Food frontiers最新文献

{"title":"Flavor compound geraniol induces inhibited nutrient utilization and developmental toxicity on embryonic–larval zebrafish","authors":"Yumin Luo,&nbsp;Run Han,&nbsp;Zhengyu Ren,&nbsp;Nana Ai,&nbsp;Shaowen Yu,&nbsp;Simon Ming-Yuen Lee,&nbsp;Wei Ge,&nbsp;Ying Chen,&nbsp;Ying Zheng","doi":"10.1002/fft2.495","DOIUrl":"https://doi.org/10.1002/fft2.495","url":null,"abstract":"<p>Flavors are widely utilized in the food and oral pharmaceutical industry, particularly in products for children, to enhance palatability and promote ingestion willingness. The complex compositions of flavors potentially induce severer toxicity especially in children. In this study, zebrafish embryos are applied for toxicity screening of flavor and its compounds by immersing in flavor solutions followed by the assessment of morphology of zebrafish larvae. Geraniol is identified as the prominent toxic compound and is considered highly toxic to zebrafish embryo. In further toxicology study, geraniol demonstrates the concentration-dependent developmental toxicity as the obvious reduction of body and eye lengths, as well as the increased prevalence of tail deformities, pericardial edema, and spine deformation. Zebrafish larvae treated with geraniol exhibit reduction in liver area and exocrine pancreas length, increase in yolk sac area, as well as elevation of triglycerides and total cholesterol, which indicate the inhibited nutrient utilization. Transcriptome analysis reveals that under geraniol treatment, 248 differentially expressed genes (DEGs) are downregulated, whereas 23 DEGs are upregulated, and 110 DEGs are related to metabolic process. Biological processes of lipid metabolism, carbohydrate metabolism, protein hydrolysis, and transmembrane transport, including their involved functional genes, are all downregulated. These findings reveal the developmental toxicity of geraniol by affecting the nutrient utilization-related organs development and biological processes. This study establishes an efficient screening model for identifying toxic flavor compounds during developing stages, thereby elucidating the potential safety risks of geraniol exposure in zebrafish and providing a comprehensive understanding of its potential toxicity mechanism.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"374-387"},"PeriodicalIF":7.4,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.495","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143113074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tropical fruit-derived starch: An innovative strategy for high-value nutritional processing of agricultural solid waste","authors":"Tian Lan,&nbsp;Jiaqi Wang,&nbsp;Yongwu Li,&nbsp;Yaguo Wang,&nbsp;Xiangyu Sun,&nbsp;Yulin Fang,&nbsp;Tingting Ma","doi":"10.1002/fft2.501","DOIUrl":"https://doi.org/10.1002/fft2.501","url":null,"abstract":"<p>Tropical fruits are popular worldwide due to their appealing flavors and diverse health benefits. However, a significant amount of waste is caused by inferior fruits that are partly eliminated from the fresh fruit market and by-products produced during transportation, storage, and processing. With increasing focus on environmental sustainability and resource conservation, recycling waste resources from tropical fruits has emerged as a hot topic of interest. Fruit-derived starch is an emerging approach to adding value for some tropical fruit waste and inferior fruits. This review article briefly overviews extraction methods, chemical composition, structural characteristics, physical and chemical properties, physiological benefits, modification techniques, and potential applications of new tropical fruit-derived starch. Compared with traditional starch, tropical fruit-derived starch exhibits unique structural and processing attributes, making it suitable as a supplement or replacement for industrial starch in the food industry. Moreover, tropical fruit-derived starch retains the rich nutrients and functional components present in fruits to some extent, thereby offering potential health benefits and greater consumer acceptance. Although current research on starch derived from tropical fruits is primarily at the laboratory stage, and there is limited exploration of its processing and application, evolving lifestyle trends and heightened health awareness are expected to foster its further development and utilization, paving the way for large-scale commercialization and driving future market growth.