Discover nanoPub Date : 2025-07-01DOI: 10.1186/s11671-025-04255-1
Ali N A Koam, Muhammad Faisal Nadeem, Ali Ahmad, Abdullah Ali H Ahmadini, Bahreselam Sielu Abraha, Ibtisam Masmali
{"title":"Hosoya entropy analysis of some fullerene structures.","authors":"Ali N A Koam, Muhammad Faisal Nadeem, Ali Ahmad, Abdullah Ali H Ahmadini, Bahreselam Sielu Abraha, Ibtisam Masmali","doi":"10.1186/s11671-025-04255-1","DOIUrl":"10.1186/s11671-025-04255-1","url":null,"abstract":"<p><p>This study examines the structural complexity of fullerene graphs using Hosoya entropy as a measure. The entropy values were calculated for various fullerene structures, including <math> <mrow><msubsup><mi>F</mi> <mrow><mn>3</mn> <mo>,</mo> <mn>1</mn></mrow> <mi>s</mi></msubsup> <mo>,</mo></mrow> </math> <math><msubsup><mi>F</mi> <mrow><mn>4</mn> <mo>,</mo> <mn>2</mn></mrow> <mi>s</mi></msubsup> </math> and fullerenes ranging from C20 to C100.The relationship between the size of the fullerenes and the entropy is intuitively clear: the larger the fullerenes, the higher the value of entropy because of increased structural complexity and diversity of equivalence classes. Smaller fullerenes, like C20, have lower entropy, a consequence of their simpler and more symmetrical molecular structure. These findings provide theoretical insights into structural intricacies of fullerenes and their possible applications in material science and nanotechnology.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"100"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12214216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Discover nanoPub Date : 2025-06-30DOI: 10.1186/s11671-025-04251-5
Beena Cherian, Tijo Cherian, Teena Merlin, Shilpa Jose
{"title":"Investigation of antibiosis, anti-diabetic, antioxidant, anti-inflammatory, molecular docking and dye degradation potential of green synthesized copper ferrite (CuFe<sub>2</sub>O<sub>4</sub>) nanoparticles using mushroom Pleurotus florida.","authors":"Beena Cherian, Tijo Cherian, Teena Merlin, Shilpa Jose","doi":"10.1186/s11671-025-04251-5","DOIUrl":"10.1186/s11671-025-04251-5","url":null,"abstract":"<p><p>The current study proposes a low-cost, environmentally benign manufacturing approach of copper ferrite nanoparticles (CuFe<sub>2</sub>O<sub>4</sub> NPs) via mushroom extract of Pleurotus florida (PFE) as the first-time report. Several characterization methods verified the production of PFE-CuFe<sub>2</sub>O<sub>4</sub> NPs. The absorption spectrum exhibited the peak at 420 nm; band gap of 1.85 eV. The studies of SEM and TEM confirmed spherical and homogeneously distributed CuFe<sub>2</sub>O<sub>4</sub> NPs with an average size of 22.4 ± 1.4 nm. The FTIR reported the presence of bio-essential molecules in PFE can act as a stabilizing and capping agent. The NPs were found to be fairly stable with zeta potential found at 28.9 ± 0.2 mV. Numerous in vitro biological investigations exemplified the applicability and practicality of CuFe<sub>2</sub>O<sub>4</sub> NPs and compare them with the standard. The biofunctionalized CuFe<sub>2</sub>O<sub>4</sub> NPs demonstrated a potent antibacterial activity against E. coli and S. aureus. Additionally, it was discovered that CuFe<sub>2</sub>O<sub>4</sub> NPs have superior antioxidant activity (77-83%) and their scavenging ability is more comparable to ascorbic acid (control). Furthermore, a degradation efficiency of 91-92% was observed in 10-15 min for CuFe<sub>2</sub>O<sub>4</sub> NPs in rhodamine B (RhB) and methylene blue (MB) dyes, indicating their remarkable effectiveness in this regard. Future research may focus on applying CuFe<sub>2</sub>O<sub>4</sub> NPs to comprehensive wastewater treatment and determining the degradation products and ecological consequences.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"99"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Discover nanoPub Date : 2025-06-24DOI: 10.1186/s11671-025-04235-5
G Krishna Podagatlapalli
