Engineered regeneration最新文献

{"title":"Suppression of NFATc1 through NF-kB/PI3K signaling pathway by Oleandrin to inhibit osteoclastogenesis and bone resorption","authors":"Zhikun Li ,&nbsp;Kai Chen ,&nbsp;Qifeng Yu ,&nbsp;Yifan Li ,&nbsp;Shichao Tong ,&nbsp;Ruijun Xu ,&nbsp;Ruixi Hu ,&nbsp;Yi Zhang ,&nbsp;Wei Xu","doi":"10.1016/j.engreg.2024.01.005","DOIUrl":"10.1016/j.engreg.2024.01.005","url":null,"abstract":"<div><p>Inflammation can initiate osteolysis, which is the breakdown of bone by fully developed osteoclasts. The compound Oleandrin is recognized for its effects against inflammation and tumors. Our objective was to examine the effects of Oleandrin on osteoclastogenesis and osteolysis, both in vitro and in vivo. In vitro, the impact of Oleandrin on osteoclastogenesis was assessed using CCK-8 assays, TRAP staining, and bone resorption assays. Additionally, a mouse model of osteolysis caused by LPS injection into the calvaria was used to conduct an in vivo investigation, examining bone histomorphology, histology, and immunohistochemistry. In vitro, concentrations of 5 nM and 10 nM of Oleandrin were found to be non-cytotoxic based on the results obtained. In vitro, Oleandrin hindered the osteoclastogenesis and bone resorption induced by RANKL. Oleandrin successfully inhibited the phosphorylation of NF-κB p65 and PI3K p85 in osteolytic tissue, thereby suppressing LPS-induced inflammatory osteolysis in mice calvaria during the in vivo study. Furthermore, the Oleandrin-treated group exhibited a noteworthy decrease in the expression level of NFATc1, which is a crucial controller of osteoclastogenesis. To sum up, our discoveries indicate that Oleandrin could hinder osteoclastogenesis and bone resorption, thereby having the ability to suppress inflammation-induced osteolysis. The underlying mechanism involves the NF-κB/PI3K pathway and inhibition of NFATc1 activation. Therefore, the findings suggest that Oleandrin holds potential as a therapeutic remedy for osteolytic ailments.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 3","pages":"Pages 342-349"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138124000057/pdfft?md5=78bcdfed64502d036c962f4dfed847e1&pid=1-s2.0-S2666138124000057-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139686754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Muscle Tendon Junction in vitro Using Aligned Electrospun PCL Fibres","authors":"Nodoka Iwasaki ,&nbsp;Marta Roldo ,&nbsp;Aikaterina Karali ,&nbsp;Alberto Sensini ,&nbsp;Gordon Blunn","doi":"10.1016/j.engreg.2024.01.004","DOIUrl":"10.1016/j.engreg.2024.01.004","url":null,"abstract":"<div><p>The muscle tendon junction (MTJ) transmits the force generated by the muscle to the tendon and ultimately to the bone. Tears and strains commonly occur at the MTJ where regeneration is limited due poor vascularisation and the complexity of the tissue. Currently treatments for a complete MTJ tear are often unsuccessful. The creation of a tissue engineered MTJ would therefore be beneficial in the development of a novel treatment. In this study, aligned electrospun polycaprolactone fibres were fabricated and human myoblasts and tenocytes were cultured on the scaffold. The effect of 10 % cyclic strain and co-culture of myoblasts and tenocytes on the MTJ formation was investigated. The application of strain significantly increased cell elongation, and MTJ marker gene expression. Co-culture of myoblasts and tenocytes with strain induced higher MTJ marker gene expression compared with myoblasts and tenocytes cultured separately. Paxillin and collagen 22, naturally found in the MTJ, were also produced when cells were combined and grown in a 10 % strain environment. For the first time these results showed that the combination of the strain and co-culture of myoblasts and tenocytes promotes gene expression and production of proteins that are found in the MTJ.