Dale W Edgar, Colleen M Ryan, Marianne K Nieuwenhuis, Ulrike Van Daele, Jill M Cancio
{"title":"Comment from the Enhancing Burn Rehabilitation Special Edition Editors on \"Fractional CO<sub>2</sub> Laser for Pediatric Hypertrophic Scars: Lessons Learned from a Prematurely Terminated Split-Scar Trial\".","authors":"Dale W Edgar, Colleen M Ryan, Marianne K Nieuwenhuis, Ulrike Van Daele, Jill M Cancio","doi":"10.3390/ebj6010016","DOIUrl":"10.3390/ebj6010016","url":null,"abstract":"<p><p>The Editors thank the investigators for displaying tenacity, evidenced by the significant revisions that were necessary to complete this project [...].</p>","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"6 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonathan Bayuo, Joyce Pwavra, Jephtah Davids, Anita Eseenam Agbeko, Paa Ekow Hoyte-Williams, Frank Bediako Agyei, Pius Agbenorku
{"title":"Improving Nutrition and Nutrition Education in the Burn Unit of a Developing Country: A Qualitative Study.","authors":"Jonathan Bayuo, Joyce Pwavra, Jephtah Davids, Anita Eseenam Agbeko, Paa Ekow Hoyte-Williams, Frank Bediako Agyei, Pius Agbenorku","doi":"10.3390/ebj6010015","DOIUrl":"10.3390/ebj6010015","url":null,"abstract":"<p><p>Burn injuries can trigger a series of metabolic and catabolic responses that exert significant impacts on an individual's nutritional status, necessitating continuous nutritional support and education to aid recovery. However, burn units in developing countries often face resource limitations that can negatively affect these needs. This study aimed to explore the challenges related to post-burn nutrition and nutrition education in our burn unit and identify ways to improve the situation. An interpretive description approach was used, and convenience sampling recruited fifty-three participants, including 18 adult burn survivors and their primary caregivers (each as a single dyad), 10 informal caregivers of paediatric burn survivors, and 25 burn care staff. The data were analysed through thematic analysis, revealing three main themes and seven subthemes. The findings highlight an unstructured approach to nutrition and education, along with financial constraints affecting adherence. To address these issues, strategies such as using educational materials like videos and booklets/leaflets in the local language are suggested to develop relevant interventions. In conclusion, while there are concerns about nutrition and education, there are also opportunities to improve the situation.</p>","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"6 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recreational Use of Nitrous Oxide as a Source of Frostbite Injuries to the Skin: A Review of the Literature and a Case Report.","authors":"Sebastian Holm, Reza Tabrisi, Johann Zdolsek","doi":"10.3390/ebj6010014","DOIUrl":"10.3390/ebj6010014","url":null,"abstract":"<p><p>Nitrous oxide has a wide range of medical applications, such as being used as an analgesic in general anesthesia, dental procedures, childbirth and sedation. Lately, it has also been employed as an inhalant recreational drug to induce brief euphoria. Recent studies indicate a worldwide rise in the incidence of skin frostbites associated with nitrous oxide use. A scoping review was conducted to synthesize and summarize the existing literature published in English regarding frostbite injuries associated with the recreational use of nitrous oxide. The literature search was carried out in July 2024 using databases such as Embase, Web of Science and PubMed<sup>®</sup>. From an initial pool of 83 publications, 8 studies were ultimately selected for full-text review as they met our inclusion criteria for analysis. Additionally, we provide a representative clinical case involving a 21-year-old male who experienced frostbite following skin exposure to nitrous oxide. Most publications on nitrous oxide induced frostbites are from recent years, primarily between 2022 and 2024, with the first case documented in 1996. These injuries are mostly observed in young adults, with a female dominance, and are typically localized to the inner thighs. According to the existing literature, the predominant treatment approach is conservative management, with excision and split-thickness skin grafting (STSG) in the second place. This study represents the first literature review summarizing frostbite injuries to the skin from nitrous oxide misuse. There is a need for enhanced preventive measures to raise public awareness and reduce the incidence of frostbite injuries associated with the recreational use of nitrous oxide.