European burn journal最新文献

{"title":"Sensory Denervation Delays Burn Wound Healing in Experimental Second- and Third-Degree Burns: A Histopathological Rat Study.","authors":"Ugur Horoz, Hülda Rifat Ozakpinar, Emre Inozu, Ergin Seven, Avni Tolga Eryilmaz, Haldun Umudum, Umut Dogu Akturk, Ali Teoman Tellioglu","doi":"10.3390/ebj7030039","DOIUrl":"10.3390/ebj7030039","url":null,"abstract":"<p><p><b>Background</b>: Burn wound healing is a complex biological process requiring coordinated interactions among inflammatory cells, keratinocytes, fibroblasts, endothelial cells, extracellular matrix components, and neural structures. Increasing evidence suggests that sensory nerves actively regulate tissue repair through modulation of inflammation, angiogenesis, epithelial regeneration, and tissue remodeling. However, the role of sensory innervation in burn wound healing remains incompletely understood. The aim of this study was to investigate the effects of sensory denervation on healing of experimental second- and third-degree burns in rats. <b>Methods</b>: Thirty-two adult male Wistar albino rats were randomly allocated into four groups: denervated second-degree burns (Group 1), denervated third-degree burns (Group 2), innervated second-degree burns (Group 3), and innervated third-degree burns (Group 4). Bilateral T5-T7 sensory denervation was performed microsurgically in denervated groups. Standardized contact burns were subsequently created. Histopathological assessment of inflammation, neovascularization, epithelialization, fibroblast proliferation, and collagen deposition was performed on postoperative days 3, 7, 14, and 21. <b>Results</b>: Sensory denervation adversely affected multiple parameters of burn wound healing. Delayed epithelialization, impaired fibroblast proliferation, and reduced collagen deposition were most pronounced in denervated third-degree burns. Significant differences were identified between denervated and innervated wounds, particularly during proliferative and remodeling phases of healing. <b>Conclusions</b>: Sensory denervation significantly delays burn wound healing, particularly following third-degree thermal injury. Intact sensory innervation appears essential for successful epithelial regeneration, fibroblast activation, and extracellular matrix remodeling.</p>","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"7 3","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Cohort Study Evaluating Time to Graft Between Intact Fish Skin Grafts and a Synthetic Matrix Used in Complex Full-Thickness Acute Traumatic and Burn Wounds.","authors":"David M Hill, Muntazim Mukit, Kais Atmeh, Karapet Davtyan, Dani Kruchevsky, Xiangxia Liu, Mahmoud Hassouba","doi":"10.3390/ebj7030038","DOIUrl":"10.3390/ebj7030038","url":null,"abstract":"<p><p><b>Introduction</b>: While global burden is underappreciated, traumatic wounds account for 23 million annual emergency department visits in the United States, accounting for trillions in medical costs and work and quality of life loss. We hypothesized that the use of intact fish skin grafts (IFSGs) would result in faster time to obtain a graftable wound bed compared to a synthetic matrix (SM). <b>Methods</b>: This retrospective analysis of patients with full-thickness acute traumatic wound was conducted on a matched sample of patients receiving IFSG versus SM. We hypothesized that there would be at least a 10-day difference between the two treatments. Two surgeons reviewed electronic charts for primary outcomes. Incomplete charts were excluded. For sensitivity analysis, both simple linear regression and generalized linear mixed models were utilized to adjust the primary outcome to potential confounders. <b>Results</b>: Data were reviewed for 80 patients. The final cohort included 38 patients [IFSG (<i>n</i> = 12) and SM (<i>n</i> = 26)]. Demographics were not different between groups. The mean age was 42.4 ± 20.7 years, with 62.2% being male and equal proportions having burns treated vs. another traumatic wound. The most common site was the lower extremity. All IFSG patients had negative pressure wound therapy (NPWT) placed at the time of implantation vs. 50% of SM (<i>p</i> = 0.001). The SM group had a larger TBSA (<i>p</i> < 0.001) and wound size (<i>p</i> = 0.001). Differences were subsequently used to adjust primary outcomes via regression. Patients with IFSG had faster time to a graftable wound bed compared to SM (mean ± SD: 13.9 ± 5.3 vs. 29.1 ± 10.3, <i>p</i> < 0.001). Neither wound size, burn severity, presence of infection, nor use of NPWT significantly altered the inference. <b>Conclusions</b>: In this paired sample, the use of IFSG as a dermal template for full-thickness traumatic injuries was associated with faster time to obtain a graftable wound bed compared to an SM. However, regression analysis alone is not enough to conclude that the same difference would exist in a prospectively controlled experiment, which should be performed.