Jennifer Dziwis MD MPH , Xiangfeng Dai PhD , Chelsea Anderson PhD MPH , Ellyn Kodroff , Mary Jo Strobel , Amy Zicarelli , Sarah Gray , Amanda Cordell , Girish Hiremath MD MPH , Evan S. Dellon MD MPH , Elizabeth T. Jensen MPH PhD
{"title":"肠外疼痛症状在嗜酸性胃肠道疾病患者中很常见","authors":"Jennifer Dziwis MD MPH , Xiangfeng Dai PhD , Chelsea Anderson PhD MPH , Ellyn Kodroff , Mary Jo Strobel , Amy Zicarelli , Sarah Gray , Amanda Cordell , Girish Hiremath MD MPH , Evan S. Dellon MD MPH , Elizabeth T. Jensen MPH PhD","doi":"10.1016/j.gastha.2025.100732","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and Aims</h3><div>Extraintestinal symptoms are well-documented in systemic, inflammation-predominant conditions. Less is understood about extra-gastrointestinal symptoms among individuals with eosinophilic esophagitis (EoE) and non-EoE eosinophilic gastrointestinal diseases (EGIDs). We aimed to describe the differences in the frequency of patient reported joint or leg pain, and headache for EoE and non-EoE EGIDs individuals.</div></div><div><h3>Methods</h3><div>Adult subjects and caregivers of children were recruited via the EGID Partners network and completed the Short Form-McGill Pain Questionnaire and Migraine Disability Assessment Test. T-tests were used to evaluate differences in extraintestinal pain symptomology by EGID type.</div></div><div><h3>Results</h3><div>We analyzed 95 subjects with EoE only and 24 subjects with non-EoE only EGIDs. Both EoE and non-EoE EGID subjects described frequent leg pain (50% and and 78%, respectively). While no significant difference was observed in number of days of leg pain, pain severity was higher for non-EoE EGID subjects (p<0.01). Additionally, 78% of EoE only and 89% of non-EoE only EGID subjects reported joint pain, with no significant difference in the number of days of pain, but with higher pain severity for non-EoE EGID subjects (p<0.01). Headache disability scores for non-EoE EGID subjects were more severe compared to subjects with EoE alone (17% of non-EoE EGIDs with severe disability vs 9% for EoE; p=0.01).</div></div><div><h3>Conclusions</h3><div>Patients with EGIDs may experience extraintestinal symptoms of pain. These symptoms may be more prominent in patients with non-EoE only EGIDs. Understanding of the underlying factors contributing to these symptoms is needed to guide mitigating approaches for these symptoms.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 10","pages":"Article 100732"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Extraintestinal symptoms of pain are common in patients with eosinophilic gastrointestinal diseases\",\"authors\":\"Jennifer Dziwis MD MPH , Xiangfeng Dai PhD , Chelsea Anderson PhD MPH , Ellyn Kodroff , Mary Jo Strobel , Amy Zicarelli , Sarah Gray , Amanda Cordell , Girish Hiremath MD MPH , Evan S. Dellon MD MPH , Elizabeth T. Jensen MPH PhD\",\"doi\":\"10.1016/j.gastha.2025.100732\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and Aims</h3><div>Extraintestinal symptoms are well-documented in systemic, inflammation-predominant conditions. Less is understood about extra-gastrointestinal symptoms among individuals with eosinophilic esophagitis (EoE) and non-EoE eosinophilic gastrointestinal diseases (EGIDs). We aimed to describe the differences in the frequency of patient reported joint or leg pain, and headache for EoE and non-EoE EGIDs individuals.</div></div><div><h3>Methods</h3><div>Adult subjects and caregivers of children were recruited via the EGID Partners network and completed the Short Form-McGill Pain Questionnaire and Migraine Disability Assessment Test. T-tests were used to evaluate differences in extraintestinal pain symptomology by EGID type.</div></div><div><h3>Results</h3><div>We analyzed 95 subjects with EoE only and 24 subjects with non-EoE only EGIDs. Both EoE and non-EoE EGID subjects described frequent leg pain (50% and and 78%, respectively). While no significant difference was observed in number of days of leg pain, pain severity was higher for non-EoE EGID subjects (p<0.01). Additionally, 78% of EoE only and 89% of non-EoE only EGID subjects reported joint pain, with no significant difference in the number of days of pain, but with higher pain severity for non-EoE EGID subjects (p<0.01). Headache disability scores for non-EoE EGID subjects were more severe compared to subjects with EoE alone (17% of non-EoE EGIDs with severe disability vs 9% for EoE; p=0.01).</div></div><div><h3>Conclusions</h3><div>Patients with EGIDs may experience extraintestinal symptoms of pain. These symptoms may be more prominent in patients with non-EoE only EGIDs. Understanding of the underlying factors contributing to these symptoms is needed to guide mitigating approaches for these symptoms.</div></div>\",\"PeriodicalId\":73130,\"journal\":{\"name\":\"Gastro hep advances\",\"volume\":\"4 10\",\"pages\":\"Article 100732\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gastro hep advances\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2772572325001190\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gastro hep advances","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772572325001190","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Extraintestinal symptoms of pain are common in patients with eosinophilic gastrointestinal diseases
Background and Aims
Extraintestinal symptoms are well-documented in systemic, inflammation-predominant conditions. Less is understood about extra-gastrointestinal symptoms among individuals with eosinophilic esophagitis (EoE) and non-EoE eosinophilic gastrointestinal diseases (EGIDs). We aimed to describe the differences in the frequency of patient reported joint or leg pain, and headache for EoE and non-EoE EGIDs individuals.
Methods
Adult subjects and caregivers of children were recruited via the EGID Partners network and completed the Short Form-McGill Pain Questionnaire and Migraine Disability Assessment Test. T-tests were used to evaluate differences in extraintestinal pain symptomology by EGID type.
Results
We analyzed 95 subjects with EoE only and 24 subjects with non-EoE only EGIDs. Both EoE and non-EoE EGID subjects described frequent leg pain (50% and and 78%, respectively). While no significant difference was observed in number of days of leg pain, pain severity was higher for non-EoE EGID subjects (p<0.01). Additionally, 78% of EoE only and 89% of non-EoE only EGID subjects reported joint pain, with no significant difference in the number of days of pain, but with higher pain severity for non-EoE EGID subjects (p<0.01). Headache disability scores for non-EoE EGID subjects were more severe compared to subjects with EoE alone (17% of non-EoE EGIDs with severe disability vs 9% for EoE; p=0.01).
Conclusions
Patients with EGIDs may experience extraintestinal symptoms of pain. These symptoms may be more prominent in patients with non-EoE only EGIDs. Understanding of the underlying factors contributing to these symptoms is needed to guide mitigating approaches for these symptoms.