{"title":"The fundamentals of synthesis of the nanomaterials, properties, and emphasis on laser ablation in liquids: a brief review.","authors":"G Krishna Podagatlapalli","doi":"10.1186/s11671-025-04235-5","DOIUrl":"10.1186/s11671-025-04235-5","url":null,"abstract":"<p><p>Materials whose dimensions are less than 100 nm of diverse sizes and different shapes of the metal/semiconductor/insulator particles are known as nanomaterials. Nanomaterials exhibit very peculiar thermal, mechanical, electrical, optical, and chemical properties compared to their bulk counterparts. When a bulk material is chopped to a nano-dimension, electrons are subjected to peculiar boundary conditions, eventually leading to the nanomaterials' special properties. Due to their exceptional properties, nanomaterials have unique applications in all branches of science. Consequently, the researchers explored many methods of synthesis of the nanomaterials. However, each method has its advantages and disadvantages, some methods are flexible in synthesizing nanoparticles with uniform size distribution and some are feasible to produce nanomaterials at higher yields. Different methods follow their own synthesis protocols, time durations, economical feasibility, and reproducibility. Most methods complement one another by producing nanomaterials of evenly distributed sizes, shapes, properties, etc. Amongst, the, laser ablation of metals/semiconductors/insulators immersed in a liquid medium is a well-known method of green synthesis of nanomaterials that utilizes no hazardous chemical precursors. Laser ablation in liquids (LAL) combines top-down and bottom-up approaches that do not require lengthy sample preparations, chemical surfactants, and sophisticated experimental methodologies. The physical processes involved in the LAL of different metals/semiconductors are discussed briefly. Additionally, the applications of nanomaterials in various fields of science are included and the review is concluded with the challenges and the future scope of LAL.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"98"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Discover nanoPub Date : 2025-06-20DOI: 10.1186/s11671-025-04286-8
Ankush Goyal, Sachin S Chavan, Rajendra A Mohite, Israr A Shaikh, Yogesh Chendake, Dadaso D Mohite
{"title":"Emerging trends and perspectives on nano-fertilizers for sustainable agriculture.","authors":"Ankush Goyal, Sachin S Chavan, Rajendra A Mohite, Israr A Shaikh, Yogesh Chendake, Dadaso D Mohite","doi":"10.1186/s11671-025-04286-8","DOIUrl":"10.1186/s11671-025-04286-8","url":null,"abstract":"<p><p>The intensifying global demand for agricultural products has been met with the excessive use of conventional fertilizers, leading to significant environmental pollution, soil and water degradation, and public health concerns. This challenge has been further exacerbated by the pressures of globalization, necessitating the adoption of more sustainable and efficient farming practices. As a promising solution to these issues, nanotechnology has been explored for its innovative approaches to enhance nutrient delivery and reduce environmental impact. In this review, the potential of various nano-fertilizers-including nano-NPK, nano-nitrogen (N), nano-phosphorous (P), nano-potassium (K), nano-iron (Fe), hydroxyapatite (HAP)-modified urea nanoparticles, and nano-zeolite composite fertilizers-has been investigated for improving crop productivity and sustainability. The applications in key crops such as wheat, potato, maize, and rice have been analyzed, with significant yield improvements reported: 20-55% for wheat, 20-35% for potato, 20-40% for maize, and 13-25% for rice. Additionally, grain yield enhancements of 20-55% for wheat, 22-50% for maize, and 30-40% for rice have been observed. It has been emphasized that the optimization of nano-fertilizer concentrations and application methods is crucial to ensure plant health and environmental safety. The transformative role of nano-fertilizers in advancing sustainable agriculture to address global food security challenges has been underscored.