nbsp;William Wilson ,&nbsp;Joseph L. Pipicella ,&nbsp;Simon Ghaly ,&nbsp;Jakob Begun ,&nbsp;Ian C. Lawrance ,&nbsp;Richard Gearry ,&nbsp;Jane M. Andrews ,&nbsp;Susan J. Connor","doi":"10.1016/j.gastha.2024.100594","DOIUrl":"10.1016/j.gastha.2024.100594","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Fistulizing Crohn’s Disease (fCD) affects up to 50% of people with Crohn’s Disease over their lifetime. Despite this high prevalence, the burden of disease, treatment and natural history in the current biologic era are poorly described. This study explores demographic, disease and treatment factors in a real-world Australasian cohort.</div></div><div><h3>Methods</h3><div>A large real-world cohort of people with inflammatory bowel disease under routine care was interrogated in August 2023. Current fCD was defined as fistula(e) on most recent clinical, radiologic or endoscopic investigation; prior fCD was defined as the resolution of fistula(e) on most recent documentation.</div></div><div><h3>Results</h3><div>Of 3075 people with Crohn’s Disease, 7.4% had current and 10.1% prior fCD (n = 224 &amp; 311). Most patients were in Australia (77%), where 19.3% had current or previous fCD compared to 11% in New Zealand (<em>P</em> &lt; .001). Patients with current or previous fCD were younger compared to those without (<em>P</em> = .003 &amp; <em>P</em> &lt; .001). Males were more commonly affected (<em>P</em> = .021). Current or prior fCD were more likely to be on biologic therapy (<em>P</em> &lt; .001), with anti-tumor necrosis factor agents most frequently utilized. Conversely, those without fCD were more likely on Ustekinumab or Vedolizumab compared to current and prior fCD groups. People with fistulizing disease had higher hospitalization rates, while the prior fCD cohort had longer hospital admissions and more frequently required surgical intervention.</div></div><div><h3>Conclusion</h3><div>People with fCD used more health-care resources, making this an important area for further research into care gaps to improve outcomes and optimal treatment approaches.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 4","pages":"Article 100594"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143237533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ulcerative Colitis but Not Dextran Sodium Sulfate–Induced Colitis–Associated Microbiota Promotes Early Biomarkers of Colitis in Interleukin-10 −/− Mice","authors":"Kayla Roy,&nbsp;Edward Moncada,&nbsp;Lavanya Reddivari","doi":"10.1016/j.gastha.2025.100636","DOIUrl":"10.1016/j.gastha.2025.100636","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis (UC), are inflammatory gastrointestinal conditions in which the pathogenesis is influenced by immune dysfunction, genetics, and environmental factors. Of the 2 conditions, UC is more prevalent, and there is a positive correlation between bacterial dysbiosis and colitis severity and incidence. Therefore, we hypothesize that mice that are genetically predisposed to colitis when colonized with colitic associated bacteria will exhibit an early onset of colitis biomarkers.</div></div><div><h3>Methods</h3><div>Four sets of germ-free interleukin-10 −/− mice were gavaged orally with pooled fecal samples from 2 healthy individuals or an individual with severe colitis or healthy mice or dextran sodium sulfate (DSS)–induced colitis mice. The disease activity index was used to rank colitis severity weekly in transplanted mice for eight weeks.</div></div><div><h3>Results</h3><div>There were significant differences in alpha (Shannon Index) and beta diversity (Bray-Curtis) between healthy and colitic-associated microbiota recipients, indicating dysbiosis (human fecal microbial transplantation <em>P</em> = 8.09∗10^-6, <em>P</em> = .001); (Mice fecal microbiota transplant <em>P</em> = .0197, <em>P</em> = .025). Despite the lack of colitis development, UC-associated microbiota recipients had reduced mucus thickness and increased expression of proinflammatory cytokines in the distal colon compared to healthy-associated microbiota recipients. However, DSS-induced colitis associated microbiota recipients did not show an increase in colitis biomarkers compared to healthy associated microbiota recipients.</div></div><div><h3>Conclusion</h3><div>This study demonstrates that UC-associated bacterial dysbiosis induces colonic inflammation and mucus thinning, biomarkers of early colitis onset, in interleukin-10 −/− mice compared to mice with healthy human associated bacteria.</div><div>Colitis induction depends on bacterial community stability as DSS-induced colitis associated microbiota recipients did not show an increase in colitis or colitis biomarkers in the absence of DSS.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 6","pages":"Article 100636"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143917641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dupilumab Improves Histopathologic Features in Patients With Eosinophilic Esophagitis: LIBERTY EoE TREET Study Results","authors":"Margaret H. Collins ,&nbsp;Marc E. Rothenberg ,&nbsp;Evan S. Dellon ,&nbsp;Albert J. Bredenoord ,&nbsp;Ikuo Hirano ,&nbsp;John Leung ,&nbsp;Xian Sun ,&nbsp;Lila Glotfelty ,&nbsp;Arsalan Shabbir","doi":"10.1016/j.gastha.2025.100646","DOIUrl":"10.1016/j.gastha.2025.100646","url":null,"abstract":"<div><h3>Background and Aims</h3><div>This post hoc analysis assessed the effect of dupilumab on the individual components of the Eosinophilic Esophagitis Histology Scoring System (EoEHSS) and the relationship between histopathologic and endoscopic measures in the LIBERTY eosinophilic esophagitis (EoE) TREET population.