Engineered regeneration最新文献_第7页

Bis-5HT modified Paris Saponin II nanoparticles treat neutrophil infiltrating allergic rhinitis by regulating the alanine metabolism pathway Bis-5HT修饰的巴黎皂苷II纳米颗粒通过调节丙氨酸代谢途径治疗中性粒细胞浸润性变应性鼻炎

Engineered regeneration Pub Date : 2024-12-01 Epub Date: 2024-03-05 DOI: 10.1016/j.engreg.2024.02.004

Wenwen Qi , Lei Shi , Xinhao Wu , Fangyuan Zhu , Zhenxiao Teng , Xiaochen Gao , Xin Bing , Na Guo , Xue Cao , Chengzhilin Li , Houyang Hu , Fanyu Yuan , Yuhan Dong , Ming Xia , Chengcheng Liu

{"title":"Bis-5HT modified Paris Saponin II nanoparticles treat neutrophil infiltrating allergic rhinitis by regulating the alanine metabolism pathway","authors":"Wenwen Qi , Lei Shi , Xinhao Wu , Fangyuan Zhu , Zhenxiao Teng , Xiaochen Gao , Xin Bing , Na Guo , Xue Cao , Chengzhilin Li , Houyang Hu , Fanyu Yuan , Yuhan Dong , Ming Xia , Chengcheng Liu","doi":"10.1016/j.engreg.2024.02.004","DOIUrl":"10.1016/j.engreg.2024.02.004","url":null,"abstract":"<div><div>Allergic rhinitis (AR) has emerged as a global concern, particularly due to the recent rise in disease incidence. There is an urgent need for safer, more effective, and shorter-term targeted immunotherapy approaches. Our previous studies have demonstrated the potential of paris saponins II in mitigating neutrophil infiltration in the nasal mucosa of AR mice. However, its clinical applicability has been hampered by limited by bio availability and bioactivity. In response to these limitations, we have developed bis-5HT-modified paris saponins II (designated as PLGA-5HT-PSII-Ce6) to target neutrophil-specific myeloperoxidase. Our verification, using metabolomics and other techniques, has affirmed the enhanced therapeutic efficacy of this targeted drug for allergic rhinitis. Furthermore, the incorporation of photosensitizers has improved the treatment effect particularly when light induction is introduced. This development lead to promising prospects for the treatment of AR.</div></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 4","pages":"Pages 452-467"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143094066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyphenol-based photothermal nanoparticles with sprayable capability for self-regulation of microenvironment to accelerate diabetic wound healing 基于多酚的光热纳米颗粒具有可喷洒功能，可自我调节微环境以加速糖尿病伤口愈合

Engineered regeneration Pub Date : 2024-12-01 Epub Date: 2024-06-08 DOI: 10.1016/j.engreg.2024.05.003

Xiuhong Huang , Meimei Fu , Min Lu , Xiaoxian Wu , Weiqian David Hong , Xiaoying Wang , Panpan Wu , Keke Wu

{"title":"Polyphenol-based photothermal nanoparticles with sprayable capability for self-regulation of microenvironment to accelerate diabetic wound healing","authors":"Xiuhong Huang , Meimei Fu , Min Lu , Xiaoxian Wu , Weiqian David Hong , Xiaoying Wang , Panpan Wu , Keke Wu","doi":"10.1016/j.engreg.2024.05.003","DOIUrl":"10.1016/j.engreg.2024.05.003","url":null,"abstract":"<div><div>Current treatments for diabetic wounds have some curative effect, but the process is complicated and lack user-friendly wound dressings. Nanozymes have gained significant attention for wound healing due to their striking merits. Herein, we have developed a novel sprayable tannin acid-cobalt coordination nanozyme (TACo) for diabetic wound healing. TACo nanozyme offers a convenient and efficient methods by spraying directly onto wounds surface, reducing infection risk by avoiding direct contact. Notably, its antioxidant properties contribute to scavenging the reactive oxygen species (ROS), alleviating oxidative stress and inflammation of wound microenvironment. Additionally, TACo nanozyme could promote cell survival and multiplication, which is crucial for the wound healing process. Importantly, TACo nanozyme facilitates angiogenesis by enhancing cell viability, migration, and tube formation. The unique coordination between metal and phenolic components confers pH-responsive cobalt ion and TA release properties, avoiding secondary damage during the wound cleaning. This unique composition seamlessly integrates photothermal antibacterial therapy, inflammatory microenvironment management, supporting for angiogenesis, and effective promotion of extracellular matrix production sequentially by harnessing the acidic pH environment of diabetic wounds. In conclusion, the development of a sprayable TACo nanozyme presents a promising therapeutic approach for the treatment of diabetic wounds, addressing the complexities of current treatments and providing a user-friendly application method.</div></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 4","pages":"Pages 505-520"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141401788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel injectable composite incorporating denosumab promotes bone regeneration via bone homeostasis regulation 含有地诺单抗的新型可注射复合材料通过调节骨平衡促进骨再生

