Diseases (Basel, Switzerland)最新文献

{"title":"Association Between Sleep Disturbance and Behavioral Feeding Problems in Children and Adolescents with Autism Spectrum Disorder.","authors":"Milagros Fuentes-Albero, Mayra Alejandra Mafla-España, José Martínez-Raga, Omar Cauli","doi":"10.3390/diseases13090280","DOIUrl":"10.3390/diseases13090280","url":null,"abstract":"<p><strong>Introduction: </strong>Children and adolescents with autism spectrum disorder (ASD) often present sleep and eating problems. However, the relationship between these two factors has seldom been studied.</p><p><strong>Objective: </strong>This paper aimed to examine the association between sleep disturbances and feeding problems in children and adolescents with ASD.</p><p><strong>Methods: </strong>This cross-sectional observational study assessed feeding behaviors using the Behavioral Pediatrics Feeding Assessment Scale (BPFAS) and assessed sleep problems with the Sleep Disturbance Scale for Children (Bruni scale). Bivariate analyses and multivariate logistic and linear regression analyses were performed.</p><p><strong>Results: </strong>Sleep disturbances were significantly associated with autism severity (<i>p</i> = 0.003), but not with BPFAS subscale scores. Multivariate logistic regression indicated that sleep disturbances were independently associated with autism severity (<i>p</i> = 0.01; OR = 0.23; 95% CI: 0.06-0.77) and the BPFAS frequency subscale score (<i>p</i> = 0.01; OR = 1.04; 95% CI: 1.01-1.07). A secondary logistic regression identified five BPFAS items significantly associated with sleep disturbances: difficulty chewing (<i>p</i> = 0.02, OR = 0.12, 95% CI 0.02-0.74), voluntary attendance at meals (<i>p</i> = 0.01, OR = 0.60, 95% CI 0.39-0.90), tantrums during meals (<i>p</i> < 0.001; OR = 2.08, 95% CI 1.21-3.56), poor appetite (<i>p</i> < 0.001; OR = 2.63, 95% CI 1.43-4.82), and the caregiver's perception that the child's eating habits negatively affected their health (<i>p</i> = 0.03; OR = 1.53, 95% CI 1.03-2.40). No significant associations were found with age, sex, medical comorbidities, behavioral disorders or genetic factors.</p><p><strong>Conclusions: </strong>The findings suggest that greater autism severity and more pronounced feeding behaviors are independently associated with an increased risk of sleep disturbances in children and adolescents with ASD. Specific maladaptive mealtime behaviors, such as poor appetite, tantrums, and chewing difficulties, may serve as predictors of sleep problems, highlighting the need for integrated screening and early intervention strategies.</p>","PeriodicalId":72832,"journal":{"name":"Diseases (Basel, Switzerland)","volume":"13 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12469203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of Circulating miR-31-3p and miR-196a-5p as Liquid Biopsy Markers in HPV-Negative Primary Laryngeal Squamous Cell Carcinoma.","authors":"Gergana Stancheva, Silva Kyurkchiyan, Iglika Stancheva, Julian Rangachev, Venera Dobriyanova, Diana Popova, Radka Kaneva, Todor M Popov","doi":"10.3390/diseases13090279","DOIUrl":"10.3390/diseases13090279","url":null,"abstract":"<p><strong>Background and objectives: </strong>Laryngeal cancer is a common head and neck tumor burden, with no significant improvements in long term patient survival. Despite the progress of molecular genetics and oncology strategies, there is still a lack of biomarker use in routine clinical practice for early laryngeal cancer screening or diagnosis. miRNAs are explored as promising molecules, that could serve as liquid biopsy. Our goal is to explore the screening potential of miR-31-3p and miR-196a-5p in early- and advanced-stage laryngeal HPV-negative plasma samples.</p><p><strong>Methods: </strong>In this study, 50 plasma samples obtained from early and advanced HPV-negative laryngeal cancer patients were included. The expression levels of mir-31-3p and miR-196a-5p were analyzed via TaqMan RT-qPCR. SPSS v27.0 was used for statistical analysis.