</div></div><div><h3>Methods</h3><div>The analysis included patients who received dupilumab 300 mg weekly (qw) or placebo for 24 weeks (Parts A and B). Eligible patients who completed Parts A or B entered Part C and received dupilumab 300 mg qw for 28 weeks (week 52). Changes from baseline to week 24 and week 52 in the EoEHSS grade/stage components were assessed. Associations between histopathologic, symptomatic, and endoscopic features were evaluated using Spearman correlation.</div></div><div><h3>Results</h3><div>At week 24, dupilumab improved most EoEHSS grade/stage component scores vs placebo. These improvements were sustained at week 52 in patients continuously on dupilumab; patients who switched from placebo to dupilumab at week 24 improved EoEHSS grade/stage component scores at week 52 to levels similar to those observed in patients continuously on dupilumab. Dupilumab also increased the proportion of patients in remission at week 24 vs placebo, with further increases at week 52, as assessed by the EoE histology remission score. EoEHSS grade and stage total scores correlated strongly with peak eosinophil count (PEC), moderately to strongly with Endoscopic Reference Score, and weakly with Dysphagia Symptom Questionnaire score. Several EoEHSS grade/stage component scores correlated strongly with PEC but not with Dysphagia Symptom Questionnaire scores.</div></div><div><h3>Conclusion</h3><div>Dupilumab 300 mg qw improved histopathologic measures of EoE beyond PEC at week 24, with improvements sustained to week 52 (<span><span>Video 1</span></span>).</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 6","pages":"Article 100646"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparity in Access to Physicians With High Adenoma Detection Rates","authors":"Adedeji Adenusi ,&nbsp;Xucong Meng ,&nbsp;Mohammad Bilal ,&nbsp;Seth Gross ,&nbsp;Mark Pochapin ,&nbsp;Aasma Shaukat","doi":"10.1016/j.gastha.2025.100672","DOIUrl":"10.1016/j.gastha.2025.100672","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 7","pages":"Article 100672"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ulcerative Colitis Preceding Asymptomatic Wilson’s Disease: A Case Report and Literature Review","authors":"Jun Kunizaki ,&nbsp;Yuko Yoto ,&nbsp;Yoshinobu Nagaoka ,&nbsp;Akira Ishii ,&nbsp;Tomoe Kazama ,&nbsp;Kohei Wagatsuma ,&nbsp;Noriyuki Akutsu ,&nbsp;Aki Ishikawa ,&nbsp;Toju Tanaka ,&nbsp;Shintaro Sugita ,&nbsp;Takeshi Tsugawa ,&nbsp;Hiroshi Nakase","doi":"10.1016/j.gastha.2024.09.003","DOIUrl":"10.1016/j.gastha.2024.09.003","url":null,"abstract":"<div><div>An 11-year-old girl with quiescent ulcerative colitis had sustained elevation of liver enzymes. Although she had no clinical symptoms suggestive of Wilson’s disease, such as Kayser–Fleischer rings, laboratory data showed decreased serum copper and ceruloplasmin levels and increased urinary copper excretion. Genetic testing showed pathogenic variants in <em>ATP7B</em> allele 1: c.2004_2006delGAT (p. Met668del) and allele 2: c.1708-5T&gt;G. After starting copper chelators, her liver function normalized, and she maintained clinical and endoscopic remission of ulcerative colitis. Mutations or defective functions of <em>ATP7B</em> lead to hepatic dysfunction and intestinal inflammation.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 1","pages":"Article 100548"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11714711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Endoscopic Retrograde Cholangiopancreatography for Management of Choledocholithiasis in a Patient With Situs Inversus Totalis: A Case Report and Literature Review","authors":"Bashayer Alrufayi ,&nbsp;Saad Almutairi ,&nbsp;Abbas Zagnoon","doi":"10.1016/j.gastha.2024.09.010","DOIUrl":"10.1016/j.gastha.2024.09.010","url":null,"abstract":"<div><div>Situs inversus totalis is a rare congenital disorder defined by the transposition of all viscera to the opposite side of the body. Because of this anatomical alteration, endoscopic retrograde cholangiopancreatography (ERCP) in such a population is significantly challenging.</div><div>Herein we report a case of a 50-year-old woman presented with epigastric and left upper quadrant pain. Preoperative examination revealed abnormal liver chemistries, situs inversus totalis, and multiple distal common bile duct stones with intrahepatic and extrahepatic bile duct dilatation on abdominal ultrasound. The patient underwent a successful ERCP to relieve biliary obstruction. It was performed while the patient was placed in a supine position with the endoscopist standing on the left side of the patient.</div><div>The major emphasis in ERCP is adjusting the patient and endoscopist positions during the procedure. The advantage of the supine position is that the endoscope could easily reach the pyloric ring and, after reaching the duodenum, the papilla could be reached without difficulty.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 2","pages":"Article 100555"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}