Gastro hep advances最新文献

{"title":"Activation of VEGFR3 and MLC2 are Critical for GLP-2 Enhancement of Chylomicron Transport","authors":"Lili Tian ,&nbsp;Majid Mufaqam Syed-Abdul ,&nbsp;Gary F. Lewis","doi":"10.1016/j.gastha.2024.100605","DOIUrl":"10.1016/j.gastha.2024.100605","url":null,"abstract":"<div><h3>Background and Aims</h3><div>A significant proportion of absorbed dietary triglycerides (TGs) remain in various intracellular and extracellular intestinal compartments for many hours after fat ingestion, including in the lymphatic circulation. TGs retained in the intestine or lymphatics can be mobilized by the gut peptide glucagon-like peptide 2 (GLP-2) and other stimuli. Our previous published data demonstrated that GLP-2 enhances lymph flow by acting distal to the enterocyte, specifically by enhancing lacteal contractility, in an enteric nervous system–dependent fashion. The objective of the present study was to further explore various intermediates in the signaling pathway whereby GLP-2 enhances mesenteric lymph flow. In this study we focused on the roles of vascular endothelial growth factor receptor 3 (VEGFR3) and myosin light chain 2 (MLC2), known to play important roles in lymphangiogenesis and lymphatic contractility, respectively.</div></div><div><h3>Methods</h3><div>A rat lymph fistula model was utilized in this study. An intraduodenal lipid bolus was applied to the rats 5 hours before the following intraperitoneal (i.p.) administrations: 1) saline (placebo), 2) GLP-2, 3) GLP-2 + MAZ-51 (a VEGFR3 inhibitor), 4) GLP-2 + SAR131675 (a second VEGFR3 inhibitor), 5) GLP-2 + ML-7 (a MLCK inhibitor). Lymph flow and TG output were assessed for 60 minutes after the i.p. administrations. In another set of animals, post-i.p. administration, tissue samples were collected to quantify VEGFR3 and MLC2 activation (via phosphorylation).</div></div><div><h3>Results</h3><div>We showed that GLP-2 treatment acutely activated VEGFR3 and MLC2, and that inhibition of VEGFR3 (via MAZ-51/SAR131675) and MLC2 (via ML-7) abolished GLP-2-induced lymph flow and TG output. Furthermore, VEGFR3 inhibition blocked MLC2 activation.</div></div><div><h3>Conclusion</h3><div>Our data suggest that the activation of VEGFR3 and MLC2 play critical roles in GLP-2’s enhancement of chylomicron secretion and that VEGFR3 activation is an important intermediary step in GLP-2’s activation of MLC2.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 4","pages":"Article 100605"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidimensional Experience of Pain in Adults With Cirrhosis: A Cross-sectional Survey Study","authors":"Franklin F.F. Gorospe IV ,&nbsp;David Wong ,&nbsp;Elizabeth Lee ,&nbsp;Martine Puts ,&nbsp;Sarah Brennenstuhl ,&nbsp;Craig M. Dale","doi":"10.1016/j.gastha.2025.100734","DOIUrl":"10.1016/j.gastha.2025.100734","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Patients with liver disease report unrelieved pain. Exploring the multidimensional nature of pain provides insights into its burden and management needs in cirrhosis. This study explored biopsychosocial factors of pain and the relationship between pain intensity and liver disease severity.</div></div><div><h3>Methods</h3><div>A cross-sectional survey design was conducted at a Canadian ambulatory hepatology clinic in 2021. Eligible participants were ≥18 years with a documented the Model for End-stage Liver Disease with Sodium (MELD-Na) score. We report pain characteristics, self-care management, and pain interference using the Brief Pain Inventory. Multiple linear regression analyses examined the relationship between MELD-Na and pain intensity.</div></div><div><h3>Results</h3><div>Of 118 participants (98% response rate), 61.9% were male, 59 ± 11.8 years of age. Leading diagnoses were alcohol related (34.7%) and viral hepatitis (21.2%), and 89.8% had decompensated cirrhosis. The composite pain intensity mean score was 4 ± 2.4. Common pain sites included: abdomen (83.1%), lower legs (59.3%), and lower back (56.8%). Pain interference scores ranged from general activity 5.8 ± 3.1, walking ability 5.7 ± 3.3, and sleep 5.6 ± 3.6. Use of self-management strategies for pain was reported by 37.3%, primarily oral analgesics; no social or psychological strategies were reported. Multiple regression analysis indicated that pain intensity was associated with liver disease severity. MELD-Na 23–31 (β = 0.43), 21–22 (β = 0.28), and 17–20 (β = 0.19). Physical factors associated with pain intensity included ascites (β = 0.16) and edema (β = 0.28).</div></div><div><h3>Conclusion</h3><div>We observed moderate pain and pain-related activity interference in adults with cirrhosis. Ascites, edema, and liver disease severity were associated with pain intensity. More research is needed to explore biopsychosocial pain management interventions for this population.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 10","pages":"Article 100734"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ileal Tuft Cell Depletion Is Associated With Preterm Necrotizing Enterocolitis","authors":"Shirley Wang,&nbsp;Addison Franca,&nbsp;Adam Wilson,&nbsp;Hala Chaaban,&nbsp;Kathryn Y. Burge","doi":"10.1016/j.gastha.2025.100744","DOIUrl":"10.1016/j.gastha.2025.100744","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 10","pages":"Article 100744"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Native Liver Post-Kasai Portoenterostomy for Biliary Atresia Through Stool Proteome Analysis","authors":"Eiichiro Watanabe ,&nbsp;Takeshi Saito ,&nbsp;Masahito Yoshihara ,&nbsp;Ryo Konno ,&nbsp;Jun Fujishiro ,&nbsp;Shinya Takazawa ,&nbsp;Akinori Ichinose ,&nbsp;Kazue Miyake ,&nbsp;Tomo Kakihara ,&nbsp;Tetsuya Ishimaru ,&nbsp;Akira Nishi ,&nbsp;Akinari Fukuda ,&nbsp;Mureo Kasahara ,&nbsp;Osamu Ohara ,&nbsp;Yusuke Kawashima","doi":"10.1016/j.gastha.2025.100688","DOIUrl":"10.1016/j.gastha.2025.100688","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Biliary atresia (BA) is a severe neonatal condition, characterized by jaundice and hyperbilirubinemia, resulting in cholestasis. Although early diagnosis followed by Kasai portoenterostomy (KPE) can rescue patients, they are prone to complications such as cholangitis. Moreover, a comprehensive study assessing intestinal environment is currently lacking. Therefore, in this study, we aimed to elucidate the stool protein profiles of patients with BA following KPE, provide insights into the native liver condition of BA, and open new avenues for clinical approaches through stool proteome analysis.