</p><p><strong>Results: </strong>For the first time, miR-31-3p and miR-196a-5p were analyzed in plasma samples from early HPV-negative primary LSCC patients. Both circulating miRNAs showed significantly elevated expression levels in early and advanced laryngeal cancer samples. miR-31-3p was significantly associated with T stages (<i>p</i> < 0.001) and N stages (<i>p</i> = 0.009). The ROC analysis revealed that miR-31-3p could significantly discriminate early-stage from advanced-stage LSCC with an AUC of 0.850 (95% CI: 0.743-0.956, <i>p</i> < 0.001) at an RQ cutoff of 2.03, achieving a sensitivity of 95.5% and a specificity of 64%. Nevertheless, miR-196a-5p was found to be significantly overexpressed in early-stage LSCC, which could contribute to the development of its screening potential. For the first time, both miRNAs revealed a significant positive correlation, which indicates that miR-31-3p and miR-196a-5p could coregulate cancerogenesis.</p><p><strong>Conclusions: </strong>In conclusion, the data revealed that miR-31-3p has greater potential as an LSCC screening marker in comparison to miR-196a-5p. Still, miR-196a-5p also showed promising results in early-stage laryngeal cancer monitoring. The utilization of circulating miR-31-3p or miR-196a-5p analysis could enable liquid biopsy approaches, with results potentially informing treatment monitoring strategies, personalized oncological protocols, and early diagnosis. These advancements could ultimately benefit patient outcomes by improving laryngeal organ preservation and survival rates.</p>","PeriodicalId":72832,"journal":{"name":"Diseases (Basel, Switzerland)","volume":"13 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Management in Liver Cirrhosis: A Combined Systematic Review and Observational Study.","authors":"Valentina Amariței, Roxana-Elena Gheorghita, Olga Adriana Caliman Sturdza","doi":"10.3390/diseases13090278","DOIUrl":"10.3390/diseases13090278","url":null,"abstract":"<p><strong>Background: </strong>Liver cirrhosis is a complex and chronic pathology with the potential to impact a number of factors, including the patient's health, nutritional status and diet. Proper nutritional intake plays an essential role alongside the necessary medical and recovery treatments.</p><p><strong>Methods: </strong>This study was conducted on a group that included patients of varying age demographics. They were required to undertake a 24 h food recall as well as two other questionnaires (CNAQ and CLDQ-NASH) that reported the level of appetite and nutrition and other aspects that focused on the patient's general health and quality of life, respectively.</p><p><strong>Results: </strong>The results of the study indicated the presence of reduced appetite and a decrease in quality of life, as reported by questionnaire scores of less than 28 points for appetite and less than 4 points for quality of life. The 24 h dietary recalls revealed that the majority of patients exhibited a preference for meals comprising red and processed meats and traditional foods such as soups and animal foods and a low consumption of white meat, fish, legumes and fiber.</p><p><strong>Conclusions: </strong>The study's findings reveal an imbalance in the patients' nutritional intake and underscore the critical importance of nutritional support for patients with liver cirrhosis. However, further research is needed in this regard to determine the factors leading to nutritional deficiencies and the causes leading to refusal of nutritional intervention within the management of this disease.</p>","PeriodicalId":72832,"journal":{"name":"Diseases (Basel, Switzerland)","volume":"13 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Titers of IgG, IgM, and IgA Against SARS-CoV-2 in Healthcare Workers from a General Hospital in Mexico City.","authors":"Nelly Raquel González-Arenas, Mariana Dinazar Chavez-Vargas, Hector Prado-Calleros, Juan Pablo Ramírez-Hinojosa, Fernando Martinez-Hernandez, Angélica Olivo-Díaz, Pablo Maravilla, Mirza Romero-Valdovinos, Guillermina Ávila-Ramírez","doi":"10.3390/diseases13090276","DOIUrl":"10.3390/diseases13090276","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the present study was to better understand the antibody concentrations in healthcare workers (HCWs) from a hospital in Mexico City with a high density of COVID-19 patients.</p><p><strong>Methods: </strong>Up to 243 HCWs were recruited in 2020 and 2022 and were sorted into three groups: hybrid immunity (HI, natural infection plus vaccination), vaccine-induced immunity (VI), and unvaccinated but RT-qPCR negative at the beginning of the pandemic (UV). Peripheral blood and nasopharyngeal swab samples were obtained; additionally, saliva samples were obtained from the UV group. The titers of IgG, IgM, and IgA against the SARS-CoV-2 receptor-binding domain (RBD) and nucleocapsid (NCP) proteins were assessed using an in-house ELISA, and positivity to the virus was determined via RT-qPCR.