Engineered regeneration Pub Date : 2024-12-01 Epub Date: 2024-05-11 DOI: 10.1016/j.engreg.2024.05.001

Guang Yang , Zili Guo , Xiangfeng Zhang , Jiayu Chen , Jie Weng , Jiapeng Bao , Xiaohua Yu

{"title":"Novel injectable composite incorporating denosumab promotes bone regeneration via bone homeostasis regulation","authors":"Guang Yang , Zili Guo , Xiangfeng Zhang , Jiayu Chen , Jie Weng , Jiapeng Bao , Xiaohua Yu","doi":"10.1016/j.engreg.2024.05.001","DOIUrl":"10.1016/j.engreg.2024.05.001","url":null,"abstract":"<div><div>Repair of large bone defects remains to be clinically challenging, yet current bone repair strategies focus on optimizing the osteogenic capacity of bone grafts, while the role of osteoclasts in bone regeneration has been largely ignored. Herein, we designed a injectable self-curing bone grafting paste capable of regulating both anabolic/catabolic activities during bone healing by immobilizing the RANKL inhibitor denosumab on dermal-derived extracellular matrix (ECM) microfibres, which were then incorporated into an injectable paste via a hydration reaction between β-tricalcium phosphate (β-TCP), monocalcium phosphate monohydrate (MCPM) and calcium sulfate hemihydrate (CSH). The incorporation of ECM microfibres not only serves as a sustained-release denosumab carrier to inhibit osteoclastogenesis but also improves the mechanical properties of the resulting composite by increasing the interaction between the organic and inorganic phases. <em>In vitro</em>, calcium supply from the composite along with ECM enhanced osteogenic differentiation of BMSC while release of denosumab effectively inhibits osteoclast fusion and alleviate osteoclastic activity. <em>In vivo</em>, it was observed that CSH/CP@ECM-Deno significantly reduced the number of osteoclasts, slowed down the process of bone resorption, and accelerated collagen deposition to promote new bone generation. These results suggest that modulation of osteoclastogenesis by interfering with bone homeostasis may be an effective bone repair strategy.</div></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 4","pages":"Pages 482-494"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141026424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ginsenoside Rb1 improves human nonalcoholic fatty liver disease with liver organoids-on-a-chip 人参皂苷 Rb1 通过芯片上的肝脏器官改善人类非酒精性脂肪肝

Engineered regeneration Pub Date : 2024-09-01 Epub Date: 2024-06-21 DOI: 10.1016/j.engreg.2024.06.002

Hui Wang , Yue Zhu , Pengcheng Shi , Xiangyang Li , Qingyun Bu , Yachun Li , Xiaoyan You , Guoping Zhao

{"title":"Ginsenoside Rb1 improves human nonalcoholic fatty liver disease with liver organoids-on-a-chip","authors":"Hui Wang , Yue Zhu , Pengcheng Shi , Xiangyang Li , Qingyun Bu , Yachun Li , Xiaoyan You , Guoping Zhao","doi":"10.1016/j.engreg.2024.06.002","DOIUrl":"https://doi.org/10.1016/j.engreg.2024.06.002","url":null,"abstract":"<div><p>Non-alcoholic fatty liver disease (NAFLD), a type of liver disease for which no treatment is currently approved, remains a major concern worldwide. It is manifested as simple hepatocyte steatosis and can develop into inflammation, fibrosis, cirrhosis and liver cancer in severe cases. However, due to the lack of appropriate <em>in vitro</em> drug testing platforms, an in-depth understanding of the therapeutic activity of ginsenoside Rb<sub>1</sub> in NAFLD remains challenging. Here, we proposed a NAFLD model on a liver organoids (LOs)-on-a-chip platform to evaluate the therapeutic effect of ginsenoside Rb<sub>1</sub> in a dynamic, multi-condition and high-throughput manner. This platform allowed us to reshape certain features such as multicellular types and liver-specific functions of the physiology of the human-relative liver. Free fatty acids (FFAs)-induced LOs displayed typical pathological characteristics of NAFLD progression, including steatosis, oxidative stress, lipid peroxidation, inflammation and fibrosis. With ginsenoside Rb<sub>1</sub> intervention, these pathological features can be significantly improved, which may provide new insights into the potential mechanisms of NAFLD progression and treatment and suggest the clinical implications for humans. The proposed system enables the formation, differentiation, and function of LOs to serve as a scalable, high-throughput and sensitive drug testing model, to potentially expedite the NAFLD drug discovery.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 3","pages":"Pages 283-294"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138124000355/pdfft?md5=9242bd2656ea0d7f1e8b7950d5896503&pid=1-s2.0-S2666138124000355-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141484059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microalgae-based drug delivery systems in biomedical applications 生物医学应用中的微藻给药系统