</p>","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"6 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel Techniques in Fractional Skin Replacement.","authors":"Courtney Kelly, Rodney K Chan, Anders H Carlsson","doi":"10.3390/ebj6010013","DOIUrl":"10.3390/ebj6010013","url":null,"abstract":"<p><p>The gold standards for coverage of wounds that cannot be primarily closed are full thickness skin grafts (FTSGs) and split thickness skins graft (STSGs). FTSGs harvest sites generally require primary closure, which limits availability, especially when treating larger wounds. STSGs have many shortcomings, including donor site morbidity. Fractional autologous skin replacement can be utilized in conjunction with or in lieu of STSGs to both improve graft outcomes of large wounds and to decrease donor site morbidity. Skin can be mechanically or chemically fractionated. Fractionated skin can be advantageous, as adnexal structures provide additional functionality without donor site morbidity. In this review, we will discuss current and emerging techniques in fractional skin replacement.</p>","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"6 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hyunjun Shin, Gyung-Jin Jeon, Seok-Jin Hwang, Hyeonseok Cho, Young-Min Cho, Hyoung-Soon Youn, Jisu Seo, Sehoon Park, Yoon-Soo Cho, Gyu-Seok Kim
{"title":"Preliminary Study on the Development of a Real-Time Pressure-Monitoring Facial Mask for Burn Rehabilitation.","authors":"Hyunjun Shin, Gyung-Jin Jeon, Seok-Jin Hwang, Hyeonseok Cho, Young-Min Cho, Hyoung-Soon Youn, Jisu Seo, Sehoon Park, Yoon-Soo Cho, Gyu-Seok Kim","doi":"10.3390/ebj6010012","DOIUrl":"10.3390/ebj6010012","url":null,"abstract":"<p><p>The most common aftereffect of severe burns in patients is hypertrophic scarring. Hypertrophic scars typically form following severe burns; it refers to excessive collagen production in the dermal layer during the healing process, resulting in an abnormal raised scar. Currently, practical treatments for suppressing hypertrophic scars include laser therapy, pressure therapy, and the application of silicone sheets for moisture retention. The most extensively used treatment involves compression therapy using specially designed garments for the affected areas. However, this method has limitations when applied to curved surfaces like the face. To address this issue, three-dimensional (3D) scanning and 3D printing techniques have been actively developed for face masks and have shown promising clinical results. Unfortunately, current facial masks under development lack a sensor system to measure pressure, making it difficult to ensure consistent and appropriate pressures during clinical trials. In this study, we have developed a burn pressure mask capable of real-time pressure monitoring. The facial mask developed in this study utilizes an FSR-type sensor to measure the pressure applied to the skin. We have also embedded electrical wires within the mask to enhance its comfort and wearability. For this study, two patients wore the facial mask with real-time pressure measurement capabilities for 4 weeks in 12 h per day on average. We evaluated whether the mask maintained the appropriate pressure range (15-25 mmHg) throughout the clinical trial and whether it effectively inhibited scar formation. Through the analysis of recorded pressure signal data, we confirmed that the patients consistently maintained the appropriate pressure while wearing the mask during the clinical trial. Additionally, we observed significant differences in skin moisture levels, transepidermal water loss, and scar thickness before and after the experiment. These findings suggest that the facial mask, featuring real-time monitoring capabilities, effectively prevents the formation of hypertrophic scars.</p>","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"6 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Niamh Keohane, Jennifer Driver, Randeep Mullhi, Elizabeth Chipp, Barbara Torlinska, Tomasz Torlinski
{"title":"Mind the Gap! Core-Peripheral Temperature Gradient and Its Relationship to Mortality in Major Burns.","authors":"Niamh Keohane, Jennifer Driver, Randeep Mullhi, Elizabeth Chipp, Barbara Torlinska, Tomasz Torlinski","doi":"10.3390/ebj6010011","DOIUrl":"10.3390/ebj6010011","url":null,"abstract":"<p><p>The association between hypothermia and poor outcomes in severe burn injury is well established. However, the significance of the core-peripheral temperature gradient has not previously been investigated. Institutional guidance at our burns centre advocates avoiding hypothermia and targeting a body temperature between 37.5 and 39.5 °C. The core-peripheral temperature gap should be ≤2 °C, based on expert opinion. Data from 61 patients admitted to the Intensive Care Unit (ICU) with severe burns between 2016 and 2022 were analysed. A higher core temperature at 48 h, avoidance of hypothermia and a core-peripheral temperature gap > 2 °C were associated with reduced odds of mortality. The mean core body temperature and core-peripheral temperature gap increased over the first 48 h (r = 0.5, <i>p</i> < 0.001). All non-survivors had a core-peripheral gap < 2 °C at 48 h. Survivors had a higher mean 48 h gap (1.6 [95%CI:1.3-1.9]) than non-survivors (0.8 [95%CI:0.2-1.4; <i>p</i> = 0.04]). Our findings support previous studies suggesting that avoiding hypothermia and achieving a higher target temperature are associated with reduced mortality. However, it challenges the previous expert consensus that a lower core-peripheral gap indicates better outcomes. Further research with a larger cohort of patients is required to identify whether a higher core-peripheral temperature gap predicts outcomes in critically ill patients with severe burns.