Discover nano最新文献

{"title":"Dimensions, structure, and morphology variations of carbon-based materials for hydrogen storage: a review.","authors":"Shadykulova Assyl, Suleimenova Botakoz, Zholdayakova Saule","doi":"10.1186/s11671-025-04229-3","DOIUrl":"10.1186/s11671-025-04229-3","url":null,"abstract":"<p><p>The swift and far-reaching evolution of advanced nanostructures and nanotechnologies has accelerated the research rate and extent, which has a huge prospect for the benefit of the practical demands of solid-state hydrogen storage implementation. Carbonaceous materials are of paramount importance capable of forming versatile structures and morphology. This review aims to highlight the influence of the carbon material structure, dimension, and morphology on the hydrogen storage ability. An extensive range of synthesis routes and methods produces diverse micro/nanostructured materials with superb hydrogen-storing properties. The structures of carbon materials used for hydrogen adsorption, from 0 to 3D, and fabrication methods and techniques are discussed. Besides highlighting the striking merits of nanostructured materials for hydrogen storage, remaining challenges and new research avenues are also considered.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"115"},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biogenic α-Fe₂O₃ nanoparticles from Sorghum bicolor leaf extracts and assessment of the anticancer and antioxidant properties.","authors":"Lerato D Msimango, Mercy C Ogwuegbu, Doctor M N Mthiyane, Damian C Onwudiwe","doi":"10.1186/s11671-025-04281-z","DOIUrl":"10.1186/s11671-025-04281-z","url":null,"abstract":"<p><p>The synthesis of nanomaterials has recently shifted toward environmentally benign approaches that mitigate the drawbacks of conventional chemical methods. In this context, plant-mediated green synthesis offers a sustainable and versatile alternative for producing nanoparticles with unique physicochemical properties and diverse applications. This study presents the green synthesis of hematite iron oxide nanoparticles (α-Fe₂O₃ NPs) using aqueous leaf extracts of Sorghum bicolor. The resulting nanoparticles were characterized using X-ray diffraction (XRD), UV-visible spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy-dispersive X-ray spectroscopy (EDX). XRD analysis confirmed the formation of a crystalline rhombohedral hematite phase with an average crystallite size of 46.8 nm. SEM and TEM images revealed predominantly spherical particles with evident agglomeration, while EDX analysis confirmed iron (Fe) and oxygen (O) as the primary elemental constituents. Antioxidant activity assessed via the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay showed a concentration-dependent radical scavenging effect, with higher α-Fe₂O₃ NP concentrations required to achieve 50% inhibition. Cytotoxicity studies on HeLa (cancer) and HEK293 (normal) cell lines indicated selective toxicity, with the nanoparticles preferentially affecting cancer cells while sparing healthy ones. Although the α-Fe₂O₃ NPs exhibited lower potency compared to the standard chemotherapeutic agent 5-fluorouracil, their concentration-dependent reduction in cell viability supports the hypothesis that cancer cells are particularly vulnerable to disruptions in iron homeostasis. This cost-effective and eco-friendly synthesis method underscores the potential of Sorghum bicolor-mediated α-Fe₂O₃ nanoparticles for future biomedical applications.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"113"},"PeriodicalIF":4.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ni₃S₂@MoO₃@Co₃O₄@AMO/NF core-shell heterostructure for high performance alkaline overall water splitting.","authors":"Jiabang Liang, Yu Liu, Zegao Wang, Yifan Jia, Zhao Ding, Liangjuan Gao","doi":"10.1186/s11671-025-04283-x","DOIUrl":"10.1186/s11671-025-04283-x","url":null,"abstract":"<p><p>The urgent need for bi-functional high-performance non-noble metal-based catalysts for water splitting requires the integration of both oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) together, which not only increases the energy efficiency but also reduces fabrication cost. However, most non-noble metal-based catalysts for OER are not stable under alkaline conditions, while HER shows poor kinetic performance under alkaline conditions, which prevents the water splitting from scale-up applications. Therefore, in this paper, non-noble