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 3","pages":"Pages 409-420"},"PeriodicalIF":0.0,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138124000045/pdfft?md5=55ab791f447bb5a77a770af7438e5fa5&pid=1-s2.0-S2666138124000045-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139634864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-talk between biometal ions and immune cells for bone repair","authors":"Shubo Liu ,&nbsp;Zhengjie Lin ,&nbsp;Wei Qiao ,&nbsp;Bin Chen ,&nbsp;Jie Shen","doi":"10.1016/j.engreg.2024.01.003","DOIUrl":"10.1016/j.engreg.2024.01.003","url":null,"abstract":"<div><p>Biometal ions are crucial in the structure and function of living organisms and have extensively been employed to promote bone tissue regeneration. Nevertheless, the biological functions of biometal ions and the underlying mechanisms responsible for their pro-regenerative effects remain incompletely understood, since bone repair is an intricate physiological process involving multiple cell types and signals. Recent accomplishments in the osteoimmunological field have revealed the momentous involvement of the immune system in mediating the therapeutic effects of biometal ions. The inflammatory factors secreted by immune cells contribute to bone cell migration, activation, and proliferation. This review summarizes the immune system and its constituent cells, followed by the current perspective on immunomodulation during bone healing. Next, the physicochemical and physiological properties of various biometal ions, including lithium, sodium, potassium, magnesium, calcium, strontium, vanadium, iron, cobalt, copper, and zinc, are thoroughly reviewed. In addition, the interactions between biometal ions, immune cells, and bone tissue are discussed, aiming to provide insights into the prospective development of novel approaches to bone tissue regeneration by harnessing the therapeutic potential of these biometal ions.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 3","pages":"Pages 375-408"},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138124000021/pdfft?md5=317cfda685dd368b344b03045d820968&pid=1-s2.0-S2666138124000021-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139539552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microalgae-based drug delivery systems in biomedical applications","authors":"Hui Huang ,&nbsp;Yutong Lang ,&nbsp;Shoujie Wang ,&nbsp;Min Zhou","doi":"10.1016/j.engreg.2024.01.002","DOIUrl":"10.1016/j.engreg.2024.01.002","url":null,"abstract":"<div><p>Over decades of development, the modern drug delivery system continues to grapple with numerous challenges, including drug loading inefficiencies, issues of immunogenicity, and cytotoxicity. These limitations restrict its application across various systems. Microalgae, as a natural resource, are not only abundant in bioactive compounds but also possess multiple biological properties, including active surface, photosynthesis capabilities, and excellent biocompatibility. These attributes make microalgae highly promising as carriers for targeted drug delivery, offering significant potential for the diagnosis and treatment of various diseases. Therefore, leveraging the exceptional properties of microalgae for drug delivery and optimizing their qualities is of paramount importance. This article focuses on elucidating the biological characteristics of microalgae and their applications in drug delivery, with a particular emphasis on emerging strategies for efficient drug loading and precise targeted delivery. Microalgae, as a natural biomaterial, hold immense potential for both commercial and clinical applications.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 3","pages":"Pages 361-374"},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138124000033/pdfft?md5=a493ff0d8eca7ab0559446389aa566d9&pid=1-s2.0-S2666138124000033-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139539603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrastable in-situ silver nanoparticle dressing for effective prevention and treatment of wound infection in emergency","authors":"Wei Wang ,&nbsp;Ziwei Hu ,&nbsp;Wanying Mo ,&nbsp;Min Ouyang ,&nbsp;Shihao Lin ,&nbsp;Xiang Li ,&nbsp;Chengxinqiao Wang ,&nbsp;Feng Yu ,&nbsp;Yupeng Wang ,&nbsp;Dongfang Zhou","doi":"10.1016/j.engreg.2024.01.001","DOIUrl":"https://doi.org/10.1016/j.engreg.2024.01.001","url":null,"abstract":"<div><p>The use of antibacterial dressings is crucial in the prevention and treatment of wound infection in emergency situations. However, the efficacy of dressings is compromised by long-term storage or exposure to harsh conditions. Here, an ultrastable in-situ silver nanoparticle dressing (AgSNP@CD) was prepared for effective prevention and treatment of wound infection in emergency. The fabrication