</p>","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"6 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarthak Sinha, Altay Baykan, Karen Hulin, Doug Baron, Vincent Gabriel, Frankie O G Fraulin
{"title":"Fractional CO<sub>2</sub> Laser for Pediatric Hypertrophic Scars: Lessons Learned from a Prematurely Terminated Split-Scar Trial.","authors":"Sarthak Sinha, Altay Baykan, Karen Hulin, Doug Baron, Vincent Gabriel, Frankie O G Fraulin","doi":"10.3390/ebj6010010","DOIUrl":"10.3390/ebj6010010","url":null,"abstract":"<p><strong>Background: </strong>Assessing hypertrophic scar (HTS) interventions is challenging because scars continue to undergo dynamic changes. A split-scar design can distinguish treatment effects from natural HTS evolution. Despite promising reports of ablative fractional CO<sub>2</sub> lasers (AFCO<sub>2</sub>Ls) for HTS, split-scar evidence, particularly in pediatric scars, remains limited.</p><p><strong>Objective: </strong>To explore the feasibility of a split-scar design in assessing AFCO<sub>2</sub>L's impact on pediatric HTS and to identify potential trends in treatment outcomes.</p><p><strong>Methods: </strong>Initially designed as a prospective single-center split-scar randomized controlled trial, our study transitioned to a feasibility trial due to recruitment challenges. Pediatric patients aged 1-17 years with HTS suitable for split-scar evaluation received three AFCO<sub>2</sub>L treatments at 6-8-week intervals, with outcomes assessed using the Vancouver Scar Scale (VSS), SCAR-Q, and Cutometer.</p><p><strong>Results: </strong>Recruitment was limited by COVID-19 restrictions, concerns about general anesthesia for split-scar treatment, and low interest in divided-scar interventions, resulting in only 6 participants with 9 scars enrolled, far below the target sample size of 44. This small heterogeneous sample precluded meaningful clinical outcome analysis.</p><p><strong>Conclusions: </strong>Our feasibility trial highlights challenges in conducting rigorous pediatric HTS studies and the need for careful interpretation of evidence due to potential publication bias. Future trials should focus on tailored recruitment and comprehensive reporting to improve feasibility and reliability.</p>","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"6 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dinithi Atapattu, Victoria M Shoesmith, Eva Kierath, Mark W Fear, Fiona M Wood, Lisa J Martin
{"title":"Bouncing Back: The Psychosocial Benefits of a Community-Based Exercise Program for Children with Non-Severe Burns.","authors":"Dinithi Atapattu, Victoria M Shoesmith, Eva Kierath, Mark W Fear, Fiona M Wood, Lisa J Martin","doi":"10.3390/ebj6010009","DOIUrl":"10.3390/ebj6010009","url":null,"abstract":"<p><p>Burns significantly impact children's physical and psychosocial recovery, even in cases of non-severe injuries, leading to long-term health and mental health risks. This study explores the psychosocial benefits of a community-based exercise program for children recovering from burn injuries, addressing concerns such as anxiety, reduced physical activity, and social challenges. A pre-test-post-test design assessed the effects of an 8-week community-based trampoline exercise intervention on psychosocial outcomes in children and their caregivers. No significant or clinically meaningful physical improvements were observed across measures such as MET score, grip strength, BMI percentile, or heart-rate recovery despite a significant improvement in trampolining performance (<i>p</i> < 0.0001). Psychosocial outcomes showed improved child emotional function (PedsQL, <i>p</i> = 0.024) as reported by parents, though children's self-reported emotional function and Child PTSD Symptom Scale (CPSS) scores remained unchanged. Parent-reported strengths and difficulty scores for the child remained stable over time but were higher than population norms for hyperactivity and emotional difficulty. Parental post-traumatic stress symptoms decreased significantly over time (<i>p</i> = 0.050), with reductions in avoidance (<i>p</i> = 0.009), hypervigilance (<i>p</i> = 0.007), and intrusion scores (<i>p</i> = 0.026). Children significantly improved their trampolining performance, while parents reported enhanced emotional function for their child. However, children's self-reports did not reflect these emotional improvements.</p>","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"6 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara Guila Fidel-Kinori, Vicente García-Sánchez, Maria Sonsoles Cepeda-Diez, Carmina Castellano-Tejedor, Josep Antoni Ramos-Quiroga, Joan Pere Barret-Nerín