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"97"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"2009-2023 Bibliometric analysis of the clinical value of graphene quantum dots in glioblastoma treatment.","authors":"Jingyan Zhu, Xiaoqing Li, Zhenhua Lin, Linzhuo Qu, Hongjian Guan","doi":"10.1186/s11671-025-04277-9","DOIUrl":"10.1186/s11671-025-04277-9","url":null,"abstract":"<p><p>Glioblastoma (GBM) is the most common primary brain tumour in adults and poses a serious health risk. Graphene quantum dots (GQDs) are zero-dimensional crystalline discs de-rived from two-dimensional graphene, which contribution of GQDs in the treatment of GBM and the great potential for future development. In this study, the Web of Science database was applied to search 462 relevant papers published between 2009 and 2023, and analyzed using VOS viewer and CiteSpace software tools. This analysis aims to provide researchers with insights into the current state of applications and to facilitate a clearer understanding of potential pathways and directions for future research in this field. Our study showed a continuous increase in the number of papers about GQDs in the treatment of GBM. In the field for more than a decade, GQDs has been a research priority in drug delivery due to their excellent optical and chemical properties. It is reasonable to believe that the use of GQDs for drug delivery for the treatment of GBM will be-come one of the extremely important research topics in the future.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"96"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gamma radiolytically synthesized phosphate decorated gold nanoparticles for ultra-trace level detection of U(VI) in water.","authors":"Nilanjal Misra, Swarnima Rawat, Shubhangi A Shelkar, Ayan Ghosh, Sanjay Kumar, Virendra Kumar","doi":"10.1186/s11671-025-04275-x","DOIUrl":"10.1186/s11671-025-04275-x","url":null,"abstract":"<p><p>We describe the <sup>60</sup>Co-Gamma radiolytic synthesis of stable poly(bis[2-(methacryloyloxy)ethyl] phosphate) (PB2MEP) -decorated gold nanoparticles (PB2MEP-Au) for spectrophotometric detection of uranium (U(VI)) in the ppb level. The developed technique is based on the Localize Surface Plasmon Resonance (LSPR) band intensity quenching, accompanied by a red shift in the wavelength range 523-545 nm at higher concentrations, due to interaction between U(VI) ion and phosphate group bearing PB2MEP-Au. The response was linear in the 5-80 ppb U(VI) concentration range, with LOD of 8.6 ppb. Samples were characterized by transmission electron microscopy, Particle Size Analysis and Zeta Potential measurements to determine morphological transitions upon analyte interaction. Density Functional Theory (DFT) calculations were invoked to study the Au nanoparticle stabilization mechanism, and revealed the interaction of U(VI) with PB2MEP-Au to be thermodynamically spontaneous for the formation of [UO<sub>2</sub>(B2MEP)<sub>2</sub>(H<sub>2</sub>O)]<sup>2+</sup> complex, the stability primarily driven by entropy. Interference by other coexisting metal ions was negligible up to interferent:target ratios of 10:1. The method was validated through quantification of U(VI) in water samples spiked with known U(VI) concentrations, the results being in corroboration with those reported using laser fluorimetric method. A T-test confirmed the results derived from the proposed method were not significantly different from those obtained using the standard estimation protocol at a 95% confidence level.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"95"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Discover nanoPub Date : 2025-06-16DOI: 10.1186/s11671-025-04279-7
Simon Bbumba, Moses Kigozi, Ibrahim Karume, Solomon Yiga, Hussein Kisiki Nsamba, Muhammad Ntale