metal-based catalyst of Ni₃S₂@MoO₃@Co₃O₄@AMO/NF was prepared by a two-step hydrothermal method followed by a galvanic replacement reaction with morphological characterization, demonstrating that the synthesized material has a core-shell structure. The electrochemical properties of Ni₃S₂@MoO₃@Co₃O₄@AMO/NF were tested and analyzed, which confirmed its efficient electrocatalytic activity. The catalyst exhibited excellent OER in 1 M KOH solution, and a low overpotential of 248 mV was achieved at a current density of 10 mA cm^-2. In addition, the catalyst maintained competitively low overpotentials even at high current densities, 281 mV and 303 mV at 50 mA cm^-2 and 100 mA cm^-2, respectively. Remarkably, only an overpotential of 185 mV was required to reach the current density of 10 mA cm^-2 for HER. The excellent OER and HER performances could be attributed to the synergistic effects among AMO, Co₃O₄ and MoO₃. In addition, Ni₃S₂@MoO₃@Co₃O₄@AMO/NF required only 1.414 V at 10 mA cm^-2 to complete the overall water splitting and exhibited excellent competitiveness also at high current densities (1.769 V and 1.975 V at 50 mA cm^-2 and 100 mA cm^-2, respectively). The morphology of Ni₃S₂@MoO₃@Co₃O₄@AMO remained stable after long time i-t tests, which proved its long-term operational stability. The Faraday efficiencies of the OER and HER could reach 75.92% and 97.51%, respectively, which showed excellent electrocatalytic performance. Therefore, the synthesis of high-performance bifunctional catalysts based on a two-step hydrothermal reaction followed by a galvanic replacement reaction proposed in this study provides a new strategy for the simple and efficient synthesis of non-noble metal-based catalysts for high-performance overall water splitting.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"112"},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in nanoparticle-based doxorubicin delivery: precision strategies for targeted treatment of triple-negative breast cancer.","authors":"Navakanth Raju Ramayanam, Sarad Pawar Naik Bukke, Murali Krishna Moka, Himanshu Dehingia, Aditya Bordoloi, Riya Debbarma, Purushothama Reddy Kudumula, Balakrishna Vuyyala, P Dharani Prasad, Akugizibwe Catherine","doi":"10.1186/s11671-025-04308-5","DOIUrl":"10.1186/s11671-025-04308-5","url":null,"abstract":"<p><p>Triple-negative breast cancer (TNBC) is a prevalent and aggressive subtype of breast cancer, accounting for approximately 10-15% of all cases. Its lack of hormone receptors and poor clinical prognosis make targeted therapy particularly challenging, leaving chemotherapy as the mainstay treatment. However, conventional chemotherapy is associated with significant limitations, including cardiotoxicity and inadequate tumor cell specificity. Nanoparticle-based drug delivery systems have emerged as a promising strategy for enhancing the therapeutic efficacy of doxorubicin (DOX) in TNBC. Among these, cell membrane-coated nanoparticles, exosome-sheathed porous silica nanoparticles, and FZD7-targeted nanoparticles have demonstrated substantial potential. These platforms improve drug delivery efficiency while minimizing systemic toxicity and adverse effects. Cell membrane-coated nanoparticles evade immune surveillance, allowing for selective targeting of TNBC cells. Exosome-sheathed nanoparticles facilitate the co-delivery of DOX with other therapeutic agents aimed at inhibiting cancer stem cell-driven epithelial-to-mesenchymal transition. FZD7-targeted nanoparticles enhance DOX accumulation within tumor cells by binding specifically to FZD7 receptors, leading to increased apoptosis and reduced cancer cell metabolic activity. This review aims to examine recent advancements in nanoparticle-based delivery systems for DOX in the treatment of TNBC. It further explores various formulations-including liposomes and polymeric nanoparticles-used for DOX delivery, assesses active and passive targeting strategies, and evaluates the advantages of controlled drug release. The review also identifies current gaps in the literature and proposes future research directions to advance the clinical applicability of these systems. Emerging concepts such as the active transport and retention mechanism and macrophage-mediated delivery systems offer new opportunities to improve tumor localization and retention of DOX-loaded nanoparticles. Collectively, these developments underscore the transformative potential of nanoparticle-based DOX delivery in revolutionizing TNBC therapy.