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"142-162"},"PeriodicalIF":7.4,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.501","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143113619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How do various encapsulation techniques improve the oral delivery of food protein hydrolysates?","authors":"Seid Reza Falsafi,&nbsp;Sneh Puniabangar,&nbsp;Monica Trif,&nbsp;Katarzyna Samborska,&nbsp;Alicja Barańska,&nbsp;Basheer Aaliya,&nbsp;Kappat Valiyapeediyekkal Sunooj,&nbsp;Merve Tomas,&nbsp;Esra Capanoglu,&nbsp;Hadis Rostamabadi","doi":"10.1002/fft2.492","DOIUrl":"https://doi.org/10.1002/fft2.492","url":null,"abstract":"<p>The development of bioformulations based on food protein hydrolysates (FPHs) has gained significant traction in the food and pharmaceutical sectors due to their biophysical and biochemical properties, including health-promoting effects, biocompatibility, and biodegradability. However, the oral delivery of FPHs presents notable technical challenges, largely due to their inherent limitations such as (bio)stability, permeability, bioavailability, and molecular size. This review provides a comprehensive overview of FPHs, including their structural characteristics, origins, methods of preparation, and associated health benefits. Additionally, it highlights the challenges related to their oral delivery. Recent advancements in the formulation and delivery of FPHs through biopolymeric controlled release systems—such as micro- and nanoparticles, hydrogels, biofunctional films and composites, and electrospun fibers—are discussed. We also explore lipid-based delivery platforms, including liposomes, chitosomes, emulsions, Pickering emulsions, nanostructured lipid carriers, solid lipid nanoparticles, and surfactant-based carriers. Furthermore, this article emphasizes the importance of controlled delivery and targeted release of FPHs following oral administration. The challenges in designing effective lipid/biopolymer-based carriers for FPHs, along with future prospects and opportunities in this growing field, are also thoroughly examined.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"40-64"},"PeriodicalIF":7.4,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.492","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143113231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real meat shows good performance in maintaining colonic barrier function at a recommended amount of intake in mice","authors":"Yunting Xie,&nbsp;Linlin Cai,&nbsp;Isaiah Henry Ibeogu,&nbsp;Guanghong Zhou,&nbsp;Chunbao Li","doi":"10.1002/fft2.497","DOIUrl":"https://doi.org/10.1002/fft2.497","url":null,"abstract":"<p>This study aimed to investigate the effects and underlying mechanisms of real meat and plant-based meat analogs on intestinal barrier function. Methods including PacBio sequencing, HPLC, histological observation, western blotting, and RT-qPCR were jointly applied. The results indicated that the 20-day intake of real meat and plant-based meat analogs did not induce pathological changes in the colon of mice. However, when the feeding period was extended to 68 days, inflammatory infiltration was observed in the colon tissue of mice fed plant-based meat analogs. In contrast, the intake of real meat for 68 days performed better in maintaining colonic barrier function by reducing cell apoptosis, increasing the number of goblet cells and mucin secretion, and upregulating the expression of tight junction proteins. High-throughput sequencing revealed that the intake of real meat significantly altered the composition of the gut microbiota, reducing pro-inflammatory bacteria (such as <i>Bacteroides</i>, <i>Desulfovibrio</i>, or <i>Colidextribacter</i>) or pathogenic bacteria (such as <i>Mucispirillum</i> and <i>Helicobacter</i>) while increasing beneficial bacteria (such as <i>Lactobacillus</i>, <i>Bifidobacterium</i>, or <i>Roseburia</i>). Additionally, the consumption of real meat markedly decreased protein fermentation in the colon, leading to lower levels of cadaverine, putrescine, and spermine. These changes associated with real meat consumption reduced the activation of the pro-inflammatory pathway (lipopolysaccharide/Toll-like receptor 4/nuclear factor kappa B), ultimately maintaining colonic homeostasis in mice. Collectively, the findings suggest that the proper intake of real meat is more beneficial for colon health in mice compared to plant-based meat analogs.