Discover nano最新文献

{"title":"Phytochemical based on nanoparticles for neurodegenerative alzheimer disease management: Update review.","authors":"Basma Youssef, Ehab A Ibrahim, Said S Moselhy, Shaimaa ElShebiney, Walaa K Elabd","doi":"10.1186/s11671-025-04356-x","DOIUrl":"https://doi.org/10.1186/s11671-025-04356-x","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is one of the most common chronic neurodegenerative diseases and dementia, with about 46 million cases worldwide and going to become tripled by 2050. It is characterized by formation and aggregation of amyloid-β plaques, tau tangles, and inflammatory mediators. The treatment protocol poses challenging obstacles particularly, effectiveness drug delivery to the brain. However, the available therapies with low potency and blood-brain barrier (BBB) are most challenges for developing novel treatments. New delivery systems that interact with biological systems at the molecular level, such as nanotechnology can overcome these problems and open new therapeutic avenues. Nanoparticles showed different applications in medicine due to its bioavailability, transport and low toxicity. This review explored the therapeutic potential of natural phytochemical nanomedicine that important in AD treatment through improving drug delivery system across BBB, increasing bioavailability and minimizing neurotoxicity.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"176"},"PeriodicalIF":4.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface-specific performance of metal and metal oxide nanoparticles in latent fingerprint visualisation.","authors":"Anuj Sharma, Mahipal Singh Sankhla, Sumeet Singh Bhati, Anugya Agrawal, Shivani Tyagi","doi":"10.1186/s11671-025-04317-4","DOIUrl":"https://doi.org/10.1186/s11671-025-04317-4","url":null,"abstract":"<p><p>Latent fingerprint (LFP) visualisation remains a cornerstone method in forensic science, with ongoing developments aimed at enhancing clarity, sensitivity, and substrate compatibility. Due to their ability to tailor surface chemistry and optical properties, nanoparticles present a promising avenue for fingerprint development, especially on various types of surfaces. However, there has been a lack of understanding regarding the comparative behaviour of nanoparticles across different substrates. This review aims to address this gap by critically comparing the surface-specific performance of metal and metal oxide nanoparticles. In which we consider common nanoparticles for LFP development, such as Gold, Silver, silica, zinc oxide, Titanium dioxide, iron oxide, Copper oxide, and Aluminium oxide. Our review examines how various nanoparticles influence fingerprint residue on porous and non-porous surfaces and assesses their effectiveness in terms of clarity, durability using these nanoparticles. Our key finding of comparative analysis highlights that gold nanoparticles yield promising outcomes even on historically challenging porous substrates due to their affinity for sweat and amino acids. Conversely, zinc oxide and titanium dioxide exhibit superior fluorescence-based contrast on non-porous surfaces such as glass and plastics, as well as some porous surfaces. The rest of the nanoparticles were able to achieve their success on porous and non-porous surfaces with some limitations. We also outline diverse methods employed by various researchers, including dusting, brushing, spraying, and fluorescence imaging, while emphasising the role of substrate texture and the functionalization of nanoparticles. The review provides insights using comparative tables on selecting effective nanoparticle-based methods for specific forensic contexts to achieve more stable and universal fingerprint recovery in criminal investigations.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"175"},"PeriodicalIF":4.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of grain types and graphene nanopowder characteristics on insecticidal efficacy against common grain insects.","authors":"Evagelia Lampiri, Pei Lay Yap, Christos G Athanassiou, Dusan Losic","doi":"10.1186/s11671-025-04359-8","DOIUrl":"https://doi.org/10.1186/s11671-025-04359-8","url":null,"abstract":"<p><p>The increasing resistance of insects to chemical-based pesticides is a critical challenge in crop production, demanding the urgent development of sustainable and effective pest control alternatives. In response, this study presents the insecticidal potential of graphene materials in the form of nanopowders as new chemical and resistance free grain protectants. The influence of the grain types such as rice, maize, and wheat and graphene nanopowder characteristics on insectidicial efficacy against common grain insects was evaluated against three most destructive grain insects including: the rice weevil, Sitophilus oryzae (L.) (Coleoptera; Curculionidae), the maize weevil, Sitophilus zeamais Motschulsky (Coleoptera; Curculionidae), and the red flour beetle, Tribolium castaneum Herbst (Coleoptera; Tenebrionidae). Three industrially produced graphene nanopowders with distinct physicochemical properties (particle size, surface chemistry, hydrophobicity) were used at two dosage rates (500 and 1000 