Engineered regeneration Pub Date : 2024-09-01 Epub Date: 2024-01-15 DOI: 10.1016/j.engreg.2024.01.002

Hui Huang , Yutong Lang , Shoujie Wang , Min Zhou

{"title":"Microalgae-based drug delivery systems in biomedical applications","authors":"Hui Huang , Yutong Lang , Shoujie Wang , Min Zhou","doi":"10.1016/j.engreg.2024.01.002","DOIUrl":"10.1016/j.engreg.2024.01.002","url":null,"abstract":"<div><p>Over decades of development, the modern drug delivery system continues to grapple with numerous challenges, including drug loading inefficiencies, issues of immunogenicity, and cytotoxicity. These limitations restrict its application across various systems. Microalgae, as a natural resource, are not only abundant in bioactive compounds but also possess multiple biological properties, including active surface, photosynthesis capabilities, and excellent biocompatibility. These attributes make microalgae highly promising as carriers for targeted drug delivery, offering significant potential for the diagnosis and treatment of various diseases. Therefore, leveraging the exceptional properties of microalgae for drug delivery and optimizing their qualities is of paramount importance. This article focuses on elucidating the biological characteristics of microalgae and their applications in drug delivery, with a particular emphasis on emerging strategies for efficient drug loading and precise targeted delivery. Microalgae, as a natural biomaterial, hold immense potential for both commercial and clinical applications.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 3","pages":"Pages 361-374"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138124000033/pdfft?md5=a493ff0d8eca7ab0559446389aa566d9&pid=1-s2.0-S2666138124000033-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139539603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Instability-Driven 3D bioprinting for engineering composite bio-inks 用于工程复合生物墨水的不稳定性驱动三维生物打印技术

Engineered regeneration Pub Date : 2024-09-01 Epub Date: 2023-12-30 DOI: 10.1016/j.engreg.2023.12.004

Jing Ma , Cheng Qi , Zhou Liu , Si Meng , Tiantian Kong

{"title":"Instability-Driven 3D bioprinting for engineering composite bio-inks","authors":"Jing Ma , Cheng Qi , Zhou Liu , Si Meng , Tiantian Kong","doi":"10.1016/j.engreg.2023.12.004","DOIUrl":"10.1016/j.engreg.2023.12.004","url":null,"abstract":"<div><p>Extrusion-based 3D bioprinting techniques are revolutionizing bioengineering by facilitating the creation of complex 3D microstructures. This review offers a thorough overview of extrusion-based 3D bioprinting methods, particularly highlighting the innovative electric-assisted coil-write 3D bioprinting technology. The review begins by explicating the fundamental principles underlying various extrusion-based 3D bioprinting technologies. It covers the printing equipment composition, suitable materials for 3D bioprinting, and the latest breakthroughs in technology. A critical aspect of this review is the in-depth comparison of the strengths and weaknesses associated with each 3D bioprinting approach. The electro-microfluidic extrusion method and the electric-assisted coil-write 3D bioprinting technology are highlighted. This advanced technology successfully overcomes the limitations of conventional extrusion-based methods, notably in the precise printing of intricately curved line structures with high resolution and speed. This method ingeniously integrates mechanical motion for creating microscale features with electrical coiling for sub-micron details, thus achieving remarkable printing speeds and structural complexity. This review concludes by exploring the potential applications and future advancements of this state-of-the-art technology. It underscores the ability of electric-assisted coil-write 3D bioprinting to develop pioneering materials and micro-devices for a variety of technological sectors, highlighting its transformative impact in bioengineering.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 3","pages":"Pages 350-360"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138123000658/pdfft?md5=34dafb2b4b8cfbcefd7aae76e19a4aa4&pid=1-s2.0-S2666138123000658-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139195519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Muscle Tendon Junction in vitro Using Aligned Electrospun PCL Fibres 利用对齐的电纺 PCL 纤维体外开发肌肉肌腱接合处