</p>","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"7 3","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IgM- and IgA-Enriched Intravenous Immunoglobulin Combined with Cryopreserved Human Amniotic Membrane for Pediatric Toxic Epidermal Necrolysis: A Case Report.","authors":"Alfio Luca Costa, Alessandro Bastin, Alessandro Jad Patelli, Aurora Carnio, Vincenzo Vindigni, Franco Bassetto","doi":"10.3390/ebj7030037","DOIUrl":"10.3390/ebj7030037","url":null,"abstract":"<p><p><b>Introduction:</b> Toxic epidermal necrolysis in children is a life-threatening emergency requiring prompt withdrawal of the culprit drug, transfer to an experienced center, and intensive supportive care. <b>Case Report:</b> An 11-year-old girl developed toxic epidermal necrolysis involving 90 percent of total body surface area after exposure to a nonsteroidal anti-inflammatory drug, with concomitant viral positivity. At the referring pediatric hospital, on day 2 the patient received high-dose intravenous immunoglobulin 2 g/kg and a single infusion of infliximab 5 mg/kg. She was transferred on day 6 to our Burn Unit. Histopathology confirmed complete epidermal loss. Treatment included IgM- and IgA-enriched intravenous immunoglobulin over 72 h and methylprednisolone 0.74 mg/kg/day for 30 days. Cryopreserved amniotic membrane was applied to trunk and limbs, and fluorescent light energy to the face. Complete re-epithelialization occurred within 14 days without complications. Pain resolved rapidly, with a Visual Analog Scale score of 0 on day 2. At 6 months, skin and mucosae were intact with only transient dyschromia. <b>Conclusions:</b> In this child with extensive toxic epidermal necrolysis and high predicted mortality, IgM/IgA-enriched immunoglobulin, low-dose corticosteroid and early staged cryopreserved amnion were associated with infection-free, complete re-epithelialization and full functional recovery.</p>","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"7 3","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lightning Strike-Induced Cutaneous Burns and Airway Injury: A Case Report Highlighting Recurrent Extubation Failure in a Critically Ill Patient.","authors":"Robert Canelli, Dhanesh D Binda, Maxwell B Baker, Christa M Lam, Ala Nozari","doi":"10.3390/ebj7030036","DOIUrl":"10.3390/ebj7030036","url":null,"abstract":"<p><strong>Introduction: </strong>Lightning strikes cause a unique spectrum of cutaneous burn injuries that differ substantially from conventional thermal or high-voltage electrical burns. Despite the well-documented systemic lethality of lightning injuries, the burn-specific sequelae-including airway involvement and its contribution to ventilatory failure-remain underreported in the burn literature.</p><p><strong>Case report: </strong>We present a 31-year-old woman who sustained multiple cutaneous burns following a lightning strike, including a circumferential necklace-pattern burn to the neck, a large midline torso burn, and burns to the right lower extremity and foot. Following resuscitation from ventricular fibrillation cardiac arrest, she required mechanical ventilation and experienced three sequential extubation failures before ultimately requiring tracheostomy. We propose that direct supraglottic and glottic injury, together with airway mucosal edema from localized thermal and electrical injury of the neck, compounded further by systemic inflammatory and infectious complications, contributed to her inability to sustain independent ventilation.</p><p><strong>Conclusions: </strong>In lightning strike victims with burns involving the neck or thorax, direct upper airway injury should be actively considered, excluded when possible, and closely monitored as a potential cause of extubation failure. A low threshold for early bronchoscopic airway assessment and conservative extubation protocols is warranted.</p>","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"7 3","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in Antimicrobial Treatment and Antimicrobial Stewardship in Hospital-Acquired Infections in Adult Burn Patients.","authors":"Gianpiero Tebano, Caterina Convertino, Luigi Raumer, Rossella Sgarzani, Davide Melandri, Francesco Cristini","doi":"10.3390/ebj7020035","DOIUrl":"10.3390/ebj7020035","url":null,"abstract":"<p><p><b>Background</b>: Hospital-acquired infections (HAIs) represent the most significant complications in patients hospitalized for severe burn injuries, after the immediate post-burn resuscitation phase, and are associated with substantial morbidity and mortality. <b>Methods</b>: This is a narrative review. Evidence was extracted mainly with an in-depth search of MEDLINE, focusing on guidelines, randomized controlled trials, and relevant observational studies published in the last 25 years. The reference lists of the most relevant publications were screened to retrieve additional relevant information. <b>Results</b>: Wound infections, bloodstream infections, pneumonia, and urinary tract infections account for the majority of infectious complications. Their diagnosis can be challenging, particularly in the context of wound infections and sepsis. Burn severity and the resulting disruption of tissue and organ homeostasis can alter the pharmacokinetic and pharmacodynamic (PK/PD) properties of antibiotics, rendering standard dosing and administration strategies inadequate. Higher doses, prolonged or continuous infusions, and therapeutic drug monitoring may be required to optimize antibiotic exposure. The emergence of multidrug-resistant (MDR) pathogens (particularly MDR Gram-negative bacilli) has been widely reported across diverse epidemiological settings and occurs frequently in patients with prolonged hospitalization, further complicating treatment. As a result, the use of broad-spectrum antibiotics is substantial, both for empirical therapy and for targeted treatment. Although antimicrobial stewardship programs can promote more appropriate antibiotic use, evidence on how to effectively implement these strategies in Burn Intensive Care Units remains limited. <b>Conclusions</b>: HAIs in burn patients represent a highly complex clinical scenario. Clinical severity is often significant, diagnosis can be challenging, and MDR pathogens are very prevalent, with high consumption of broad-spectrum antibiotics. Moreover, PK/PD properties of antibiotics can be altered. Antimicrobial stewardship can promote appropriate antimicrobial use, but implementation in this setting has not been adequately studied. Close multidisciplinary collaboration between burn specialists and infectious diseases physicians is essential to ensure effective patient management.</p>","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"7 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13297938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148320990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated Classification of Second- and Third-Degree Burn Images Using Convolutional Neural Networks.","authors":"Yamile Montecinos-Rodríguez, Francisco J Torres-Santana, Noureddine Lakouari, Lorena Díaz-González","doi":"10.3390/ebj7020033","DOIUrl":"10.3390/ebj7020033","url":null,"abstract":"<p><strong>Background: </strong>Burn severity assessment is clinically relevant and often requires timely decision-making. Visual classification of second- and third-degree burns remains subjective and prone to observer variability.</p><p><strong>Methods: </strong>This study aimed to develop and evaluate a deep learning model for the automatic classification of second- and third-degree burn images. A dataset of clinical burn images from a private wound care clinic was used to train a convolutional neural network. Hyperparameter optimization and color channel sensitivity analysis were performed to identify the optimal model configuration. Model performance was evaluated using standard classification metrics on training, validation, and independent test datasets, and results were compared with transfer learning approaches.</p><p><strong>Results: </strong>The best performance was achieved using a compact model trained exclusively with the green color channel, obtaining an accuracy of 0.94, precision of 0.96, recall of 0.92, and an F1-score of 0.94 on the independent test set. This model outperformed more complex transfer learning approaches while reducing computational complexity.</p><p><strong>Conclusions: </strong>These findings indicate that using only the green color channel enables efficient and accurate burn classification. The proposed model was also integrated into a graphical user interface, supporting its potential application in clinical and educational environments.</p>","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"7 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13297944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148320957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Single-Centre Review of Outcomes of Delayed Admission to a Burns Unit.","authors":"Quentin Isaacs, Chrysis Sofianos, Adelin Muganza, Brian Brummer","doi":"10.3390/ebj7020032","DOIUrl":"10.3390/ebj7020032","url":null,"abstract":"<p><p><b>Background:</b> Timely admission to a specialised burn unit is considered crucial for optimising outcomes in burn patients. However, the impact of delayed admission on hospital length of stay and clinical outcomes remains unclear, particularly in resource-constrained settings such as South Africa. This retrospective study aimed to determine whether admission to a burn unit more than 24 h after injury was associated with increased length of stay, sepsis, or mortality. <b>Methods:</b> A retrospective case-audit study was conducted at the Chris Hani Baragwanath Academic Hospital Adult Burn Unit, Johannesburg, from January 2018 to December 2022. Patients were categorised into early (≤24 h) and delayed (>24 h) admission groups. The primary outcome was length of stay; secondary outcomes included sepsis incidence and in-hospital mortality. <b>Results:</b> A total of 123 files were analysed; 71 (58%) were admitted within 24 h. The median length of stay was 14 days, with no statistical difference between the two groups (<i>p</i> = 0.7). The overall mortality rate was 13%, with 68% occurring in the early admission group. Sepsis occurred in 27% of patients. Multivariate analysis revealed that early admission was independently associated with longer length of stay. <b>Conclusions:</b> In this single-centre retrospective case note audit with a limited sample size and significant risk of selection bias, delayed admission to a burn unit was not associated with increased length of stay, mortality, or sepsis. However, these findings should be considered preliminary and require confirmation in larger, prospective studies. The higher rate of surgical intervention in the delayed admission group warrants further investigation.