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"111"},"PeriodicalIF":0.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xenes-based QCM sensors: exploring borophene and silicene for humidity sensing.","authors":"Ahmet Gulsaran, Bersu Bastug Azer, Gamze Gursu, Cihat Tasaltin, Nevin Tasaltin, Dogu Ozyigit, A-Reum Kim, Boxin Zhao, Michael A Pope, Mustafa Yavuz","doi":"10.1186/s11671-025-04284-w","DOIUrl":"10.1186/s11671-025-04284-w","url":null,"abstract":"<p><p>Borophene and silicene, two novel members of the Xene family, feature high surface reactivity and stability suitable for sensing applications. However, the gas sensing capabilities of these materials in their pristine form have not been systematically investigated. Here we show that borophene- and silicene-based quartz crystal microbalance (QCM) sensors achieve stable and sensitive relative humidity detection and we model their adsorption-desorption mechanisms. Borophene and silicene nanosheets were synthesized via liquid-phase exfoliation and characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy, and Brunauer-Emmett-Teller surface area analysis. The QCM sensors exhibited sensitivities of 3.2 Hz/%RH and 3.9 Hz/%RH, response/recovery times of 122/65 s and 47/130 s and hysteresis of 1.8% and 3.8% hysteresis for borophene and silicene, respectively. The dominant sensing mechanism was determined to be chemisorption, supported by thermodynamic modeling. These results suggest that 2D borophene and silicene can significantly contribute to sensing applications, especially in environments requiring air stability.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"110"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12254456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of Al, Ga, and In doping on ZnO nanorod arrays grown via citrate-assisted hydrothermal technique for highly efficient and fast scintillator screens.","authors":"Murat Kurudirek, Sinem V Kurudirek, Anna Erickson, Nolan Hertel, Benjamin J Lawrie, Yauhen Tratsiak, Benjamin Klein, Charles L Melcher, Christopher J Summers, Paul J Sellin","doi":"10.1186/s11671-025-04227-5","DOIUrl":"10.1186/s11671-025-04227-5","url":null,"abstract":"<p><p>To be used as efficient alpha particle scintillator in the fields of nuclear security, nuclear nonproliferation and high-energy physics, scintillator screens must have high light output and fast decay properties. While there has been a great deal of progress in scintillation efficiency, achieving fast decay time properties are still a challenge. In this work, the near band edge (NBE) UV luminescence and alpha particle induced scintillation properties of vertically aligned densely packed ZnO nanorods (NRs) doped with Al, Ga, and In have been thoroughly investigated. The high crystalline hexagonal wurtzite structure with a strong orientation through the c-axis plane (002) and aspect ratios in the range 13-22 have been observed for all ZnO NRs. Electron paramagnetic resonance (EPR) analysis exhibited paramagnetic signals at g ≈ 1.96 for all ZnO NRs. A cost effective green hydrothermal synthesis technique was employed to grow well-aligned NRs. Using citrate as an additive acting as a strong reducing agent in the solution during the crystal growth, defects on the surface are significantly suppressed, thereby enhancing the NBE UV emission. Significantly higher NBE UV emission was observed from the top surface of ZnO NRs in cathodoluminescence (CL) microscopy. Results show that citrate assisted donor doping of ZnO NRs not only reduces the defect emission and NBE self-absorption, but also induces fast decay time (~ 600-700 ps), which makes ZnO NRs a good candidate for fast alpha particle scintillator screens used in associated particle imaging for time and direction tagging of individual neutrons generated in D-T and D-D neutron generators.