</p><p><strong>Results: </strong>Most HI and VI participants were positive for serum anti-RBD IgG (92.8% and 100%, respectively), while 26.6% (for HI) and 19% (for VI) were positive for anti-NCP IgG. Regarding serum anti-RBD IgA, the VI and HI groups had positive rates of 87.3% and 66%, respectively. In contrast, the UV group showed a rate of 5.7% but the positivity for IgA in saliva was higher (52% for RBD and 35% for NCP). In addition, the highest antibody titers were obtained for anti-RBD IgG and IgA in the HI and VI groups, respectively. In saliva, the IgA antibody titer was higher for the RBD antigen (1:1280).</p><p><strong>Conclusions: </strong>These results strengthen our understanding of antibody concentrations in HCWs during two critical years of the pandemic in a general hospital with many COVID-19 patients.</p>","PeriodicalId":72832,"journal":{"name":"Diseases (Basel, Switzerland)","volume":"13 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive Increase in Small Intestinal Bacterial Overgrowth Risk Following COVID-19 Infection: A Global Population-Based Study.","authors":"Yilin Song, Thai Hau Koo, Benjamin D Liu, Linda L D Zhong, Tao Bai, Xiaohua Hou, Lei Tu, Gengqing Song","doi":"10.3390/diseases13090275","DOIUrl":"10.3390/diseases13090275","url":null,"abstract":"<p><strong>Background/objectives: </strong>Coronavirus disease 2019 (COVID-19) is associated with gastrointestinal (GI) symptoms. Small intestinal bacterial overgrowth (SIBO) is emerging as a significant GI sequela post-COVID-19 infection. This study aimed to evaluate the prevalence and incidence of SIBO post-COVID-19 infection across different age groups and to identify associated risk factors in a global cohort.</p><p><strong>Methods: </strong>A retrospective study utilized the TriNetX database and included adult patients (≥18 years) diagnosed with SIBO following COVID-19 infection (1 January 2022-30 May 2024). A propensity score matching (1:1) was used to adjust for demographics and SIBO risk factors. Kaplan-Meier survival analysis assessed the SIBO incidence within 12 months.</p><p><strong>Results: </strong>Among 1,660,092 COVID-19 patients and 42,322,017 controls, SIBO was diagnosed in 353 COVID-19 patients without hydrogen breath tests (BT) and 78 with BT, compared to 3368 controls without BT and 871 with BT. Age-specific analysis demonstrated a clear, progressive increase in the SIBO incidence, becoming distinctly significant by 6 months and highest at 12 months post-infection. The highest risks were noted in ages 60-69 (0.011% vs. 0.004%, OR 2.6, <i>p</i> = 0.0003) and 70-79 (0.011% vs. 0.005%, OR 2.0, <i>p</i> = 0.0004), with younger age groups (30-49 years) also showing significantly increased risks. The medication analysis revealed strong associations with chronic opioid, proton pump inhibitor, and antidiarrheal medication.</p><p><strong>Conclusions: </strong>COVID-19 significantly increased the risk of SIBO, particularly within the first 12 months post-infection, across various age groups and, notably, in association with certain chronic medications. Clinical vigilance and targeted management strategies are recommended to mitigate long-term GI consequences.</p>","PeriodicalId":72832,"journal":{"name":"Diseases (Basel, Switzerland)","volume":"13 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12469215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Activity of Silver-Bound Titanium Dioxide (Tiab) Against Multidrug-Resistant Bacteria from Dermatological Infections.","authors":"Lorenzo Drago, Fabiana Giarritiello, Loredana Deflorio, Angela Uslenghi, Vincenzo Minasi, Matteo Covi, Luigi Regenburgh De La Motte","doi":"10.3390/diseases13090277","DOIUrl":"10.3390/diseases13090277","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the in vitro antimicrobial activity of TiAB, a compound based on silver-bound titanium dioxide, against clinical isolates from dermatological infections.</p><p><strong>Methods: </strong>We tested 155 strains clinically isolated from ulcers and skin infections, including MRSA, ESBL-producing <i>Enterobacterales</i>, and <i>P. aeruginosa</i>. MIC and MBC values were determined using broth microdilution according to CLSI guidelines. Time-kill assays were performed at 0.5×, 1×, and 2× MIC. Median values were used to describe susceptibility profiles.