</div></div><div><h3>Methods</h3><div>In this prospective study, stool proteome analysis was conducted on samples from 4 patients with well-controlled conditions, 4 patients with repeated cholangitis, and 3 patients with prolonged jaundice without cholangitis, all of whom had undergone KPE. Fifteen healthy individuals without BA were included for comparison.</div></div><div><h3>Results</h3><div>Principal component analysis revealed that the stool profiles of patients post-KPE with favorable outcomes closely resembled those of healthy controls, whereas the profiles of patients with unfavorable outcomes showed distinct patterns. Notably, C-reactive protein levels were elevated, whereas sodium/hydrogen exchanger 3 levels were decreased in the group with repeated cholangitis.</div></div><div><h3>Conclusion</h3><div>This study highlights distinct differences in stool protein profiles following KPE, particularly in patients with poor clinical outcomes. This suggests that stool proteome analysis has the potential to provide insights into the native liver conditions of BA patients post-KPE, reflecting their clinical status.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 8","pages":"Article 100688"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 Top Reviewers for GHA","authors":"","doi":"10.1016/S2772-5723(25)00117-7","DOIUrl":"10.1016/S2772-5723(25)00117-7","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 6","pages":"Article 100730"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Need for Targeted Prevention and Screening in Gastrointestinal Cancer Disparities","authors":"Jason C. Lin,&nbsp;John C. Lin,&nbsp;Joy Zhao","doi":"10.1016/j.gastha.2025.100742","DOIUrl":"10.1016/j.gastha.2025.100742","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 10","pages":"Article 100742"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variation in Nucleos(t)ide Analogue Use in Medicare Part D Throughout the United States","authors":"Stephen E. Congly ,&nbsp;Conar O’Neil ,&nbsp;Karen E. Doucette ,&nbsp;Mang M. Ma ,&nbsp;Mayur Brahmania ,&nbsp;Carla S. Coffin","doi":"10.1016/j.gastha.2025.100740","DOIUrl":"10.1016/j.gastha.2025.100740","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 10","pages":"Article 100740"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electronic Measurement of the Anorectal Angle Versus Radiographic Assessment","authors":"Daming Sun ,&nbsp;Kaori Futaba ,&nbsp;Esther Hiu-Yee Hung ,&nbsp;Wing Wa Leung ,&nbsp;Cherry Wong ,&nbsp;Hans Gregersen","doi":"10.1016/j.gastha.2025.100718","DOIUrl":"10.1016/j.gastha.2025.100718","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 9","pages":"Article 100718"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144885989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Label-free, High-resolution Fluorescence Imaging of the Intestinal Wall by Image Scanning and Confocal Microscopy","authors":"Marwa Moulzir ,&nbsp;Doriane Hazart ,&nbsp;Martin Oheim ,&nbsp;Clément Ricard","doi":"10.1016/j.gastha.2025.100735","DOIUrl":"10.1016/j.gastha.2025.100735","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 10","pages":"Article 100735"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonselective Beta-Blocker Associated With Decreased Mortality in Patients With Gastric Varices","authors":"Rebecca H. Moon ,&nbsp;Joanie Chung ,&nbsp;Paul Chang ,&nbsp;Amandeep Sahota","doi":"10.1016/j.gastha.2025.100690","DOIUrl":"10.1016/j.gastha.2025.100690","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Gastric varices (GV) are a less common complication of portal hypertension than esophageal varices but are associated with higher mortality when hemorrhage occurs. While nonselective beta-blockers (NSBBs) have been extensively studied for the primary and secondary prevention of esophageal variceal hemorrhage, data on their efficacy in preventing gastric variceal hemorrhage remain limited. This study investigates the impact of NSBBs on clinical outcomes in patients with GV.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study of patients aged 18–75 years diagnosed with GV between January 1, 2015, and July 31, 2021, within an integrated healthcare system in Southern California. The cohort was followed until February 28, 2022. Outcomes, including gastric variceal hemorrhage, esophageal variceal hemorrhage, liver transplantation, transjugular intrahepatic portosystemic shunt placement, and mortality, were compared between NSBB users and nonusers using multivariate logistic regression analyses.</div></div><div><h3>Results</h3><div>A total of 1276 patients with GV were identified, including 767 (62.5%) on NSBBs and 509 (41.5%) not receiving NSBBs. After a 7-year follow-up, mortality was lower in the NSBB group (39.2%) than in the non-NSBB group (50.9%) (OR = 0.62; 95% CI: 0.46–0.84). No significant differences were observed between groups for other clinical outcomes. The overall mortality rate at study completion was 40.1%.</div></div><div><h3>Conclusion</h3><div>In our study, NSBB use in patients with GV was associated with reduced mortality, suggesting a potential prognostic benefit in real-world clinical settings.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 8","pages":"Article 100690"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}