Engineered regeneration最新文献_第10页

Injectable hydrogels for spinal cord injury repair 可注射水凝胶用于脊髓损伤修复

Engineered regeneration Pub Date : 2022-12-01 DOI: 10.1016/j.engreg.2022.09.001

Huan Wang , Hui Zhang , Zhongyu Xie , Keng Chen , Mengjun Ma , Yuejiao Huang , Minli Li , Zhaopeng Cai , Peng Wang , Huiyong Shen

{"title":"Injectable hydrogels for spinal cord injury repair","authors":"Huan Wang , Hui Zhang , Zhongyu Xie , Keng Chen , Mengjun Ma , Yuejiao Huang , Minli Li , Zhaopeng Cai , Peng Wang , Huiyong Shen","doi":"10.1016/j.engreg.2022.09.001","DOIUrl":"10.1016/j.engreg.2022.09.001","url":null,"abstract":"<div><p>Spinal cord injury (SCI) often causes severe functional impairment of body, which leads to a huge burden to the patient and the whole society. Many strategies, especially biomaterials, have been employed for SCI repair. Among various biomaterials, injectable hydrogels have attracted much attention because of their ability to load functional components and be injected into the lesioned area without surgeries. In this review, we summarize the recent progress in injectable hydrogels for SCI repair. We firstly introduce the pathophysiology of SCI, which reveals the mechanism of clinical manifestations and determines the therapeutic schedule. Then, we describe the original sources of polymers and the crosslinking manners in forming hydrogels. After that, we focus on the <em>in vivo</em> therapeutic strategies and effects of injectable hydrogels. Finally, the recent challenges and future outlook of injectable hydrogel for SCI repair are concluded and discussed. We believe this review can be helpful and inspire the further development of injectable hydrogels for SCI repair.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"3 4","pages":"Pages 407-419"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138122000573/pdfft?md5=bde548000bff12cc9c2159f6975e598e&pid=1-s2.0-S2666138122000573-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48380174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Adsorptive carbon-based materials for biomedical applications 用于生物医学应用的吸附性碳基材料

Engineered regeneration Pub Date : 2022-12-01 DOI: 10.1016/j.engreg.2022.08.001

Xiaomin Ye , Qihui Fan , Luoran Shang , Fangfu Ye

{"title":"Adsorptive carbon-based materials for biomedical applications","authors":"Xiaomin Ye , Qihui Fan , Luoran Shang , Fangfu Ye","doi":"10.1016/j.engreg.2022.08.001","DOIUrl":"10.1016/j.engreg.2022.08.001","url":null,"abstract":"<div><p>Adsorption or enrichment has been an indispensable and important measure in biomedical engineering since it is promising in diagnosis and treatment of complex diseases. The ongoing development in this arena starves for exploration of outstanding adsorptive materials. As an excellent candidate for adsorption or enrichment carriers, carbon-based material has demonstrated unique superiority in biomedical arena owing to its integrated characteristics. Herein, we review the lasted advance in adsorptive carbon-based materials for biomedical application with emphasis on carbon nanotubes (CNTs)-based, graphene-based, and biomass/polymer-based ones. We begin with the classification of different carbon-based materials and elaborate the respective preparation approaches that are utilized to realize optimized microstructure and physicochemical property. Afterwards, we introduce the different applications of carbon-based materials in biomedical arena, including blood purification, enrichment of glycopeptide and phosphopeptide, and breath analysis. Finally, we present a concise summary and give an outlook of this arena.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"3 4","pages":"Pages 352-364"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138122000524/pdfft?md5=22513dfe9f235c8eb9171dfe06c6b38f&pid=1-s2.0-S2666138122000524-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45894907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Acoustofluidics for cell patterning and tissue engineering 细胞图像化和组织工程的声流体学

Engineered regeneration Pub Date : 2022-12-01 DOI: 10.1016/j.engreg.2022.08.005

Zhuhao Wu , Meidie Pan , Jinglin Wang , Baojie Wen , Ling Lu , Haozhen Ren

{"title":"Acoustofluidics for cell patterning and tissue engineering","authors":"Zhuhao Wu , Meidie Pan , Jinglin Wang , Baojie Wen , Ling Lu , Haozhen Ren","doi":"10.1016/j.engreg.2022.08.005","DOIUrl":"10.1016/j.engreg.2022.08.005","url":null,"abstract":"<div><p>Acoustofluidics has been a promising approach using sound waves to manipulate particles and actuate fluids in biomedical applications. It usually generates acoustic radiation force and acoustic streaming to initiate diffraction, reflection and interference, building up a pressure distribution to facilitate accurate manipulation of micro- or nano-scale particles and fluids. Owing to its remarkable contact-free and biocompatible advantages, acoustofluidics has been used in high-throughput cell analysis, size-controllable organoid structures, and functional tissue mimics. We enumerate the basic concepts and the sufficient research of acoustofluidics in precise patterning and tissue engineering in this review, including the design and function of four typical acoustofluidic devices, various forms of cell patterning and 3D tissue engineering. Meanwhile, we outlined current challenges and future directions of acoustofluidics in biomedicine and tissue engineering.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"3 4","pages":"Pages 397-406"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138122000561/pdfft?md5=f31cb680c39eb7929cc631d8a3e55efc&pid=1-s2.0-S2666138122000561-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54300734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Wearable microneedle-integrated sensors for household health monitoring 用于家庭健康监测的可穿戴微针集成传感器

