Extraintestinal symptoms of pain are common in patients with eosinophilic gastrointestinal diseases

Jennifer Dziwis MD MPH , Xiangfeng Dai PhD , Chelsea Anderson PhD MPH , Ellyn Kodroff , Mary Jo Strobel , Amy Zicarelli , Sarah Gray , Amanda Cordell , Girish Hiremath MD MPH , Evan S. Dellon MD MPH , Elizabeth T. Jensen MPH PhD
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Abstract

Background and Aims

Extraintestinal symptoms are well-documented in systemic, inflammation-predominant conditions. Less is understood about extra-gastrointestinal symptoms among individuals with eosinophilic esophagitis (EoE) and non-EoE eosinophilic gastrointestinal diseases (EGIDs). We aimed to describe the differences in the frequency of patient reported joint or leg pain, and headache for EoE and non-EoE EGIDs individuals.

Methods

Adult subjects and caregivers of children were recruited via the EGID Partners network and completed the Short Form-McGill Pain Questionnaire and Migraine Disability Assessment Test. T-tests were used to evaluate differences in extraintestinal pain symptomology by EGID type.

Results

We analyzed 95 subjects with EoE only and 24 subjects with non-EoE only EGIDs. Both EoE and non-EoE EGID subjects described frequent leg pain (50% and and 78%, respectively). While no significant difference was observed in number of days of leg pain, pain severity was higher for non-EoE EGID subjects (p<0.01). Additionally, 78% of EoE only and 89% of non-EoE only EGID subjects reported joint pain, with no significant difference in the number of days of pain, but with higher pain severity for non-EoE EGID subjects (p<0.01). Headache disability scores for non-EoE EGID subjects were more severe compared to subjects with EoE alone (17% of non-EoE EGIDs with severe disability vs 9% for EoE; p=0.01).

Conclusions

Patients with EGIDs may experience extraintestinal symptoms of pain. These symptoms may be more prominent in patients with non-EoE only EGIDs. Understanding of the underlying factors contributing to these symptoms is needed to guide mitigating approaches for these symptoms.
肠外疼痛症状在嗜酸性胃肠道疾病患者中很常见
背景和目的:在全身性、炎症为主的疾病中,肠道症状是有充分证据的。对于嗜酸性粒细胞性食管炎(EoE)和非EoE嗜酸性粒细胞性胃肠道疾病(EGIDs)患者的胃肠道外症状了解较少。我们的目的是描述EoE和非EoE EGIDs患者报告的关节或腿部疼痛以及头痛频率的差异。方法通过EGID合作伙伴网络招募成人受试者和儿童的照顾者,完成短格式mcgill疼痛问卷和偏头痛残疾评估测试。采用t检验评价不同EGID类型肠外疼痛症状的差异。结果我们分析了95例单纯EoE患者和24例非EoE患者的egid。EoE和非EoE EGID受试者都描述了频繁的腿部疼痛(分别为50%和78%)。虽然在腿部疼痛天数上没有观察到显著差异,但非eoe EGID受试者的疼痛严重程度更高(p<0.01)。此外,78%的EoE和89%的非EoE EGID受试者报告关节疼痛,疼痛天数没有显著差异,但非EoE EGID受试者的疼痛严重程度更高(p<0.01)。非EoE型EGID患者的头痛残疾评分比单纯EoE型EGID患者更严重(17%的非EoE型EGID患者患有严重残疾,而EoE型EGID患者为9%;p=0.01)。结论egid患者可出现肠外疼痛症状。这些症状在非eoe型egid患者中可能更为突出。需要了解导致这些症状的潜在因素,以指导减轻这些症状的方法。
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来源期刊
Gastro hep advances
Gastro hep advances Gastroenterology
CiteScore
0.80
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0.00%
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审稿时长
64 days
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