ppm). Mortality of insects was assessed after 7, 14, and 21 days of exposure, and progeny production was evaluated after 65 days. The results indicated that S. oryzae exhibited the highest susceptibility among the tested species, with rice grains experiencing the most significant insect mortality across all graphene concentrations (500 and 1000 ppm). Significant reductions in progeny with minor produced insects were observed, especially in maize, highlighting the long-term protective effects of graphene nanopowders. The insectidicial mode of action is attributed to a physical mechanism involving the adhesion of graphene particles to insect bodies, obstructing respiration and disrupting the cuticle. These findings suggest that graphene nanopowders, due to their unique structural, chemical and interfacial properties, have a strong potential to be used as new grain protectants, providing unique physical mode of action.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"174"},"PeriodicalIF":4.5,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient encapsulation of CRISPR-Cas9 RNP in bioreducible nanogels and release in a cytosol-mimicking environment.","authors":"Peter Westarp, Thorsten Keller, Jessica Brand, Sonja Horvat, Krystyna Albrecht, Chase Beisel, Juergen Groll","doi":"10.1186/s11671-025-04316-5","DOIUrl":"10.1186/s11671-025-04316-5","url":null,"abstract":"<p><p>CRISPR/Cas9-mediated programmable gene editing has disrupted the biotechnology industry since it was first described in 2012. Safe in vivo delivery is a key bottleneck for its therapeutic use. Viral vector-mediated delivery raises concerns due to immunogenicity, long-term expression, and genomic disruption. Delivery of pre-complexed ribonucleoprotein (RNP) reduces off-target effects, and recombinant Cas9 production is more cost-effective than viral vector synthesis. CRISPR-Cas RNPs do not possess intrinsic cell entry mechanisms, and physical delivery methods are confined to ex vivo editing, necessitating non-viral delivery approaches. Nanogels (NG) are biocompatible polymeric nanoparticles capable of entrapping proteins. Here, we report the first proof of principle that NGs from thiol-functionalized polyglycidol can entrap active RNPs with high efficiency (60 ± 2%). We call these particles CRISPR-Gels. A commercially available E. coli lysate for cell-free transcription and translation (TXTL) was used to mimic the intracellular reductive degradation of NGs while providing a real-time fluorescence readout of RNP activity. Degradation and RNP activity were observed within 30-90 min. The described TXTL assay can be utilized to evaluate the release of RNP in a cytosol-mimicking environment from redox-sensitive nanoparticles in a high-throughput and cost-effective way. Further studies are needed to assess the in vitro and in vivo performance of CRISPR-Gels.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"119"},"PeriodicalIF":4.5,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12297123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green synthesis of silver silver chloride (Ag/AgCl) nanoparticles using macadamia nutshell xylan extract, characterization and evaluation of its antibacterial activity.","authors":"Andrew K Yegon, Joshua Akinropo Oyetade, Stanslaus G Mtavangu, Mwemezi J Rwiza, Revocatus L Machunda","doi":"10.1186/s11671-025-04192-z","DOIUrl":"10.1186/s11671-025-04192-z","url":null,"abstract":"<p><p>Currently, there is unprecedented emergence of antimicrobial resistant (AMR) bacteria which demand urgent development of novel strategies to combat bacterial infections in humans. In this study, we report on a facile and eco-friendly green synthesis of silver-silver chloride nanoparticles (Ag/AgCl-NPs) using macadamia (Macadamia integrifolia) nutshell (MNS) agro-waste. The effects of physicochemical parameters including pH, Ag ion precursor concentration, time, and temperature were investigated. The biosynthesized Ag/AgCl-NPs sample was characterized using ultraviolet visible spectroscopy (UV-Vis), Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD) spectroscopy, field emission scanning spectroscopy (FE-SEM), Transmission electron microscopy (TEM), and energy dispersive X-ray (EDX). UV-Vis spectroscopy exhibited surface plasmon resonance (SPR) between 420 and 446 nm typical for silver nanoparticles (AgNPs). FT-IR spectroscopy provided an insight of the phytochemicals responsible for the reduction of Ag⁺ into Ag^o and capping/stabilizing the formed Ag/AgCl-NPs. XRD spectroscopy revealed the formation of crystalline Ag/AgCl-NPs with characteristic peaks at around 38.3°, 44.1°, 64.6°, and 77.5° for AgNPs, and 28.9°, 31.9°, 45.4°, 56.3°, and 66.1° for AgCl NPs. FE-SEM spectroscopy exhibited spherical and block like morphologies of agglomerated Ag/AgCl-NPs. TEM illustrated polydisperse spherical shapes of Ag/AgCl-NPs with average particle sizes of 31.11 nm. EDX confirmed the presence of Ag and Cl elements confirming the formation of Ag/AgCl-NPs. The antibacterial activity of the green synthesized Ag/AgCl-NPs was performed using disc diffusion method and the zone inhibition (ZOI) evaluation showed their effectiveness against Gram negative (E. coli) and Gram positive (S. aureus).