{"title":"Carbon nanotubes and graphene as counter electrodes in dye-sensitized solar cells.","authors":"Simon Bbumba, Moses Kigozi, Ibrahim Karume, Solomon Yiga, Hussein Kisiki Nsamba, Muhammad Ntale","doi":"10.1186/s11671-025-04279-7","DOIUrl":"10.1186/s11671-025-04279-7","url":null,"abstract":"<p><p>Addressing the global demand for cost-effective and sustainable energy sources, dye-sensitized solar cells (DSSCs) have emerged as a promising alternative to conventional silicon-based photovoltaics. However, the use of platinum which is a rare and expensive counter electrode (CE) hinders the widespread application of DSSCs, necessitating the use of cheap, abundant, and efficient materials. The review therefore focuses on carbon-based nanomaterials specifically carbon nanotubes (CNTs) and graphene as CEs in DSSCs. The CE plays a vital role in regenerating the redox couple, and its charge transfer resistance (Rct) should ideally be 1 Ω cm² for optimal performance. Carbon nanotubes comprising single-walled carbon nanotubes (SWCNTs), double-walled carbon nanotubes (DWCNTs), and multiwalled carbon nanotubes (MWCNTs) are mainly prepared by chemical vapor deposition (CVD). The SWCNTs have achieved an efficiency of 7.79%, comparable to platinum electrodes, and this was due to the morphology, which influenced the redox mediator regeneration but also reduced the R<sub>ct</sub>. In addition, graphene with high transparency (97.7%), large specific surface area (2630 m<sup>2</sup> g<sup>- 1</sup>), excellent thermal conductivity (3000 W m<sup>- 1</sup> K<sup>- 1</sup>), and good carrier mobility properties (10,000 cm<sup>2</sup> V<sup>- 1</sup> S<sup>- 1</sup>) have also been applied. In this, the Graphene nanosheets demonstrated a 6.81% efficiency, comparable to platinum (7.59%) due to a high open circuit voltage (V<sub>oc</sub>), which accounts for the reduction of iodide/triiodide redox couple. Lastly, the Graphene nanoplatelets demonstrated a 9.3% efficiency comparable to that of Platinum 7.53% due to low charge transfer resistance, high electrocatalytic activity, and good fill factor.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"94"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Discover nanoPub Date : 2025-06-13DOI: 10.1186/s11671-025-04276-w
Saif Ahmad Khan, Zufika Qamar, Sunil Kamboj, Mohammad Moonis, Garima Rai, Shweta Dang, Pirthi Pal Singh, Ozair Alam, Suhel Parvez, Sanjula Baboota, Javed Ali
{"title":"Nose to brain delivery of nanostructured lipid carriers loaded with rivastigmine and nilotinib for treating Alzheimer's disease: preparation, cell line study, and in vivo evaluation.","authors":"Saif Ahmad Khan, Zufika Qamar, Sunil Kamboj, Mohammad Moonis, Garima Rai, Shweta Dang, Pirthi Pal Singh, Ozair Alam, Suhel Parvez, Sanjula Baboota, Javed Ali","doi":"10.1186/s11671-025-04276-w","DOIUrl":"10.1186/s11671-025-04276-w","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a complex neurodegenerative that affects over 55 million people worldwide, a number expected to double by 2050 due to aging populations. This growing prevalence imposes immense societal and economic burdens on healthcare systems and caregivers. AD is challenging to treat with monotherapy, making combination therapy a more effective approach. This study focuses on delivering Rivastigmine tartrate (RIV), and Nilotinib hydrochloride monohydrate (NIL), to the brain to achieve synergistic effects against AD. The optimal ratio of the drug combination was determined using the combination index that was performed using the Neuro2a cells line. It was found to be 1:1, emphasizing the synergistic effect against the cell lines. So, nanostructured lipid carriers (NLCs) were loaded with RIV and NIL, both individually and in combination, developed and optimized in this study. The developed formulations were thoroughly characterized for globule size, polydispersity index (PDI), and entrapment efficiency (EE) for each drug and the combination. The globule size was > 200 nm, PDI > 0.3; EE < 85% in all the developed formulations. On performing an in vitro cell availability study it was found that developed NLCs showed a 1.3 to 1.4-fold increase in the viability of the cells. On conducting an in vivo study, the concentration in the brain following administration of different formulations was in the order of RIV-NIL-NLC > NIL-NLC > RIV-NLC > RIV-NIL SUS > NIL-SUS > RIV-SUS. There was a 3.5 to 5-fold increase in the concentration of RIV and NIL in the brain when administered as RIV-NIL-NLC. So, it can be concluded that the NLCs with combined drugs showed promising results, enhancing drug permeability through the intranasal route, therefore could be used for treating AD.