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"109"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12254462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiscale construction of wave-absorbing carbon nanomaterials.","authors":"Tong Wu, Song Bi, Hao Li, Ruihua Xing, Jun Yang, Xuanyu Liu, Zhuoxun Li","doi":"10.1186/s11671-025-04287-7","DOIUrl":"10.1186/s11671-025-04287-7","url":null,"abstract":"<p><p>With the gradual improvement of electromagnetic protection of equipment and electromagnetic pollution prevention requirements, carbon heterostructured wave-absorbing nanomaterials have become a research hotspot due to their tunable electromagnetic properties, high stability, and lightweight advantages. In this paper, we comprehensively and deeply discuss the multi-scale construction of carbon nano-absorbent materials, and elaborate on the design strategy and research progress from the micro-, meso- and macro-levels. At the microscopic level, the structure of carbon materials is controlled at the nanoscale by means of intrinsic structural design, elemental doping and interfacial modulation to introduce more microstructural defects to enhance the polarisation and scattering of electromagnetic waves, thereby improving the wave-absorbing performance. The mesoscopic level focuses on the modulation of the micro-nano multilevel structure of carbon absorbers, such as the in situ multilevel assembly of MXene, MOFs and heterogeneous continuous fibers at the mesoscopic scale, which is conducive to the enhancement of the absorber's conductivity and interfacial loss to enhance its wave-absorbing ability. The macroscopic level focuses on structure-function integrated design, such as 3D porous structures, sandwich honeycomb structures, and surface superstructures, which enable the materials to possess excellent mechanical properties along with good wave-absorbing properties. The comprehensive use of these design strategies to optimize the whole design chain of wave-absorbing materials is conducive to maximizing the performance and application value of the materials. The aim of this paper is to elucidate the effect of multiscale heterostructures on carbon-based wave-absorbing materials, which provides a reference for the precise design of their wave-absorbing properties.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"107"},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12246295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mass and stiffness sensing performance of nanomechanical resonators: viability of infectious virus detection.","authors":"Manuel Gómez-Moreno, Juan Molina, José J Ruz, Óscar Malvar, Javier Tamayo, Montserrat Calleja, Álvaro San Paulo","doi":"10.1186/s11671-025-04295-7","DOIUrl":"10.1186/s11671-025-04295-7","url":null,"abstract":"<p><p>We examine the performance of nanomechanical resonators for mass and stiffness sensing of nanoparticulate analytes with focus on their application for untargeted infectious virus detection. The characteristic narrow mass distributions of viruses, together with the existing correlations between their stiffness and infectivity, point out to nanomechanical sensors as a particularly suited alternative to molecular detection techniques, constrained by limited processing speed, target-specificity, and the inability to directly assess infectivity. We present a theoretical analysis of the response of flexural beam resonators to the adsorption of nanoparticulate analytes, and derive analytical expressions for the mass and stiffness sensing responsivity, resolution and signal to noise ratio as a function of the beam characteristics and analyte adsorption parameters. We demonstrate that both the mass and stiffness of viruses can contribute to resonance frequency shifts that significantly exceed the fundamental detection limits of beams with plausible dimensions and for realistic adsorption parameters. Particularly, stiffness resolution can reach levels well below the stiffness variations observed in some viruses as a consequence of maturation, enabling an integrated approach for infectivity assessment. We conclude that the practical application of nanomechanical spectrometry for infectious virus detection is not limited by the performance of state-of-the-art sensor technology, but by the efficiency of analyte delivery methods, encouraging future research on optimizing their implementation.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"108"},"PeriodicalIF":4.