Engineered regeneration最新文献

{"title":"Corrigendum to “The Artificial Disc Nucleus and Other Strategies for Replacement of the Nucleus Pulposus: Past, Present and Future Designs for an Emerging Surgical Solution” [Engineered Regeneration 5(2024), 269-281]","authors":"Greg Sacks, Vincent DeStefano, Claire Parker, Ryan Lebens, Harry Mushlin","doi":"10.1016/j.engreg.2024.12.001","DOIUrl":"10.1016/j.engreg.2024.12.001","url":null,"abstract":"","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 4","pages":"Page 521"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143093253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asymmetric porous composite hydrogel patch for microenvironment-adapted repair of contaminated abdominal wall defects","authors":"Yang Yu ,&nbsp;Yinxiang Tang ,&nbsp;Weiwen Liang ,&nbsp;Yuanbin Wang ,&nbsp;Yang Ouyang ,&nbsp;Wenxuan Xiong ,&nbsp;Bingna Zheng ,&nbsp;Lili Chu ,&nbsp;Hui Wang","doi":"10.1016/j.engreg.2024.03.004","DOIUrl":"10.1016/j.engreg.2024.03.004","url":null,"abstract":"<div><div>Effective antibacterial property and long-term mechanical support are essential for the repair of complex abdominal wall defects associated with infection. However, clinically available repair materials often fail to meet these requirements, resulting in high surgical failure rate and complications. In this study, an asymmetric porous composite hydrogel patch (cCS/PVA@BAC) with antibacterial, anti-adhesion, pro-healing, and durable mechanical support properties is designed for the efficient repair of contaminated abdominal wall defects. By stepwise phase-conversion and soaking method, robust and stable polyvinyl alcohol hydrogel (PVAH) is integrated with the biocompatible multicomponent hydrogel made of chitosan and carboxymethyl chitosan (cCS), and benzalkonium chloride (BAC) is loaded to enhance the antibacterial property. The cCS layer of cCS/PVA@BAC has an extracellular matrix-like porous structure, which can promote fibroblasts adhesion and wound healing. In contrast, the PVAH layer on the other side with a smooth and dense structure, which can reduce fibroblasts adhesion and prevent visceral adhesion. In addition, the composite hydrogel patch has good anti-swelling and anti-deformation properties as well as stable mechanical strength, thus can withstand high intraperitoneal pressure in the wet internal microenvironment. The loaded BAC can efficiently kill bacteria and improve the local inflammatory microenvironment. With these advantages, cCS/PVA@BAC can significantly reduce inflammation, promote tissue remodeling, and accelerate the healing of contaminated abdominal wall defects in the rat model. These findings suggest a potential use of multifunctional hydrogel patch as an ideal material for effective repair of contaminated soft tissue defects.</div></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 4","pages":"Pages 468-481"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140756844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone improvement in osteoporotic rabbits using CoCrMo implants","authors":"Jésica I. Zuchuat ,&nbsp;Adriana S. Manzano ,&nbsp;Valeria Sigot ,&nbsp;Gastón L. Miño ,&nbsp;Oscar A. Decco","doi":"10.1016/j.engreg.2024.05.002","DOIUrl":"10.1016/j.engreg.2024.05.002","url":null,"abstract":"<div><div>The management of bone repair in patients with osteoporosis depends on the clinical situation and the extent of the damage. The repair of bone lesions by inducing new bone formation is important for maintaining bone architecture and density. Herein, we reported the use of Cobalt Chromium Molybdenum (CoCrMo) implants in osteoporotic rabbits and the regenerative outcomes <em>in vivo</em>. The aim was to determine whether the placement of CoCrMo plates would induce qualitative and quantitative differences in the osteoporotic tissue beneath and surrounding the implant. We assessed the effect of the alloy in the bone of animals receiving implants for 4 and 8 weeks and compared the results to those of the osteoporotic non-implanted bone and the healthy controls. After 4 weeks, minimal histological changes were observed, whereas after 8 weeks a marked osteogenesis was evident with both apposition and substitution of new bone. In addition, a greater number of Haversian canals with increased canal area and decreased intracortical pores were observed in the implanted <em>vs</em> non implanted limb for both experimental groups. We show for the first time that the use of CrCoMo plates induces bone formation under osteoporotic conditions. The beneficial effect is localised on the cortical bone in areas in contact with the material. Although this effect may not directly influence the OP disease itself, it has direct implications for new bone formation adjacent to the biomaterial. This potential enhancement could play a crucial role in improving implant fixation in compromised bone, offering increased biocompatibility and stability.