{"title":"Self-Inflicted Burns: A Comparative Study in a Spanish Sample.","authors":"Sara Guila Fidel-Kinori, Vicente García-Sánchez, Maria Sonsoles Cepeda-Diez, Carmina Castellano-Tejedor, Josep Antoni Ramos-Quiroga, Joan Pere Barret-Nerín","doi":"10.3390/ebj6010008","DOIUrl":"10.3390/ebj6010008","url":null,"abstract":"<p><strong>Background: </strong>In 1994, the first Spanish study on patients with self-inflicted burns (SIB) was published, showing a prototypical profile of a patient with SIB: adult male, unmarried and, in 75% of the cases, with a psychiatric background. In addition, SIB accounted for 1.98% of the total admissions in a Burns Unit between 1983 and 1991, a lower percentage than other European studies. The present study aims to replicate this work, updating this profile and comparing it with the current profile.</p><p><strong>Methods: </strong>We compared the clinical and socio-demographic characteristics of 67 patients admitted during 1983-1991 (Study I) with those of 36 patients admitted during 2010-2015 (Study II).</p><p><strong>Results: </strong>It was observed that the percentage of patients with SIB admitted to the Burns Unit was lower in Study II than in Study I (1.45% vs. 1.98%). Significant age differences were identified (<i>t</i><sub>(101)</sub> = -2.074, <i>p</i> = 0.041, 95% CI [-11.739, -0.261]). Similarly, there were statistically significant differences in several clinical characteristics, such as psychiatric history (X<sup>2</sup> = 11.591, <i>p</i> = 0.001), the occurrence of previous autolytic attempts (X<sup>2</sup> = 7.714, <i>p</i> = 0.007), the place where the incident occurred (X<sup>2</sup> = 11.647, <i>p</i> = 0.020), the etiology of the burn (X<sup>2</sup> = 13.142, <i>p</i> = 0.004), and triggers (X<sup>2</sup> = 6.420, <i>p</i> = 0.036).</p><p><strong>Conclusions: </strong>Several differences have arisen between the two studies, mainly related to the specific characteristics of SIB (e.g., etiology, triggering cause, and place of the incident), possibly attributable to the social changes that have occurred in the last 20 years. These results will add to our knowledge and will stress various precipitating factors that may lead to SIB, with the final goal of designing preventive strategies.</p>","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"6 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas Wild, Jörg Marotz, Ahmed Aljowder, Frank Siemers
{"title":"Burn Wound Dynamics Measured with Hyperspectral Imaging.","authors":"Thomas Wild, Jörg Marotz, Ahmed Aljowder, Frank Siemers","doi":"10.3390/ebj6010007","DOIUrl":"10.3390/ebj6010007","url":null,"abstract":"<p><p><b>Introduction:</b> Hyperspectral Imaging (HSI) combined with an augmented model-based data processing enables the measurement of the depth-resolved perfusion of burn wounds. With these methods, the fundamental problem of the wound dynamics (wound conversion or progression) in the first 4 days should be parametrically analyzed and evaluated. <b>Material and Methods:</b> From a cohort of 59 patients with burn injuries requiring medical intervention, 281 homogenous wound segments were selected and subjected to clinical classification based on the duration of healing. The classification was retrospectively assigned to each segment during the period from day 0 to day 2 post-burn. The perfusion parameters were presented in two parameter spaces describing the upper and deeper perfusion. <b>Results:</b> The investigation of value distributions within the parameter spaces pertaining to four distinct categories of damage from superficial dermal to full-thickness burns during the initial four days reveals the inherent variability and distinct patterns associated with wound progression, depending on the severity of damage. The analysis highlights the challenges associated with estimating the burn degrees during this early stage and elucidates the significance of deeper tissue perfusion in the classification process, which cannot be discerned through visual inspections. <b>Conclusions:</b> The feasibility of early classification on day 0 or 1 was assessed, and the findings indicate a restricted level of reliability, particularly on day 0, primarily due to the substantial variability observed in wound characteristics and inherent dynamics.</p>","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"6 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}