Gastro hep advances最新文献

{"title":"Glucagon-like Peptide-1 Receptor Agonists and Risk of Pneumonia and Postprocedure Hospitalization Among Patients Undergoing Gastrointestinal Endoscopy","authors":"Chunyuan Qiu ,&nbsp;Qiaoling Chen ,&nbsp;Stephanie Tovar ,&nbsp;Karl Kwok ,&nbsp;Antonio T. Hernandez Conte ,&nbsp;Jammie T. Ferrara ,&nbsp;Vimal Desai ,&nbsp;Jiaxiao M. Shi ,&nbsp;Andrew Q. Giap ,&nbsp;Bechien U. Wu","doi":"10.1016/j.gastha.2025.100869","DOIUrl":"10.1016/j.gastha.2025.100869","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Safety concerns have been raised regarding the glucagon-like peptide-1 receptor agonist (GLP-1RA) use in patients undergoing procedural sedation and anesthesia. The objective of this study is to assess the association between GLP-1RA use and postprocedural risk of pneumonia and all causes of urgent care (UC), emergency department, and hospitalization.</div></div><div><h3>Methods</h3><div>Using a propensity-matched retrospective cohort design, we matched patients with active GLP-1RA at the time of gastrointestinal endoscopic procedure between January 2008 and June 2023 to non–GLP-1RA–exposed controls (1:4) using propensity scores generated by logistic regression. The primary outcome was risk of postprocedural pneumonia and all-cause hospitalization further adjusted for type sedation (conscious sedation vs monitored anesthesia care) as well as study year. We further assessed association between pre-endoscopic GLP-1RA exposure and subsequent UC, emergency department visits, and 30-day mortality.</div></div><div><h3>Results</h3><div>The propensity-matched cohort comprised 63% colonoscopy, 25% esophagogastroduodenoscopy and 12% bidirectional endoscopy among 3825 patients with active GLP-1RA matched to 14,920 controls. There was no significant association between active GLP-1RA use and postprocedure pneumonia (0.13% vs 0.25%, odds ratio 0.56 (95% confidence interval: 0.22, 1.45)) or 30-day postprocedural hospitalization (1.9% vs 2.6%, 0.76 (95% confidence interval: 0.59, 0.98)) compared to nonusers. No significant association was observed for UC, emergency department visits or mortality at 7- or 30-days postprocedure.</div></div><div><h3>Conclusion</h3><div>Uninterrupted use of GLP-1RA was not associated with major adverse events among patients undergoing gastrointestinal endoscopy with sedation.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"5 3","pages":"Article 100869"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal Spatial Transcriptomics Reveals the Developing Human Liver Niche at Single-Cell Resolution","authors":"Michael Bailey ,&nbsp;Michael Leon ,&nbsp;Isabella Rosso ,&nbsp;Carolyn Sangokoya","doi":"10.1016/j.gastha.2026.100893","DOIUrl":"10.1016/j.gastha.2026.100893","url":null,"abstract":"<div><h3>Background and Aims</h3><div>A comprehensive understanding of the liver niche during development provides insights into a unique, naturally occurring multifunctional multicellular environment. We applied spatial transcriptomic and histologic approaches to identify and histologically validate RNA-based markers in human liver tissue during a critical developmental window when the liver serves as the primary site of hematopoiesis, just prior to the rapid growth phase of the third trimester. During this period, the developmental liver niche uniquely supports the coexistence of endodermal- and mesenchymal-derived cell populations that coordinate hematopoietic development and hepatocyte function.</div></div><div><h3>Methods</h3><div>Nine formalin-fixed paraffin-embedded human developmental liver samples underwent histologic processing, staining, and evaluation prior to single-cell resolution spatial molecular imaging. Spatial transcriptomic profiling was followed by single-cell transcriptomic analysis and validation using multiplexed RNA fluorescent single-molecule in situ hybridization.</div></div><div><h3>Results</h3><div>Single-cell spatial imaging identified epithelial, hematopoietic, endothelial, and stromal cell populations within shared microenvironments. This approach enabled molecular capture and histologic confirmation of 2 complex developmental phenomena: gene expression associated with the developing ductal plate and CXC motif chemokine ligand localization to the hepatic hematopoietic stem cell niche.</div></div><div><h3>Conclusion</h3><div>Integration of markers identified through spatial transcriptomics will expand molecular panel design and enable more precise characterization of developmental biliary biology and pathobiology. Importantly, RNA-based understanding of the functional diversity and in situ spatial organization of the developmental liver niche will also be essential for authenticating and re-engineering these complex regenerative environments in vitro.