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"300-315"},"PeriodicalIF":7.4,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.497","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143113230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Folic acid ameliorates high glucose–induced neurotoxicity in human forebrain organoids: Insights from proteomics","authors":"Haoni Yan,&nbsp;Shujin Chen,&nbsp;Aynur Abdulla,&nbsp;Zhile Li,&nbsp;Tsz Yui Zhuang,&nbsp;Manlin Zhang,&nbsp;Leqi Wu,&nbsp;Yizhi Zhang,&nbsp;Xianting Ding,&nbsp;Lai Jiang","doi":"10.1002/fft2.470","DOIUrl":"https://doi.org/10.1002/fft2.470","url":null,"abstract":"<p>Pregestational diabetes (PGDM) has been associated with an elevated risk of congenital abnormalities, particularly those affecting the nervous system. The efficacy of folic acid (FA) supplementation in reducing the incidence of neurodevelopmental damage caused by PGDM has been well documented. However, the exact mechanism is unclear. Here, a human forebrain organoid model, which replicates the three-dimensional structure of the early fetal neural tissue, was employed to study the neuroprotective effects of FA in PGDM. In this study, the forebrain organoids were cultured at high glucose (HG) concentrations from Days 20 to 40 with or without FA. Immunostaining revealed that the supplementation of FA significantly decreased HG-induced neuron apoptosis. The proteomics examination suggested HG caused an increase in glial fibrillary acidic protein expression, a marker of astrocytes, leading to the upregulation of metallothionein expression and perturbation of mineral absorption, whereas FA reversed this effect. Proteomics analysis further showed that FA reduced HG-induced cell migration. Moreover, Western blot analysis verified that FA mitigated HG-induced apoptosis and cell migration via AMPK/FOXO pathway. Overall, current findings indicate that FA, as a functional food ingredient, has a protective effect on HG-induced abnormal fetal neurodevelopment.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"388-401"},"PeriodicalIF":7.4,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.470","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143113256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acrylamide induces spatiotemporal metabolic profiling disturbance via targeting taurine and hypotaurine metabolism during early zebrafish development","authors":"Anli Wang,&nbsp;Jia Zeng,&nbsp;Xiaoran Song,&nbsp;Yingyu Huang,&nbsp;Jianxin Yao,&nbsp;Li Zhu,&nbsp;Yuchen Gao,&nbsp;Binjie Wang,&nbsp;Yuanzhao Wu,&nbsp;Zhongshi Xu,&nbsp;Ruonan Zheng,&nbsp;Yazhou Qin,&nbsp;Jiye Wang,&nbsp;Weixuan Yao,&nbsp;Xuzhi Wan,&nbsp;Haoyu Li,&nbsp;Pan Zhuang,&nbsp;Jingjing Jiao,&nbsp;Shulin Zhuang,&nbsp;Yu Zhang","doi":"10.1002/fft2.504","DOIUrl":"https://doi.org/10.1002/fft2.504","url":null,"abstract":"<p>Acrylamide, an endocrine-disrupting emerging contaminant from both the environment and food processing, has been linked to cardiac developmental toxicity in zebrafish. However, the mechanisms involved in the cardiac developmental toxicity from long-term exposure to acrylamide remain unclear. This study provides in-depth evidence on the metabolic regulation of zebrafish embryos with acrylamide exposure. A comprehensive metabolites analysis of four different acrylamide exposures (0, 0.5, 1.0, and 2.0 mM) at different zebrafish developmental stages (6, 24, 48, 72, 96, and 120 h post fertilization, hpf) was performed. Metabolite changes throughout the zebrafish development (6–120 hpf) were closely associated with taurine and hypotaurine metabolism. The pattern of significantly changed metabolites revealed that acrylamide strongly disrupts taurine and hypotaurine metabolism related to a deficient cardiovascular system. Moreover, acrylamide exposure disrupted the de novo synthesis of taurine via cysteine sulfinic acid decarboxylase during early zebrafish embryogenesis. In addition, taurine supplementation (10 mM) effectively alleviates acrylamide-induced deficient cardiovascular system. Our results demonstrate that acrylamide exposure has a detrimental effect on early heart development in zebrafish due to the inhibition of de novo synthesis of taurine.