</div></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 4","pages":"Pages 495-504"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141133439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bis-5HT modified Paris Saponin II nanoparticles treat neutrophil infiltrating allergic rhinitis by regulating the alanine metabolism pathway","authors":"Wenwen Qi ,&nbsp;Lei Shi ,&nbsp;Xinhao Wu ,&nbsp;Fangyuan Zhu ,&nbsp;Zhenxiao Teng ,&nbsp;Xiaochen Gao ,&nbsp;Xin Bing ,&nbsp;Na Guo ,&nbsp;Xue Cao ,&nbsp;Chengzhilin Li ,&nbsp;Houyang Hu ,&nbsp;Fanyu Yuan ,&nbsp;Yuhan Dong ,&nbsp;Ming Xia ,&nbsp;Chengcheng Liu","doi":"10.1016/j.engreg.2024.02.004","DOIUrl":"10.1016/j.engreg.2024.02.004","url":null,"abstract":"<div><div>Allergic rhinitis (AR) has emerged as a global concern, particularly due to the recent rise in disease incidence. There is an urgent need for safer, more effective, and shorter-term targeted immunotherapy approaches. Our previous studies have demonstrated the potential of paris saponins II in mitigating neutrophil infiltration in the nasal mucosa of AR mice. However, its clinical applicability has been hampered by limited by bio availability and bioactivity. In response to these limitations, we have developed bis-5HT-modified paris saponins II (designated as PLGA-5HT-PSII-Ce6) to target neutrophil-specific myeloperoxidase. Our verification, using metabolomics and other techniques, has affirmed the enhanced therapeutic efficacy of this targeted drug for allergic rhinitis. Furthermore, the incorporation of photosensitizers has improved the treatment effect particularly when light induction is introduced. This development lead to promising prospects for the treatment of AR.</div></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 4","pages":"Pages 452-467"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143094066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyphenol-based photothermal nanoparticles with sprayable capability for self-regulation of microenvironment to accelerate diabetic wound healing","authors":"Xiuhong Huang ,&nbsp;Meimei Fu ,&nbsp;Min Lu ,&nbsp;Xiaoxian Wu ,&nbsp;Weiqian David Hong ,&nbsp;Xiaoying Wang ,&nbsp;Panpan Wu ,&nbsp;Keke Wu","doi":"10.1016/j.engreg.2024.05.003","DOIUrl":"10.1016/j.engreg.2024.05.003","url":null,"abstract":"<div><div>Current treatments for diabetic wounds have some curative effect, but the process is complicated and lack user-friendly wound dressings. Nanozymes have gained significant attention for wound healing due to their striking merits. Herein, we have developed a novel sprayable tannin acid-cobalt coordination nanozyme (TACo) for diabetic wound healing. TACo nanozyme offers a convenient and efficient methods by spraying directly onto wounds surface, reducing infection risk by avoiding direct contact. Notably, its antioxidant properties contribute to scavenging the reactive oxygen species (ROS), alleviating oxidative stress and inflammation of wound microenvironment. Additionally, TACo nanozyme could promote cell survival and multiplication, which is crucial for the wound healing process. Importantly, TACo nanozyme facilitates angiogenesis by enhancing cell viability, migration, and tube formation. The unique coordination between metal and phenolic components confers pH-responsive cobalt ion and TA release properties, avoiding secondary damage during the wound cleaning. This unique composition seamlessly integrates photothermal antibacterial therapy, inflammatory microenvironment management, supporting for angiogenesis, and effective promotion of extracellular matrix production sequentially by harnessing the acidic pH environment of diabetic wounds. In conclusion, the development of a sprayable TACo nanozyme presents a promising therapeutic approach for the treatment of diabetic wounds, addressing the complexities of current treatments and providing a user-friendly application method.</div></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 4","pages":"Pages 505-520"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141401788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel injectable composite incorporating denosumab promotes bone regeneration via bone homeostasis regulation","authors":"Guang Yang ,&nbsp;Zili Guo ,&nbsp;Xiangfeng Zhang ,&nbsp;Jiayu Chen ,&nbsp;Jie Weng ,&nbsp;Jiapeng Bao ,&nbsp;Xiaohua Yu","doi":"10.1016/j.engreg.2024.05.001","DOIUrl":"10.1016/j.engreg.2024.05.001","url":null,"abstract":"<div><div>Repair of large bone defects remains to be clinically challenging, yet current bone repair strategies focus on optimizing the osteogenic capacity of bone grafts, while the role of osteoclasts in bone regeneration