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"5 4","pages":"Article 100893"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scarred From the Inside: A Case of Idiopathic Sclerosing Mesenteritis","authors":"Miguel E. Gomez ,&nbsp;Michael L. Wells","doi":"10.1016/j.gastha.2025.100759","DOIUrl":"10.1016/j.gastha.2025.100759","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"5 1","pages":"Article 100759"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145230039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Care Coordination for Patients Admitted With Alcohol-Associated Liver Disease: An Assessment of Appropriate Follow-up and Treatment at Time of Discharge","authors":"Isabelle S. Byers ,&nbsp;Bharathi Selvan ,&nbsp;Jacqueline B. Henson ,&nbsp;Donna Niedzwiecki ,&nbsp;Andrew J. Muir ,&nbsp;Stephanie Garbarino","doi":"10.1016/j.gastha.2025.100823","DOIUrl":"10.1016/j.gastha.2025.100823","url":null,"abstract":"<div><h3>Background and Aims</h3><div>The prevalence of alcohol-associated liver disease (ALD) is on the rise in the United States, and effective management requires multidisciplinary care and coordination of services across specialties. The aim of this study is to assess whether patients hospitalized with alcohol use disorder (AUD) and ALD have access to appropriate provider follow-up and treatment at time of discharge as well as to identify factors that enable care coordination.</div></div><div><h3>Methods</h3><div>Hospital admissions for adults with ALD and AUD between January 1, 2022, and December 31, 2022, at our institution were identified. Medical records were reviewed to identify clinical characteristics as well as attendance at a hepatology appointment within 90 days of discharge (primary endpoint), referral to substance use services at discharge, and prescription of medication for AUD at discharge (secondary endpoints). Logistic regression modeling with repeated admissions within patient was performed to identify independent associations with each outcome.</div></div><div><h3>Results</h3><div>Among the hospital admissions, 417 met the inclusion criteria. Following 16% of admissions, patients attended a hepatology appointment, 4% of patients were referred to substance use services, and 14% of patients were prescribed medication for AUD. Among modifiable factors, hepatology and social work evaluation during hospitalization were associated with successful care coordination.</div></div><div><h3>Conclusion</h3><div>In our population, rates of specialist follow-up and treatment for AUD and ALD after a hospital admission were overall low. This study not only highlights a significant gap in care delivery for patients with ALD, but it also identifies a critical need to establish quality measures for the inpatient management and long-term follow-up for patients ALD.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"5 2","pages":"Article 100823"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors, Clinical Features and Diagnostic Workup of Sclerosing Mesenteritis: a Single-Center Study of 219 Patients","authors":"Bibek Saha ,&nbsp;Anjali Rajagopal ,&nbsp;June Tome ,&nbsp;Darrell S. Pardi ,&nbsp;Xiao Jing Wang","doi":"10.1016/j.gastha.2025.100826","DOIUrl":"10.1016/j.gastha.2025.100826","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"5 2","pages":"Article 100826"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in Clinical Presentation and Treatment Response of Patients With Eosinophilic Esophagitis Complicated by Esophageal Food Impaction","authors":"Walker D. Redd ,&nbsp;Trevor S. Barlowe ,&nbsp;Sean S. LaFata ,&nbsp;Timothy S. Gee ,&nbsp;Hannah L. Thel ,&nbsp;Brenderia A. Cameron ,&nbsp;Angela Z. Xue ,&nbsp;Akshatha Kiran ,&nbsp;Adolfo A. Ocampo ,&nbsp;Justin McCallen ,&nbsp;Christopher J. Lee ,&nbsp;Stephanie A. Borinsky ,&nbsp;Rayan N. Kaakati ,&nbsp;Cary C. Cotton ,&nbsp;Swathi Eluri ,&nbsp;Craig C. Reed ,&nbsp;Evan S. Dellon","doi":"10.1016/j.gastha.2025.100816","DOIUrl":"10.1016/j.gastha.2025.100816","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"5 1","pages":"Article 100816"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Jejunal Diverticulitis: A Rare Cause of Acute Abdomen","authors":"Osamah Al-obaidi ,&nbsp;Sheila Cheng ,&nbsp;Emily Nash","doi":"10.1016/j.gastha.2025.100849","DOIUrl":"10.1016/j.gastha.2025.100849","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"5 2","pages":"Article 100849"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, Serologic, and Histologic Characteristics in Screen-Detected and Clinically Diagnosed Celiac Disease Patients","authors":"Iida Ahonen ,&nbsp;Laura Kivelä ,&nbsp;Aku Paavola ,&nbsp;Pilvi Laurikka ,&nbsp;Heini Huhtala ,&nbsp;Harri Sievänen ,&nbsp;Katri Kaukinen ,&nbsp;Kalle Kurppa","doi":"10.1016/j.gastha.2026.100973","DOIUrl":"10.1016/j.gastha.2026.100973","url":null,"abstract":"<div><h3>Background and Aims</h3><div>The benefits of celiac disease screening remain debatable. We compared baseline characteristics and treatment outcomes between screen-detected and clinically diagnosed celiac disease adults in a prospective study.</div></div><div><h3>Methods</h3><div>Clinical, serologic, and histologic data and bone mineral density (BMD) were assessed in 214 patients at diagnosis and after 1 year on gluten-free diet (GFD). Validated questionnaires were used to elicit gastrointestinal symptoms (Gastrointestinal Symptoms Rating Scale) and quality of life (Psychological General Well-Being questionnaire).