</p><p><strong>Results: </strong>TiAB exhibited strong bactericidal activity against Gram-negative bacteria, including ESBL-positive <i>E. coli</i> and <i>K. pneumoniae</i>, with complete killing at 2× MIC (4-8%) within 4-8 h. Gram-positive pathogens exhibited higher MICs (≥8%) and limited response within 24 h; however, extending exposure to 48 h resulted in enhanced activity.</p><p><strong>Conclusions: </strong>TiAB exhibited in vitro bactericidal activity with median MIC values ranging from 1% to 2% (<i>w</i>/<i>v</i>) against Gram-negative clinical isolates such as <i>E. coli</i> and <i>P. aeruginosa</i>, and 2% to 4% against Gram-positive strains including MRSA. Time-kill assays confirmed ≥3 log₁₀ CFU/mL reductions for Gram-negative bacteria at 2× MIC within 24 h. These results suggest TiAB's potential as a topical antimicrobial agent, though further in vivo studies are needed to validate its safety and efficacy.</p>","PeriodicalId":72832,"journal":{"name":"Diseases (Basel, Switzerland)","volume":"13 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Fiber Intake Was Inversely Associated with All-Cause Mortality but Not with Cancer and Cardiovascular Disease Mortalities in the US.","authors":"Zoha Akbar, Sundus Fituri, Zumin Shi, Vijay Ganji","doi":"10.3390/diseases13080272","DOIUrl":"10.3390/diseases13080272","url":null,"abstract":"<p><strong>Background: </strong>Evidence linking dietary fiber intake with cancer risk and mortality is equivocal.</p><p><strong>Objective: </strong>We investigated the relationship between dietary fiber intake and all-cause, cancer, and cardiovascular disease (CVD) mortalities in US adults ≥ 20 years.</p><p><strong>Methods: </strong>Data from the National Health and Nutrition Examination Surveys (NHANES) from 2003 to 2016 were used. Seven two-year cycles were concatenated into one analytic data file, NHANES 2003-2016 (<i>n</i> = 25,868; age ≥ 20 years). Dietary fiber intakes were collected from one 24-h dietary recall. Fiber intakes were categorized into quartiles. Mortality information was obtained from data linkage. To determine mortality, subjects were followed up for 6.4 years. Association between dietary fiber and mortality from all causes, cancer, and CVD was determined with multivariable-adjusted Cox proportional hazards models. Multivariate-adjusted Cox proportional hazard regression was used to generate mortality survival rates.</p><p><strong>Results: </strong>During the follow-up period, out of 2520 deaths, 561 and 511 deaths were from cancer and CVD, respectively. Dietary fiber intake was inversely associated with all-cause mortality [RR (95% CI), 0.67 (0.56-0.80); <i>p</i> ≤ 0.001]. No relationship was observed between fiber intake and cancer mortality [RR (95% CI), 0.8 (0.55-1.17); <i>p</i> = 0.51] and CVD mortality [RR (95% CI), 0.84 (0.53-1.33); <i>p</i> = 0.67].</p><p><strong>Conclusions: </strong>In the US population, dietary fiber intake was associated with decreased all-cause mortality, but not with cancer and CVD mortality.</p>","PeriodicalId":72832,"journal":{"name":"Diseases (Basel, Switzerland)","volume":"13 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations for Augmenting Aripiprazole Long-Acting Injectables with Other Antipsychotics: A Mini-Review.","authors":"Jonathan Shaw, Ethan Kim, Emily Ton, Charles Lai, Peter Bota, Tina Allee","doi":"10.3390/diseases13080274","DOIUrl":"10.3390/diseases13080274","url":null,"abstract":"<p><p>Aripiprazole is a third-generation antipsychotic, approved in 2002, notable for its partial agonism of the Dopamine D2 receptor and lower risk of metabolic and extrapyramidal adverse effects. It is available in a long-acting injectable formulation, which is very useful for maintaining medication compliance, which is crucial for preventing recurrent psychotic episodes in patients. Additionally, the aripiprazole long-acting injectable is frequently combined with other antipsychotic medications in acute settings to manage refractory symptoms. However, there is limited literature regarding the psychopharmacology, efficacy, and adverse effect profiles of augmenting aripiprazole long-acting injectable with other antipsychotic medications. This narrative review intends to synthesize the existing literature on aripiprazole, its comparative affinity to the dopamine D2 receptor versus other antipsychotics, and the efficacy and side effect profiles of combining aripiprazole with other antipsychotics in the context of acute inpatient treatment for psychosis. Current literature on K_i values indicates that fluphenazine, pimozide, thiothixene, trifluoperazine, and perphenazine