Bone improvement in osteoporotic rabbits using CoCrMo implants

Q1 Medicine
Jésica I. Zuchuat , Adriana S. Manzano , Valeria Sigot , Gastón L. Miño , Oscar A. Decco
{"title":"Bone improvement in osteoporotic rabbits using CoCrMo implants","authors":"Jésica I. Zuchuat ,&nbsp;Adriana S. Manzano ,&nbsp;Valeria Sigot ,&nbsp;Gastón L. Miño ,&nbsp;Oscar A. Decco","doi":"10.1016/j.engreg.2024.05.002","DOIUrl":null,"url":null,"abstract":"<div><div>The management of bone repair in patients with osteoporosis depends on the clinical situation and the extent of the damage. The repair of bone lesions by inducing new bone formation is important for maintaining bone architecture and density. Herein, we reported the use of Cobalt Chromium Molybdenum (CoCrMo) implants in osteoporotic rabbits and the regenerative outcomes <em>in vivo</em>. The aim was to determine whether the placement of CoCrMo plates would induce qualitative and quantitative differences in the osteoporotic tissue beneath and surrounding the implant. We assessed the effect of the alloy in the bone of animals receiving implants for 4 and 8 weeks and compared the results to those of the osteoporotic non-implanted bone and the healthy controls. After 4 weeks, minimal histological changes were observed, whereas after 8 weeks a marked osteogenesis was evident with both apposition and substitution of new bone. In addition, a greater number of Haversian canals with increased canal area and decreased intracortical pores were observed in the implanted <em>vs</em> non implanted limb for both experimental groups. We show for the first time that the use of CrCoMo plates induces bone formation under osteoporotic conditions. The beneficial effect is localised on the cortical bone in areas in contact with the material. Although this effect may not directly influence the OP disease itself, it has direct implications for new bone formation adjacent to the biomaterial. This potential enhancement could play a crucial role in improving implant fixation in compromised bone, offering increased biocompatibility and stability.</div></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"5 4","pages":"Pages 495-504"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Engineered regeneration","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666138124000264","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

Abstract

The management of bone repair in patients with osteoporosis depends on the clinical situation and the extent of the damage. The repair of bone lesions by inducing new bone formation is important for maintaining bone architecture and density. Herein, we reported the use of Cobalt Chromium Molybdenum (CoCrMo) implants in osteoporotic rabbits and the regenerative outcomes in vivo. The aim was to determine whether the placement of CoCrMo plates would induce qualitative and quantitative differences in the osteoporotic tissue beneath and surrounding the implant. We assessed the effect of the alloy in the bone of animals receiving implants for 4 and 8 weeks and compared the results to those of the osteoporotic non-implanted bone and the healthy controls. After 4 weeks, minimal histological changes were observed, whereas after 8 weeks a marked osteogenesis was evident with both apposition and substitution of new bone. In addition, a greater number of Haversian canals with increased canal area and decreased intracortical pores were observed in the implanted vs non implanted limb for both experimental groups. We show for the first time that the use of CrCoMo plates induces bone formation under osteoporotic conditions. The beneficial effect is localised on the cortical bone in areas in contact with the material. Although this effect may not directly influence the OP disease itself, it has direct implications for new bone formation adjacent to the biomaterial. This potential enhancement could play a crucial role in improving implant fixation in compromised bone, offering increased biocompatibility and stability.
使用钴铬钼合金植入体改善骨质疏松兔子的骨质
骨质疏松患者的骨修复处理取决于临床情况和损伤程度。通过诱导新骨形成来修复骨损伤对于维持骨结构和密度是重要的。在此,我们报道了钴铬钼(CoCrMo)植入物在骨质疏松兔子体内的使用和再生结果。目的是确定CoCrMo板的放置是否会引起种植体下方和周围骨质疏松组织的定性和定量差异。我们评估了合金在接受植入物4周和8周的动物骨骼中的作用,并将结果与骨质疏松的未植入骨和健康对照进行了比较。4周后,观察到最小的组织学变化,而8周后,随着新骨的附着和替代,明显的成骨。此外,与未植入肢体相比,植入肢体的哈弗斯管数量更多,管面积增加,皮质内孔减少。我们首次证明在骨质疏松的情况下使用CrCoMo钢板诱导骨形成。这种有益作用局限于与材料接触区域的皮质骨。虽然这种作用可能不会直接影响OP疾病本身,但它对生物材料附近的新骨形成有直接影响。这种潜在的增强可能在改善受损骨的种植体固定方面发挥关键作用,提供更高的生物相容性和稳定性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Engineered regeneration
Engineered regeneration Biomaterials, Medicine and Dentistry (General), Biotechnology, Biomedical Engineering
CiteScore
22.90
自引率
0.00%
发文量
0
审稿时长
33 days
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信