Engineered regeneration Pub Date : 2024-09-01 Epub Date: 2024-01-24 DOI: 10.1016/j.engreg.2024.01.004

Nodoka Iwasaki , Marta Roldo , Aikaterina Karali , Alberto Sensini , Gordon Blunn

{"title":"Development of Muscle Tendon Junction in vitro Using Aligned Electrospun PCL Fibres","authors":"Nodoka Iwasaki , Marta Roldo , Aikaterina Karali , Alberto Sensini , Gordon Blunn","doi":"10.1016/j.engreg.2024.01.004","DOIUrl":"10.1016/j.engreg.2024.01.004","url":null,"abstract":"<div><p>The muscle tendon junction (MTJ) transmits the force generated by the muscle to the tendon and ultimately to the bone. Tears and strains commonly occur at the MTJ where regeneration is limited due poor vascularisation and the complexity of the tissue. Currently treatments for a complete MTJ tear are often unsuccessful. The creation of a tissue engineered MTJ would therefore be beneficial in the development of a novel treatment. In this study, aligned electrospun polycaprolactone fibres were fabricated and human myoblasts and tenocytes were cultured on the scaffold. The effect of 10 % cyclic strain and co-culture of myoblasts and tenocytes on the MTJ formation was investigated. The application of strain significantly increased cell elongation, and MTJ marker gene expression. Co-culture of myoblasts and tenocytes with strain induced higher MTJ marker gene expression compared with myoblasts and tenocytes cultured separately. Paxillin and collagen 22, naturally found in the MTJ, were also produced when cells were combined and grown in a 10 % strain environment. For the first time these results showed that the combination of the strain and co-culture of myoblasts and tenocytes promotes gene expression and production of proteins that are found in the MTJ.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 3","pages":"Pages 409-420"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138124000045/pdfft?md5=55ab791f447bb5a77a770af7438e5fa5&pid=1-s2.0-S2666138124000045-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139634864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immobilization of hUC-MSCs conditioned medium on 3D PLLA collagen-coated matrix enhances diabetic wound healing progression 将 hUC-MSCs 条件培养基固定在三维 PLLA 胶原包覆基质上可促进糖尿病伤口愈合进展

Engineered regeneration Pub Date : 2024-09-01 Epub Date: 2024-05-08 DOI: 10.1016/j.engreg.2024.04.005

Siufui Hendrawan , Olivia Marcelina , Sukmawati Tansil Tan , Hans Ulrich Baer

{"title":"Immobilization of hUC-MSCs conditioned medium on 3D PLLA collagen-coated matrix enhances diabetic wound healing progression","authors":"Siufui Hendrawan , Olivia Marcelina , Sukmawati Tansil Tan , Hans Ulrich Baer","doi":"10.1016/j.engreg.2024.04.005","DOIUrl":"10.1016/j.engreg.2024.04.005","url":null,"abstract":"<div><p>Conditioned medium (CM) derived from human umbilical cord-mesenchymal stem cells (hUC-MSCs) which contains numerous amounts of growth factors, has demonstrated potential in treatment of diabetic wounds. However, for practical application, a biodegradable supporting material is needed to hold the CM and fill in the injury site, where deep cavity wounds are often present in diabetic patients. Poly-<span>l</span>-lactic acid matrix coated with collagen (PLLA/CC) is a suitable carrier due to its biodegradability and biocompatibility. Thus, we present a method to immobilize the hUC-MSCs CM on PLLA/CC through freeze-drying process (PLLA/CC CM FD). When seeded on PLLA/CC CM FD, fibroblasts had an increased cellular function in producing collagen; although no enhancement in cell viability was observed. Moreover, implantation of PLLA/CC CM FD on the wound of diabetic rats showed improvement in wound closure and collagen deposition in the wound area. Altogether, this study exhibits the potential of PLLA/CC CM FD as a therapy for diabetic deep cavity wound.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 3","pages":"Pages 421-431"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138124000239/pdfft?md5=39d2a2a4e1fdbcf5b4cc3dfedc2e22ca&pid=1-s2.0-S2666138124000239-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141046404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-talk between biometal ions and immune cells for bone repair 生物金属离子与免疫细胞之间的交叉对话促进骨骼修复