</p>","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"7 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13297935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148320948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the Evidence-Practice Gap in Early Burn Injury Care: A Comprehensive Evidence Synthesis of Global Guidelines, Consensus, and Systematic Reviews for Resource-Limited Settings.","authors":"Hongyu Tang, Shenjing Yu, Rui Zhang, Zheng Zhu, Li Gui","doi":"10.3390/ebj7020034","DOIUrl":"10.3390/ebj7020034","url":null,"abstract":"<p><strong>Background: </strong>Early management of adult burn injuries in resource-constrained environments-such as battlefields and primary care facilities-remains hindered by the absence of standardized, evidence-based protocols. This study aimed to systematically synthesize existing evidence and develop an integrated framework of actionable recommendations to optimize prehospital and early emergency care.</p><p><strong>Methods: </strong>A comprehensive evidence synthesis was conducted across 14 international and domestic bibliographic databases and authoritative repositories. Eligible sources included clinical practice guidelines, expert consensus statements, evidence summaries, and systematic reviews. Literature quality was appraised using validated instruments, and best-practice recommendations were extracted and thematically synthesized across the continuum of early burn care.</p><p><strong>Results: </strong>Fifty-nine high-quality studies yielded 77 recommendations across 13 domains, spanning from scene safety and burn process cessation through airway, breathing, and circulatory management to wound care, infection control, and transfer preparation. An integrated, context-adaptive framework was established to guide resource-calibrated interventions rather than rigid protocol adherence.</p><p><strong>Conclusions: </strong>These findings provide tiered guidance for frontline healthcare providers and inform the development of emergency care standards in resource-limited settings. Future research should prioritize field validation and contextual implementation to address barriers to evidence translation and enhance real-world applicability.</p>","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"7 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13298258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simulation Enhances Resident Preparedness Using Skin Cell Suspension Autograft.","authors":"Joshua P Kronenfeld, Louis R Pizano, Ray I Gonzalez, Joyce I Kaufman, Shevonne Satahoo, Carl I Schulman","doi":"10.3390/ebj7020031","DOIUrl":"10.3390/ebj7020031","url":null,"abstract":"<p><strong>Objective: </strong>Surgical simulation has been shown to improve efficiency, performance, and time to mastery for complicated procedures, but simulation training is not always considered when introducing new devices or products. As part of a performance improvement project, we sought to design and evaluate simulation training for the skin cell suspension autograft (SCSA) with surgery residents during their Burn rotation.</p><p><strong>Methods: </strong>Residents were asked to read instructional materials and watch training videos before coming into the simulation lab for the training session supervised by a Burn surgeon. A qualitative survey was designed and administered after completion of the rotation.</p><p><strong>Results: </strong>Twelve residents have completed the training thus far. Their feedback from the training session was rated on a five-point Likert scale and indicated that the simulation activity was an appropriate length (4.6/5.0), was thorough (4.8/5.0), and led to more confidence (4.4/5.0) and less apprehension (4.4/5.0) when performing the procedure on live patients. This was followed by their use of the product in the operating room with complete success.</p><p><strong>Conclusions: </strong>The novel SCSA training shows great promise for improving the confidence and performance of surgical residents. This could allow for a shorter time for residents to become independent in its use, thereby allowing for increased operative efficiency with the opportunity to significantly improve trainee expertise.</p>","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"7 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13214940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148037847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 4th Educational Course of the European Burns Association (EBA).","authors":"Nadia Depetris, Alette E E de Jong, Clemens Schiestl, Fredrik Huss, Gregoire Bondu, Jill Meirte, Jyrki Vuola, Luís Cabral, Moustafa Elmasry, Raluca Tatar Bulea, Robert Zajíček, Stian Almeland, Yvonne Wilson","doi":"10.3390/ebj7020030","DOIUrl":"10.3390/ebj7020030","url":null,"abstract":"<p><p>Abstracts of the plenary sessions, workshops, and poster presentations of the 4th EBA Educational Course in Bucharest, Romania, 15-16 May 2026.</p>","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"7 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13214679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148037987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}