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"93"},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Camellia sinensis mediated silver nanoparticles: eco-friendly antimicrobial agent to control multidrug resistant Gram-positive Staphylococcus aureus.","authors":"Tasneem Juzer, Ranjani Soundharajan, Hemalatha Srinivasan","doi":"10.1186/s11671-025-04278-8","DOIUrl":"10.1186/s11671-025-04278-8","url":null,"abstract":"<p><p>Staphylococcus aureus provokes several clinical infections, and its treatment remains challenging due to the rise of multidrug-resistant strains. In the current scenario it's a vital need for alternative strategies to control the spread of MDR S. aureus. Therefore, considerable effort has been put forth to develop green nanoparticles. Camellia sinensis is enriched with phytocompounds with potent antibacterial properties. Green synthesis strategy is more sustainable and non-toxic compared to traditional chemical processes. CsAgNps was synthesized by mixing 1 part of fresh extract of C. sinensis extract with 2 parts of 1mM silver and employing photocatalytic reduction for the period of 8 h until visible colour change was observed. Synthesized CsAgNps were characterized by employing various techniques to study the size, charge, topography and elemental composition. According to the findings of the in-silico analysis, phytocompounds of C. sinensis including Protopine, Ellagic acid, Catechin and Techtochrysin were recognized as potential lead compounds against various virulent targets in S. aureus. CsAgNps were tested for its antimicrobial and antibiofilm activity in MDR and MTCC (1430). The study results showed that it controls growth and biofilm formation of strains at the concentration of 12.5 µg/mL. The potential lead compounds against various virulent targets in S. aureus were analyzed using in-silico technique. Future research in the development of healthcare products will focus on optimization of ecofriendly material with targeted and sustainable release and enhancing antimicrobial efficacy particularly on MDR pathogens. CsAgNps can be incorporated to develop nano-based health care products to control antibiotic resistant S. aureus infections.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"92"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Discover nanoPub Date : 2025-06-10DOI: 10.1186/s11671-025-04269-9
Chih-Chiang Wang, Arvind Mukundan, Riya Karmakar, Kadu Samarth Jalindra, Hsiang-Chen Wang
{"title":"Synthesis of 2D Tungsten disulphide WS<sub>2</sub> for biosensing: a unique perspective on emerging applications.","authors":"Chih-Chiang Wang, Arvind Mukundan, Riya Karmakar, Kadu Samarth Jalindra, Hsiang-Chen Wang","doi":"10.1186/s11671-025-04269-9","DOIUrl":"10.1186/s11671-025-04269-9","url":null,"abstract":"<p><p>Two-dimensional (2D) materials have garnered momentous consideration owing to their inimitable structural and physiochemical properties, enabling diverse technological applications. Tungsten disulfide (WS<sub>2</sub>), a prominent transition metal dichalcogenide, exhibits exceptional characteristics such as a tunable bandgap, large surface area, and strong biocompatibility, making it highly suitable for biosensing applications. This review explores various WS<sub>2</sub> synthesis techniques, including mechanical exfoliation, sonication, and chemical exfoliation, highlighting their impact on nanosheet quality and scalability. Furthermore, it examines WS<sub>2</sub>'s role in biosensing, particularly in cancer biomarker detection, DNA/RNA sensing, enzyme activity monitoring, and pathogen identification. Despite its promising applications, challenges such as oxidation, long-term stability, and large-scale synthesis persist. Future advancements in hybrid nanostructures, functionalization techniques, and AI-assisted biosensing are expected to enhance WS<sub>2</sub>'s reliability and expand its practical deployment. By addressing these challenges, WS<sub>2</sub>-based technologies can drive significant innovations in diagnostics and environmental monitoring.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"91"},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}