process of AgSNP@CD is simple, suitable for large-scale production. Due to the strong interaction between the in-situ synthesized AgNPs and the cotton fabric, AgSNP@CD owned remarkable stability, thus retaining its antimicrobial efficacy even after long-term storage (up to 2 years) and under extreme conditions (damp heat, low temperatures, low-oxygen, water immersion, acid-alkali erosion). Both <em>in vitro</em> and <em>in vivo</em> results demonstrated the extraordinary antibacterial efficacy and stability of AgSNP@CD, facilitating infection prevention and wound healing in extreme conditions. In particular, AgSNP@CD exhibited a superior treatment effect on severe bacteria-infected trauma and can prevent the occurrence of sepsis effectively. The exceptional stability and antibacterial efficacy of AgSNP@CD under complex and extreme conditions make it a well-suited dressing strategy for the prevention and treatment of wound infection in emergency.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 1","pages":"Pages 111-123"},"PeriodicalIF":0.0,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266613812400001X/pdfft?md5=f3affa19e904775f4f3e7648b6c3c75b&pid=1-s2.0-S266613812400001X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139493478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Instability-Driven 3D bioprinting for engineering composite bio-inks","authors":"Jing Ma ,&nbsp;Cheng Qi ,&nbsp;Zhou Liu ,&nbsp;Si Meng ,&nbsp;Tiantian Kong","doi":"10.1016/j.engreg.2023.12.004","DOIUrl":"10.1016/j.engreg.2023.12.004","url":null,"abstract":"<div><p>Extrusion-based 3D bioprinting techniques are revolutionizing bioengineering by facilitating the creation of complex 3D microstructures. This review offers a thorough overview of extrusion-based 3D bioprinting methods, particularly highlighting the innovative electric-assisted coil-write 3D bioprinting technology. The review begins by explicating the fundamental principles underlying various extrusion-based 3D bioprinting technologies. It covers the printing equipment composition, suitable materials for 3D bioprinting, and the latest breakthroughs in technology. A critical aspect of this review is the in-depth comparison of the strengths and weaknesses associated with each 3D bioprinting approach. The electro-microfluidic extrusion method and the electric-assisted coil-write 3D bioprinting technology are highlighted. This advanced technology successfully overcomes the limitations of conventional extrusion-based methods, notably in the precise printing of intricately curved line structures with high resolution and speed. This method ingeniously integrates mechanical motion for creating microscale features with electrical coiling for sub-micron details, thus achieving remarkable printing speeds and structural complexity. This review concludes by exploring the potential applications and future advancements of this state-of-the-art technology. It underscores the ability of electric-assisted coil-write 3D bioprinting to develop pioneering materials and micro-devices for a variety of technological sectors, highlighting its transformative impact in bioengineering.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 3","pages":"Pages 350-360"},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138123000658/pdfft?md5=34dafb2b4b8cfbcefd7aae76e19a4aa4&pid=1-s2.0-S2666138123000658-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139195519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modelling the development of biological structures displaying longitudinal geometries in vitro: culturing pluripotent stem cells on plasma-treated, growth factor-coupled polycaprolactone fibres","authors":"Badwi B. Boumelhem ,&nbsp;Stuart T. Fraser ,&nbsp;Syamak Farajikhah ,&nbsp;Rachel A. Shparberg ,&nbsp;Michael B. Morris ,&nbsp;Marcela M.M. Bilek ,&nbsp;Anyu Zhang ,&nbsp;Behnam Akhavan ,&nbsp;Simon Fleming ,&nbsp;Maryanne Large","doi":"10.1016/j.engreg.2023.12.003","DOIUrl":"10.1016/j.engreg.2023.12.003","url":null,"abstract":"<div><p>Many biological structures such as nerves, blood and lymphatic vessels, and muscle fibres exhibit longitudinal geometries with distinct cell types extending along both the length and width of internal linear axes. Modelling these three-dimensional structures <em>in vitro</em> is challenging: the best-defined