</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"120"},"PeriodicalIF":4.5,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12297126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transformative bioprinting: 4D printing and its role in the evolution of engineering and personalized medicine.","authors":"Vidhi Mathur, Prachi Agarwal, Meghana Kasturi, S Varadharajan, Elsa Sanatombi Devi, Kirthanashri S Vasanthan","doi":"10.1186/s11671-025-04230-w","DOIUrl":"10.1186/s11671-025-04230-w","url":null,"abstract":"<p><p>Transformative bioprinting, particularly 4D printing, is revolutionizing the field of biofabrication, offering dynamic solutions that respond to external stimuli. This paper explores the underlying mechanisms, materials, and stimuli that enable 4D printing to fabricate responsive and adaptive constructs. Section 1 delves into the foundational aspects of 4D bioprinting, detailing the stimuli-responsive materials, such as hydrogels and shape-memory polymers, and the mechanisms that drive their transformation. Additionally, the role of external factors, including temperature, pH, and magnetic or light-based stimuli, is analyzed to provide a comprehensive understanding of this evolving technology. Section 2 focuses on the diverse applications of 4D bioprinting, particularly in biomedical sciences. Key use cases include tissue engineering, drug delivery systems, and the creation of adaptive implants. Beyond healthcare, the potential for smart structures in fields like robotics and aerospace is highlighted, showcasing the technology's ability to deliver tailored, dynamic solutions across various domains. Section 3 categorizes additive manufacturing techniques relevant to 4D printing, offering an in-depth classification and comparison. This includes extrusion-based, vat polymerization, and inkjet printing technologies, emphasizing their compatibility with stimuli-responsive materials. Section 4 shifts focus to commercial advancements, presenting a classification of 4D bioprinters available in the market. The economic barriers, challenges in scalability, and ease of application for these printers are critically examined. Proposed solutions, such as innovative material sourcing, streamlined design strategies, and integration with AI for optimized performance, are presented to address these issues. This work provides a roadmap for integrating 4D bioprinting into scalable and cost-effective production, pushing the boundaries of biofabrication. It serves as a comprehensive guide for researchers and industries aiming to harness the transformative potential of 4D printing for adaptive and functional applications across various domains.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"118"},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nucleation in microemulsions: a case study of Ir-Pd nanoparticles.","authors":"Concha Tojo","doi":"10.1186/s11671-025-04315-6","DOIUrl":"10.1186/s11671-025-04315-6","url":null,"abstract":"<p><p>Surface segregation of components is a key factor in determining the physicochemical properties and catalytic activity of bimetallic nanoparticles. In this study, computer simulations are used to analyze the metal distribution of Ir-Pd nanoparticles synthesized via microemulsions. Based on the high difference between the reduction potentials, an Ir-core/Pd-shell structure is expected. However, experimental results have shown a higher Ir fraction at the surface (15-23%). The hypothesis is that this unexpected results may be due to differences in nucleation rates. To investigate this, we performed a systematic study on the influence of critical nucleus size on the final nanostructure when the two metals have very different reduction rates. Our aim was to determine the conditions under which Ir can reach the nanoparticle surface. The results confirm that the large difference in reduction rates mainly governs metal segregation, leading to core-shell structures. However, when the concentration is close to the critical nucleus value, a slower nucleation rate results in higher Ir enrichment at the surface. It can be attributed to both a slow homoatomic nucleation rate and to a slow heteroatomic nucleation rate of Ir-Pd. At higher concentrations, this effect disappears as the higher reactant availability facilitates nucleation, resulting in similar metal segregation regardless of the critical nucleus size. Good agreement between experimental and simulation results supports the conclusions of this study.