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"282-299"},"PeriodicalIF":7.4,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.504","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143113255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resistant starch, chronic kidney disease, and the gut microbiome: A mini-review","authors":"Jiayue Guo,&nbsp;Amy Szacilo,&nbsp;Lingyan Kong","doi":"10.1002/fft2.474","DOIUrl":"https://doi.org/10.1002/fft2.474","url":null,"abstract":"<p>The kidneys play a vital role in maintaining various homeostatic functions, yet the prevalence of chronic kidney disease (CKD) has been increasing globally. The review discusses how resistant starch supplementation in CKD patients can shift the gut microbiota composition, promoting short-chain fatty acid-producing bacteria, especially butyrate producers, and reducing mucin-degrading bacteria. This shift is posited to reduce inflammation and oxidative stress, thereby potentially alleviating CKD progression. It also highlights the complexity of establishing clear causal pathways due to the current limitations in testing techniques for gut microbiota, which often lack the resolution needed to establish clear causal mechanisms. Therefore, this review stresses the need for future research to address these gaps, refine testing methods, clarify the health implications of microbiota shifts, and consider individual metabolic differences and variations in gut microbiota.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"5-14"},"PeriodicalIF":7.4,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.474","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced gelation of sturgeon frozen surimi via egg white: Exploring the role of endogenous serine protease inhibition","authors":"Lu Tong,&nbsp;Ning Ding,&nbsp;Meng Zhou,&nbsp;Yan Zhang,&nbsp;Hui Hong,&nbsp;Yongkang Luo,&nbsp;Yuqing Tan","doi":"10.1002/fft2.463","DOIUrl":"https://doi.org/10.1002/fft2.463","url":null,"abstract":"<p>The degradation of frozen sturgeon surimi can be attributed to the endogenous serine protease. This study was first to examine the impact of egg whites on the frozen sturgeon surimi's gel properties from the perspective of inhibiting endogenous serine protease. The protease activity of egg whites group (CA + EW group, consisting of 4% egg whites and cryoprotectants) was 45.15% lower than that of cryoprotectants group (CA group, consisting of 3% sucrose, 3% sorbitol, and 0.3% sodium tripolyphosphate) at 12 weeks. From the results of inhibition kinetics, serine protease was inhibited by both anticompetitive and noncompetitive inhibition modes. Molecular docking analysis indicated that egg white achieves this inhibitory effect through ionic interactions and hydrogen bonding with serine protease. However, this inhibitory effect was absent when the freezing period was extended to 24 weeks. Compared with CA group, the CA + EW group exhibited 54.76% and 4.59% increase in gel strength and water-holding capacity, and 32.42% reduction in cooking loss after 24 weeks of freezing. Egg whites also impeded water migration and enhanced the density and smoothness of the gel microstructure, reducing protein aggregation. These results indicated that egg whites serve a dual function: inhibiting serine protease and filling the gel network within 12 weeks, mitigating protein aggregation and ice crystal formation over 24 weeks. This study elucidated the mechanism underlying the impact of egg white on endogenous serine protease in sturgeon surimi during long-term freezing, laying a theoretical foundation for the industrialization of sturgeon surimi.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"360-373"},"PeriodicalIF":7.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.463","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoglycemic and hypolipidemic bioactive compounds from edible traditional Chinese medicines and their action of mechanisms explored by multitarget affinity ultrafiltration with liquid chromatography–mass spectrometry","authors":"Xiaowen Hua,&nbsp;Mengjia Xu,&nbsp;Ming Yang,&nbsp;Yingying Zhang,&nbsp;Jianke Ma,&nbsp;Li Cheng,&nbsp;Chu Chu,&nbsp;Zimiao Wu,&nbsp;Mingquan Guo","doi":"10.1002/fft2.488","DOIUrl":"https://doi.org/10.1002/fft2.488","url":null,"abstract":"<p>Edible traditional Chinese medicines (TCMs) have a long-standing history in tackling obesity, diabetes, and metabolic diseases, which, in turn, significantly promotes the exploration of functional food products derived from edible TCMs with lower toxicity and reduced side effects. However, most of bioactive components from TCMs and their