stem-cell differentiation systems are monolayer cultures or organoids using pluripotent stem cells. Pluripotent stem cells can differentiate into functionally mature cells depending on the signals received, holding great promise for regenerative medicine. However, the integration of <em>in vitro</em> differentiated cell types into diseased tissue remains a challenge. Engineered scaffolds can bridge this gap if the appropriate signalling systems are incorporated into the scaffold. Here, we have taken a biomimicry approach to generate longitudinal structures <em>in vitro</em>. In this approach, mouse embryonic stem cells are directed to differentiate to specific cell types on the surface of polycaprolactone (PCL) fibres treated by plasma-immersion ion implantation and to which with lineage-specifying molecules have been covalently immobilised. We demonstrate the simplicity and utility of our method for efficiently generating high yields of the following cell types from these pluripotent stem cells: neurons, vascular endothelial cells, osteoclasts, adipocytes, and cells of the erythroid, myeloid, and lymphoid lineages. Strategically arranged plasma-treated scaffolds with differentiated cell types could ultimately serve as a means for the repair or treatment of diseased or damaged tissue.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 1","pages":"Pages 124-138"},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138123000646/pdfft?md5=41827318ba546a4dcc3a8b3a14af92c9&pid=1-s2.0-S2666138123000646-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139022034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulsed electromagnetic field stimulation enhances neurite outgrowth in neural cells and modulates inflammation in macrophages","authors":"Francesco Fontana ,&nbsp;Andrea Cafarelli ,&nbsp;Francesco Iacoponi ,&nbsp;Soria Gasparini ,&nbsp;Tiziano Pratellesi ,&nbsp;Abigail N． Koppes ,&nbsp;Leonardo Ricotti","doi":"10.1016/j.engreg.2023.11.003","DOIUrl":"https://doi.org/10.1016/j.engreg.2023.11.003","url":null,"abstract":"<div><p>Nerve regeneration following traumas remains an unmet challenge. The application of pulsed electromagnetic field (PEMF) stimulation has gained traction for a minimally invasive regeneration of nerves. However, a systematic exploration of different PEMF parameters influencing neuron function at a cellular level is not available. In this study, we exposed neuroblastoma F11 cells to PEMF to trigger beneficial effects on neurite outgrowth. Different carrier frequencies, pulse repetition frequencies, and duty cycles were screened with a custom <em>ad hoc</em> setup to find the most influential parameters values. A carrier frequency of 13.5 MHz, a pulse repetition frequency of 20 Hz, and a duty cycle of 10% allowed maximal neurite outgrowth, with unaltered viability with respect to non-stimulated controls. Furthermore, in a longer-term analysis, such optimal conditions were also able to increase the gene expression of neuronal expression markers NeuN and Tuj-1 and transcription factor Ngn1. Finally, the same optimal stimulation conditions were also applied to THP-1 macrophages, and both pro-inflammatory (TNF-α, IL-1β, IL-6, IL-8) and anti-inflammatory cytokines (IL-10, CD206) were analyzed. The optimal PEMF stimulation parameters did not induce differentiation towards an M1 macrophage phenotype, decreased IL-1β and IL-8 gene expression, decreased TNF-α and IL-8 cytokine release in M1-differentiated cells, increased IL-10 and CD206 gene expression, as well as IL-10 cytokine release in M0 cells. The specific PEMF stimulation regime, which is optimal <em>in vitro,</em> might have a high potential for a future <em>in vivo</em> translation targeting neural regeneration and anti-inflammatory action for treating peripheral nerve injuries.