Engineered regeneration Pub Date : 2024-09-01 Epub Date: 2024-01-17 DOI: 10.1016/j.engreg.2024.01.003

Shubo Liu , Zhengjie Lin , Wei Qiao , Bin Chen , Jie Shen

{"title":"Cross-talk between biometal ions and immune cells for bone repair","authors":"Shubo Liu , Zhengjie Lin , Wei Qiao , Bin Chen , Jie Shen","doi":"10.1016/j.engreg.2024.01.003","DOIUrl":"10.1016/j.engreg.2024.01.003","url":null,"abstract":"<div><p>Biometal ions are crucial in the structure and function of living organisms and have extensively been employed to promote bone tissue regeneration. Nevertheless, the biological functions of biometal ions and the underlying mechanisms responsible for their pro-regenerative effects remain incompletely understood, since bone repair is an intricate physiological process involving multiple cell types and signals. Recent accomplishments in the osteoimmunological field have revealed the momentous involvement of the immune system in mediating the therapeutic effects of biometal ions. The inflammatory factors secreted by immune cells contribute to bone cell migration, activation, and proliferation. This review summarizes the immune system and its constituent cells, followed by the current perspective on immunomodulation during bone healing. Next, the physicochemical and physiological properties of various biometal ions, including lithium, sodium, potassium, magnesium, calcium, strontium, vanadium, iron, cobalt, copper, and zinc, are thoroughly reviewed. In addition, the interactions between biometal ions, immune cells, and bone tissue are discussed, aiming to provide insights into the prospective development of novel approaches to bone tissue regeneration by harnessing the therapeutic potential of these biometal ions.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 3","pages":"Pages 375-408"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138124000021/pdfft?md5=317cfda685dd368b344b03045d820968&pid=1-s2.0-S2666138124000021-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139539552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing engineered approaches for sustainable wound regeneration and repair: Harnessing the potential of green synthesized silver nanoparticles 推进可持续伤口再生和修复的工程方法：利用绿色合成银纳米粒子的潜力

Engineered regeneration Pub Date : 2024-09-01 Epub Date: 2024-07-02 DOI: 10.1016/j.engreg.2024.06.004

J. Nandhini , E. Karthikeyan , E. Elizabeth Rani , V.S. Karthikha , D. Sakthi Sanjana , H. Jeevitha , S. Rajeshkumar , Vijayan Venugopal , A. Priyadharshan

{"title":"Advancing engineered approaches for sustainable wound regeneration and repair: Harnessing the potential of green synthesized silver nanoparticles","authors":"J. Nandhini , E. Karthikeyan , E. Elizabeth Rani , V.S. Karthikha , D. Sakthi Sanjana , H. Jeevitha , S. Rajeshkumar , Vijayan Venugopal , A. Priyadharshan","doi":"10.1016/j.engreg.2024.06.004","DOIUrl":"https://doi.org/10.1016/j.engreg.2024.06.004","url":null,"abstract":"<div><p>Wound healing is a crucial biological process for tissue repair and regeneration, preventing infections and complications. There's been a growing interest in exploring sustainable wound healing strategies in recent years. This review examines the use of green-synthesized silver nanoparticles (AgNPs) in sustainable wound healing strategies. It highlights the need for innovative approaches and the challenges posed by infections. The current wound therapies and treatments, highlighting gaps in existing methodologies, are evaluated. This review provides a comprehensive overview of the current state-of-the-art in green synthesis techniques for the synthesis of AgNPs. The properties and characterization of AgNPs are elucidated, providing insights into their efficacy. The biocompatibility of AgNPs in wound healing is also explored, emphasizing safety in medical applications. Green synthesized AgNPs incorporated wound dressings are detailed, showcasing their potential in clinical settings. Challenges and future perspectives are discussed, addressing hurdles to widespread implementation. The conclusion consolidates key findings, offering a synthesized perspective on the potential of green-synthesized AgNPs in revolutionizing current knowledge on innovative approaches for sustainable wound healing practices.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 3","pages":"Pages 306-325"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666138124000379/pdfft?md5=4d51fa5cd78a53e4abd401c3ebcd1952&pid=1-s2.0-S2666138124000379-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0