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"117"},"PeriodicalIF":4.5,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micro-nanoscale laser subsurface vertical modification of 4H-SiC semiconductor materials: mechanisms, processes, and challenges.","authors":"Hongmei Li, Hongwei Wang, Yuxin Li, Xiwen Lu, Lin Li, Yinzhou Yan, Wei Guo","doi":"10.1186/s11671-025-04309-4","DOIUrl":"10.1186/s11671-025-04309-4","url":null,"abstract":"<p><p>Wide-bandgap semiconductor materials, exemplified by silicon carbide (SiC), have emerged as pivotal materials in semiconductor devices due to their exceptional chemical stability, high electron mobility, and thermal stability. With the rapid development of microelectronic devices and integrated optical circuits, the demand for high-yield and high-quality processing of SiC wafer has intensified. Traditional SiC wafer processing technologies suffer from low efficiency and high material loss, making it difficult to meet industrial demands. Therefore, the development of efficient, low-damage processing techniques has become a pressing issue in the SiC wafer processing field. Ultrashort pulsed laser processing, with its advantages of contact free processing, no mechanical stress, and small heat-affected zones, has garnered significant attention in SiC wafer processing in recent years. By generating a modified layer within the material, laser processing plays a crucial role in wafer fabrication. However, the key challenge lies in precisely controlling the thickness of the modified layer down to the micro-nano scale to minimize material loss. This review systematically discusses the interaction mechanisms and modification processes of laser with wide-bandgap semiconductor SiC materials. It focuses on the core issue in laser modification technology, where nonlinear effects make it difficult to precisely control the modification layer depth, thereby affecting both modification quality and processing efficiency. To address this, the paper summarizes the differences in modification mechanisms with lasers of varying pulse durations and proposes a multi-strategy solution to improve modification quality and processing efficiency through pulse control and synergistic optimization of process parameters. Additionally, this review provides a comprehensive overview of advanced SiC wafer detachment processes, including cold cracking stripping, chemically assisted stripping, ultrasonic stripping, and multi-laser composite stripping, and identifies the primary challenges and future directions in the field of SiC wafer processing.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"116"},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biofilms and oral health: nanotechnology for biofilm control.","authors":"Deenadayalan Karaiyagowder Govindarajan, Maline Mohanarangam, Lohita Kadirvelu, Sowmiya Sri Sivaramalingam, Deepsikha Jothivel, Anand Ravichandran, Saravanan Periasamy, Kumaravel Kandaswamy","doi":"10.1186/s11671-025-04299-3","DOIUrl":"10.1186/s11671-025-04299-3","url":null,"abstract":"<p><p>Dental biofilms are complex microbial communities enclosed by a self-produced extracellular matrix, leading to dental caries, periodontitis, and other oral diseases. These biofilms are often resistant to conventional antibiotics and result in persistent infections that negatively impact oral health. Recent advances in nanotechnology have demonstrated nanoparticles as a promising therapeutic alternative for controlling dental biofilms. In addition, such nanoparticles possess unique physicochemical properties such as high surface area-to-volume ratio, enhanced reactivity, and ability to penetrate biofilm structures. Therefore, this review explores the potential of various nanoparticles, such as silver, zinc oxide, and titanium dioxide, in disrupting biofilm formation and removal of pathogenic oral biofilm forming bacteria. Additionally, this review critically examines various strategies for surface functionalization of nanoparticles to enhance their antimicrobial efficacy and biofilm-targeting capabilities. Furthermore, the article also presents various applications of dental materials coated with nanoparticles in preventing biofilm adhesion and growth. In essence, this review article will provide collective information on various approaches in using nanoparticles to reduce the risk of recurrent oral infections and enhance overall dental health.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"114"},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dimensions, structure, and morphology variations of carbon-based materials for hydrogen storage: a review.","authors":"Shadykulova Assyl, Suleimenova Botakoz, Zholdayakova Saule","doi":"10.1186/s11671-025-04229-3","DOIUrl":"10.1186/s11671-025-04229-3","url":null,"abstract":"<p><p>The swift and far-reaching evolution of advanced nanostructures and nanotechnologies has accelerated the research rate and extent, which has a huge prospect for the benefit of the practical demands of solid-state hydrogen storage implementation. Carbonaceous materials are of paramount importance capable of forming versatile structures and morphology. This review aims to highlight the influence of the carbon material structure, dimension, and morphology on the hydrogen storage ability. An extensive range of synthesis routes and methods produces diverse micro/nanostructured materials with superb hydrogen-storing properties. The structures of carbon materials used for hydrogen adsorption, from 0 to 3D, and fabrication methods and techniques are discussed. Besides highlighting the striking merits of nanostructured materials for hydrogen storage, remaining challenges and new research avenues are also considered.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"115"},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}