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 1","pages":"Pages 80-91"},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138123000610/pdfft?md5=d981f29c3e72d71a4838a1137ba90bfa&pid=1-s2.0-S2666138123000610-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138657215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fully umbilical cord-derived adhesive materials enable to recruit and segregate immune cells for the reversal of acute liver failure","authors":"Xiao Yi ,&nbsp;Feng Chen ,&nbsp;Kunjie Gao ,&nbsp;Huayan Li ,&nbsp;Yuan Xie ,&nbsp;Shao Li ,&nbsp;Jiajun Zhang ,&nbsp;Qing Peng ,&nbsp;Weijie Zhou ,&nbsp;Shutao Wang ,&nbsp;Jun-Bing Fan ,&nbsp;Yi Gao","doi":"10.1016/j.engreg.2023.12.001","DOIUrl":"https://doi.org/10.1016/j.engreg.2023.12.001","url":null,"abstract":"<div><p>Inflammatory cytokine storms can trigger disease exacerbation and even death and have reached a consensus in the clinical treatment of acute organ failure. However, the existing strategies remain a great challenge to efficiently suppress inflammatory cytokine storms for promoting organ repair and regeneration. Herein, fully human umbilical cord (UC)-derived adhesive materials (UCAM) that integrate decellularized extracellular matrix (ECM) nanofiber hydrogel and homologous mesenchymal stem cells (MSCs) are demonstrated to greatly suppress inflammatory cytokine storms, demonstrating high efficacy in treating acute liver failure (ALF) in rats with 90% hepatectomy. The UC-derived adhesive materials have the capacity to secrete a significant quantity of cytokines by MSCs to recruit activated immune cells to migrate into their ECM nanofiber networks, segregating them away from the infection area and thereby greatly suppressing the inflammatory cytokine storms. As expected, the UC-derived adhesive materials can significantly promote hepatocyte proliferation to achieve functional recovery and regeneration of the liver, significantly improving the survival rate in rats. Our fully human UC-derived adhesive materials provide a new avenue in suppressing inflammatory cytokine storms for promoting organ regeneration that would be really utility in clinical organ transplantation-related treatment.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 1","pages":"Pages 70-79"},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138123000622/pdfft?md5=3a99a1df061811a8c3d4815825d385a7&pid=1-s2.0-S2666138123000622-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138657214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microenvironment-responsive nanosystems for osteoarthritis therapy","authors":"Song Li ,&nbsp;Yuan Xiong ,&nbsp;Hao Zhu ,&nbsp;Tian Ma ,&nbsp;Xuying Sun ,&nbsp;Jun Xiao","doi":"10.1016/j.engreg.2023.12.002","DOIUrl":"10.1016/j.engreg.2023.12.002","url":null,"abstract":"<div><p>Osteoarthritis (OA) represents an enduring and widespread global burden, causing significant morbidity and disability, whose pathology is characterized by persistent inflammation, progressive cartilage degeneration, abnormal bone homeostasis, and excessive synovial hyperplasia, resulting from its complex microenvironment. Unfortunately, current therapeutic approaches for OA remain suboptimal, prompting increased interest in advanced nanotechnology as a means to enhance therapeutic effects. In recent years, significant progress has been made in the development of versatile nanoplatforms designed to the specific microenvironment of OA, resulting in promising results and introducing the concept of “OA nanomedicine”. Compared to the conventional therapies like non-steroidal anti-inflammatory drugs (NSAIDs), OA nanomedicine offers precise targeted, controllable and personalized ways for OA therapy, contributing to better outcomes. However, a comprehensive review consolidating the “OA nanomedicine” is currently absent from literature. Therefore, in this review, we aim to unravel the key pathological and microenvironmental characteristics of OA while summarizing the properties and advantages of nanosystems possessing microenvironment-reprogramming capabilities for OA therapy. First, we make a retrospection of the features of OA pathology and OA microenvironment. Furthermore, we provide an overview of the advances in OA nanomedicine. Eventually, we discuss the present challenges associated with OA nanomedicine and provide insights into its future prospects from a clinical-translational lens. By doing so, this review can foster and propel the successful development of OA nanomedicine, addressing the unmet needs in OA therapy.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 1","pages":"Pages 92-110"},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138123000634/pdfft?md5=0c655be8ba5af5861c0281a7d50337bd&pid=1-s2.0-S2666138123000634-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139014823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}