bind more strongly to dopamine D2 receptors than aripiprazole. However, there is a knowledge gap regarding antipsychotic polypharmacy with aripiprazole and these first generation antipsychotics, limiting the discussion of these drug combinations to theory. Additionally, the muscarinic effects of aripiprazole suggest the possibility of augmentation with clozapine or xanomeline-trospium, albeit the peer-reviewed literature on this was also limited. Overall, it is difficult to draw conclusions regarding best clinical practices for these scenarios, as the existing literature is contradictory. Nonetheless, the application of the dopamine and muscarinic pathway theories for schizophrenia opens venues for future research and consideration.</p>","PeriodicalId":72832,"journal":{"name":"Diseases (Basel, Switzerland)","volume":"13 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Obesity in the Regulation of Immunosuppressive Cell Infiltration and Immunosurveillance in Cancers.","authors":"Chunye Zhang, Keyao Zhu, Jiazheng Liu, Ming Yang","doi":"10.3390/diseases13080271","DOIUrl":"10.3390/diseases13080271","url":null,"abstract":"<p><p>Cancer is a leading cause of death worldwide, causing about 10 million deaths annually. Obesity contributes to cancer progression by inducing chronic inflammation, immunosuppressive microenvironment, metabolic dysfunction, and therapeutic resistance. Accumulating evidence shows that obesity can advance the infiltration of immunosuppressive cells and ameliorate the function and cytotoxicity of tumor-killing cells such as natural killer cells, natural killer T cells, macrophages, and CD8 T cells in cancer patients, resulting in cancer progression. Understanding the molecular signaling pathways involved in obesity-induced immunosuppression and cancer cell proliferation enables us to screen new biomarkers for cancer early diagnosis and improve anti-tumor therapeutic efficacy in obese patients with cancer. In this review, we first review the molecular mechanisms by which obesity induces the immunosuppressive landscape in the tumor microenvironment and some key obesity-associated factors causing immunotherapeutic suppression and metabolic dysfunction. Then, the application of natural products in the treatment of obesity and obesity-associated cancers is summarized. In addition, we discuss the contradictory functions of obesity in cancer risk and treatment outcome. The potent roles of precision medicine and artificial intelligence in the management of obesity-related cancers are highlighted.</p>","PeriodicalId":72832,"journal":{"name":"Diseases (Basel, Switzerland)","volume":"13 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endobiliary Radiofrequency Ablation for Hepato-Biliary Diseases: A Narrative Review.","authors":"Tawfik Khoury, Wisam Sbeit, Andrea Lisotti, Bertrand Napoléon","doi":"10.3390/diseases13080273","DOIUrl":"10.3390/diseases13080273","url":null,"abstract":"<p><strong>Background/objectives: </strong>Malignant biliary diseases still represent a therapeutic challenge given its poor prognosis, and limited response to the available curative treatments. Recently, endobiliary radiofrequency ablation (RFA) has been increasingly reported as an adjunct therapeutic option for biliary diseases, especially malignant biliary obstruction (MBO), due to potentially improving survival and stent patency.</p><p><strong>Methods: </strong>Herein, we provide a comprehensive review article discussing the indication, procedural details, safety, and comparative efficacy of endobiliary RFA to aid in providing an in-depth understanding of the clinical indications and future implications of this specific option.</p><p><strong>Results: </strong>Overall, endobiliary RFA is technically feasible, being associated with a high safety profile, significantly improving biliary stent patency, and having a potential benefit in extending the survival of patients with MBO who were treated with endobiliary RFA combined with biliary stenting vs. stenting alone. Moreover, it has a promising role in the treatment of intraductal extension of ampullary tumors.</p><p><strong>Conclusions: </strong>Endobiliary RFA had a beneficial therapeutic effect in biliary strictures, with potential impact on patients outcome and survival.</p>","PeriodicalId":72832,"journal":{"name":"Diseases (Basel, Switzerland)","volume":"13 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12386107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}