</div></div><div><h3>Results</h3><div>Screen-detected patients (n = 102) were older (median, 54 vs 43 years; <em>P</em> = .005), more often men (50% vs 16%; <em>P</em> &lt; .001), and had higher mean lumbar T-score (−0.8 vs −1.2 standard deviation; <em>P</em> = .011) and hemoglobin levels (140 vs 128 g/dL; <em>P</em> &lt; .001) at diagnosis than clinically diagnosed patients (n = 112). The groups were comparable in transglutaminase 2 (24.5 vs 47.7 U/mL; <em>P</em> = .051) and endomysial (1:200 vs 1:200; <em>P</em> = .385) autoantibody levels and histology assessed by villous height/crypt depth ratio (0.3 vs 0.3; <em>P</em> = .964). Screen-detected patients had fewer gastrointestinal symptoms (Gastrointestinal Symptoms Rating Scale total score 1.9 vs 2.6; <em>P</em> &lt; .001) and better quality of life (Psychological General Well-Being questionnaire total score 107 vs 98; <em>P</em> = .001). After 1 year, both groups showed similar GFD adherence (94% vs 95%; <em>P</em> = .000) and improvements in histology, BMD, and quality of life. Asymptomatic and symptomatic screen-detected patients were comparable in histologic findings at diagnosis, adherence to GFD, and improvements in symptoms and quality of life.</div></div><div><h3>Conclusion</h3><div>Screen-detected celiac disease patients demonstrated less severe symptoms and BMD impairment at diagnosis but advanced histologic and serologic disease similar to those identified on clinical grounds. Adherence to GFD and treatment response were comparable between the groups.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"5 7","pages":"Article 100973"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147946962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative Diagnosis of Idiopathic Myointimal Hyperplasia of Mesenteric Veins in a Post–Liver Transplant Patient","authors":"Ryan F. Hughes ,&nbsp;Danielle Morelli ,&nbsp;Eliza Cricco-Lizza ,&nbsp;Emily Schonfeld ,&nbsp;Arun B. Jesudian ,&nbsp;Jose Jessurun ,&nbsp;Carl V. Crawford","doi":"10.1016/j.gastha.2026.100965","DOIUrl":"10.1016/j.gastha.2026.100965","url":null,"abstract":"<div><div>Idiopathic myointimal hyperplasia of the mesenteric veins is a rare cause of ischemic colitis resulting from luminal obliteration of medium- to large-sized mesenteric veins, which may mimic inflammatory bowel disease and infectious colitis, typically diagnosed following surgical resection. Delays in diagnosis are common and often preceded by extended hospitalizations and failed medical therapies including antibiotics and anti-inflammatories. Here, we present a rare instance of the preoperative diagnosis of idiopathic myointimal hyperplasia of the mesenteric veins in a woman who had previously received a liver transplant.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"5 7","pages":"Article 100965"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147946963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life in Patients With Primary Sclerosing Cholangitis","authors":"Emilie Eifer Møller ,&nbsp;Rasmus Hvidbjerg Gantzel ,&nbsp;Emma Celia Herting ,&nbsp;Anders Mellemkjær ,&nbsp;Lars Bossen ,&nbsp;Matias Hauge Bötcher ,&nbsp;Søren Peter Jørgensen ,&nbsp;Holger Jon Møller ,&nbsp;Henning Grønbæk","doi":"10.1016/j.gastha.2026.100964","DOIUrl":"10.1016/j.gastha.2026.100964","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Primary sclerosing cholangitis (PSC) is an autoimmune chronic cholestatic liver disease causing inflammation, fibrosis, and increased risk of cholangitis, cirrhosis, and hepatobiliary cancers. How PSC affects patient-reported quality of life (QoL) is sparsely studied. We aimed to investigate the impact of PSC on QoL.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 101 patients with PSC. We investigated QoL using the PSC-specific PSC patient-reported outcome (PRO) instrument, the generic health-related QoL questionnaire EQ-5D-5L, and the fatigue visual analog scale (VAS) score. We also investigated associations between QoL and noninvasive inflammation and fibrosis measures; the macrophage marker soluble (s)CD163, fibrosis-4 score, and transient elastography.</div></div><div><h3>Results</h3><div>The median age was 45 years, 65% were males, 10% had PSC with autoimmune hepatitis overlap disease, and 92% had inflammatory bowel disease. Eighty-five patients completed all QoL questionnaires and reported high QoL across all PSC PRO instrument items and EQ-5D-5L. sCD163 correlated modestly with PSC PRO total score (rho = 0.28) and fatigue VAS score (rho = 0.26) but not EQ-5D-5L. Patients with any previous episode of cholangitis reported lower QoL than cholangitis-naive patients on the PSC PRO score (21 vs 15, <em>P</em> = .04) and EQ-5D-5L VAS score (71 vs 86, <em>P</em> = .01). There was no association between noninvasive markers of liver fibrosis and QoL.</div></div><div><h3>Conclusion</h3><div>In this cohort, patients with PSC reported high QoL. The PSC PRO score correlated with sCD163 and was sensitive to cholangitis episodes, validating the instrument as a true PSC-specific QoL tool.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"5 6","pages":"Article 100964"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147952633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}