has been largely ignored. Herein, we designed a injectable self-curing bone grafting paste capable of regulating both anabolic/catabolic activities during bone healing by immobilizing the RANKL inhibitor denosumab on dermal-derived extracellular matrix (ECM) microfibres, which were then incorporated into an injectable paste via a hydration reaction between β-tricalcium phosphate (β-TCP), monocalcium phosphate monohydrate (MCPM) and calcium sulfate hemihydrate (CSH). The incorporation of ECM microfibres not only serves as a sustained-release denosumab carrier to inhibit osteoclastogenesis but also improves the mechanical properties of the resulting composite by increasing the interaction between the organic and inorganic phases. <em>In vitro</em>, calcium supply from the composite along with ECM enhanced osteogenic differentiation of BMSC while release of denosumab effectively inhibits osteoclast fusion and alleviate osteoclastic activity. <em>In vivo</em>, it was observed that CSH/CP@ECM-Deno significantly reduced the number of osteoclasts, slowed down the process of bone resorption, and accelerated collagen deposition to promote new bone generation. These results suggest that modulation of osteoclastogenesis by interfering with bone homeostasis may be an effective bone repair strategy.</div></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 4","pages":"Pages 482-494"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141026424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A patch comprising human umbilical cord-derived hydrogel and mesenchymal stem cells promotes pressure ulcer wound healing","authors":"Liqin Chen ,&nbsp;Ying Zhang ,&nbsp;Kexin Wang ,&nbsp;Meixian Jin ,&nbsp;Qi Chen ,&nbsp;Simin Wang ,&nbsp;Wei Hu ,&nbsp;Zhai Cai ,&nbsp;Yang Li ,&nbsp;Shao Li ,&nbsp;Yi Gao ,&nbsp;Shuqin Zhou ,&nbsp;Qing Peng","doi":"10.1016/j.engreg.2024.10.002","DOIUrl":"10.1016/j.engreg.2024.10.002","url":null,"abstract":"<div><div>Pressure ulcers (PUs) are common skin injuries known for their high morbidity, rapid onset, susceptibility to infection, and challenging healing process. One potential therapy for PUs is cell-based therapy using mesenchymal stem cells (MSCs). However, poor survival and low cell retention of MSCs on skin lesions limit their therapeutic effects and applications. In this study, we prepared an extracellular matrix (dECM) hydrogel decellularized from the human umbilical cord (UC). A patch composed of UC-dECM and UC-MSCs was employed in the treatment of PUs in C57BL/6 mice. Our results indicate that the UC-dECM hydrogel effectively sustains cell viability, enhances the stemness-related gene expression in UC-MSCs, and promotes human umbilical vein endothelial cells (HUVECs) migration and angiogenesis. Compared to the groups treated with the patch containing only UC-dECM, injection of UC-MSCs or gauze dressing, the patch combining UC-dECM hydrogel with UC-MSCs significantly accelerated PU healing. This positive outcome can be attributed to the promotion of tissue re-epithelialization, collagen deposition, angiogenesis, and inflammation inhibition. Our results suggest that the composite patch, comprised of UC-dECM hydrogel and UC-MSCs, may be a promising therapeutic approach for PU treatment.</div></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 4","pages":"Pages 433-442"},"PeriodicalIF":0.0,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cochlear implant/MXene-based electroacoustic stimulation modulates the growth and maturation of spiral ganglion neurons","authors":"Yangnan Hu ,&nbsp;Hao Wei ,&nbsp;Menghui Liao ,&nbsp;Shanying Han ,&nbsp;Xin Gao ,&nbsp;Yusong Wang ,&nbsp;Shan Zhou ,&nbsp;Dongyu Xu ,&nbsp;Xugang Zhuang ,&nbsp;Ye Yang ,&nbsp;Hong Cheng ,&nbsp;Bin Zhang ,&nbsp;Qingyue Cui ,&nbsp;Jieyu Qi ,&nbsp;Lei Tian ,&nbsp;Wenyan Li ,&nbsp;Xia Gao ,&nbsp;Renjie Chai","doi":"10.1016/j.engreg.2024.10.001","DOIUrl":"10.1016/j.engreg.2024.10.001","url":null,"abstract":"<div><div>Cochlear implantation (CI) offers a dependable treatment for sensorineural hearing loss, with precision electroacoustic stimulation parameters showing great potential in improving auditory outcomes in CI patients. Here, we report the attachment of MXene into CI systems which effectively mimic the neural electrode interface due to MXene's excellent electrical conductivity and biocompatibility. Low-frequency short-term biphasic electrical pulses emitted by the MXenes-based CI promoted the outgrowth of spiral ganglion neuron (SGN) neurites and growth cones, substantially boosting the calcium activity in SGNs. This study lays a theoretical foundation for the precision medicine approaches in CI patient care, and informs the selection of materials for cochlear implant electrode materials in the future.