mechanisms in regulating blood glucose and lipids remain elusive, which poses a challenge for the development of safer and more effective TCM products. In this context, the development of high-throughput screening methods has become even more important for the identification of active components and the in-depth evaluation of hypoglycemic and hypolipidemic activity in vitro and in vivo. Therefore, this work provides an overview of edible TCMs for managing glucose and lipid metabolism disorders and summarizes the most recent progresses in identifying hypoglycemic and hypolipidemic bioactive compounds in edible TCMs through various screening methods. One significant approach involves the utilization of multitarget-based ultrafiltration liquid chromatography coupled with mass spectrometry. This technique enables the concurrent screening and identification of potential pharmacodynamically active components in TCMs, as well as the investigation of their mechanisms of action. The bioactive compounds identified may serve as crucial active agents in reducing blood glucose and lipids, exhibiting promising potential for incorporation into functional foods or natural health products.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"65-85"},"PeriodicalIF":7.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.488","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From small-scale studies to an encompassing view: Inhibiting inflammation and clinically relevant enzymes with various extracts of Primula vulgaris using in vitro and in silico techniques","authors":"Inci Kurt-Celep,&nbsp; Nilofar,&nbsp;Mehmet Veysi Cetiz,&nbsp;Dimitrina Zheleva-Dimitrova,&nbsp;Reneta Gevrenova,&nbsp;Engin Celep,&nbsp;Kouadio Ibrahime Sinan,&nbsp;Evren Yildiztugay,&nbsp;Claudio Ferrante,&nbsp;Gokhan Zengin","doi":"10.1002/fft2.473","DOIUrl":"https://doi.org/10.1002/fft2.473","url":null,"abstract":"<p>The genus <i>Primula</i> holds great importance as a source of traditional remedies in various folk medicine systems. In the present study, we investigated the chemical composition and biological properties of different extracts (ethyl acetate, ethanol, ethanol/water, and water) of aerial parts and rhizomes of <i>Primula vulgaris</i>. To determine the chemical profile, the extracts were analyzed using ultrahigh performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) technique and flavonoids were a major group in this profile. The antioxidant capacity was demonstrated by in vitro chemical tests and in general the ethanol/water extract was found to be the most potent. Enzyme inhibition was studied against various enzymes and ethanol and ethanol/water extracts were more active than others. To assess the anti-inflammatory potential of the extracts at the molecular level, human dermal fibroblasts (HDF) were treated with lipopolysaccharide (LPS). In vitro experiments showed that the levels of nuclear factor kappa B (NFKB), receptor for advanced glycation endproducts (RAGE), activator protein-1 (AP-1), interleukin 6 (IL-6), interleukin 17 (IL-17) and tumor necrosis factor (TNF)-alpha were significantly reduced after treatment with the tested extracts. In addition, the extracts showed an inhibitory effect on the enzymes collagenase, elastase, and hyaluronidase, which are involved in the inflammatory process and destabilization of the extracellular matrix (ECM). <i>P. vulgaris</i> has been observed to modulate matrix metalloproteinase (MMP) synthesis by decreasing the concentration of cellular reactive oxygen species (ROS) during LPS-induced inflammation. This study also examined the molecular binding and dynamic behavior of various enzymes and proteins associated with skin and infections using ligands derived from the tested extracts. Simulations with AutoDock Vina V1.1.2 and GROMACS 2023.1 showed that isoquercetin in particular showed superior performance in interactions with hyaluronidase. These findings are important for the development of potential therapeutic strategies for skin health and infection control. In summary, <i>P. vulgaris</i> can be considered as an important source of natural bioactive compounds for the development of effective health-promoting applications in nutraceuticals, pharmaceuticals, and cosmetics</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"329-359"},"PeriodicalIF":7.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.473","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}