Engineered regeneration Pub Date : 2022-12-01 DOI: 10.1016/j.engreg.2022.09.002

Zezun Xie , Xiaoxuan Zhang , Guopu Chen , Junyi Che , Dagan Zhang

引用次数: 3

Engineered microneedles arrays for wound healing 用于伤口愈合的工程微针阵列

Engineered regeneration Pub Date : 2022-09-01 DOI: 10.1016/j.engreg.2022.05.003

Shun Yao, Yuan Luo, Yongan Wang

引用次数: 14

Construction and application of liver cancer models in vitro 肝癌体外模型的构建及应用

Engineered regeneration Pub Date : 2022-09-01 DOI: 10.1016/j.engreg.2022.07.004

Changmin Shao , Qingfei Zhang , Gaizhen Kuang , Qihui Fan , Fangfu Ye

引用次数: 6

Engineered extracellular vesicles: Regulating the crosstalk between the skeleton and immune system 工程细胞外囊泡:调节骨骼和免疫系统之间的串扰

Engineered regeneration Pub Date : 2022-09-01 DOI: 10.1016/j.engreg.2022.06.004

Wei-Wei Yu , Qian-Qian Wan , Yu Wei , Yu-Tao Li , Qi-Hong Li , Tao Ye , Ke-Hui Xu , Jing-Han Song , Chen Lei , Mei-Chen Wan , Kai Jiao , Franklin R Tay , Li-Na Niu

{"title":"Engineered extracellular vesicles: Regulating the crosstalk between the skeleton and immune system","authors":"Wei-Wei Yu , Qian-Qian Wan , Yu Wei , Yu-Tao Li , Qi-Hong Li , Tao Ye , Ke-Hui Xu , Jing-Han Song , Chen Lei , Mei-Chen Wan , Kai Jiao , Franklin R Tay , Li-Na Niu","doi":"10.1016/j.engreg.2022.06.004","DOIUrl":"10.1016/j.engreg.2022.06.004","url":null,"abstract":"<div><p>Osteoimmunology has gained momentum in recent years, focusing on the crosstalk between the skeleton and the immune system. Extracellular vesicles (EVs) are nanoscale vesicles that are potential candidates for cell-free tissue regeneration strategies. They may be used for repairing damaged tissues and regulating the body's immune system and bone-related metabolic activities. Because of the ability of EVs to deliver bioactive signals and mediate intercellular communication, they can decipher the complex mechanisms of interaction within the “osteoimmune system” at the molecular level. To address the lack of targeting ability caused by vesicle heterogeneity in the clinical applications of EVs, these nanoscopical entities may be modified by bioengineering techniques to optimize the interaction between bone repair and immunomodulation for improving treatment efficacy, specificity and safety. In the present review, the endogenous properties that make EVs natural delivery agents are outlined. Properties that may be improved by bioengineering are highlighted. The therapeutic applications of EVs in the rehabilitation of bone defects are discussed. The opportunities and challenges that need to be addressed for translating this field of research into clinical practice are brought into perspectives.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"3 3","pages":"Pages 270-282"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266613812200041X/pdfft?md5=40c721e736ea55df4b9dcba95c381f09&pid=1-s2.0-S266613812200041X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45874124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

3D Bioprinting with Live Cells 活细胞3D生物打印

Engineered regeneration Pub Date : 2022-09-01 DOI: 10.1016/j.engreg.2022.07.002

Alicia Persaud , Alexander Maus , Lia Strait , Donghui Zhu

{"title":"3D Bioprinting with Live Cells","authors":"Alicia Persaud , Alexander Maus , Lia Strait , Donghui Zhu","doi":"10.1016/j.engreg.2022.07.002","DOIUrl":"10.1016/j.engreg.2022.07.002","url":null,"abstract":"<div><p>In recent years, the shortage of available organs for transplant patients has grown exponentially across the globe. Consequently, the healthcare industry is in dire need of artificial substitutes. Many recent research studies and tissue engineering groups have decided to utilize 3D bioprinting to produce these artificial organs. This synthetic organ printing is made possible by advancements in the materials required for the constructs, the printing methodologies used to produce them, and the final physical structures’ varying properties. The cutting-edge research and technology related to 3D and 4D live cell bioprinting have recently allowed researchers to produce multiple types of artificial organs and tissues. These tissues can be utilized for drug screening and organ replacement applications. This article provides an extensive review of all the pertinent 3D live cell bioprinting technologies. First, we describe scaffolding methods and their comparison with the traditional technologies. Second, we explain the 3D bioprinting technology, its evolution, and its multiple types. Moreover, we describe the pros and cons of each bioprinting method. Third, we have discussed the critical bioink properties and their impact on the formation of 3D bioprinting models. In addition, we also describe the mechanical properties of bioprinters. Fourth, we have thoroughly discussed the various types of hydrogels and their properties. Every kind of hydrogel is utilized in specific applications, and we have presented a comprehensive list of its advantages and disadvantages. Fifth, we have discussed various applications of 3D bioprinting technology. We have considered a case study of human organs and elaborated on how bioprinters can revolutionize the organ replacement industry. Finally, we evaluated the possibility of 4D printing in the future organ industry, incorporating temporal factors into the bioprinting process.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"3 3","pages":"Pages 292-309"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138122000433/pdfft?md5=c32d5492d1365b7393fe9b4f617ef698&pid=1-s2.0-S2666138122000433-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43242459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Ellipsoidal porous patch with anisotropic cell inducing ability for inhibiting skin scar formation 具有各向异性细胞诱导能力的椭球状多孔贴片