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12246276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered NiO/TiO₂ and CuO/NiO/TiO₂ heterojunctions for sustainable direct photocatalytic epoxidation of propylene using molecular oxygen.","authors":"Nicola Morante, Katia Monzillo, Alessandro Padua, Andrea Muscatello, Diana Sannino, Serena Esposito, Vincenzo Vaiano","doi":"10.1186/s11671-025-04296-6","DOIUrl":"10.1186/s11671-025-04296-6","url":null,"abstract":"<p><p>The selective photocatalytic epoxidation of propylene using molecular oxygen under UV-A irradiation presents a promising sustainable alternative for propylene oxide (PO) production. In this study, NiO/TiO₂ and CuO/NiO/TiO₂ heterojunction photocatalysts were synthesized via the thermal annealing of sol-gel-derived TiO₂ and tested in a fluidized bed photoreactor. Structural and optical characterizations confirmed the successful deposition of NiO onto TiO₂ and highlighted the crucial role of NiO content in optimizing charge separation and catalytic efficiency. Among the NiO/TiO₂ series, the NiO(1.1%)/TiO₂ composite exhibited the lowest photoluminescence intensity, indicating reduced electron-hole recombination, while UV-Vis DRS analysis revealed a red shift in the absorption onset and a reduction in the band gap energy. These features resulted in enhanced light absorption and facilitated charge transfer, leading to superior photocatalytic performance compared to lower and higher NiO loadings. Under irradiation, NiO(1.1%)/TiO₂ achieved a propylene conversion of 52.5%, a selectivity to PO of 83.4%, and a PO yield of 43.8%, confirming its effectiveness in promoting selective epoxidation. The introduction of CuO to form the CuO(1.1%)/NiO(1.1%)/TiO₂ heterojunction further enhanced the catalytic performance, reaching 61% propylene conversion, 92% selectivity to PO, and a PO yield of 56%. The improved activity was attributed to the efficient conversion of molecular oxygen into hydrogen peroxide, which acts as a selective oxidant for epoxide formation. Process optimization revealed that water vapor (1000 ppm) significantly enhanced PO selectivity, while incident light intensity played a crucial role in determining conversion rates. The system exhibited excellent stability over 24 h of continuous operation, with no observable deactivation. Furthermore, an energy efficiency analysis demonstrated an exceptionally low energy consumption of 0.019 kWh per mole of propylene converted, significantly outperforming existing photocatalytic systems. These findings highlight the potential of CuO/NiO/TiO₂-based photocatalysts, combined with fluidized bed reactors, as an energy-efficient and scalable approach for sustainable PO production.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"104"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advancement of fisetin-based nanoformulations in the management of psoriasis.","authors":"Umesh B Telrandhe, Anjum N Hasnain, Sachin N Kothawade, Darshan R Telange","doi":"10.1186/s11671-025-04298-4","DOIUrl":"10.1186/s11671-025-04298-4","url":null,"abstract":"<p><p>Psoriasis is a chronic inflammatory autoimmune skin disease with enhanced skin cell turnover. Despite the therapies currently available, better and target-oriented therapies are needed. Fisetin is a flavonoid with antioxidant, anti-inflammatory, and immunomodulatory properties. It shows therapeutic potential, but its poor bioavailability and penetration into the skin cannot be used effectively to treat psoriasis. While fisetin-loaded nanoformulations in cancer and other diseases have been explored, their potential as a therapy for psoriasis is unexplored. Most reviews detail the biological activities of fisetin or nanoformulations for psoriasis therapy but not their combination. The review here compiles fisetin's chemical and pharmacological properties along with the problems with conventional drug delivery and fisetin-loaded nanoformulations such as polymeric nanoparticles, liposomes, solid lipid nanoparticles, nanogels, and micelles. It also discusses their mechanisms, preclinical results, and potential for the clinic. Preclinical studies demonstrate fisetin nanoformulations to enhance penetration into the skin, reduce inflammation, promote skin regeneration in psoriasis models, and alleviate symptoms of redness and scaling. Clinical trials are lacking, and studies are needed to assess safety and efficacy. Fisetin nanoformulations are a potential target-oriented psoriasis therapy with better drug delivery and fewer side effects than conventional therapies. Despite formulation stability, scalability, and regulatory issues, the potential for fisetin-loaded nanoformulations is excellent and needs further exploration for their safety and efficacy in patients.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"20 1","pages":"105"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12234425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}