</div></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 4","pages":"Pages 443-451"},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing engineered approaches for sustainable wound regeneration and repair: Harnessing the potential of green synthesized silver nanoparticles","authors":"J. Nandhini ,&nbsp;E. Karthikeyan ,&nbsp;E. Elizabeth Rani ,&nbsp;V.S. Karthikha ,&nbsp;D. Sakthi Sanjana ,&nbsp;H. Jeevitha ,&nbsp;S. Rajeshkumar ,&nbsp;Vijayan Venugopal ,&nbsp;A. Priyadharshan","doi":"10.1016/j.engreg.2024.06.004","DOIUrl":"https://doi.org/10.1016/j.engreg.2024.06.004","url":null,"abstract":"<div><p>Wound healing is a crucial biological process for tissue repair and regeneration, preventing infections and complications. There's been a growing interest in exploring sustainable wound healing strategies in recent years. This review examines the use of green-synthesized silver nanoparticles (AgNPs) in sustainable wound healing strategies. It highlights the need for innovative approaches and the challenges posed by infections. The current wound therapies and treatments, highlighting gaps in existing methodologies, are evaluated. This review provides a comprehensive overview of the current state-of-the-art in green synthesis techniques for the synthesis of AgNPs. The properties and characterization of AgNPs are elucidated, providing insights into their efficacy. The biocompatibility of AgNPs in wound healing is also explored, emphasizing safety in medical applications. Green synthesized AgNPs incorporated wound dressings are detailed, showcasing their potential in clinical settings. Challenges and future perspectives are discussed, addressing hurdles to widespread implementation. The conclusion consolidates key findings, offering a synthesized perspective on the potential of green-synthesized AgNPs in revolutionizing current knowledge on innovative approaches for sustainable wound healing practices.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 3","pages":"Pages 306-325"},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138124000379/pdfft?md5=4d51fa5cd78a53e4abd401c3ebcd1952&pid=1-s2.0-S2666138124000379-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in nano silver-based biomaterials and their biomedical applications","authors":"Punuri Jayasekhar Babu ,&nbsp;Akriti Tirkey ,&nbsp;Abraham Abbey Paul ,&nbsp;Kathelina Kristollari ,&nbsp;Jugal Barman ,&nbsp;Kingshuk Panda ,&nbsp;Neha Sinha ,&nbsp;Birudu Ravi Babu ,&nbsp;Robert S. Marks","doi":"10.1016/j.engreg.2024.07.001","DOIUrl":"https://doi.org/10.1016/j.engreg.2024.07.001","url":null,"abstract":"<div><p>Silver nanoparticles are among the most widely researched and used for nanotechnology-derived structures due to their extraordinary inherent optical properties, chemical stability, catalytic activity, and high conductivity. These idiosyncratic properties can be attributed to their unique physico-chemical characteristics, such as ultrafine sizes, high surface area, diverse shapes, and strong localized surface plasmon resonance. These distinctive features can be tailored using various physical, chemical, and biological synthesis methods. Various physical techniques are viable for producing silver nanoparticles on a large scale, but they suffer from drawbacks such as high-power consumption, expensive set-up, and limited control over nanoparticle size distribution. Chemical methods provide benefits like high yield, consistent shape and size distribution, and cost efficiency, but the residual toxicity of the chemicals involved hinders their biological applications. Biological synthesis approaches effectively overcome the limitations of both physical and chemical methods by eliminating the need for hazardous chemicals, requiring less energy, enabling diverse nanoparticle morphologies, and offering eco-friendliness and exceptional biocompatibility. The novel and promising properties of nanosilver-based biomaterials have been demonstrated to be suitable for a wide range of pharmacological and therapeutic biomedical applications. Their extensive application in wound healing, dentistry, cardiovascular disease treatment, nerve tissue engineering, cancer treatment, and biosensing can be attributed to their inherent antimicrobial and antibiofilm activity, antithrombotic properties, potential for nerve regeneration, photothermal conversion efficiency and sensitivity, respectively. This review discusses the different methods employed for synthesising silver nanoparticles and focuses on using nanosilver-based biomaterials for various biomedical applications.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 3","pages":"Pages 326-341"},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138124000380/pdfft?md5=03491503b1860689dc45fea734a0f5e4&pid=1-s2.0-S2666138124000380-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}