Engineered regeneration Pub Date : 2022-09-01 DOI: 10.1016/j.engreg.2022.06.003

Wanqing Weng , Junjie Chi , Xiaocheng Wang , Keqing Shi , Fangfu Ye , Yuanjin Zhao

{"title":"Ellipsoidal porous patch with anisotropic cell inducing ability for inhibiting skin scar formation","authors":"Wanqing Weng , Junjie Chi , Xiaocheng Wang , Keqing Shi , Fangfu Ye , Yuanjin Zhao","doi":"10.1016/j.engreg.2022.06.003","DOIUrl":"10.1016/j.engreg.2022.06.003","url":null,"abstract":"<div><p>Scar formation has always been a difficult point to overcome in the field of clinical wound care. Here, we present an ellipsoidal porous patch with cell inducing ability for inhibiting scar formation. The patch was prepared by stretching a poly (lactic-co-glycolic acid) (PLGA) inverse opal film at the glass transition temperature to form a neatly arranged three-dimensional ellipsoidal porous structure. Such anisotropic structure showed dramatic capability in directing cell growth and arrangement by reconstructing cell morphology. Besides, the proliferation of cells growing on the stretched patch was significantly suppressed without cell cytotoxicity. In addition, benefitting from the abundant and connected nanopores, the patch could be imparted with a potent ability to promote cell migration by encapsulating fibroblast growth factor 2 (FGF2) <em>via</em> the second filling of functional gelatin methacryloyl (GelMA) hydrogel into its scaffold. In a typical scar model, we have demonstrated that the resultant patch performed well in inhibiting scar formation characterized by inhibiting the excessive proliferation of fibroblasts, decreasing the deposition of type I collagen, reducing the scar index and achieved complete tissue reconstruction. These results indicate the anisotropic inverse opal patch has an excellent application prospect in inhibiting scar formation during wound repair.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"3 3","pages":"Pages 262-269"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138122000354/pdfft?md5=ecf9a79c6e560983cb717c365498af79&pid=1-s2.0-S2666138122000354-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48668890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Recent advances in chiral aggregation-induced emission fluorogens 手性聚集诱导排放氟化物的研究进展

Engineered regeneration Pub Date : 2022-09-01 DOI: 10.1016/j.engreg.2022.07.003

Rui Hu , Yuncong Yuan , Meijia Gu , You-Quan Zou

{"title":"Recent advances in chiral aggregation-induced emission fluorogens","authors":"Rui Hu , Yuncong Yuan , Meijia Gu , You-Quan Zou","doi":"10.1016/j.engreg.2022.07.003","DOIUrl":"10.1016/j.engreg.2022.07.003","url":null,"abstract":"<div><p>Over the past decade, aggregation-induced emission (AIE) molecules have played a pivotal role in bioimaging, anti-microbial, and photodynamic therapy, and have been at the forefront of several disciplines worldwide. When combined with chiral moieties, they can easily collide with dazzling sparks and exhibit exceptional and unique advantages. In the application of chiral recognition and measurement of enantiomeric excess, it can identify chiral molecules visually based on color change and precipitation reaction, quantitatively analyze chiral molecules while determining the enantiomeric composition based on the fluorescence intensity change at different wavelengths, and obtain two parameters about chiral molecules from one measurement, thereby demonstrating its high selectivity, sensitivity and accuracy in chiral identification. In the field of organic circularly polarized luminescent (CPL) materials, the asymmetry (g<sub>lum</sub>) of common organic light emitting elements is usually between 10<sup>−5</sup> and 10<sup>−2</sup>, whereas the CPL asymmetry factor (g<sub>lum</sub>) of chiral AIE fluorogens (AIEgens) can reach 1.42, which is very close to the theoretical value of 2. Therefore, the combination of chiral elements and luminescent groups promotes their adoption in the field of organic CPL materials. Herein we have summarized the recent applications of chiral AIEgens in both chiral molecule recognition and circularly polarized organic light-emitting diode (CP-OLED) in order to provide future researchers with a more comprehensive and detailed understanding of chiral AIEgens and to encourage more scientists to contribute to the development of AIEgens.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"3 3","pages":"Pages 323-338"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138122000445/pdfft?md5=27ba85b89296089eac1826f370f7597a&pid=1-s2.0-S2666138122000445-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49100154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0